The article defines the methodology of process control based on key performance indicators (KPI) in the business environment and its importance for the management of manufacturing facilities. The important aspects of the implementation of the system for measuring the efficiency of manufacturing and related to manufacturing areas of enterprises are described. It is noted that such control will contribute to timely response to threats of reduced production efficiency and further adjustment of the development strategy. The main goal of the article is the selection and justification of those indicators that are relevant for modern production and allow to assess its effectiveness. The authors substantiated that the process control method based on KPI is one of the most common methods of managing business units. Which involves finding and implementing a system of key performance indicators for most important elements of the manufacturing process. The details of some basic KPIs and their interdependence are described in the article. The main focus of authors is on the selection of appropriate KPIs and their impact on the goals achievement. Authors stating, that for the successful implementation of KPE, key factors are simplicity, comprehensibility and transparency for employees responsible for achieving of defined metrics. Equally important are the methods of evaluating the performance of related or supporting functions of the enterprise (personnel department, building maintenance service, information technology department, etc.). The authors emphasize the important criteria of the KPE system, which will allow to objectively evaluate effective work, manage it and motivate personnel. It is also noted that KPIs should have an impact on the financial motivation of employees, that’s why transparency and reach-ability are critical for their effective implementation. Equally important is the ability to track progress in achieving goals, create a foundation for an objective assessment of effectiveness, make operational decisions, compare results and form a responsible environment.