As a modern design approach, biophilic design encourages the incorporation of natural components into the built environment, which has a substantial impact on human health, well-being, and productivity. The research aims to shed light on the architecture trends during the past period that addressed the design of children’s hospitals, and among these recent trends is the biophilic design, which addresses with the impact of the natural environment surrounding users within health care buildings and its great impact on improving the mental health of children’s hospital users, to suit it with the personality and tendencies of the child, and its reflection on raising the child’s morale which brings him comfort during his treatment period, and increased recovery rates. The research is based on a common strategy between the historical and the descriptive approach, to evaluate the experience of adding biophilic design patterns as a competitive advantage to raise the efficiency of children’s hospitals, which is reflected in providing a good experience for patients. The results will indicate Biophilic architecture is more inclusive than trends that uses or mimics nature in design, because of it is the genetic tendencies that humans have to be affected by nature, whether physical, emotional, or psychological.