Solubility measurement, correlation and mixing properties of thioacetamide in fifteen pure solvents

Abstract

The solubility of thioacetamide in fifteen pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, ethyl acetate, 2-butanone, 2-pentanone, acetone, acetonitrile, ethyl formate and methyl acetate) was determined by a gravimetric method from 272.85 K to 323.95 K under ambient pressure. Four thermodynamic models, including the modified Apelblat equation, Buchowski-Ksiazaczak λh equation, non-random two-liquid (NRTL) model and the Wilson model were used to correlate the solubility data. And the NRTL model provides the best data fitting results among the four models. To elucidate the dissolution behavior of thioacetamide, the KAT-LSER model was introduced to analyze the solvent effect. The results revealed that hydrogen bond basicity and bipolarity/polarizability had a similar and significant favorable effect to the dissolution of thioacetamide. The mixing thermodynamic properties such as enthalpy, entropy and Gibbs free energy were calculated and the results indicated that the dissolution process of thioacetamide was spontaneous and favorable.