Mechanical Function Research Articles

Respiratory Infections in the Aging Lung: Implications for Diagnosis, Therapy, and Prevention.

Respiratory infections pose a significant health problem among elderly individuals, particularly during the COVID-19 pandemic. The increased mortality and morbidity rates among individuals over 65 highlight the criticality of these infections. The normal aging process in the lungs increases vulnerability to respiratory infections due to the accumulation of cellular damage and senescence. Consequently, the lung environment undergoes major changes in mechanical function and other systemic factors. This review aims to examine the influence of aging on respiratory infections from a clinical perspective by analyzing clinical studies. Additionally, the review will emphasize potential prevention and diagnostic developments to enhance therapy options available for elderly patients over 65 years of age.

Atomic surface of quartz glass induced by photocatalytic green chemical mechanical polishing using the developed SiO2@TiO2 core-shell slurry.

High-performance devices of quartz glass demand an atomic surface, which induces a challenge for chemical mechanical polishing (CMP) with a high material removal rate (MRR). Moreover, traditional CMP usually employs toxic and corrosive slurries, leading to the pollution of the environment. To overcome these challenges, a novel green photocatalytic CMP is proposed. In the CMP, SiO2@TiO2 core-shell abrasives were developed, and the CMP slurry included the developed abrasives, sodium carbonate, hydrogen peroxide and sorbitol. After photocatalytic CMP, the surface roughness Sa of quartz glass is 0.185 nm, with a scanning area of 50 × 50 μm2, and the MRR is 8.64 μm h-1. To the best of our knowledge, the MRR is the highest on such a big area of atomic surface for quartz glass. X-ray photoelectron spectroscopy reveals that SiO2@TiO2 core-shell abrasives were used as photocatalysts motivated by simulated solar light, generating electrons and holes and producing hydroxyl radicals through hydrogen peroxide. As a result, OH- could combine with Si atoms on the surface of quartz glass, forming Si-OH-Si bonds. Then the formed bonds were removed based on the balance between chemical and mechanical functions. The proposed CMP, developed SiO2@TiO2 abrasives and slurry provide new insights to achieve an atomic surface of quartz glass with a high MRR.

The impact of characteristic function of Shapley value mechanism in distributed machine learning environment for equipment diagnosis

The distributed machine learning environment with multiple data providers has recently gotten attention. By using this environment, a production equipment manufacturer and its customer companies can collaboratively perform large-scale machine learning for equipment diagnosis. To construct a high-performance machine learning model, the environment should compensate and reward each data provider for sensing, collecting, and cleansing relevant and informative data. Most previous studies use Shapley-value-based incentive mechanism for this purpose. However, they do not consider the impact of the characteristic function used to evaluate the Shapley value on the behavior of the data providers and the performance of the final machine learning model. This research evaluates the impact through evolutionary game simulation.

Особенности рассмотрения обращений граждан о защите трудовых прав на примере Кемеровской области - Кузбасса

The appeal of a citizen to state bodies and local self-government bodies in order to protect their violated rights or make certain kinds of proposals to improve the activities of public authorities is guaranteed by the Constitution of the Russian Federation. The procedure for working with appeals is quite clearly regulated by a number of federal laws, as well as regulations of ministries and departments, and an algorithm for responding to oral, written and electronic appeals from citizens is provided. Purpose. The purpose of the paper is to find out criteria for the effectiveness of the functioning of the administrative mechanism for considering citizens' appeals on the protection of rights in the sphere of labor at the federal and regional levels. Methodology. With the use of system-structural and formal-legal methods, based on the analysis of statistical data, the activities of the competent authority to consider the appeals of employees and other persons on the protection of their labor rights and interests are studied. Results. The Federal Service for Labor and Employment is one of the key state bodies designed to protect the labor rights of citizens. For the period from 2012 to 2022, this service considered and answered 350,000 appeals related to violations of labor laws. In the Kemerovo region - Kuzbass, there is also a well-functioning system for handling appeals, which is based not only on federal, but also on regional legislation. Appeals of citizens of Kuzbass are recorded in a timely manner, work is carried out on them in the appropriate structure of the regional or local levels of government and a reasoned answer is given. In 2019-2022, about 5,000 complaints were considered in the region on the topic “Labor and Employment of the Population”. Conclusion. The right of citizens to appeal is inseparably connected with the duty of responding to it on the part of state bodies and local governments, while this chain of actions should be based on the basic principles of law: equality, humanism, legality, justice, etc.

РЕАЛІЗАЦІЯ ПРАВ ТА ОБОВ’ЯЗКІВ ПЛАТНИКІВ ПОДАТКІВ ЯК ОБ’ЄКТ АДМІНІСТРАТИВНО-ПРАВОВОГО РЕГУЛЮВАННЯ

The article is devoted to the exercise of rights and obligations of taxpayers as an object of administrative and legal relations. The author notes that payment of taxes is a taxpayer's obligation to ensure the overall functioning of the State mechanism and is an indicator of special attention to the economic and social well-being of the population. After all, a high level of tax payment may indicate that people have a stable income, well-being and trust in the state, while a low level, in turn, may indicate economic problems, shadow economy, distrust in the state or a low level of social guarantees. Particular attention is paid to administrative law rules, which define general principles and rules applicable to all administrative and legal relations, including in the exercise of taxpayers' rights and obligations, while tax law rules establish specific rules and procedures for taxation, as well as the rights and obligations of taxpayers and the State Tax Service of Ukraine. At the same time, administrative and legal relations in the tax sphere are not static, since they are constantly evolving and changing as a result of changes in tax legislation. It is determined that administrative and legal regulation of the exercise of taxpayers' rights and obligations is aimed at ensuring law and order in the tax area, protecting the rights and legitimate interests of taxpayers and facilitating the good faith performance by taxpayers of their duties, since taxpayers are obliged to pay taxes and fees in a timely manner and in full, to keep tax records, to keep documents confirming payment of taxes and fees, and to provide the State Tax Service of Ukraine with information on the payment of taxes and fees.The author comes to the conclusion that administrative and legal regulation of the exercise of rights and obligations of taxpayers is aimed at: ensuring law and order in the tax area, protecting the rights and legitimate interests of taxpayers and facilitating the good faith performance of taxpayers' obligations, etc.

Polyethylene microplastics affect behavioural, oxidative stress, and molecular responses in the Drosophila model.

The escalating presence of microplastic pollution poses a significant environmental threat, with far-reaching implications for both ecosystems and human health. This study investigated the toxicological impact of polyethylene microplastics (PE MPs) using Drosophila melanogaster, fruit flies, as a model organism. Drosophila were exposed to PE MPs orally at concentrations of 1 mg ml-1 and 10 mg ml-1 agar food. The study assessed behavioural parameters and biochemical markers including reactive oxygen species (ROS), superoxide dismutase (SOD), and glutathione-S-transferase (GST) activity. The expression levels of key genes (Hsp70Bc, rpr, and p53) were also analysed using the RT-qPCR technique. Results indicated a significant decline in climbing activity among adult flies and crawling behaviour in larvae, indicating potential disruption of motor function. Biochemical analysis revealed elevated ROS levels, indicative of oxidative stress, in both larval and fly stages. Moreover, the antioxidant defence system exhibited decreased SOD activity and a concentration-dependent increase in GST activity indicating the functioning of a quick xenobiotic clearance mechanism. Gene expression analysis demonstrated upregulation of rpr, p53, and Hsp70Bc genes, suggesting activation of cell death pathways and stress response mechanisms. Overall, these findings underline the adverse effects of PE MPs on Drosophila, including behavioural impairment, oxidative stress, and activation of stress response pathways.

ЛІЗИНГ ЯК ІНСТРУМЕНТ СТИМУЛЮВАННЯ ІННОВАЦІЙ: ПЕРСПЕКТИВИ ТА СТРАТЕГІЇ

Amid the spread of the global crisis and the shortage of financial resources, innovation is becoming one of the most important elements in ensuring survival and growth in the market. Therefore, leasing as one of the options for raising capital plays an important role in the innovative development of enterprises. The article considers the use of leasing as a tool for stimulating innovation in business and analyzes the impact of leasing relations on the development of enterprises and increasing their competitiveness. The research shows that today the leasing services market is characterized by a variety of leasing forms, models of leasing agreements and a diverse system of legal forms regulating the functioning of the leasing mechanism. The main stages of the leasing mechanism include: selection of the leased asset, selection of the lessor, conclusion of the lease agreement, payment of the lease fee under the agreement, use of the leased asset and termination of the lease agreement. The use of leasing has a positive impact on the operations of enterprises by reducing costs, improving productivity and product quality, accelerating the turnover of assets, and improving profitability. Due to the involvement of leasing companies in the process of innovation and their integration into the formation of innovative infrastructure, the issue of developing and expanding tools for the implementation of innovative leasing is important. Innovative leasing is distinguished by its uniqueness and high level of specialization of the equipment that is the object of leasing. We consider innovative leasing to be an effective and promising tool for technical modernization and innovation. Increasing the level of technological equipment in the leasing services market will help to expand the leasing portfolio, including attracting new types of assets. Considering innovative approaches to the provision of leasing services, in particular, the introduction of blockchain and other advanced technologies, it is obvious that such initiatives will have a significant positive impact on the competitiveness of leasing. The main advantage of innovative leasing is that it helps to respond more quickly to market changes and, if necessary, to quickly update the company's innovation strategies.

Circular RNA IGF1R Promotes Cardiac Repair via Activating β-Catenin Signaling by Interacting with DDX5 in Mice after Ischemic Insults.

The potential of circular RNAs (circRNAs) as biomarkers and therapeutic targets is becoming increasingly evident, yet their roles in cardiac regeneration and myocardial renewal remain largely unexplored. Here, we investigated the function of circIGF1R and related mechanisms in cardiac regeneration. Through analysis of circRNA sequencing data from neonatal and adult cardiomyocytes, circRNAs associated with regeneration were identified. Our data showed that circIGF1R expression was high in neonatal hearts, decreased with postnatal maturation, and up-regulated after cardiac injury. The elevation was validated in patients diagnosed with acute myocardial infarction (MI) within 1 week. In human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and myocardial tissue from mice after apical resection and MI, we observed that circIGF1R overexpression enhanced cardiomyocyte proliferation, reduced apoptosis, and mitigated cardiac dysfunction and fibrosis, while circIGF1R knockdown impeded endogenous cardiac renewal. Mechanistically, we identified circIGF1R binding proteins through circRNA precipitation followed by mass spectrometry. RNA pull-down Western blot and RNA immunoprecipitation demonstrated that circIGF1R directly interacted with DDX5 and augmented its protein level by suppressing ubiquitin-dependent degradation. This subsequently triggered the β-catenin signaling pathway, leading to the transcriptional activation of cyclin D1 and c-Myc. The roles of circIGF1R and DDX5 in cardiac regeneration were further substantiated through site-directed mutagenesis and rescue experiments. In conclusion, our study highlights the pivotal role of circIGF1R in facilitating heart regeneration and repair after ischemic insults. The circIGF1R/DDX5/β-catenin axis emerges as a novel therapeutic target for enhancing myocardial repair after MI, offering promising avenues for the development of regenerative therapies.

МОТИВАЦІЙНИЙ МЕХАНІЗМ РЕГУЛЮВАННЯ СИСТЕМИ УПРАВЛІННЯ ПЕРСОНАЛОМ

This article examines the features of the motivational mechanism for regulating the personnel management system. Modern conditions affecting the choice of tools for stimulating and encouraging employees to high work results are analyzed. The interpretation of the concept of motivation and the motivational mechanism of regulation of the personnel management system are defined. The characteristics of the main types of employee motivation are considered in detail. Formed tasks, which are solved thanks to the effective use of the motivational mechanism of regulation of the personnel management system. Aspects that affect the combination of different types and types of motivational mechanisms are provided. The requirements for increasing the efficiency of the use of personnel potential during the formation of the motivational mechanism for the regulation of the personnel management system are defined. The functions of the motivation mechanism for regulating the personnel management system of the enterprise have been established. At the current stage of the functioning of the country's economy, there is an active revival of attention to the issues of personnel management and its motivation, new ways of influencing the interest of employees in high work results are being sought and developed, but, unfortunately, such factors as the decline in production in connection with military actions on the territory of Ukraine, a large outflow of labor force outside the country, difficult conditions of economic activity require the formation of new views on the mechanism of effective labor motivation, which would take into account modern realities. Skillfully selected and formed personnel of the enterprise today is the key to the successful implementation of competitive activities of any enterprise. The high results of the company depend on the professionalism, perseverance and responsibility of the employees. In turn, the motivation of employees is the main factor of these results. Therefore, it becomes necessary to create a high-quality motivational mechanism for regulating the personnel management system, which will ensure the creation of favorable working conditions. Modern realities of the competitive environment force business entities to expand their opportunities to reach and maintain a market position thanks to the use of new types of behavior, focus on digitization and ensuring sustainable development.

KRAS depletion suppresses ferroptosis and affects Hippo pathway in cataract.

Cataract, a painless and progressive disorder is manifested as the opacification of the lens that represents the most significant cause of blindness worldwide. The objective of this study is to unveil the function of Kirsten rat sarcoma (KRAS) and potential action mechanisms against cataract. The ferroptosis-associated differentially expressed genes (DEGs) and pivot genes were extracted through the comprehensive bioinformatics methods. Erastin was applied for inducing ferroptosis in hydrogen peroxide (H2O2)-treated SRA01/04 cells, and validated by detecting content of intracellular iron, glutathione (GSH), malondialdehyde (MDA). Additionally, the effects of KRAS deficiency on ferroptosis were determined by functional assays. The proteins expression related to ferroptosis and Hippo pathway were determined by Western blotting. A total of 73 ferroptosis-related DEGs were discovered, and 6 critical core genes were confirmed upregulation in cataract cell model. The H2O2-treated SRA01/04 cells exhibited decrease of cell viability and proliferation, iron accumulation, MDA increase, GSH consumption, rise of COX2 and decline of GPX4, with further aggravated under erastin treatment, while the phenomena were improved by KRAS knockdown. Additionally, KRAS deficiency was involved in the Hippo signalling pathway activation. Downregulation of KRAS might restrain ferroptosis and affect Hippo pathway in cataract.

MORTGAGE REAL ESTATE MARKET: LENDING TO HOUSEHOLDS BY COMMERCIAL BANKS OF UKRAINE DURING THE STATE OF MARTIAL

MORTGAGE REAL ESTATE MARKET: LENDING TO HOUSEHOLDS BY COMMERCIAL BANKS OF UKRAINE DURING THE STATE OF MARTIAL

Generalizing to Out-of-Sample Degradations via Model Reprogramming.

Existing image restoration models are typically designed for specific tasks and struggle to generalize to out-of-sample degradations not encountered during training. While zero-shot methods can address this limitation by fine-tuning model parameters on testing samples, their effectiveness relies on predefined natural priors and physical models of specific degradations. Nevertheless, determining out-of-sample degradations faced in real-world scenarios is always impractical. As a result, it is more desirable to train restoration models with inherent generalization ability. To this end, this work introduces the Out-of-Sample Restoration (OSR) task, which aims to develop restoration models capable of handling out-of-sample degradations. An intuitive solution involves pre-translating out-of-sample degradations to known degradations of restoration models. However, directly translating them in the image space could lead to complex image translation issues. To address this issue, we propose a model reprogramming framework, which translates out-of-sample degradations by quantum mechanic and wave functions. Specifically, input images are decoupled as wave functions of amplitude and phase terms. The translation of out-of-sample degradation is performed by adapting the phase term. Meanwhile, the image content is maintained and enhanced in the amplitude term. By taking these two terms as inputs, restoration models are able to handle out-of-sample degradations without fine-tuning. Through extensive experiments across multiple evaluation cases, we demonstrate the effectiveness and flexibility of our proposed framework. Our codes are available at https://github.com/ddghjikle/Out-of-sample-restoration.

The Impact of Pes Planus on Knee Function and Its Association with Medial Compartment Knee Osteoarthritis.

Pes planus, commonly known as flat foot, is characterized by the lowering of the medial longitudinal arch of the foot, leading to alterations in lower limb biomechanics and potential pain and injury. This condition can affect the mechanical alignment and dynamic function of the lower limb, potentially contributing to the development and progression of knee osteoarthritis (OA). This study aims to investigate the association between pes planus and medial compartment knee OA as well as its impact on the knee functional score. This cross-sectional study included 165 patients aged 20-72 years. Inclusion criteria were individuals with unilateral or bilateral flat feet, while exclusion criteria were other foot conditions, history of knee or ankle surgeries, rheumatoid arthritis, and limb length discrepancies. Clinical assessments included knee joint tenderness, foot arch measurement using the foot arch index, and radiographic evaluations of Meary's angle and tibiofemoral (TF) angle. The knee injury and osteoarthritis outcome score (KOOS) was used to assess knee function. The study population had a mean age of 43.98 ± 13.17 years. Meary's angle ranged from 5 to 19° (mean 9.46), and the foot arch index ranged from 0.220 to 0.520 (mean 0.33). The TF angle ranged from 1.7 to 7.5° (mean 4.98). KOOS scores varied from 10 to 100 (mean 62.40). Patients with more severe flat feet (higher Meary's angle and foot arch index) had significantly lower KOOS scores, indicating worse knee function and greater pain. The correlations between foot arch index, Meary's angle, and KOOS scores were statistically significant (P = 0.001). This study demonstrates a strong association between flat foot severity and knee OA. Increased Meary's angle and foot arch index were correlated with worsened knee function and increased pain, as measured by KOOS scores. These findings highlight the importance of assessing foot posture in patients with medial compartment OA and suggest that early intervention and orthotic management could be beneficial in mitigating the progression and severity of knee OA in patients with pes planus.

Improved YOLOv5s Algorithm for Target Detection in Highlighted Field Camera Surveillance Images

Abstract The complex and changing environment in the field brings a more significant detection challenge to camera surveillance. This paper proposes target detection in camera surveillance images using the improved YOLOv5s algorithm for target tracking in surveillance images. Firstly, to address the weak feature extraction ability of YOLOv5s for small-scale and overlapping targets, the feature extraction performance of YOLOv5s is improved by combining the attention mechanism and substitution loss function in the deep learning network to improve the feature extraction performance of YOLOv5s for target detection in field camera surveillance images. Then, to test the improved algorithm’s performance, the improved algorithm in this paper is compared with SSD, Faster R-CNN, and YOLOv5s detection methods, and performance comparison experiments are done on the basis of the dataset. The results show that the average detection accuracy (MAP) of the algorithm in this paper is improved by 19%, 14.5% and 6.3% than SSD, Faster R-CNN, and YOLOv5s, respectively, and the average speed of detection is 324 FPS, the accuracy is improved, the detection is faster, and for the YOLOv5 m with DA and PT has a higher AP than the other models in this paper. This study enhances the scalability of YOLOv5s algorithm in complex environments, which is crucial for advancing image target detection.

SOUVENIR AUSHADH 2K24 CONFERENCE PROCEEDINGS

Intercellular junctions known as desmosomes facilitate cell-cell adhesion and secure the intermediate filament network to the plasma membrane, giving tissues like the heart and epidermismechanical robustness. Desmosomal proteins play essential roles in adhesion, but they are now becoming known as cell signalling mediators that are necessary for healthy cell and tissue functioning. The knowledge on desmosomal proteins controlling adhesion and signalling in healthy skin, including morphogenesis, differentiation and homeostasis, wound healing, and defence against environmental harm, is summarised in this study. We also talk about howpathogenesis is aided by human disorders that either directly or indirectly interfere with these mechanical and signalling functions of desmosome molecules. At least three distinct protein families are represented in desmosomes: armadillo proteins like plakoglobin (Pg) and plakophilin (Pkp2) isoforms, cadherin-type adhesion proteins that are members of the desmoglein (Dsg) and desmocollin (Dsc) subfamily, and the plakin family member desmoplakin (Dp). Lipid raft membrane domains closely control desmosome turnover, while post-translational changes of plaque proteins, such as Dp phosphorylation, which finetunes the cytoskeletal anchoring of desmosomes, control their construction and disintegration.

Artificial cells with viscoadaptive behavior based on hydrogel-loaded giant unilamellar vesicles.

Viscoadaptation is an essential process in natural cells, where supramolecular interactions between cytosolic components drive adaptation of the cellular mechanical features to regulate metabolic function. This important relationship between mechanical properties and function has until now been underexplored in artificial cell research. Here, we have created an artificial cell platform that exploits internal supramolecular interactions to display viscoadaptive behavior. As supramolecular material to mimic the cytosolic component of these artificial cells, we employed a pH-switchable hydrogelator based on poly(ethylene glycol) coupled to ureido-pyrimidinone units. The hydrogelator was membranized in its sol state in giant unilamellar lipid vesicles to include a cell-membrane mimetic component. The resulting hydrogelator-loaded giant unilamellar vesicles (designated as HL-GUVs) displayed reversible pH-switchable sol-gel behavior through multiple cycles. Furthermore, incorporation of the regulatory enzyme urease enabled us to increase the cytosolic pH upon conversion of its substrate urea. The system was able to switch between a high viscosity (at neutral pH) and a low viscosity (at basic pH) state upon addition of substrate. Finally, viscoadaptation was achieved via the incorporation of a second enzyme of which the activity was governed by the viscosity of the artificial cell. This work represents a new approach to install functional self-regulation in artificial cells, and opens new possibilities for the creation of complex artificial cells that mimic the structural and functional interplay found in biological systems.

Analysis of the peel structure of different Citrus spp. via light microscopy, SEM and μCT with manual and automatic segmentation.

The peels of lime, lemon, pomelo and citron are investigated at macroscopic and microscopic level. The structural composition of the peels is compared and properties such as peel thickness, proportion of flavedo, density and proportion of intercellular spaces are determined. μCT images are used to visualize vascular bundles and oil glands. SEM images provide information about the appearance of the cellular tissue in the outer flavedo and inner albedo. The proportion of intercellular spaces is quantitatively determined by manual and software-assisted analysis (ilastik). While there are macroscopic differences in the fruits, they differ only slightly in the orientation of the vascular bundles and the arrangement of the oil glands. However, in peel thickness and flavedo thickness, the fruit peels differ significantly from each other. There are no significant differences between the two analysis methods used, although the use of ilastik is preferred due to time reduction of up to 70%. The large amount of intercellular spaces in the albedo but also the denser flavedo both have a mechanical protective function to prevent damage to the fruit. In addition, the entire peel structure is mechanically reinforced by vascular bundles. This combination of penetration protection (flavedo) and energy dissipation (albedo) makes Citrus spp. peels a promising inspiration for technical material systems.

Bending fatigue performance due to different roughing-finishing sequences and post-processing of components produced by Wire EDM

The relationships between machining conditions, boundary layer and mechanical component functionality are known qualitatively for selected Wire Electrical Discharge Machining (Wire EDM/WEDM) applications and continuous further developments of this manufacturing technology minimize the thermal influences significantly. Nevertheless, the use of WEDM processes has so far been severely limited in safety-critical applications, especially in the field of turbomachinery construction and aerospace. For example, the removal of the generated surface layers is often still mandatory, although cutting processes can also leave a distinct thermo-mechanically influenced rim zone on the component. This conservative approach currently unnecessarily reduces the manufacturing potential of WEDM processes considerably and calls for an objective comparison of component function. In this paper, therefore, the flexural bending fatigue strengths of differently wire-eroded surfaces based on roughing-finishing sequences and optional post-processing treatment are compared with industrially established reference process chains.

Regulatory effects of stress release from decellularized periosteum on proliferation, migration, and osteogenic differentiation of periosteum-derived cells.

Bone injury is often associated with tears in the periosteum and changes in the internal stress microenvironment of the periosteum. In this study, we investigated the biological effects of periosteal prestress release on periosteum-derived cells (PDCs) and the potential mechanisms of endogenous stem cell recruitment. Decellularized periosteum with natural extracellular matrix (ECM) components was obtained by a combination of physical, chemical, and enzymatic decellularization. The decellularized periosteum removed immunogenicity while retaining the natural network structure and composition of the ECM. The Young's modulus has no significant difference between the periosteum before and after decellularization. The extracted PDCs were further composited with the decellularized periosteum and subjected to 20% stress release. It was found that the proliferative capacity of PDCs seeded on decellularized periosteum was significantly enhanced 6 h after stress release of the periosteum. The cell culture supernatant obtained after periosteal prestress release was able to significantly promote the migration ability of PDCs within 24 h. Enzyme-linked immunosorbnent assay (ELISA) experiments showed that the expression of stroma-derived factor-1α (SDF-1α) and vascular endothelial growth factor (VEGF) in the supernatant increased significantly after 3 h and 12 h of stress release, respectively. Furthermore, periosteal stress release promoted the high expression of osteogenic markers osteocalcin (OCN), osteopontin (OPN), and collagen type I of PDCs. The change in stress environment caused by the release of periosteal prestress was sensed by integrin β1, a mechanoreceptor on the membrane of PDCs, which further stimulated the expression of YAP in the nucleus. These investigations provided a novel method to evaluate the importance of mechanical stimulation in periosteum, which is also of great significance for the design and fabrication of artificial periosteum with mechanical regulation function.

Guidelines derived from biomineralized tissues for design and construction of high-performance biomimetic materials: from weak to strong.

Living organisms in nature have undergone continuous evolution over billions of years, resulting in the formation of high-performance fracture-resistant biomineralized tissues such as bones and teeth to fulfill mechanical and biological functions, despite the fact that most inorganic biominerals that constitute biomineralized tissues are weak and brittle. During the long-period evolution process, nature has evolved a number of highly effective and smart strategies to design chemical compositions and structures of biomineralized tissues to enable superior properties and to adapt to surrounding environments. Most biomineralized tissues have hierarchically ordered structures consisting of very small building blocks on the nanometer scale (nanoparticles, nanofibers or nanoflakes) to reduce the inherent weaknesses and brittleness of corresponding inorganic biominerals, to prevent crack initiation and propagation, and to allow high defect tolerance. The bioinspired principles derived from biomineralized tissues are indispensable for designing and constructing high-performance biomimetic materials. In recent years, a large number of high-performance biomimetic materials have been prepared based on these bioinspired principles with a large volume of literature covering this topic. Therefore, a timely and comprehensive review on this hot topic is highly important and contributes to the future development of this rapidly evolving research field. This review article aims to be comprehensive, authoritative, and critical with wide general interest to the science community, summarizing recent advances in revealing the formation processes, composition, and structures of biomineralized tissues, providing in-depth insights into guidelines derived from biomineralized tissues for the design and construction of high-performance biomimetic materials, and discussing recent progress, current research trends, key problems, future main research directions and challenges, and future perspectives in this exciting and rapidly evolving research field.