In the eastern mining area of Ningxia, China, multi-layered sandstone aquifers are widely distributed in the underground. However, the water abundance of these aquifers is not clear, which brings great challenges to the prevention and control of mine water disaster. In this paper, five mining areas in eastern Ningxia were taken as the study area, and the distribution characteristics of aquifer and the mine water filling source were analyzed through the analysis of geological data and numerical simulation. Finally, the lithology influencing index (LII) was constructed, and the water abundance of the aquifer was evaluated. The results show that the sandstone aquifer III in the lower part of the Jurassic Zhiluo formation is the main water-source aquifer of the #2 coal seam in the study area, while the middle aquifer II and the upper aquifer I are indirect water-source aquifers; the areas with extremely strong and strong water abundance are Maiduoshan, Hongliu, the south of Shicaocun, southeast and southwest of Meihuajing, and the central and southern areas of Shuangma mining areas; when the depth of water drainage boreholes in the roof reaches the development height of the water-conducting fracture zone, the pre-drainage measures can effectively control the mining inrush water of the working face and ensure the safety production. This research is of great significance to the prevention and control of mine water disaster.