In order to characterize the crack tip stress field in three-dimensional fatigue and fracture problems, stress intensity factor and T-stress solutions are usually necessary. In this paper, extensive three-dimensional (3D) finite element models are constructed for Compact-Tension-Shear (CTS) specimen, which is one of the most widely used specimens for fatigue and fracture tests under mixed-mode I&II loading. In-plane and out-of-plane geometric dimensions including varying crack depths ratios (a/W = 0.3, 0.5 and 0.7) and thicknesses ratios (B/W = 0.1, 0.3 and 0.5) are considered under different loading angles (β = 0°, 15°, 30°, 45°, 60°, 75° and 90°). The results of stress intensity factors (KI,KII and KIII) and T-stresses (T11 and T33) along the crack front are computed and analyzed. The combined effects of geometric dimensions and loading angles on these fracture parameters have been illustrated. The solutions of the parameters are then described using empirical formulae by fitting numerical results with the least-squares method. Solutions obtained have been used to predict the crack initiation angles for CTS specimens based on mixed-mode fracture criteria including the maximum tangential stress (MTS) criterion, the generalized MTS (GMTS) criterion, the strain energy density (SED) criterion and the generalized SED (GSED) criterion. Solutions are useful for fracture and fatigue problems of mixed-mode I&II, such as analysis of the constraint effects on fracture toughness and propagation path of fatigue crack.