The solid-liquid equilibrium data and solution thermodynamics of chemicals are indispensable for the synthesis and purification of crystalline products in industry. The selection of a solvent directly influences the yield and purity of a product. In this work, the solubility of p-toluenesulfonamide (p-TSA) in 16 pure solvents, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, acetone, ethyl acetate, acetonitrile, cyclohexanone, cyclopentanone, methyl acetate, ethyl formate and dichloromethane, was determined by a static gravimetric method at temperatures ranging from 273.15 to 324.75 K under atmospheric pressure. The results indicate that the mole fraction solubility of p-TSA increased with increasing temperature in all 16 solvents. The solubility value in the selected alcohols ranks in the following order: methanol > ethanol >n-propanol > isopropanol >n-butanol >n-pentanol > isopentanol > isobutanol, and the polarity of a solvent seems to be an important factor influencing the solubility of p-TSA in alcohols. In the other eight solvents, the solubility sequence is cyclopentanone > acetone > cyclohexanone > (acetonitrile, methyl acetate) > ethyl acetate > ethyl formate > dichloromethane, which strongly deviates from the order of solvent polarities. Then, the measured solubility data were correlated with four thermodynamic models, i.e., the modified Apelblat equation, λh equation, non-random two-liquid (NRTL) equation and the Wilson equation. Overall, the NRTL model provided the most satisfactory fitting results. Furthermore, the dissolution thermodynamic parameters, Gibbs energy (△disG), molar enthalpy (△disH) and molar entropy (△disS) were calculated according to the Wilson model. The values of △disH and △disS are positive in all selected solvents, showing that the dissolution process of p-TSA in the selected solvents is endothermic and entropy-driven. The △disG values are negative in all selected solvents and decrease with increasing temperature, which demonstrates that dissolution of p-TSA in the selected solvents is favorable and spontaneous.