Lifestyle is well known to be a player in the health of society, increasing the number of concerns on lifestyle diseases accounting to increase in the mortality to the coronavirus pandemic make it more evident. The COVID-19 pandemic is a dreadful disease caused by the recently discovered coronavirus, still at large affecting the lives of millions across the globe. The lockdown and social distancing are known key factors that can slow down the spread apart from host immunity. The objective of this study is to find the effect of many lifestyle components in influencing host immunity and health. Methods: COVID lifestyle questionnaire was designed by experts and digitally circulated. The aim of the study is to determine the importance of the various lifestyle components in health, during the Covid 19 pandemic. The questionnaire was related to pandemic lockdown work style, stress, sleep, food habit, physical activity, social connectivity, personal habits, perception of health factors and healthy practices. Results: The 94 valid responses in total, and the data showed that the lifestyle component of (i) work duration was high in (n=37, 35.6%), (ii) physical stress at work was high and above in (n=49, 46.6%), mental stress at work (n=65, 61.9%), (iii) sleep -bedtime beyond 11: 00 PM (n=71.68.3%), sleep duration below 6 hours (n=54, 51.4%), (iv) change of food habit (n= 61, 58%), (v) low physical activity (n=42, 40.4%), low exercise (n=56, 53.3%), (vi) social interaction, decrease in peer (n=60, 57.1%), decline in friends (n=55, 52.4%), increase in a family circle (n=64, 61%), increase socializing activities (n= 74, 71.1%). Chi-square test to determine the association between categorical variables showed an association between Lockdown, Food, Social habits, and personal time with a significance of p <0.000. Perception to boost immunity and health were food, exercise and immunity enhancer intake. Whereas the factors assumed to affect health were food, stress and sleep. Conclusion: It is certain that lifestyle components are to be considered in a wholesome approach to health promotion in society to improve overall well-being and potential defense against infections like coronavirus. Value of the data • These data provide information on health-related behavior and lifestyle, which is important for understanding the lockdown impact due to COVID-19 on the healthy population. • The diverse data on various aspects of lifestyle provides key understanding to healthcare teams on priorities to be made based on subject preferences. • The authorities can benefit from these data to set up adequate protocols for the post-confinement and a possible future similar crisis. • Other researchers around the world can use these data to conduct comparative studies in other countries. • These data would be very useful for the marketing teams of the lifestyle variables described so as to enhance their focus. Objective COVID-19 as a pandemic had raised many concerns on how certain people or communities have been immune to it completely or with minimum toll. As the saying “survival of the fittest”, Lifestyle factors is mostly believed to be the answer to the question that the pandemic has raised. Further, during the pandemic, it was evident that people had modified their lifestyles in the best way possible to keep themselves secure.