SOUVENIR AUSHADH 2K24 CONFERENCE PROCEEDINGS

Abstract

Intercellular junctions known as desmosomes facilitate cell-cell adhesion and secure the intermediate filament network to the plasma membrane, giving tissues like the heart and epidermismechanical robustness. Desmosomal proteins play essential roles in adhesion, but they are now becoming known as cell signalling mediators that are necessary for healthy cell and tissue functioning. The knowledge on desmosomal proteins controlling adhesion and signalling in healthy skin, including morphogenesis, differentiation and homeostasis, wound healing, and defence against environmental harm, is summarised in this study. We also talk about howpathogenesis is aided by human disorders that either directly or indirectly interfere with these mechanical and signalling functions of desmosome molecules. At least three distinct protein families are represented in desmosomes: armadillo proteins like plakoglobin (Pg) and plakophilin (Pkp2) isoforms, cadherin-type adhesion proteins that are members of the desmoglein (Dsg) and desmocollin (Dsc) subfamily, and the plakin family member desmoplakin (Dp). Lipid raft membrane domains closely control desmosome turnover, while post-translational changes of plaque proteins, such as Dp phosphorylation, which finetunes the cytoskeletal anchoring of desmosomes, control their construction and disintegration.