Abstract
Oncocytic sialolipoma is an exceedingly rare tumor of the salivary gland (SG), being considered as a variant of SG lipomas. Clinically, swelling in the SG affected is observed, and this tumor is most common in the parotid gland of men. We report 2 cases of oncocytic sialolipomas affecting a 44-year-old man and a 49-year-old woman. Partial parotidectomy was performed in both cases. The histopathologic examination revealed well-circumscribed tumors with a biphasic pattern: the oncocytic epithelial component showing cells with different sizes organized in nests or ductal structures and a well-recognized adipocytic background. Immunohistochemical reactions were performed, and the oncocytic epithelial component was positive for CK7, CK14, and anti-mitochondrial antigen. After the surgical excision, no sign of recurrence was observed. As these tumors may have a clinical presentation similar to other benign and malignant SG tumors, histopathologic examination is mandatory to establish the proper diagnosis. Oncocytic sialolipoma is an exceedingly rare tumor of the salivary gland (SG), being considered as a variant of SG lipomas. Clinically, swelling in the SG affected is observed, and this tumor is most common in the parotid gland of men. We report 2 cases of oncocytic sialolipomas affecting a 44-year-old man and a 49-year-old woman. Partial parotidectomy was performed in both cases. The histopathologic examination revealed well-circumscribed tumors with a biphasic pattern: the oncocytic epithelial component showing cells with different sizes organized in nests or ductal structures and a well-recognized adipocytic background. Immunohistochemical reactions were performed, and the oncocytic epithelial component was positive for CK7, CK14, and anti-mitochondrial antigen. After the surgical excision, no sign of recurrence was observed. As these tumors may have a clinical presentation similar to other benign and malignant SG tumors, histopathologic examination is mandatory to establish the proper diagnosis.
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