Loss Of Stability Research Articles

Modeling of heat transfer at local convection over a vertical throughflow in a two-layered air-heat generating porous system

Convective heat transfer in an air layer partially filled with a heat-generating granular porous medium is studied. There is a slow seepage of air through the layer in the vertical direction with a constant velocity. Equal temperatures are maintained at the outer solid permeable boundaries, and the heat source strength is constant within the porous sublayer and is proportional to the solid volume fraction. The permanent heat generation within the porous sublayer, combined with the vertical throughflow, causes a nonlinear thermal profile which is conducive for convection to occur. The Boussinesq approximation and Darcy's law are used to describe this convection. Numerical solution of the nonlinear convective problem is obtained on the basis of Newton's method. In the limiting case, the numerical data for the onset of convection are compared with the results of the earlier paper of the authors, where a linear stability theory and a method for constructing of the fundamental system of partial solution vectors have been applied, and with the data by other authors. The stationary regimes of local convection, which occurs in an “air – heat-generating porous medium-air” system over the basic vertical throughflow, and its effect on the heat transfer from the porous air sublayer with the growth of supercriticality are studied. It is shown that, depending on the velocity of the basic throughflow (the Peclet number), convection excitation can be both soft (due to supercritical pitchfork bifurcation) and hard (when the loss of stability of the basic throughflow is accompanied by subcritical pitchfork bifurcation that gives rise to an unstable secondary convective regime). This secondary regime is replaced by a stable tertiary convective regime with increasing supercriticality. It has been found that the total heat transfer rate for the upward basic throughflow exceeds that for the downward basic throughflow significantly, and that local convection at any direction of this throughflow increases the heat transfer rate in the system. An increase in the Nusselt number with the growth of supercriticality is recorded. However, a noticeable contribution of local convection to the total heat transfer is observed only when all values of the Pecklet number are negative and its positive values are lower than 2.

Improvement of the Ductility of Environmentally Friendly Poly(lactide) Composites with Posidonia oceanica Wastes Plasticized with an Ester of Cinnamic Acid.

New composite materials were developed with poly(lactide) (PLA) and Posidonia oceanica fibers through reactive extrusion in the presence of dicumyl peroxide (DCP) and subsequent injection molding. The effect of different amounts of methyl trans-cinnamate (MTC) on the mechanical, thermal, thermomechanical, and wettability properties was studied. The results showed that the presence of Posidonia oceanica fibers generated disruptions in the PLA matrix, causing a decrease in the tensile mechanical properties and causing an impact on the strength due to the stress concentration phenomenon. Reactive extrusion with DCP improved the PO/PLA interaction, diminishing the gap between the fibers and the surrounding matrix, as corroborated by field emission scanning electron microscopy (FESEM). It was observed that 20 phr (parts by weight of the MTC, per one hundred parts by weight of the PO/PLA composite) led to a noticeable plasticizing effect, significantly increasing the elongation at break from 7.1% of neat PLA to 31.1%, which means an improvement of 338%. A considerable decrease in the glass transition temperature, from 61.1 °C of neat PLA to 41.6 °C, was also observed. Thermogravimetric analysis (TGA) showed a loss of thermal stability of the plasticized composites, mainly due to the volatility of the cinnamate ester, leading to a decrease in the onset degradation temperature above 10 phr MTC.

Optimization of distribution network operating parameters in grid tied microgrid with electric vehicle charging station placement and sizing in the presence of uncertainties

ABSTRACT The power generated by renewable sources is prone to uncertainties which encourages to perform effective modelling to ensure the reliable operation of the grid-connected microgrid (MG) system. This work focuses on the uncertainty modelling of primary sources of solar power, wind power and electric vehicle (EV) load considering three factors battery capacity, state of charge (SoC) and type of EVs charged by employing Monte-Carlo Simulation (MCS) to minimize the distribution system's voltage stability, reliability and power loss (VRP) index. The objective function is tested on the modified IEEE-33 bus distribution system under three diverse scenarios with optimum sizing and placement of RESs and EVCS. To obtain optimal solutions for the proposed problem in a reasonable computation time, modified version of teaching and learning-based optimization (TLBO) and the JAYA algorithm are applied as the rate of convergence is superior to other existing methods in the literature and does not require any precise control parameters. For all the scenarios, it can be seen that the modified JAYA algorithm outperforms TLBO and other existing approaches. The findings of the results reveal the efficacy of uncertainty modelling in a proposed grid-connected DC MG to curtail the VRP index.

Comparative analysis of the stability and natural vibrations of shallow panels under the action of thermomechanical loads

The work is a continuation of research devoted to substantiating the reliability of solutions obtained by the finite element method for the analysis of nonlinear deformation, buckling and vibrations of thin elastic shells under the action of thermomechanical loads. The method is based on geometrically nonlinear relations of the three-dimensional theory of thermoelasticity and the principles of the moment finite element scheme. A thin elastic shell of an inhomogeneous structure is modeled by a universal spatial isoparametric finite element. The modal analysis of the shell is implemented at each step of the static thermomechanical load. The subspace iteration method is used to determine the spectrum of the lowest frequencies of natural vibrations of shells. A shallow spherical panel with a square plan is considered. The effect of preheating on the loss of stability and vibrations of an elastic isotropic shell under uniform pressure loading is investigated. The behavior of the shell weakened by two pairs of cross-channels is analyzed. The weakening of the panel by narrow and wide channels, which can be eccentrically located relative to the middle surface of the shell, is considered. The effectiveness and adequacy of the method is confirmed by a comparative analysis of solutions with results obtained using modern multifunctional software systems LIRA-SAPR and SCAD. The features of using the systems for solving the problems under consideration are given. Analysis of the results made it possible to evaluate the possibilities of using these software systems to substantiate the reliability of solutions to certain classes of problems of geometrically nonlinear deformation, buckling and vibrations of elastic shells.

Parental Involvement in the Transition from Paediatric to Adult Care for Youth with Chronic Illness: A Scoping Review of the North American Literature.

With medical advancements and improvements in medical technology, an increasing number of children with chronic conditions survive into adulthood. There is accordant growing interest toward supporting adolescents throughout the transition from paediatric to adult care. However, there is currently a paucity of research focusing on the role that these patients' parents should play during and after the transition to adult care and if maintained parental involvement is beneficial during this transition within a North American context. Accordingly, this scoping review utilized Arksey and O'Malley's five-step framework to consider parental roles during chronically ill children's transition to adult care. APA PsycInfo, CINAHL, EMBASE, MEDLINE, ProQuest, and Scopus were searched alongside advanced Google searches. Thematic content analysis was conducted on 30 articles meeting the following inclusion criteria: (1) published in English between 2010 and 2022, (2) conducted in Canada or the United States, (3) considered adolescents with chronic conditions transitioning to adult care, (4) family being noted in the title or abstract, and (5) patient populations of study not being defined by delays in cognitive development, nor mental illness. Three themes emerged from the literature: the impacts of maintaining parental involvement during transition to adult care for patients, parents experiencing feeling loss of stability and support surrounding the transition of their child's care, and significant nonmedical life events occurring for youths at the time of transition of care. Parents assuming supportive roles which change alongside their maturing child's needs were reported as being beneficial to young peoples' transition processes, while parents who hover over or micromanage their children during this time were found to hinder successful transitions. Ultimately, the majority of reviewed articles emphasized maintained parental involvement as having a net positive impact on adolescents' transitions to adult care. As such, practice and policies should be structured to engage parents throughout the transition process to best support their chronically ill children during this time of change.

On the partition noise in chosen particle weighted methods and its consequences for weakly-compressible flow models

The Meshless Finite Volume (MFV) method, which is a member of the particle weighted methods (PWM) family, is analysed in the context of the so-called partition noise problem. This issue is inherent to PWM-type discretisation which is based on compact support kernel functions and particle sampling. The partition noise exhibits itself as spurious oscillations observed in the solution; they are caused by unphysical source terms in the discretised equations and approximate local volumes computation. Unfortunately, decreasing the discrete length scale which controls the spatial resolution reduces the partition noise only weakly (and never completely). When choosing numerical schemes, a special care is required since in naive implementations the partition noise may even lead to loss of stability. However, even when stability is assured, PWM does not fulfil the assumptions of the Lax equivalence theorem (i.e. the discretised equations are not consistent), therefore convergence in the classical meaning cannot be guaranteed.As an example of a problematic use of MFV, we investigate its application to the solution of fluid flow equations at low Mach numbers, aiming to mimic truly incompressible flow conditions. Taken here as isothermal Euler equations, they are the basis of the so-called weakly-compressible (WC) flow models. Such modelling does not involve any elliptic-type equation and, due to the algorithmic and computational reasons, seems to be well-suited for particle methods. The WC flow model imposes, however, a serious challenge for PWM since: (i) the method is not gauge invariant and the disparity between the speed of sound and the convective velocity scale causes a significant spurious source of momentum; (ii) the inaccuracy in the local volumes approximation leads to errors in the computed density which are comparable to physically relevant slight variations, inherent to the WC approach. We propose specific numerical and modelling measures: controlled relaxation of initial particle distribution, particle volumes computation using an optimal kernel function, a choice of gradient limiting techniques and a carefully chosen background pressure. Although these improvements significantly increase the accuracy (however at remarkably increased computational cost), the theoretical 2nd-order convergence is achieved only at lower spatial resolutions when the truncation errors dominate. The accuracy of mesh-based methods is achieved in PWM only for the pressure field; the errors in the velocity field are much larger and convergence is at most 1st-order. We point some contradictory requirements of the model equations and the numerical method. One of the conclusions is that it is doubtful to construct a convergent truly Lagrangean method of PWM type at reasonable computational cost. The present findings also apply to conservative variants of the weakly-compressible Smoothed Particle Hydrodynamics which, being first order consistent in the best case, suffers from the partition noise even more severely than the considered MFV approach which is theoretically second order consistent. The conclusions pose a question about a rationale for the use of WC-PWM approach in chosen applications, in particular free surface and interfacial flows.

Lattice Distortion and Low-Frequency Anharmonic Phonons Suppress Charge Recombination in Lead Halide Perovskites upon Pseudohalide Doping: Time-Domain Ab Initio Analysis.

Perovskite solar cells have witnessed a surge in interest as a promising technology for low-cost, high-efficiency photovoltaics with certified power conversion efficiencies beyond 25%. However, their commercial development is hindered by poor stability and nonradiative losses that restrict their approach to the theoretical efficiency limit. Using ab initio nonadiabatic molecular dynamics, we demonstrate that nonradiative charge recombination is suppressed when the iodide in formamidinium lead iodide (FAPbI3) is partially replaced with pseudohalide anions (SCN-, BF4-, and PF6-). The replacement breaks the symmetry of the system and creates local structural distortion and dynamic disorder, decreasing electron-hole overlap and nonadiabatic electron-vibrational coupling. The charge carrier lifetime is found to increase with increased structural distortion and is the longest for PF6-. This work is fundamentally relevant to the design of high-performance perovskite materials for optoelectronic applications.

Methodology for Power Systems’ Emergency Control Based on Deep Learning and Synchronized Measurements

Modern electrical power systems place special demands on the speed and accuracy of transient and steady-state process control. The introduction of renewable energy sources has significantly influenced the amount of inertia and uncertainty of transient processes occurring in energy systems. These changes have led to the need to clarify the existing principles for the implementation of devices for protecting power systems from the loss of small-signal and transient stability. Traditional methods of developing these devices do not provide the required adaptability due to the need to specify a list of accidents to be considered. Therefore, there is a clear need to develop fundamentally new devices for the emergency control of power system modes based on adaptive algorithms. This work proposes to develop emergency control methods based on the use of deep machine learning algorithms and obtained data from synchronized vector measurement devices. This approach makes it possible to ensure adaptability and high performance when choosing control actions. Recurrent neural networks, long short-term memory networks, restricted Boltzmann machines, and self-organizing maps were selected as deep learning algorithms. Testing was performed by using IEEE14, IEEE24, and IEEE39 power system models. Two data samples were considered: with and without data from synchronized vector measurement devices. The highest accuracy of classification of the control actions’ value corresponds to the long short-term memory networks algorithm: the value of the accuracy factor was 94.31% without taking into account the data from the synchronized vector measurement devices and 94.45% when considering this data. The obtained results confirm the possibility of using deep learning algorithms to build an adaptive emergency control system for power systems.

Mathematical Modeling of the Evolutionary Dynamics of a Planktonic Community Using a Discrete-Time Model

This study proposes a discrete-time eco-genetic model of a planktonic community that includes zooplankton and two competing phytoplankton haplotypes with and without a toxicity trait. The Holling type II response function describes predator consumption. We use the Ricker model to consider density limitation and regulation. The model is analytically and numerically studied. The loss of stability of fixed points occurs via the Neimark–Sacker scenario and a cascade of period-doubling bifurcations. The model reveals bistability and multistability. Therefore, the initial conditions can determine which of the coexisting dynamic modes will be attracted. If the competition of haplotypes is weaker than their self-regulation, then the variation in the current densities of community components can shift the observed dynamics, while the evolution direction remains unchanged. The ratio of haplotype fitnesses and predator pressure generally determines the asymptotic genetic composition of phytoplankton. If competition of haplotypes is higher than their self-regulation, then the bistability of monomorphic fixed points occurs when the displacement of one haplotype by another depends on initial conditions. The presence of predators can maintain the genetic polymorphism of the prey. This system shows dynamic modes similar to experimental dynamics: oscillation with delay, long-period antiphase fluctuations, and cryptic cycles emerging due to rapid evolution.

Characterization of the degradation products of biodegradable and traditional plastics on UV irradiation and mechanical abrasion

Biodegradable plastics are popular alternatives to traditional plastics in packaging, mulch sheets, and other applications. However, there are concerns regarding the potential for pollution as a result of their abiotic degradation. In this study, we investigated the degradation of biodegradable polybutylene adipate terephthalate/polylactic acid (PBAT/PLA) and traditional polyethylene (PE) plastic under two typical abiotic conditions: ultraviolet (UV) irradiation and mechanical abrasion (MA) for up to nine months. The physical and chemical properties of the two plastics during the degradation period were assessed. In addition, quantitative analysis of the degradation products was carried out using a new method called membrane filtration and total organic carbon determination (MF-TOCD). The results revealed that PBAT/PLA underwent a greater number of changes in surface morphology, thermal stability, and mass loss compared to PE when exposed to UV and MA during the test period. Further analysis of the released products revealed that PBAT/PLA released more products than PE. Overall, PE mainly produced microplastics (MPs) larger than 0.22 μm, whereas PBAT/PLA produced products <0.22 μm (nanoplastics and soluble molecules) on UV exposure. In contrast, when subjected to MA, PBAT/PLA produced MPs larger than 0.22 μm, and these accumulated gradually; this behavior is similar to that of PE. By combining the mass loss and the TOC data for the degradation products, we determined that long-term UV irradiation generated a large number of smaller particles from PBAT/PLA that could further degrade rather than accumulate in the environment. In summary, we established a new method to separate and characterize MPs as well as nanoplastics and soluble molecules, and provided new insights into the fate of PBAT/PLA during abiotic degradation.

The visible-light-promoted intermolecular para-cycloadditions of allenamides on naphthalene

The preparation of bridged bicyclooctadienes through the dearomatization of simple arenes is an interesting synthetic tool to access a vast chemical space of elegant molecular architectures from a wide range of simple and cheap building blocks. However, the energetic toll due to the loss of the aromatic stabilization has greatly limited the development of para-cycloadditions, especially with respect to intermolecular processes. We report herein the first general approach for the selective dearomatization of simple naphthalene. The visible-light-promoted reaction occurs under mild conditions over an ample range of substrates and it involves the initial sensitization of an acylallenamide. Moreover, complete control on the difunctionalization of either the internal or the terminal C–C double bond is observed depending on the substrate functionalization.

Lipid and cholesterols modulate the dynamics of SARS-CoV-2 viral ion channel ORF3a and its pathogenic variants

SARS-CoV-2 accessory protein, ORF3a is a putative ion channel which immensely contributes to viral pathogenicity by modulating host immune responses and virus-host interactions. Relatively high expression of ORF3a in diseased individuals and implication with inflammasome activation, apoptosis and autophagy inhibition, ratifies as an effective target for developing vaccines and therapeutics. Herein, we present the elusive dynamics of ORF3a-dimeric state using all-atoms molecular dynamics (MD) simulations at μ-seconds scale in a heterogeneous lipid-mimetic system in multiple replicates. Additionally, we also explore the effect of non-synonymous pathogenic mutations on ORF3a ion channel activity and viral pathogenicity in different SARS-CoV-2 variants using various structure-based protein stability (ΔΔG) tools and computational saturation mutagenesis. Our study ascertains the role of phosphatidylcholines and cholesterol in modulating the structure of ORF3a, which perturbs the size and flexibility of the polar cavity that allows permeation of large cations. Discrete trend in ion channel pore radius and area per lipid arises the premise that presence of lipids might also affect the overall conformation of ORF3a. MD structural-ensembles, in some replicates rationalize the crucial role of TM2 in maintaining the native structure of ORF3a. We also infer that loss of structural stability primarily grounds for pathogenicity in more than half of the pathogenic variants of ORF3a. Overall, the effect of mutation on alteration of ion permeability of ORF3a, proposed in this study brings mechanistic insights into variant consequences on viral membrane proteins of SARS-CoV-2, which can be utilized for the development of novel therapeutics to treat COVID-19 and other coronavirus diseases.

A Comparative Analysis of CFD and the Potential Flow Method for the Pure Loss of Stability in Following Waves

Improving the cognition and numerical accuracy of stability failure is urgent for carrying forward the direct assessment stability of the new-generation performance-based criteria for intact stability issued by the International Maritime Organization (IMO) in 2020. Firstly, the CFD method utilizing commercial software is developed for predicting stability failure in following seas. The CFD method employed overlapping grid techniques to achieve coupled motion calculations with a free-running model. The actual propeller rate, the implemented auto polite course-keeping, the coupled effect of the ship hull–propeller–rudder, and the instantaneous wet hull are considered in the CFD method. Secondly, a comprehensive 6-DOF mathematical model, employing the MMG framework and potential flow theory, is utilized to predict stability failure in the following waves. The radiation and diffraction forces are calculated around the mean wet hull using an enhanced strip method, and the FK and hydrostatic forces are calculated around the exact wet hull in waves. Thirdly, the occurrence of pure stability loss and subsequent large roll motions or capsizing for the ONR tumblehome ship are simulated by the time domain CFD and potential flow method. Finally, the computed results are cross-referenced with the available experimental data, and the trends of maximum roll angle are found to be consistent with the test data. Additionally, the alterations in thrust and torque exerted by the twin rudders and propellers are assessed across various sailing speeds, as well as the characteristics of the flow field distribution around the hull and appendages during capsizing at the critical sailing speed, which are newly analyzed by the CFD method.

FEATURES OF RISK DETERMINATION AND CONTROL OF THE UNDERGROUND FACILITIES STABILITY LOSS UNDER CONDITIONS OF ROCKS PROPERTIES VARIATION

Problem statement. Modern geotechnical production or an underground structure used as a military-industrial facility must meet the requirements of international risk management standards, which form the basis of safe and effective management. Implementation of effective risk management improves the quality of decision making, and has a positive impact on the benefit of the enterprises and society as a whole. The purpose of the article. To improve the method of risks’ determining for the mining stability loss and other underground structures, taking into acount the variability of the physical and mechanical properties of rocks. Methods. The use of a systematic approach in analytical studies of literary sources, systematization of modern approaches and methods in determining risks in the life safety system, processing by statistical methods, and the use of probability theory. Research results. Based on the results of field studies of the underground mining of the Yubileynaya mine at the Pershotravenskoye Mining Structural Division of PuAT DTEK Pavlogradugol, graphs of roof deformations were constructed, displacements were determined, dependencies were obtained, and the risks of underground mining destruction were identified. Scientific novelty. For the first time, the use of the parameters’ scatter by their standard deviation in identifying the risk of stability loss for underground mining is proposed. Practical value. A methodology for identifying and predicting geomechanical parameters for a risk-oriented system for monitoring the stability of the rock mass while ensuring safety when using developments as military-industrial complexes is proposed.

Estimating the Slope Safety Factor Using Simple Kinematically Admissible Solutions.

Determining soil and water conditions is essential for designing the optimal foundation and safely transferring loads, including the self-weight of structures, to the ground. Excessive or uneven settlement of the subsoil may ultimately lead to the formation of structural cracks in buildings or the loss of slope stability. In extreme cases, the damage results in structural failure. This paper presents the application of simple solutions from plasticity theory-an evaluation of the upper and lower bounds of the exact solution-to estimate the slope safety factor. It is demonstrated that simple kinematically admissible mechanisms for the non-associated flow rule provide solutions are close to those obtained from the traditional Fellenius method.

Seismic assessment of a long-term lunar habitat

The establishment of secure earth-independent long-term lunar habitats has been envisioned by numerous government agencies and private companies. Recent advancements in assessing seismic hazards caused by shallow moonquakes have highlighted the importance of incorporating this phenomenon into the design of robust and resilient lunar structures. However, further research is required to explore lunar habitat design that considers seismic loads. This paper proposes assessing the structural response of a lunar habitat made of sulfur concrete covered with a regolith layer. The numerical model of the structure is subjected to gravitational, internal pressure and seismic loads. The seismic analysis of the structure is carried out using spectral and nonlinear time history methods. Conditional mean spectra for shallow moonquakes with return periods of 75, 475, 970 and 2475 years are used in the seismic analysis. The records used for the temporal analyses were ground motions that agree with a preliminary seismic hazard on the Moon. The results of temporal analyses reveal that shallow moonquakes with return periods greater than 475 years can lead to the loss of the global stability of the structure. Consequently, the findings imply that seismic loads have the potential to impose unacceptable demands on lunar structures constructed from in-situ materials like sulfur concrete. Hence, it is imperative to incorporate seismic considerations in the design process for developing resilient and long-term lunar habitats.

Impact of ground surface subsidence caused by underground coal mining on natural gas pipeline

Underground mining of minerals is accompanied by a change in the rock mass geomechanical situation. This leads to the redistribution of stresses in it and the occurrence of unexpected displacements and deformations of the earth's surface. A significant part of the civil and industrial infrastructure facilities are located within the mine sites, where mining and tunneling operations are constantly conducted. Irrational planning of mining operations can lead to loss of stability and destruction of undermined facilities. Therefore, it is important to study the earth’s surface deformation processes during mining operations, which ensures safe and sustainable operating conditions. The research objective of this paper is to analyse the behaviour of a natural gas pipeline under the influence of underground mining activities, with a particular focus on understanding the effects of horizontal surface deformations and their potential impact on pipeline safety and structural integrity. Its performance and safety are determined on the basis of the found parameters of the earth's surface horizontal deformations and their comparison with permissible parameters characterizing the conditions for laying pipelines, depending on the mining-geological conditions and the degree of their undermining. Based on determined conditions for the safe undermining of the natural gas pipeline, it has been revealed that in its section between the PK212+40 and PK213+80 (140 m) pickets, the estimated parameters of the earth's surface horizontal deformations exceed their permissible values. This can cause deformation and damage to the pipeline. For the safe operation of the pipeline during the period of its undermining, in order to eliminate the hazardous impact of mining the longwall face, additional protection measures must be applied. It is therefore recommended that the gas pipeline between the PK212 and PK214+20 pickets be opened prior to the displacement process (200 m from the stoping face), thus reducing the density of the gas pipeline-soil system. Recommendations for controlling the earth’s surface deformations within the natural gas pipeline route are also proposed, which will ensure premature detection of the negative impact of mining operations.

VAYHIT3: An Open-Label, Single-Arm, Phase II Trial to Evaluate the Efficacy and Safety of Ianalumab in Patients with Primary Immune Thrombocytopenia (ITP) Previously Treated with at Least 1 Corticosteroid and 1 Thrombopoietin Receptor Agonist (TPO-RA)

Background: In patients with ITP, autoreactive B cells mediate the production of autoantibodies that target platelets and megakaryocytes, resulting in an increased rate of platelet destruction and decreased platelet production. B-cell activating factor (BAFF) regulates the differentiation, proliferation and survival of B cells via interactions with the BAFF receptor (BAFF-R). Patients with ITP have elevated serum BAFF levels, which positively correlate with increased disease activity. Ianalumab is a novel, fully human immunoglobulin G1 monoclonal antibody that targets BAFF-R and has a unique dual mechanism of action: direct B-cell depletion mediated by antibody-dependent cellular cytotoxicity and inhibition of B-cell differentiation, proliferation and survival via blockade of BAFF-R-mediated signaling. Following first-line corticosteroids, TPO-RAs are a standard second-line treatment for ITP; however, patients often require chronic TPO-RA treatment and endure potential side effects with increased costs. For patients who previously received corticosteroids and a TPO-RA, the choice of subsequent therapy (eg a different TPO-RA, rituximab, fostamatinib, mycophenolate mofetil, splenectomy) is not well defined. Thus, in patients with ITP requiring additional lines of therapy, there is an unmet need for new, well-tolerated therapies with disease-modifying potential that can safely induce high response rates after a short therapeutic course and maintain durable responses after treatment discontinuation. Trial design: VAYHIT3 (NCT05885555) is a multicenter, open-label, single-arm, Phase II trial enrolling approximately 40 adult patients with primary ITP who have previously received at least 1 corticosteroid and 1 TPO-RA. Additional prior therapies are allowed. Eligible patients must have lost response, had an insufficient response, had no response or been intolerant to their last ITP therapy. Along with a platelet count of &amp;lt;30 G/L, patients must be assessed by the investigator as needing treatment. Exclusion criteria include a neutrophil count of &amp;lt;1000/mm 3 and prior splenectomy. All patients will receive intravenous ianalumab every 4 weeks (Figure). Patients may receive concomitant therapy with a corticosteroid or TPO-RA if clinically indicated, which may be tapered. The primary efficacy analysis will occur after all patients have been followed up until Week 25 Day 1 or discontinued the study earlier. All patients with a platelet count of ≥30 G/L in the absence of a rescue therapy in the last 4 weeks or new ITP therapy at Week 25 Day 1 visit will continue efficacy monitoring until they have a platelet count of &amp;lt;30 G/L, start a new ITP therapy or require a rescue therapy. Safety will be monitored in all patients for up to 2 years after the last dose of ianalumab. Endpoints: The primary endpoint is confirmed response, defined as a platelet count of ≥50 G/L for 2 or more consecutive assessments at least 7 days apart between Week 1 Day 1 and Week 25 Day 1 visits and in the absence of both a rescue therapy for ≥4 weeks prior to the assessment of platelet count and the receipt of a new ITP therapy. Secondary endpoints include time to confirmed response, time to loss of response, quality and stability of response, proportions of patients experiencing bleeding events and requiring rescue therapies, changes in B cell and immunoglobulin levels, and pharmacokinetics, immunogenicity and safety of ianalumab. Exploratory biomarker assessments are also included to expand upon the understanding of ianalumab pharmacodynamics and exposure-response in patients with ITP. Conclusions: VAYHIT3 will evaluate the ability of a short therapeutic course of ianalumab to induce durable responses in patients who have received 2 or more prior lines of therapy, including at least 1 corticosteroid and 1 TPO-RA, for whom significant unmet needs exist. Current status: VAYHIT3 is recruiting. Ianalumab is also being investigated in 2 ongoing, randomized, double-blind, Phase III ITP trials: VAYHIT1 (NCT05653349) is assessing ianalumab versus placebo in addition to first-line corticosteroids, and VAYHIT2 (NCT05653219) is assessing ianalumab versus placebo in addition to eltrombopag in patients who failed first-line corticosteroid treatment.

Analysis of the Exothermic Reaction of Flame Ignition in the Combustion Chamber of a Gas Turbine Unit

This article analyses the exothermic reaction of flame ignition in the combustion chamber of a gas turbine unit, which is characteristic of combustion chambers operating on traditional hydrocarbon fuels. The combustion of gases as an explosive process in confined and semi-enclosed areas remains a poorly understood section of thermal physics. Without a detailed review of the physical and chemical processes taking place in the combustion chamber, it cannot be said whether the gas turbine unit will run sustainably. It is also important to know what combustion modes are in principle possible after a loss of stability in the combustion chamber in order to take action against this in advance. To describe flame ignition and quenching in the flow of the fuel–air mixture through a combustion chamber, a system of differential conservation equations of energy and reactive species supplemented with the equation of state is used. Nonstationary combustion processes in gas-turbine engines were studied, and flame ignition and blow-off were determined by the heat balance and by the continuity of chemical processes. Calculation methodologies for various operating modes of the combustion chamber of a gas turbine unit are developed and realized. The results of the calculations that were carried out are presented with graphical interpretation and with their analysis provided in sufficient detail. Based on this analysis, recommendations are then provided. From the graphs, it can be observed that the combustion chamber of a gas turbine unit reaches its maximum limit of stable operation at the optimum value of the reduced flow velocity in the openings of the air supply to the combustion and the mixing zones of the flame tube (λOC)opt = 0.22 when the fuel–air mixture is at maximum depletion, ensuring that combustion does not stop and flame failure does not occur. The topic of this article relates to the intensification of hydrocarbon fuel combustion and the technological improvement of combustion chambers in gas turbine units. This topic is of exceptional importance and relevance, emphasizing its significance. The purpose of this work is to develop and implement a methodology for calculating various modes of operation of the combustion chamber of a gas turbine unit.

Analytical Dual-Sequence Current Injections Feasible Region of Weak-Grid Connected VSC Under Asymmetric Grid Faults

For phase-locked-loop synchronization (PLL-Syn) based Weak-Grid connected Voltage Source Converter (WG-VSC) system under asymmetric grid faults, published works mainly focus on existing of equilibrium point and small signal stability, which cannot address PLL-Syn transient stability problems. For the first time, we have proposed an analytical solution to the question of “ <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Whether the WG-VSC system can reach to a new available equilibrium point (EP) of fault-on state from original EP of pre-fault state without loss of PLL-Syn transient stability under asymmetric faults?</i> ”. Dual-sequence current injections feasible region (CIFR) of WG-VSCs in positive and negative sequence current injection space is defined firstly. Then, by considering <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">PLL-Syn transient stability constraint, Maximum available current constraint, and PCC Voltage constraint</i> , an analytical expression of CIFR has been obtained. Finally, experiments results based on detailed switching model in RT-BOX hardware-in-loop platform have been provided to verify the CIFR constructed in this paper. It should be noted that the work of this paper can not only address PLL-Syn transient stability problems of WG-VSC system under asymmetric faults, but also can pave the way for asymmetric fault ride-through control considering transient stability constraints.