Solubility Measurement and Correlation of Probenecid in 12 Pure Organic Solvents and Thermodynamic Properties of Mixing of Solutions

Abstract

The solubility data of probenecid in 12 different organic solvents including methanol, methyl acetate, ethanol, ethyl acetate, n-propanol, n-butanol, butyl acetate, n-pentanol, isopropanol, isobutanol, acetone, and methyl tert-butyl ether was measured using the gravimetric method over the temperatures range from 283.15 to 323.15 K at 0.1 MPa. The acetone had much higher solubility to probenecid than to other solvents. Three models, including the modified Apelblat equation, the van’t Hoff model, and the nonrandom two-liquid (NRTL) model, were applied to correlate the measured solubility data. The correlation results were evaluated by the average relative deviation (ARD). All of the ARD values were less than 4.522%, which indicated that the three models have a satisfactory correlation. The thermodynamic properties of mixing of probenecid in 12 pure organic solvents including the enthalpy of mixing, Gibbs energy of mixing, and entropy of mixing were calculated by the NRTL model using the correlation results.