Malignant Salivary Gland Tumors Research Articles

Myoepithelial Carcinoma of the Floor of the Mouth: A Rare Salivary Gland Tumor in an Unusual Location

Myoepithelial carcinomas are rare malignant salivary gland tumours encountered most commonly in the parotid gland and are amenable to surgical resection. However, when they occur at complex anatomical locations, complete resection becomes difficult due to their locally aggressive nature. Here we describe a case of a large myoepithelial carcinoma arising in the floor of the mouth and involving major structures at the skull base.A 30-year-old female presented with a slow-growing mass in the oral cavity. Computed tomography (CT) scan showed a heterogeneous appearing lesion in the mouth floor measuring 6.7 x 5.8 x 7.3 cm. Superiorly, the lesion was extending up to the skull base, laterally extending up to the parotid gland and inferiorly up to the submandibular gland. This lesion was also encasing the internal carotid artery. Incisional biopsy under local anaesthesia was performed, and the specimen was sent for histopathological analysis. Microscopic examination showed a neoplastic lesion composed of sheets of cells with oval nuclei and clear cytoplasm with a myxoid background. Immunohistochemical expression of pan-cytokeratin (CKAE1/AE3), p63, anti-smooth muscle actin (ASMA) and glial fibrillary acidic protein (GFAP) supported the diagnosis of myoepithelial neoplasm. The patient then underwent excision of the mass followed by histological analysis, which further showed microscopic evidence of infiltration into the surrounding tissue along with areas of atypia and significant mitoses. These morphological findings supported the diagnosis of myoepithelial carcinoma. The excised tumour was reaching up to the excision margin.Myoepithelial carcinomas are rare malignant tumours with diverse histomorphological patterns frequently present as a diagnostic challenge. The mainstay of treatment is complete surgical excision with disease-free margins, which can be challenging due to local aggressiveness and large size of these tumours. When these tumours occur in complex anatomical locations, complete excision becomes difficult, resulting in a dismal prognosis.

The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors

Salivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic therapy. Angiogenesis is considered one of the contemporary hallmarks of cancer and anti-angiogenic factors have already been approved for the treatment of several cancer types. This review aims to summarize, in a histotype-specific manner, the most current available data on the angiogenic factors implicated in SGC angiogenesis, in order to highlight the differences between the most common SGC histotypes and the factors that may have a potential role as therapeutic targets.

Cell adhesion molecules\u2019 altered profile in benign and malignant salivary gland tumors. The paradigm of beta4-integrin, desmoglein-2, ICAM-1 and CD44s

BackgroundAlterations in intercellular and cell-extracellular matrix connections contribute to tumour development. This study investigates the expression of specific cell adhesion molecules (CAMs) in salivary gland tumors (SGTs).MethodsFormalin–fixed, paraffin– embedded tissue specimens of different types of 34 benign and 31 malignant SGTs and normal salivary glands were studied using Envision/HRP immunohistochemical technique for Desmoglein-2 (Dsg-2), beta4-integrin, CD44s and ICAM-1. Intensity of staining was evaluated in a semi-quantitative manner. Results were analyzed using Kendall’s τ and Spearman’s ρ as correlation criteria.ResultsDsg-2 in intercellular space, beta4-integrin in cell-basal membrane, and CD44s in both types of contacts were strongly expressed in normal acinar and ductal cells, whereas ICAM-1 was expressed only at the endothelium and sparse stromal cells and monocytes. Strong correlation was found between Dsg-2 expression in adenomas and controls and between adenocarcinomas and controls. In adenomas, a distinct cytoplasmic presence of Dsg-2 was observed in addition to the usual membranous expression, with decreased expression in comparison with normal tissue. In malignant SGTs, Dsg-2 expression was absent. In most SGTs, beta4-integrin was expressed also with a distinct pattern, involving the cytoplasm and the unpolarised membrane, while CD44 was found only on the membrane. Strong correlation between beta4-integrin expression in adenomas and controls was noted, while CD44 expression was found to be correlated significantly between adenocarcinomas and controls (p < 0.001). Regarding ICAM-1, its expression was found increased in adenomas, with non-specific distribution in malignant SGTs and strong correlation between the histological subtypes and controls (p < 0.001).ConclusionThe different expression profile of CAMs in SGTs could possibly suggest a role on their pathogenesis, representing a model of how neoplastic cells can take advantage of normal tissue architecture and cell-extracellular matrix interactions.

Imaging of Malignant Minor Salivary Gland Tumors of the Head and Neck.

Minor salivary gland carcinomas (MSGCs) are nonminor tumors in the head and neck region and account for about half of all salivary gland carcinomas. Imaging evaluation based on the anatomy of minor salivary and mucous glands in the head and neck region as well as invasion patterns in each site helps in identifying optimal treatment modalities and planning suitable treatment strategies. MSGCs can be divided radiologically into localized and invasive subtypes on the basis of the clinical utility of such categorization. Characteristic invasion patterns of the invasive type include deep submucosal extension, bone marrow infiltration, and perineural spread, which are difficult to assess clinically. MSGCs easily invade adjacent structures because of their submucosal location and may spread along the muscles, nerves, periosteum, and dura mater. Moreover, the tumor may spread into the bone marrow without obvious bone destruction. In addition to imaging classification, examining the anatomy and distribution of the minor salivary glands, including the palatal, lingual, buccal, labial, and retromolar glands, as well as other mucous glands, including the glands of the sinonasal cavity and nasopharynx, lacrimal glands, ceruminous glands, laryngeal glands, and tracheal glands, facilitates MSGC diagnosis and tumor extension assessment. The authors review the precise anatomy of the minor salivary and mucous glands in the head and neck region, discuss the MSGC imaging classifications, and describe how to evaluate the extent of MSGCs in each site on the basis of the imaging classification and invasion patterns. ©RSNA, 2020.

Acinic cell carcinoma of the parotid gland with neuroendocrine differentiation

Acinic cell carcinoma (ACC) is a malignant salivary gland tumor characterized by tumor cells displaying acinar features. Usually presenting as a slow-growing tumor, ACC, however, may show dedifferentiation to a higher grade including neuroendocrine carcinoma. In addition, ACC may rarely show focal neuroendocrine differentiation without any frank evidence of neuroendocrine carcinoma. We describe such a case of ACC of the parotid gland in a 65-year-old female, which showed neuroendocrine differentiation. The diagnostic clues, immunohistochemistry panel, and prognostic and treatment aspects are also presented.

Salivary gland tumours: a hospital-based study on demographic and incidence pattern, histopathological types and treatment strategy

&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Salivary gland tumours constitute 3-4% of all head and neck cancers (mostly benign). These tumours are epithelial (95%) or mesenchymal in origin. Pleomorphic adenoma is the most common benign salivary gland tumour and mucoepidermoid carcinoma (45%) is the most common malignant salivary gland tumour followed by adenoid cystic carcinoma (30%). The parotid, submandibular and the minor salivary glands of palate are commonly involved and the sublingual gland is rarely affected.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Hospital based cross sectional study was done in a tertiary care centre during a period of 1 year, which included 21 patients (10 men and 11 women). Patients were analysed according to age, gender, food habits, histopathological type and site of the tumour and treatment strategy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All the cases were from upper Assam province sharing a particular demographic pattern between 19-65 years. Peak incidence in males was fourth decade and females was third decade. Male female ratio was 0.9:1. Out of 21 cases, 14 were parotid gland tumours, 6 submandibular gland tumours and 1 minor salivary gland tumour. Most of the tumours were benign (16) and 5 were malignant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Two patients were of age 19 years which is conflicting the normal national incidence. All cases belonged to lower economic strata with decreased intake of beta carotene enriched food items. The most common site is parotid gland and most common tumour is pleomorphic adenoma which is in accordance to other studies. Benign cases were subjected to superficial parotidectomy and malignant cases to total parotidectomy with neck dissection.&lt;/p&gt;

Clinical Utility of Qualitative Elastography Using Acoustic Radiation Force Impulse for Differentiating Benign from Malignant Salivary Gland Tumors

The goal of the work described here was to evaluate the utility of acoustic radiation force impulse (ARFI) imaging, a novel elastography technique, for differentiating benign from malignant salivary gland tumors. With the use of conventional strain elastography (SE) and ARFI imaging with a four-pattern scoring system, 185 tumors were examined (163 benign/22 malignant). When a score of ≥3 was used to define malignancy, the sensitivity, specificity and accuracy were higher for ARFI imaging (77.3%, 63.8% and 65.4%, respectively) than for conventional SE (54.5%, 56.4% and 56.2%, respectively). ARFI imaging findings revealed that most (92%) Warthin tumors, but only 24% of pleomorphic adenomas, were benign (score: 1 or 2). Attenuation of acoustic push pulses made it difficult to determine the stiffness of malignant tumors in the deep parotid lobes. Thus, ARFI imaging is a useful tool for screening Warthin tumors and exhibits high sensitivity for malignant tumors of salivary glands, other than deep parotid lobe tumors.

DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors

ObjectiveTo analyze the immunohistochemical expression of the base excision repair (BER) proteins apurinic/apyrimidinic endonuclease 1 (APE1) and X-ray repair cross-complementing protein 1 (XRCC1) and nucleotide excision repair (NER) protein xeroderma pigmentosum group F (XPF) in malignant salivary gland tumors (MSGTs). DesignSixty-two cases of MSGTs were selected, including 14 acinic cell carcinomas (AcCC), 15 polymorphous adenocarcinomas (PAC), 16 adenoid cystic carcinomas (ACC), and 17 mucoepidermoid carcinomas (MEC). The specimens were submitted to quantitative immunohistochemical analysis. ResultsAll MSGTs exhibited nuclear or nucleo-cytoplasmic immunostaining of APE1, XRCC1 and XPF, with a high percentage of positive cells (median = 78.31, 70.48 and 75.46, respectively). XRCC1 expression was higher in PAC compared to MEC (p = 0.032). Nuclear APE1 immunostaining was significantly higher than nucleo-cytoplasmic expression in the selected MSGTs (p < 0.0001). APE1 expression was significantly associated with T1-T2 tumors in ACC (p = 0.006). Increased expression of XPF was associated with age older than 60 years in MEC (p = 0.015) and with ACC involving the minor salivary gland (p = 0.012), while a lower expression was found in AcCC and ACC patients treated by surgery combined with adjuvant therapy (p = 0.036 and p = 0.020, respectively). Low expression of XRCC1 in the nucleus (p = 0.028) and concomitant expression of this protein in the nucleus/cytoplasm were associated with a lower overall 5-year survival rate (p = 0.017). ConclusionsThis study showed that BER and NER proteins evaluated are highly expressed in the MSGTs studied, indicating mechanisms of genotoxic control in these tumors. In addition, the dysregulation of XRCC1 expression was a prognostic predictor in MSGTs analyzed.

Comparison of Diagnostic Reliability of p63 and Smooth Muscle Actin in Salivary Gland Neoplasms.

Salivary gland neoplasms pose considerable diagnostic difficulty owing to their diverse histological features in individual lesions and the presence of a number of types and variants & similar histological features with other tumor entities. Myoepithelial and basal cells play a significant role in the pathogenesis of salivary gland neoplasm. p63 and smooth muscle actin are more reliable markers for identifying these cells and not studied much comparing their reliability in the diagnosis of salivary gland neoplasms. Hence, the aim of this study is to evaluate and compare the diagnostic reliability of immunohistochemical markers such as p63 and smooth muscle actin (SMA) in the diagnosis of various benign and malignant salivary gland neoplasms. The study comprises of 18 samples categorized into two groups: Group I comprised 9 cases, of which 4 cases were Pleomorphic adenoma, 2 cases were Myoepithelioma, 2 cases of Basal cell adenoma and 1 case was Warthin's tumor; and Group II consisted of 9cases, of which 3 was Mucoepidermoid carcinoma, 1 cases were Myoepithelial carcinoma and 5 cases were Adenoid cystic carcinoma. The selected cases were subjected to immunohistochemistry (IHC) procedure to assess the expression pattern of p63 and smooth muscle actin. The obtained data was analysed statistically by using Mann-Whitney test. In SMA, strong positivity for epithelial and connective tissue components of benign salivary neoplasm is about 22.2%respectively. In malignant salivary neoplasm, SMA was strongly positive for the epithelial and connective tissue component of about 77.7% and 88.8% cases respectively. The difference in the connective tissue components was found to be statistically significant (U = 24, P = 0.032). P63 was strongly positive for the epithelial and connective tissue component of benign salivary neoplasm of about 33.3% and 11.1% cases respectively.In malignant salivary neoplasm, p63 was strongly positive for the epithelial component of about 66.6% cases and connective tissue is completely negative. Alpha-SMA can be utilized as reliable IHC markers for salivary gland neoplasms due to its diagnostic importance in tumors with myoepithelial origin indicative of the histogenesis of salivary gland tumors and even p63 can be used as specific markers for differentiation of malignant salivary gland tumors.

Salivary gland tumours in Iceland 1986-2015: a nationwide epidemiological analysis over a 30-year time period.

Salivary gland tumours (SGT) are a vast and heterogenous group of neoplasms. There is a relative lack of comprehensive nationwide epidemiological studies on the subject. The aim of this nationwide analysis was to gain insight into epidemiological traits, such as site, incidence and histological subtypes of SGT in general. Patients diagnosed with a primary SGT between 1986 and 2015 were identified from The Icelandic Cancer Registry and registries from all pathology departments in Iceland. Information on age, sex, tumour location and histology was retrieved from pathology reports. A total of 687 patients were diagnosed with a SGT, 609 (89%) were benign and 78 (11%) malignant. 9% of parotid gland tumours, 22% of submandibular gland tumours and 26% of minor SGT were malignant. The most common malignant tumours were mucoepidermoid carcinoma, acinic cell carcinoma and adenoid cystic carcinoma. The incidence of benign SGT was 4.9 per 100000 among men and 7.0 per 100000 among women. The incidence of malignant tumours was 0.59 per 100000 for men and 0.79 per 100000 for women. The proportion of malignant SGT is lower than most often reported. Only 10% of parotid gland tumours, 20% of submandibular gland tumours and 25% of minor salivary gland tumours are malignant.

Clinicopathological and Incidence Analysis of Malignant Salivary Gland Tumours: A 16-year Retrospective Study in the North of Portugal

Objectives: A) Evaluate the clinical-pathological characteristics of malignant neoplasms of salivary glands: A.1) Quantify the numbers of which tumor subtype. A.2) Gender, age and the type of salivary gland influence tumor behavior? A.3) Describe 16 years of evolution in a target portuguese population. B) What are the treatments chosen in which subtype? C) What is the prognosis? And what can influence the prognosis? Study Design: A 16-year retrospective study of 138 patients with salivary gland tumors from 2000 to 2016 in the Anatomical Pathology Department of Centro Hospitalar do Porto, Hospital Geral de Santo António. The histological diagnoses - according to the 2017 World Health Organization classification. Results: In the present study, we revised all the cases of salivary gland pathology from 396 cases. A total of 138 tumors were identified in 91 male and 47 female patients. The mean age was 58 years. The frequency of major salivary gland tumors was 56.3%, and that of minor salivary gland tumors was 43.7%. Mucoepidermoid carcinoma was the most common malignant tumor. Conclusions: Knowledge of the different clinic characteristics is important and essential to a better prognosis and in many cases a reduction of the mortality.

Increased expression of ALDH-1 is associated with clinical parameters of salivary glands neoplasms

The enzyme aldehyde dehydrogenase-1 (ALDH-1) is a known putative tumour stem cells (TSC) marker, and these cells are implicated in carcinogenesis and progression of human neoplasms. We aimed to evaluate ALDH-1 expression in benign and malignant salivary gland neoplasms and its clinicopathological and prognostic significance. Expression of ALDH-1 was investigated by immunohistochemistry and confirmed by Western Blot analysis in 154 salivary gland neoplasms (103 malignant and 51 benign neoplasms). The expression was identified in the parenchyma of malignant (n = 88; 85.6%) and benign (100%) neoplasms. Overall, expression in the parenchyma varied considerably and was not associated with clinical parameters in most malignant neoplasms, however, a high expression in mucoepidermoid carcinomas (MEC) was associated with advanced pathological TNM stage (p = 0.047). The presence of ALDH-1 in stromal cells of malignant neoplasms (n = 67; 65.0%) was associated with lymph node metastasis (p = 0.032), tumour recurrence (p = 0.006) and death (p = 0.013). Overall and disease-free survival in 5 and 10 years was lower in patients with diagnosis of adenoid cystic carcinoma, tumour recurrence, advanced staging, and presence of ALDH-1 in the stroma. When adjusted by multivariate analysis, advanced staging and stromal expression were independent prognostic factors affecting disease-free survival. Our findings provide evidence that cells characterized as TSC in the parenchyma and stroma are differentially present among the different types of neoplasms studied and may be related to tumourigenesis, biological behaviour and persistence capacity of malignant tumours of the salivary gland.

Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.

Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in both adults and children. Histological grading of MEC is subjective, but plays an important role in predicting patient prognosis. Epithelial mucin (MUC) status may aid in establishing a more accurate grade. This study aimed to investigate the expression of various mucins (MUC1, MUC2, MUC4 and MUC5AC) in MECs to determine a possible correlation with tumour grade. Fifteen cases of each tumour grade (low-, intermediate-, and high-grade) were retrieved from the pathology archives of the Department of Oral Pathology and Oral Biology at the University of Pretoria. The patients included 23 men and 22 women, and ranged from 13 to 85years (mean 49.8years). Sections from formalin-fixed paraffin-embedded (FFPE) tissue were used for fluorescence in situ hybridization (FISH) for MAML2 rearrangements and MUC immunohistochemical analysis. The percentage immunohistochemical expression of the neoplastic mucous cells was evaluated first, followed by the overall percentage expression of all tumour cells. The results indicated that MUC1 overexpression may be a reliable marker of high-grade MECs, whereas MUC4 overexpression may be more indicative of low-grade tumours. MUC5AC expression was considered an unreliable marker in determining grade. MUC2 was only expressed in a single case of MEC and may be considered a useful marker to exclude MEC as a diagnostic possibility. This study demonstrates that MECs show an altered MUC expression pattern that can be used for diagnostic purposes and to aid in establishing a more accurate tumour grade.

ONCOCYTIC SIALOLIPOMA OF THE PAROTID GLAND: A REPORT OF 2 CASES

Oncocytic sialolipoma is an exceedingly rare tumor of the salivary gland (SG), being considered as a variant of SG lipomas. Clinically, swelling in the SG affected is observed, and this tumor is most common in the parotid gland of men. We report 2 cases of oncocytic sialolipomas affecting a 44-year-old man and a 49-year-old woman. Partial parotidectomy was performed in both cases. The histopathologic examination revealed well-circumscribed tumors with a biphasic pattern: the oncocytic epithelial component showing cells with different sizes organized in nests or ductal structures and a well-recognized adipocytic background. Immunohistochemical reactions were performed, and the oncocytic epithelial component was positive for CK7, CK14, and anti-mitochondrial antigen. After the surgical excision, no sign of recurrence was observed. As these tumors may have a clinical presentation similar to other benign and malignant SG tumors, histopathologic examination is mandatory to establish the proper diagnosis. Oncocytic sialolipoma is an exceedingly rare tumor of the salivary gland (SG), being considered as a variant of SG lipomas. Clinically, swelling in the SG affected is observed, and this tumor is most common in the parotid gland of men. We report 2 cases of oncocytic sialolipomas affecting a 44-year-old man and a 49-year-old woman. Partial parotidectomy was performed in both cases. The histopathologic examination revealed well-circumscribed tumors with a biphasic pattern: the oncocytic epithelial component showing cells with different sizes organized in nests or ductal structures and a well-recognized adipocytic background. Immunohistochemical reactions were performed, and the oncocytic epithelial component was positive for CK7, CK14, and anti-mitochondrial antigen. After the surgical excision, no sign of recurrence was observed. As these tumors may have a clinical presentation similar to other benign and malignant SG tumors, histopathologic examination is mandatory to establish the proper diagnosis.

SPINDLE CELL CARCINOMA OF THE MAXILLARY SINUS: FROM DIAGNOSIS TO REHABILITATION

Male patient, 79 years old, denies smoking or alcoholism. He attended the appointment reporting pain and edema after a tooth extraction. At physical examination, a nodular lesion of ulcerated surface on the right upper alveolar ridge was observed, extending to the hard palate and measuring approximately 3.0 x 2.0 cm in diameter. The diagnostic hypotheses were squamous cell carcinoma, malignant neoplasm of salivary glands, and paracoccidioidomycosis. After the incisional biopsy, the histopathological analysis revealed a well differentiated squamous cell carcinoma. The patient was referred for a head and neck surgery, and the treatment was maxillectomy, followed by radiotherapy. After the surgical treatment, the patient received rehabilitation with a temporary provisional obturator prosthesis, being successively replaced, until the radiotherapy was completed, which allowed the correct conformation of the healing tissues and maintained the aesthetics and local function. The patient is under a strict clinical and imaging control.

CYSTIC ADENOID CARCINOMA IN UNCOMMON LOCATION: A CASE REPORT

Cystic adenoid carcinoma (CAC) is a malignant neoplasm of salivary glands that mainly affects the parotid. We report a CAC case in a rare site. A 35-year-old female patient, smoker, was referred to the stomatology clinic with a progressive lesion in the left jugal mucosa. Oroscopy revealed a submucosal nodule, firm and with an evolution of 2 years. Hematologic examinations were requested for the incisional biopsy, which did not present alterations. The histopathologic analysis revealed a malignant neoplasm of glandular epithelium organized in islands and composed of myoepithelial and ductal cells in a pattern sometimes cribriform or tubular with muscular, vascular, and neural invasions concluded as CAC. The patient was referred to the oncology service. Histopathologic analysis is important for the accurate diagnosis of CAC because of the possibility of involvement of unusual regions and the reserved prognosis of the lesion.

MUCOEPIDERMOID CARCINOMA: AN EVOLUTION OF 21 YEARS

A female patient, 37 years of age, reported volume increase in the right side of the face in 5 months with painful symptoms. An intraoral examination revealed an endophytic palatal and vestibular lesion, extending from the premolar region to the molar region. The radiographic examination showed a radiolucent lesion with radiopaque areas near the maxillary sinus. The patient presented a history of untreated lesion on the palate diagnosed as adenocarcinoma in 1997. In 2018, a new incisional biopsy was performed. The histologic examination showed the malignant neoplasm of salivary gland characterized cystic spaces lined by a single layer of mucous cells and areas with epidermoid cells. Histochemical analysis of the mucous cells and contents of the microcystic spaces were stained positive with the mucicarmine. The final diagnosis of mucoepidermoid carcinoma was issued. The patient was referred for treatment in the Liga norterriograndense contra o câncer and is followed up.

INTRA-ORAL PLEOMORPHIC ADENOMA IN THE PALATE: A REPORT OF 4 CASES

Pleomorphic adenoma (PA) is the most common salivary glands tumor, mainly involving the parotid gland. The aim of this study was to report a PA series of cases, which were diagnosed intra-orally, and their relation to clinical, epidemiologic data and histopathologic findings. The age ranged from 30 to 60 years, being observed mainly in the female gender. All cases were located on the palate, and only 1 was painful. The most common histopathologic findings were epithelial and myoepithelial cells distributed in several morphologic patterns of mesenchymal differentiation. Epithelial cells formed ducts and cystic structures and had islands or sheets of neoplastic cells. Excisional surgery was the treatment of choice, with excellent prognosis. In conclusion, it is always necessary to perform incisional biopsy in intra-oral PAs, because these lesions occur preferentially on palatal minor salivary glands, which could be a challenge to diagnosis due to their similarity with malignant salivary glands tumors.

MORBIDITY AND MORTALITY DUE TO ORAL CANCER IN BRAZIL IN THE LAST 10 YEARS

Oral cancer (OC) is the fifth most prevalent cancer in males and its morbidity-mortality can be measured by data of hospitalization related to oral squamous cell carcinoma, malignant salivary glands tumors, sarcomas, lymphomas, leukemia, and melanomas. The objective of this study was to identify the morbidity-mortality profile of OC in Brazil in the last 10 years. This is a retrospective, descriptive study with OC data cases registered and extracted from DATASUS, using the descriptors lips and oral cavity cancer, from 2008-2018. A total of 289 293 cases of hospitalization were reported. Of the total, 71% were male, in which 42% were white-skinned. The southeast region registered 45% of the cases. The most prevalent age group was 50 to 59 years of age (29%), with 78% being males. Eleven percent of hospitalized patients died. Data collected emphasize the importance of a multidisciplinary team working toward the prevention and treatment of OC in order to decrease its morbidity and mortality.

EPIDEMIOLOGIC ANALYSIS OF SALIVARY GLAND TUMORS OVER A 10-YEAR PERIOD DIAGNOSED IN A NORTHEAST BRAZILIAN POPULATION

Objective: To analyze the clinical profile of a series of salivary gland tumors diagnosed in the state of Sergipe. Study Design: This is an epidemiologic, analytical, and retrospective study of the clinical characteristics of salivary gland tumors, carried out in medical/oral pathology reference services in the state of Sergipe. The cases were collected in the laboratories database. All cases of major and minor salivary gland tumors that met the diagnostic criteria established by the World Health Organization (WHO) and diagnosed between 2006 and 2016 were selected. Cases were diagnosed by fine needle aspiration; inconclusive reports and secondary tumors were excluded. Results: A total of 588 cases were found. The majority of tumors occurred in women (55.7%), ranging from 41 to 50 years of age (19.06%). Benign tumors were more common (79.5%), and major salivary glands were more affected (61.73%), particularly the parotid gland (51.7%). Pleomorphic adenoma (88.96%) and Warthin tumor (6.8%) were the most common benign tumors, whereas mucoepidermoid carcinoma (24.58%), not otherwise specified adenocarcinoma (20.34%), and adenoid cystic carcinoma (17.8%) were the most frequent malignant tumors. Conclusions: Pleomorphic adenoma and mucoepidermoid carcinoma were the most common benign and malignant salivary gland tumors, respectively, and the parotid gland was the most affected anatomic site.