Low Average Score Research Articles

P687 Early and sustained improvement in stool frequency and rectal bleeding following 52 weeks of mirikizumab treatment

Abstract Background Interleukin (IL)-23 is a key cytokine in inflammatory bowel disease pathogenesis. Mirikizumab (miri), a p19-directed IL-23 antibody, demonstrated efficacy and was well-tolerated in patients with moderate-to-severely active ulcerative colitis (UC) during 52 weeks of a Phase 2 randomised clinical trial (AMAC, NCT02589665). The effects of miri on stool frequency (SF) and rectal bleeding (RB) through Week 52 are reported. Methods Patients (Mayo score 6–12 with endoscopic subscore [ES] ≥2) were randomised 1:1:1:1 to receive intravenous (IV) placebo (n = 63), miri 50 mg (n = 63) or 200 mg (n = 62) with possibility of exposure-based (EB) dose increases, or fixed miri 600 mg (n = 61) every 4 weeks (Q4W). Responders to miri at Week 12 (9-point Mayo score decrease ≥2 points and ≥35% change from baseline, with RB=0 or 1 or decrease ≥1) were re-randomised 1:1 into a double-blind maintenance period to receive miri 200 mg subcutaneously (SC) Q4W (n = 47) or every 12 weeks (Q12W; n = 46), and were treated through Week 52. Patients reported UC symptoms, including SF and RB, via a daily diary. Changes from baseline in average Mayo SF and RB subscores at Weeks 2, 4, and 12 were analysed using a mixed model repeated-measures method to account for missingness and baseline characteristics. Results Significant improvement in SF was observed as early as Week 2 in the miri 600 mg Q4W group and as early as Week 4 in the miri 200 mg Q4W group (Figure). Similarly, significant improvement in RB was observed as early as Week 2 in both the miri 200 mg Q4W and 600 mg Q4W groups. Patients who received miri 200 mg Q4W or 600 mg Q4W had a significantly greater reduction in both SF and RB compared with placebo at Week 12 (all p < 0.001) (Figure). Patients who achieved clinical response at Week 12 and were treated with miri 200 mg SC Q4W or SC Q12W maintained a low average SF and RB score at Week 52. Conclusion Significant improvements in SF and RB occurred as early as Week 2 of induction treatment and continued to improve during maintenance treatment with mirikizumab. These data demonstrate the early efficacy and longer-term effects of an IL-23p19 antibody on these patient-reported outcomes.

An olympiad in Biology as an evaluation tool of the educational process quality at a university

The paper discusses the importance of using extracurricular forms of education-Biology olympiads for the development of students creative potential, their professional development and quality improvement of the educational process. The tasks of the subject olympiad are grouped into three blocks depending on the degree of complexity, allowing to assess the level of intellectual capacity and creative thinking. The number of correctly completed tasks with a choice of one answer is more than 52%, it indicates the students ability to apply basic knowledge in the field of Biology for the solution of the standard problems. 86,06% of students are able to use critical thinking by performing tasks of increased complexity with a multiple choice of answers, to solve standard professional tasks in accordance with the algorithm. 56,74% of students have a high level of intellectual activity, creative approach for solving practice-oriented problems with a free answer. The tasks in the field of molecular Biology of cells, regardless of their type, caused students difficulties. A low average score is typical for practice-oriented tasks associated with the assessment of the organism response to environmental factors and patterns of several traits inheritance with different types of inheritance (0,72 and 0,39, respectively, with a maximum score of 5). The results of the olympiad indicate that the competence approach should be used in Biology teaching for education quality.

Analysis of Cesarean Section Clinical Pathway Compliance at a Private Hospital in Yogyakarta

This study aims to analyze the relationship between the compliance with the implementation of clinical pathways to therapeutic outcomes (ILO events, length of stay, pain intensity) and the total real cost of cesarean section patients. The study was conducted at a type C private hospital in Yogyakarta. This study is a non-experimental analytical study (observational analytic) with a cross sectional design using a retrospective data collection method and analyzed using Chi square test and non parametric regression test. Descriptive analysis for compliance with the implementation of clinical pathways was carried out by assessing the compliance of each care point contained in the clinical pathway section of the cesarean consisting of 12 points of care and will be grouped into two categories namely low compliance category with the average compliance value for clinical pathway <85% and good compliance with the average compliance value for clinical pathway ≥85%. Descriptions of adherence to the implementation of clinical pathway cesarean section each patient showed that as many as 686 patients (98%) had a good average compliance score and 14 patients (2%) had a low average compliance score. Outcome description 700 patients with cesarean section were found 1 patient experienced ILO, LOS according to clinical pathway (≤3 days) as many as 620 patients and 700 patients with pain scale ≤3. The results of the analysis of the relationship between the compliance and the implementation of the clinical pathway to the outcome of therapy (ILO events, length of stay, and pain intensity) showed the existence of a compliance relationship to the implementation of the clinical pathway with a value of p<0.05. The analysis of the relationship between the compliance to the implementation of the clinical pathway and the total real costs shows the relationship between the compliance with the implementation of the caesarean section clinical pathway at a type C private hospitals in Yogyakarta with the total real costs with p value of 0,000 and r value of 0.014.

Valproate-induced reversible atrophy and cognitive decline: a case

Background: Valproate (VPA) has been previously described to cause reversible cerebral atrophy and cognitive decline, but few cases are reported and neuropsychological data is lacking. We report a case of VPA induced encephalopathy in an 11-year-old girl with temporal lobe epilepsy, presenting with impaired cognition and sedation combined with cerebral atrophy.
 Methods: Cognitive capacity was assessed using Wechsler Intelligence Scales for Children IV (WISC), non-standardised word lists and visual reproduction. Brain magnetic resonance imaging (MRI) was performed prior to, during and post VPA therapy.
 Results: Our patient demonstrated average full-scale intelligence quotient, verbal comprehension, perceptual reasoning and working memory. There was a marked discrepancy in processing speed, which ranked low average (score – 80; 9th percentile). Difficulties with mental abstraction and manipulation were noted. Brain MRI (3T) demonstrated mild generalised parenchymal atrophy. Cessation of VPA resulted in dramatic improvement in clinical symptoms (1 month after cessation) and normalisation of brain MRI (11 months after cessation). Progress neuropsychological testing 13 months after cessation showed marked improvements in processing speed. 
 Conclusion: This case provides an important reminder of this rare but importantly reversible syndrome with new information supporting the neuropsychological changes involved.

PO475 Potential of a Principal-Run Rheumatic Heart Disease Prevention Program In Samoa

As radiologic assessment is a key part in evaluating patients visited in emergency department, this survey was conducted to measure emergency medicine residents’ competency in choosing appropriate diagnostic imaging in different clinical scenarios.All emergency medicine residents enrolled in an academic emergency medicine discipline in the three medical universities of Tehran, Iran were recruited. A questionnaire was designed consisting of 10 clinically common scenarios selected from the American College of Radiology appropriateness criteria. Each resident completed the survey separately with answers only given after all residents participated.196 residents completed the survey (95% of all residents). The results were stratified by post-graduate year and university. The average number of correct answers was 6.2. First, second and third year residents scored the average of 6.1, 5.8 and 6.5, respectively (P = 0.04). The average score of residents from different universities did not differ significantly.According to the low average score, it is recommended that attentive educational perfections are needed to help residents order more appropriate diagnostic images, which may also be helpful for other healthcare providers. However, it seems that our emergency medicine academic curriculum is relatively efficient to enhance residents’ skills in choosing proper imaging.

USING ANIMATED FILM AS TEACHING MEDIA TO IMPROVE THE STUDENTS’ NARRATIVE TEXT WRITING SKILL OF THE TENTH GRADERS OF SMA EL SHADAI MAGELANG IN THE SCHOOL YEAR 2016/2017

Writing is important for the high school students. The students do not reach the standard score of writing. There are several factors which may cause it less than minimum standard. The most prominent problems identified are the students have low motivation in learning English and the teacher uses monotonous technique in teaching writing. Therefore, the writer conducted a research to overcome the problem by using Animated Film as a teaching media. There are two objectives of the study. The first is to describe the use of animated film as a teaching media increases the students‟ learning motivation of the narrative text writing skill of the tenth graders of SMA El Shadai Magelang in the school year 2016/2017. The second is to explain the improvement of the narrative text writing skill of the tenth graders of SMA El Shadai Magelang in the school year 2016/2017 taught by using animated film as a teaching media is. The writer conducted classroom action research which was divided into Pre-Cycle, Cycle I and Cycle II. To collect the data, the writer used non-test (observation, questionnaire, and documentation) and test technique. The data were analyzed using quantitative and qualitative data analyses technique. The writer took XC class of SMA El Shadai Magelang as the subject of the research because it has low average score of the writing test. Based on the data analysis, it shows that there are some changes in the students’ learning motivation after the writer taught using Animated Film as a teaching media.

PENERAPAN MODEL PEMBELAJARAN DIRECT IINSTRUCTION (DI) TERHADAP PRESTASI BELAJAR MAHASISWA PRODI PENDIDIKAN TIK IKIP PGRI PONTIANAK

<p><em>The </em>aims<em> of this study were to investigate the </em><em>improvement of student achievement after given DI model. </em><em>This research used quasi experimental research. </em><em>The data collection technique was include test methods for data for student achievement. The data was analyzed </em><em>using n-gain analyzed (before-after analyzed)</em><em>. Based on these results it can be concluded there is improvement of student achievement after given DI model. </em><em>The result of the normalized gain score analysis obtained 2 students (6.25%) got high gain score, 14 students (43,75%) got medium gain score and 16 student (50%) got low gain score and overall average gain score students of 0.26 are categorized as low.</em></p>

The Good Governance Level’s Profile of Sport Organization in Central Java

The aim of this research is to get the level of good governance of Sports Organization in Central Java. This quantitative descriptive research conducted at sports organization in 29 cities throughout Central Java. The questionnaire used was the Action for Good Governance in the International Sports Organization (AGGIS) Sports Governance Observer developed by the Danish Institute of Sports Studies, Denmark and data analysis used the Sports Governance Observer (SGO) Index to generate the average percentage score of four dimensions. From the analysis result, Kota Salatiga and Kota Pekalongan have the highest level of good governance with 60%. However, Kabupaten Tegal becomes the lowest level of good governance, 21.88%, and overall, the average level of good governance of sports organizations in Central Java is only 38.62%. The low average score has affected by the transparency rate, only 37%, because the organization does not have a website or social media so the community to monitor the use of budget and activities. Later this initial data could be a basis for determining the policy in improving the good governance and similar research can be done every one period

PENGARUH KEMAMPUAN NUMERIK TERHADAP HASIL BELAJAR TOPIK ALJABAR DI KELAS VIII MTs PERSIAPAN NEGERI BINTANG SEMBILAN SIBABANGUN KABUPATEN TAPANULI TENGAH

This research is motivated by the fact that there are still many students in class VIII MTs Preparation of Negeri Bintang Sembilan Sibabangun Tapanuli Tengah who have not understood and understood about the material of alajabar which resulted in the lack of students' reasoning so that the impact on student learning outcomes on algebra topic material. The purpose of this study are: to determine the significant effect of Numerical Ability Students Against Topic Algebra class VIII MTS preparations Negeri Sembilan Sibabangun Negeri. Tapanuli Tengah. This research is a quantitative research universal. The total population in this research is 91 students. Sampling was done in a way as a whole with a sample of 91 students. To obtain this research data using test instrument. As for hypothesis testing by using correlation analysis (product moment and spearman rank), simple linear regression tdan test using SPSS Statistic V.21. Based on the research results can be seen that: there is no significant influence between the numerical ability of students (X) on the topic of algebra (Y). Where the results of product moment correlation analysis with SPSS resulted in correlation coefficient of 0.859, while the rtabel value of 0.207. This shows that rhitung> rtabel. As for the significance of the calculation of t test obtained for t count> ttable, namely 51.036> 1.9863. And for regression equation obtained Y = 12,737 + 0,275X. The regression equation of Y over X indicates that the low average score of algebra topic (Y) of 34.10 does not affect the score of students numerical ability (X) of 77.8. It shows that there is no effect of X to Y. As for F test, the result is 984,836 with Ftable equal to 1,698495, it can be concluded that Fcount> Ftable = 984,836> 1,698495. This means there is a Significant Influence Between Student Nmerik Ability on Learning Outcomes Algebra Topics in Class VIII MTs Pesiapan Negeri Bintang Sembilan Sibabangun.

Maturity levels for private internal investigations

The purpose of private internal investigations by fraud examiners is to reconstruct the past by identifying past events and sequences of events. In this article, work by fraud examiners is studied in terms of maturity; introduce a five-stage model for investigation maturity: chaos, mess, disclosure, clarification, and investment. Based on student term papers in a financial crime class, six investigation reports are allocated to levels in the maturity model. The average score for the investigation reports is a level 3 disclosure, where the investigation is problem-oriented and often limited by the mandate. Based on the low average score, this article discusses the privatization of law enforcement, secrecy of investigation reports, lack of disclosure to the police, competence of private investigators, and limits of the investigation mandate.

THE ANALYSIS OF ANTI-CORRUPTION BEHAVIOR (CASE STUDY: BATAM CENTRAL BUREAU OF STATISTIC (BPS) SERVICES)

Anti-Corruption Behaviour Survey is a national programme that measures individual Indonesians' anti-corruption knowledge, attitudes and experiences. The Survey also assesses the nationwide implementation of the National Anti-Corruption Strategy for the Prevention and Eradication of Corruption (STRANAS-PPK) to establish a culture of zero tolerance for corruption in the country. A key activity in support of this assessment is to set the baselines for the STRANAS-PPK anti-corruption strategies.This study is aimed to analyze the mainly determined the anti-corruption behavior on Batam Central Bureau of Statistic (BPS). This research used descriptive statistical analysis method. Data collected in this research use interview technique, observation, and questioner. This sample of this research has been taken from government institution/ Regional Work Unit (SKPD)/ Research and Education Institution : National and International/ Mass Media/ Banking/ Private.The result of the analysis indicates that Batam Central Bureau of Statistic (BPS) is relatively high compared with the average score of hope, The low average score of expectation shows that anti-corruption conditions in Batam Central Bureau of Statistic (BPS) services are clean enough

Imaging appropriateness in an academic emergency medicine program

IntroductionAs radiologic assessment is a key part in evaluating patients visited in emergency department, this survey was conducted to measure emergency medicine residents’ competency in choosing appropriate diagnostic imaging in different clinical scenarios. MethodsAll emergency medicine residents enrolled in an academic emergency medicine discipline in the three medical universities of Tehran, Iran were recruited. A questionnaire was designed consisting of 10 clinically common scenarios selected from the American College of Radiology appropriateness criteria. Each resident completed the survey separately with answers only given after all residents participated. Results196 residents completed the survey (95% of all residents). The results were stratified by post-graduate year and university. The average number of correct answers was 6.2. First, second and third year residents scored the average of 6.1, 5.8 and 6.5, respectively (P=0.04). The average score of residents from different universities did not differ significantly. ConclusionAccording to the low average score, it is recommended that attentive educational perfections are needed to help residents order more appropriate diagnostic images, which may also be helpful for other healthcare providers. However, it seems that our emergency medicine academic curriculum is relatively efficient to enhance residents’ skills in choosing proper imaging.

Grau de integração da Atenção Primária à Saúde de município de pequeno porte na Rede de Atenção à Saúde

Resumo A integração da atenção à saúde tem representado importante desafio na prestação de cuidados à saúde. Mas, estudos brasileiros ainda não a avaliaram de forma objetiva e consideraram, apenas, o contexto de grandes municípios em suas análises. Diante disso, o objetivo deste estudo foi mensurar o grau de integração (GI) da Atenção Primária à Saúde (APS) na Rede de Atenção à Saúde (RAS) em município de pequeno porte. Para tal, elaborou-se, a partir da literatura científica e de recomendações técnicas sobre o tema, uma matriz com 25 indicadores, acompanhados dos respectivos parâmetros de avaliação e pontuados com zero a três pontos. Para responder aos indicadores, pontuando-os, questionários foram aplicados a profissionais de saúde. Além disso, formulários de encaminhamentos para consultas e exames especializados na RAS foram analisados. A partir da pontuação atribuída aos indicadores, o GI foi calculado pela relação entre a soma dos pontos recebidos e o total de pontos esperados, multiplicado por 10. A extensão do GI foi interpretada considerando a integração como um contínuo. Os resultados evidenciaram pontuação média por indicador muito baixa. O GI atingiu o escore 3,86, indicando pouca integração da APS na RAS, revelando indicadores críticos e dificuldades para a integração em município de pequeno porte.

Environmental impact assessment of perennial crops cultivation on marginal soils in the Mediterranean Region

Perennial crops, as energy feedstocks, offer ecological advantages over fossil fuels by contributing to the reduction of greenhouse gases and fossil energy savings. Yet, the intensity of agricultural production may increase the pressure on soil, water resources and on biological and landscape diversity. Moreover, land use competition with food crops is demanding a spatial segregation of energy producing areas to land currently marginal for agricultural production. Therefore, the objective of this work was to determine the local and site-specific environmental impacts associated with the cultivation of perennial crops in marginal soils. The study, supported by the European Union (project OPTIMA - Optimization of Perennial Grasses for Biomass Production), was developed and applied to the cultivation phase of several perennial crops, in marginal soils of the Mediterranean region, using environmental impact assessment (EIA) protocols. Investigated crops include Miscanthus (Miscanthus × giganteus Greef et Deu), giant reed (Arundo donax L.), switchgrass (Panicum virgatum L.) and cardoon (Cynara cardunculus L.). Different categories were studied: fertilizers and pesticides related emissions, impact on soil and water resources and biological and landscape diversity. Results suggest that growing perennial crops in marginal Mediterranean soils do not inflict a higher impact to the environment than wheat farming (the current land use). At a scale from 0 (lower impact) to 10 (higher impact), against idle land (the reference system with a score of 5), wheat and giant reed showed the highest scores (6.7–7.3 and 6.7–7.1, respectively). Impact scores of the remaining perennials decreased in the order cardoon (5.7–6.0), Miscanthus (5.4–5.6), and switchgrass (5.2–5.5), the last one showing the lowest difference to the reference system. Overall results suggest that perennial crops provide benefits regarding soil properties and erodibility (with an average score of 2.2 and 5.6, respectively). Cardoon also showed benefits related with the biological and landscape diversity, scoring 5.0, like the reference system. On average, perennial crops showed a score of 6.3 and 6.9 towards the same categories. Impacts associated with water resources and N-fertilizer related emissions were high (with average scores of 8.1 and 8.3, respectively) but impacts associated with pesticide related emissions were low (average score of 5.4).

Climate change perceptions and response strategies of forest fringe communities in Indian Eastern Himalaya

The study documented perception of forest fringe community of Chilapata reserve forest in West Bengal, India, from September 2013 to May 2015 through questionnaire-based personal in-depth interviews involving 400 respondents and group discussions. Adaptation strategies used by the community in response to impact of climate change were also documented. Majority of the respondents were farmers with marginal land holding. Almost all the respondents perceived the phenomena of climate change. The overall perception of the community toward change in temperature-related events and precipitation is high with average perception score of 0.74, while it is medium for change in regularity of climate events with score of 0.51. In spite of such perceptions, the community had low average livelihood impact perception score of 0.23. Considering the adaptation strategies based on knowledge–adoption index, the adaptation in response to climate change is at medium level with average mean score of 0.63. A total of 17 coping options were identified. Pre-monsoon dry seeding, agroforestry, crop rotation, short duration crop varieties and use of organic products were popular. The study recommend a need for scientists, government and non-government agents and other stakeholders to support efforts by farmers to adapt to effects of climate change through technological, policy and financial interventions with an aim of improving livelihoods and food security.

Observer et évaluer la qualité des interactions enseignant.e/enfants à l'école maternelle en Belgique pour soutenir le développement langagier des enfants de 4 ans : une étude exploratoire

Early childhood education is a privileged context for children to develop their language and communication abilities (Dickinson, 2011). More specifically, it is demonstrated that the quality of the interactions between teachers and children plays a protective role on language and communication development for more vulnerable children (Burchinal et al. 2010; Simard et al. 2013). The current study explores the quality of interactions in kindergarten in the French-speaking part of Belgium (second year for children of 4-5 years old). Observations took place in 17 classes, using the CLASS® Pre-K (Classroom Assessment Scoring System®, Pianta et al. 2008). Similar to other international investigations, our results show heterogeneity in the scores of the different classes. But overall, emotional support and classroom organization reach medium to high quality level, while instructional support shows a low average score. Some dimensions of the instructional support vary as a function of the teacher/children ratio and the type of activity. This exploratory study enables a reflection about language development support in early childhood education and raises questions about creative ways to optimize it.

Derive Program Implementation in Mathematics (The Math Learning of State Polytechnic Malang

a lot of students have difficulty in Math. Every semester there are always students who get D or E for Math. It makes low average score and the students who get E or IP<2,00 are dropped out. The lecturer must have many methods to help them. The Derive Program of Window software can help the students to increase their motivation. The functions of Derive Program are like a calculator. The subjects depend on the needs of the Department. For Civil Engineering needs the subject of Matrix, Determinant, Equation, Graphs, Derivative, and Integral. The result of average Math score of Derive Program is better than the Theory. The motivation of students has increased and students have enjoyed, have fun and spirit, and are more interested to solve problems in Math.Keywords: learning; motivation; derive program

Lichen fungi in the Atlantic rain forest of Northeast Brazil: the relationship of species richness with habitat diversity and conservation status

Although lichens develop their highest biomass in cool-temperate climates, lichen fungi may form highly diverse assemblages in tropical lowland rain forests. The reasons for such high species richness are not well known. The present study tested the hypothesis that lichen diversity in the northern Atlantic rain forest mainly depends on habitat diversity and conservation status of forest fragments. To this end, the known lichen biota of 23 forest remnants in the region was analyzed. We identified 784 species, with 11 taxa newly reported from Brazil and 44 from Bahia. The vast majority (711) are principally corticolous, while 53 are saxicolous and 20 terricolous. The most frequent species in terms of site occurrence were found at 13 sites, whereas over half of the taxa (462) were only found at a single site. This coincides with an overall low average sampling score, with only six sites being moderately well to well sampled. The number of species per site varied between 5 and 371. Multiple linear regression of species richness with the parameters, site extension, habitat diversity, sampling effort, conservation status, and elevation, was strong and highly significant, with site extension, habitat diversity, and sampling effort being the best predictors for species richness. Site ordination based on species composition suggested a correlation with conservation status and species richness, as well as site extension and habitat diversity. There was no overall correlation between species composition and geographical location of sites along a north–south gradient, but an underlying pattern was detected, suggesting some species turnover along a macroecological gradient. A predictive model using a combined score from the five parameters resulted in a strong and highly significant linear correlation with observed species richness. Using a quantitative, site-based method, we predicted a minimum of 44 and a maximum of 583 species per studied site and we estimated the overall richness for the northern Atlantic rain forest to be 1017 species. Traditional estimators (Chao 1, Chao 2, Jackknife 1, Jackknife 2, Bootstrap) resulted in predicted values ranging between 971 and 1527 species overall. The results of the study are relevant for conservation priorities, as they show that well-conserved areas with a higher habitat diversity (e.g., including transitional forest types and open areas) are an important component preserving the original diversity of the Atlantic Rain Forest, accounting for a large part of the extant biodiversity of this biome.

Assessing the Efficiency of Small-Scale and Bottom Trawler Vessels in Greece

This study explores the technical and scale efficiency of two types of Greek fishing vessels, small-scale vessels and bottom trawlers, using a bias-corrected input-oriented Data Envelopment Analysis model. Moreover, the associations between efficiency scores and vessel’s and skipper’s characteristics are also explored. The results indicate that small-scale vessels achieve a very low average technical efficiency score (0.42) but a much higher scale efficiency score (0.81). Conversely, bottom trawlers achieve lower scale but higher technical efficiency scores (0.68 and 0.73, respectively). One important finding of this study is that the technical efficiency of small-scale vessels, in contrast to trawlers, is positively associated with the experience of the skipper. In a looser context, it can be said that small-scale fisheries mainly rely on skill, whereas bottom trawlers rely more on technology. This study concludes that there is space for improvement in efficiency, mainly for small-scale vessels, which could allow the achievement of the same level of output by using reduced inputs.

Neurophysiologic Evaluation of Children with Beta-Thalassemia Major

Neural pathway involvement is considered to be a neurological complication in Beta-thalassemia major (BTM). This study aimed to detect possible involvement of central and peripheral neural pathways in a group of neurologically asymptomatic patients with BTM. It was performed on 30 patients diagnosed as having BTM (group I), and 10 healthy children who were matched for age, sex, and height (group II). Serum ferritin, iron, glucose tolerance test, intelligence quotient (IQ) test, and electroencephalogram (EEG) were assessed in BTM patients. Electrophysiologic study was assessed in both groups. The mean age of the patients was 10.45 ± 2.88 years. They were 14 males and 16 females. The results of the present study showed that 66.7% of patients had subclinical sensory peripheral neuropathy. Twenty percent of the patients had abnormal somatosensory evoked potentials. Low average and slow learner total IQ score were found in 63.3% of the studied patients. These findings did not correlate with age, disease duration, serum iron, and ferritin. Twenty-three patients had mature EEG background activity, while seven patients had immature background activity. The EEG background maturity had significant correlation with age, duration of desferrioxamine therapy, and serum iron. There was no correlation between serum ferritin level, EEG, and electrophysiologic findings. Regular electrophysiologic monitoring and intellectual evaluation are recommended to detect relevant abnormalities and apply appropriate management.