Cracks are often exposed to mixed mode I/II loading because of the random direction of crack relative to the external load, causing rock failure in rock engineering. However, many mixed mode I/II fracture properties of rock with different loading angles (β) are still poorly understood. To investigate the influence of β on mixed mode I/II fracture behavior, cracked straight through Brazilian disc tests were performed on sandstone under various β at the loading rate of 0.2 kN/s. The results show that the effect of β on the peak load and crack propagation velocity is slight. The mode I stress intensity factor (SIF) decreases from positive to negative with increasing β, while mode II SIF first increases and then decreases as β exceeds approximately 30°. The mixed mode I/II fracture toughness increases linearly with increasing β. When β exceeds 60°, the crack initiation location shifts from the center of the semi-circular notch tip to the surface of preset crack. For non-tip cracking, the crack propagates toward the loading point in a direction approximately perpendicular to the preset crack. The threshold β for it decreases with increasing internal friction coefficient and relative crack length. Moreover, the mixed-mode fracture surface becomes smoother as the mode I component contribution drops. There are remarkable differences in the prediction of fracture initiation angles and SIFs of various rock types applying the generalized maximum tangential stress criterion. The findings of this study could help understand the mixed mode I/II fracture observed in rock engineering.