In this paper, a prediction model for the crystallization fouling was proposed on the basis of the Kern-Seaton model for the heat transfer and fouling process in circulated cooling water. The fouling deposition and removal process were analyzed, respectively, for the fouling process, on which the coupling effects of the scale layer, temperature and ions concentration were considered. The model calculation may predict the fouling resistance variations in fouling process, which were in good agreement with experimental data from references within a range of given conditions especially for the turbulent flow, indicating the model applicability for actual process. Since the model can be used without requirement of a large amount of measured data for fitting, it gives a more convenient way for predicting fouling process of heat exchangers in industry.