Incidence Rate Of Adverse Reactions Research Articles

Clinical application of gabapentin in the treatment of recurrent trigeminal neuralgia

Objective To investigate the clinical application effects of gabapentin in the treatment of recurrent trigeminal neuralgia. Methods 68 patients with recurrent trigeminal neuralgia were chosen as study subjects, and they were divided into control group and research group according to the digital table.The research group was treated with gabapentin, the control group was treated with carbamazepine. After treatment for 4 weeks, the clinical effects, life satisfactory index, pain, drug dosage and adverse reaction between the two group were compared. Results Each group had 32 patients completed the study.The total effective rate of the research group was higher than that of the control group(68.75% vs.59.37%), the difference was not statistically significant(χ2=0.611, P 0.05). At 7 d after treatment, the VAS scores in the research group was lower than that in the control group[(4.09±0.83)points vs.(4.63±0.79)points], the difference was statistically significant (t=2.666, P 0.05). Before treatment and 7 d after treatment, the life satisfaction index B(LSI-B) scores between the two groups had no statistically significant difference(t=0.049, 0.224, all P>0.05). At 14 d and 28 d after treatment, LSI-B scores in the two groups were both increased, which in the research group was higher than taht in the control group[14 d: (15.09±3.68)points vs.(12.91±3.45)points, 28 d: (16.48±3.43)points vs.(13.35±3.14)points], the differences were statistically different(t=2.445, 3.808, all P<0.05). The incidence rate of adverse reaction of the research group was lower than that of the control group(15.63% vs.37.50%), the difference was statistically significant (χ2=3.925, P<0.05). Conclusion Gabapentin has similar treatment effects in recurrent trigeminal neuralgia as carbamazepin, and gabapentin has better improvement in patients' life quality, and with better safety. Key words: Trigeminal neuralgia; Gabapentin; Carbamazepine

Effect of alprostadil on hemorrheological indicators of patients with multiple lacunar infarcts

Objective To observe the effect of alprostadil on hemorrheological indicators of patients with multiple lacunar infarcts. Methods 146 cases with multiple lacunar infarcts were randomly divided into observation group(76 cases) and control group(70 cases) by using the method of random number table.The two groups were given conventional treatment.In addition to this, the observation group was treated with alprostadil.NIHSS was used to evaluate neurological deficits, MMSE was used to evaluate cognitive function.The indicators of hemorheology and nailfold microcirculation integral were detected, adverse drug reactions of the two groups were observed. Results After treatment, the MMSE scores of the two groups [(24.09±3.88)points, (22.41±4.06)points] were significantly higher than before treatment, the NIHSS scores [(3.67±1.39)points, (4.35±1.62)points] decreased significantly (t=7.241, 21.095, 6.017, 14.179, all P 0.05). Conclusion In the treatment of multiple lacunar infarcts, alprostadil can effectively improve hemorrheological and nailfold microcirculation integral indicators, improve the nerve defect and cognitive function of patients, the incidence rate of adverse reaction is low, it has high value in clinical application. Key words: Brain infarction; Alprostadil; Prostaglandin E1; Hemorheology

Clinical application effect evaluation of Kanglaite combined with DCF chemotherapy program in patients with gastric cancer

Objective: To evaluate the clinical application effect of Kanglaite combined with DCF chemotherapy program in the patients with gastric cancer. Methods: 86 cases who were all the gastric cancer patients admitted to our hospital from February 2014 to June 2016 were selected, according to randomly divided into two groups, control group and experimental group. The control group was treated with DCF treatment, and the experimental group were treated with Kanglaite combined DCF chemotherapy program, and the therapeutic effects, the quality of life of patients and incidence rate of adverse reactions in two groups were observed and compared. Result: Compared with the control group, the total effective rate and the quality of life score of the experimental group were significantly higher, and the incidence of adverse reactions was less (P &lt; 0.05). Conclusion: In clinic, Kanglaitecombined with DCF chemotherapy program on patients with gastric cancer, can improve the treatment effect and life quality of patients, with less adverse reaction and high application value.

Clinical effects of somatostatin combined with Qingyi decoction in the treatment of acute pancreatitis

Objective To investigate the clinical effects of somatostatin combined with Qingyi decoction in the treatment of acute pancreatitis. Methods 120 patients with acute pancreatitis were chosen as observation subjects, and they were randomly divided into control group and observation group according to the digital table.The control group was treated with somatostatin, the observation group was treated with Qingyi decoction on the basis of control group.The clinical effects, improvements of clinical indicators and symptom, adverse reaction between the two groups were compared. Results The total effective rate of the observation group(100.00%) was higher than that of the control group(90.00%), the difference was statistically significant (χ2=6.316, P 0.05). After treatment, the albumin of the observation group was higher than that of the control group, white blood cell count, APACHEⅡ score, C reactive protein, serum amylase, aspartate aminotransferase and lactate dehydrogenase were lower than those in the control group, the differences were statistically significant (t=14.822, 11.654, 15.849, 20.000, 10.509, 15.213, 15.191, all P<0.05). The blood amylase, abdominal pain relief, recovery of gastrointestinal function, urinary amylase, abdominal distension, ventilator weaning, abdominal tenderness disappeared and so on symptom improvement time of the observation group were earlier than those of control group, the hospital stay was shorter than that of the control group, the differences were statistically significant (t=10.479, 15.855, 8.705, 13.064, 8.965, 11.783, 11.347, 17.069, 7.058, all P<0.05). The incidence rate of adverse reactions in the control group was higher than that in the observation group(11.67% vs.1.67%), the difference was statistically significant (χ2=4.821, P<0.05). Conclusion Qingyi decoction combined with somatostatin can effectively improve the clinical symptom of acute pancreatitis, and with good clinical effects and safety. Key words: Pancreatitis; Pancreatitis mixture; Somatostatin

Efficacy of alendronate combined with atorvastatin in the treatment of type 2 diabetes mellitus with osteoporosis

Objective To explore the therapeutic effect of alendronate combined with atorvastatin in the treatment of patients with type 2 diabetes mellitus complicated with osteoporosis. Methods 80 patients with diabetic osteoporosis(DOP) treated by endocrinology were selected.They were divided into observation group and control group by random number table method.The patients in the control group were given alendronate sodium, and the patients in the observation group were given alendronate and atorvastatin at the same time.The bone mineral density (BMD) of the forearm, lumbar vertebra, femoral neck and femoral trochanter Numeric rating scales(NRS score) were measured before and after treatment. Results Before treatment, the BMD in forearm, lumbar vertebra, femoral neck and femoral trochanter, and NRS score between the two groups had no statistically significant differences (all P>0.05). After treatment, the BMD of forearm[(0.64±0.10)g/cm2 vs.(0.68±0.11)g/cm2, t=2.563]and lumbar vertebrae[(0.82±0.28)g/cm2 vs.(0.70±0.11)g/cm2, t=2.448], femoral neck[(0.71±0.09)g/cm2 vs.(0.66±0.05)g/cm2, t=3.002], femoral trochanter[(0.76±0.14)g/cm2 vs.(0.70±0.08)g/cm2, t=2.302] of the observation group were higher than those of the control group, and the NRS score[(1.32±0.10)points vs.(2.47±0.67)points]was lower than the control group(t=23.651, P<0.05). There were 2 cases of nausea, 1 case of abdominal pain and 1 case of muscle pain in the observation group, and 1 case of nausea occurred in the control group, the incidence rate of adverse reaction between the two groups had no statistically significant difference(χ2=1.478, P=0.224). Conclusion Alendronate combined with atorvastatin can improve BMD, relieve pain in patients with DOP, and it is safe and worthy of clinical application. Key words: Diabetes mellitus; Osteoporosis; Alendronate; Atorvastatin

Safety assessment of niacin in the US Food and Drug Administration's mini-sentinel system.

The Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) trial found higher incidence rates of adverse reactions, including bleeding, in patients receiving the combination of extended-release niacin and laropiprant versus placebo. It is not known whether these adverse events are attributable to laropiprant, not approved in the USA, or to extended-release niacin. We compared rates of major gastrointestinal bleeding and intracranial hemorrhage among initiators of extended-release niacin and initiators of fenofibrate. We used Mini-Sentinel (now Sentinel) to conduct an observational, new user cohort analysis. We included data from 5 Data Partners covering the period from January 1, 2007 to August 31, 2013. Individuals who initiated extended-release niacin were propensity score-matched to individuals who initiated fenofibrate. Within the matched cohorts, we used Cox proportional hazards models to compare rates of hospitalization for major gastrointestinal bleeding events and intracranial hemorrhage assessed using validated claims-based algorithms. A total of 234242 eligible extended-release niacin initiators were identified, of whom 210 389 (90%) were 1:1 propensity score-matched to eligible fenofibrate initiators. In propensity score-matched analyses, no differences were observed between exposure groups in rates of major gastrointestinal bleeding (hazard ratio [HR], 0.98; 95% confidence interval [CI], 0.82 to 1.18) or intracranial hemorrhage (HR, 1.21; 95% CI, 0.66 to 2.22). Results were similar in pre-specified sensitivity and subgroup analyses. We did not observe evidence for an association between extended-release niacin versus fenofibrate and rates of major gastrointestinal bleeding or intracranial hemorrhage.

Retrospective analysis of concurrent radiotherapy for locally advanced head and neck squamous cell carcinoma combined with platinum based chemotherapy

Objective To observe the efficacy of nedaplatin (NDP), Asha Leigh Per (L-OHP) and cisplatin (DDP) combined with radiotherapy and chemotherapy in the treatment of locally advanced head and neck squamous cell carcinoma. Methods The clinical data of ninety-seven cases of locally advanced squamous cell carcinoma of head and neck treated in Guigang City People′s Hospital from May 2012 to May 2017 were retrospectively analyzed.33 cases were treated with NDP+ 5-Fu (5- fluorouracil, 5-Fu) (group NDP), 32 cases were treated with L-OHP+ 5-Fu (group L-OHP), 32 cases were treated with DDP+ 5-Fu (group DDD). The three groups were treated with radiotherapy.Curative effect and adverse reaction of the three groups were compared. Results The results showed that the effective rate of the NDP group was 78.8%, slightly higher than that in the group L-OHP(75.0%) and group DDP(62.5%), the difference among the 3 groups was statistically significant (χ2=2.365, P=0.031). In the course of treatment, there were various degrees of adverse reactions in the three groups, no grade IV adverse reactions occurred.The incidence rate of adverse reactions in group NDP was (49.78±3.22)%, lower than that of group L-OHP (50.89±3.47)%, and that of group L-OHP was lower than that of group DDP (53.26±4.19)%.But the difference among the three groups was not statistically significant (P=0.099). Conclusion NDP and L-OHP have good curative effect on head and neck squamous cell carcinoma, and NDP performs better than L-OHP. Key words: NDP; L-OHP; DDP; HNSCC

Clinical effect of laparoscopic surgery combined with gonadotropin-releasing hormone agonist in the treatment of endometriosis

Objective To investigate the clinical efficacy of laparoscopic surgery combined with gonadotropin-releasing hormone agonist (GnRH-a) in the treatment of endometriosis (EMs). Methods 86 patients with EMs were selected as study subjects.The patients were divided into two groups by random number table.43 patients in the control group underwent laparoscopic surgery, while 43 patients in the observation grouop received GnRH-a treatment based on laparoscopic surgery, and the clinical effect was analyzed. Results The total effective rate was 93.02% in the observation group, which was significantly higher than 72.09% in the control group.The recurrence rate in the observation group was 11.63%, which was significantly lower than 32.56% in the control group, the difference was statistically significant (χ2=7.55, 8.41, all P<0.05). After treatment, the levels of FSH, LH, and E2 of the observation group were (1.71±0.64)U/L, (2.66±0.75)U/L, (96.72±14.51)pmol/L, respectively, which were significantly lower than before treatment (t=8.80, 7.80, 7.55, all P<0.05), and the differences were statistically significant compared with the control group (t=8.55, 7.48, 7.19, all P<0.05). The total pregnancy rate of the observation group was 70.59%, which was significantly higher than 38.71% of the control group, the difference was statistically significant (χ2=7.77, P<0.05). The pain relief rate, dysmenorrhea rate, remission rate of chronic pelvic pain in the observation group were 90.70%, 86.05%, 93.02%, which were significantly higher than those in the control group (χ2=6.55, 7.01, 7.88, all P<0.05). The incidence rate of adverse reactions in the observation group was 11.63%, which was significantly lower than 27.91% in the control group, the difference was statistically significant (χ2=7.06, P<0.05). The main adverse reactions were hot flashes sweating, vaginal dryness, insomnia, fatigue and other low estrogen symptoms, which could tolerate, after treatment to relieve or disappear, liver and kidney function tests had no abnormalities. Conclusion Laparoscopic surgery combined with GnRH-a in the treatment of endometriosis can improve the treatment effect, improve the symptoms and reproductive hormone levels, improve the postoperative pregnancy rate, reduce the recurrence rate, and with high safety, it is worthy of clinical promotion and application. Key words: Endometriosis; Laparoscopic surgery; Gonadotropin-releasing hormone agonists

Clinical observation of budesonide suspension combined with antibiotics in the treatment of children with acute otitis media

Objective To observe the clinical efficacy of budesonide suspension combined with antibiotics in the treatment of children with acute otitis media. Methods 256 children with acute otitis media in Shaoxing Central Hospital from January 2016 to December 2016 were selected, and they were randomly divided into observation group and control group by using the method of random number table, 128 cases in each group.Both two groups were given antibiotic therapy (azlocillin sodium), on this basis, the observation group was given budesonide suspension, the control group was given chloramphenicol ear drops.At the end of treatment, the treatment effect of the two groups was compared. Results Compared with the control group, the improvement of hearing in the observation group was significantly improved (χ2=21.05, P<0.01), the rate of tympanic effusion was significantly lower (t=15.30, P<0.01), and the effective decrease rate of tympanic cavity pressure was significantly higher (t=10.61, P<0.01). The clinical symptom score of the observation group was significantly reduced, and the degree of improvement was much better than that of the control group (t=16.99, P<0.01). The onset time and hospitalization time of the observation group were significantly shortened, and the differences were statistically significant (t=13.37, 13.89, all P<0.01). The total effective rate of the observation group was 95.3%, which of the control group was 78.9%, and there was statistically significant difference between the two groups (χ2=20.19, P<0.01). The incidence rate of adverse reactions in the observation group was significantly lower than that in the control group, the difference was statistically significant (χ2=8.07, P<0.05). Conclusion Budesonide suspension combined with antibiotics in the treatment of children with acute otitis media has significant effect, it is conducive to reduce the formation of tympanic effusion, improve children's hearing and treatment effect, and worthy of further clinical application. Key words: Acute otitis media; Budesonide suspension; Antibiotics

Analysis of curative effect of Bushenantai recipe combined with progesterone soft capsules in the treatment of recurrent spontaneous abortion

Objective To investigate the clinical effect of progesterone soft capsules combined with Bushenantai recipe in the treatment of anticardiolipin antibody positive recurrent abortion. Methods 98 patients with positive anticardiolipin antibody and recurrent spontaneous abortion were selected, and they were randomly divided into observation group and control group according to the digital table, 49 cases in each group.The control group was given progesterone soft capsules treatment, the observation group was given the combined treatment of Bushenantai recipe and progesterone soft capsules.The medication time, live birth rate and antibody clearance rate were compared between the two groups. Results The treatment time of the observation group was (179.5±12.8)d, which was significantly shorter than (288.6±14.5)d of the control group, the difference was statistically significant(t=6.249, P<0.05). The live birth rate, antibody clearance rate of the observation group were 91.8%, 79.6%, respectively, which were significantly higher than those of the control group(79.6%, 36.7%), the differences were statistically significant(χ2=5.247, 4.998, all P<0.05). The observation group had 3 cases of adverse reactions(6.0%), the control group had 15 cases of adverse reactions (30.6%), the incidence rate of adverse reactions between the two groups had statistically significant difference(χ2=8.250, P<0.05). Conclusion Progesterone soft capsules combined with Bushenantai recipe in the treatment of anticardiolipin antibody positive patients with recurrent spontaneous abortion can shorten the treatment time, improve pregnancy outcome, improve the antibody clearance rate. Key words: Abortion, habitual; Progesterone; Bushenantai recipe

Comparison of the effect and prognosis of intermittent blue light and continuous blue light therapy for neonatal jaundice

Objective To observe the effect of intermittent and continuous blue light therapy for pathological neonatal jaundice, and to evaluate the prognosis of newborns. Methods 214 patients with pathologic neonatal jaundice who treated with blue light irradiation were slected, they were randomly divided into two groups according to the admission number combined with single and double numbers, 107 patients in each group.Group A received continuous blue light irradiation treatment.Group B received intermittent blue light irradiation.The clinical efficacy and prognosis of children, blue light exposure time, serum total bilirubin (TBiL) recovery time, the hospitalization time and the adverse reactions during the treatment were observed.The levels of serum TBiL were measured before and after light exposure 3, 5 days. Results The total effective rate of group B was 97.18% (104/107), which was higher than that of group A [90.65%(97/107)], the difference was statistically significant (χ2=10.30, P<0.05). The time of blue light irradiation and hospital stay time of group B were (71.59±7.05)d and (11.51±1.23)d, respectively, which were significantly shorter than those of group A [(79.54±6.82)d and (13.64±1.18)d], the differences were statistically significant(u=11.42, 9.87, all P<0.05). The level of TBiL of group B was (96.28±10.25)μmol/L, which was significantly lower than (104.52±10.31) μmol/L of group A (u=8.94, P<0.05). The incidence rate of adverse reactions in group B was 2.55% (4/157), which was lower than that in group A [7.01%(11/157)], the difference was statistically significant (χ2=9.66, P<0.05). The prognosis of neonatal in the two groups was good. Conclusion The intermittent and continuous blue light in the treatment of pathological neonatal jaundice has good clinical effect and the neonatal prognosis is good.The clinical efficacy of intermittent blue light irradiation is better, which can significantly shorten the treatment time and has higher safety. Key words: Jaundice, neonatal; Photochemotherapy; Prognosis

Efficacy of recombinant human endostatin combined with TP regimen on patients with advanced EGFR wild type squamous cell lung carcinoma

Objective To evaluate the efficacy of recombinant human endostatin combined with TP (paclitaxel + cisplatin) in the treatment of advanced epidermal growth factor receptor (EGFR) squamous cell lung carcinoma. Methods From January 2012 to February 2015, 100 patients with squamous cell lung carcinoma in Chongqing Three Gorges Central Hospital for medical treatment were selected as the subjects. Accor-ding to different treatment methods, they were divided into single group (n=50) and combined group (n=50). The single group used the TP protocol and the combined group was treated with recombinant human endostatin on the basis of the TP protocol. The therapeutic effect was evaluated according to the Response Evaluation Criteria In Solid Tumors 1.1 (RECIST 1.1). The short-term effects, long-term effects, adverse reactions, hospitalization time and expenses were also analyzed. Results The objective effective rate in the combined group [52.0% (26/50)] was significantly higher than that in the single group [16.0% (8/50)], with a significant difference (χ2=14.429, P=0.007). The disease control rate in the combined group was higher than that in the single group (80.0% vs. 52.0%), with a significant difference (χ2=8.734, P=0.009). Compared with the patients in the single group, the median progression free survival (8.4 months vs. 6.3 months) and overall survival (17.7 months vs. 11.5 months) in the combined group were prolonged obviously, with significant differences (χ2=5.390, P=0.025; χ2=3.993, P=0.035). The incidence rates of adverse reactions in single group were basically the same compared with the combined group, and the difference was not statistically significant (all P>0.05). Compared with the single group, the hospitalization time in combined group was longer [(23.5±2.8) weeks vs. (18.2±3.5) weeks], and the expenses in combined group was higher [(112 453.9±994.9) yuan vs. (87 821.4±943.2) yuan], with significant differences (t=8.361, P<0.001; t=127.051, P<0.001). But the satisfaction of patients in combined group was significantly higher than that in single group (88.0% vs. 64.0%, χ2=4.210, P=0.017). Conclusion Recombinant human endostatin combined with TP regimen is effective in the treatment of advanced EGFR wild-type squamous cell lung carcinoma, and has a low incidence of adverse reactions. It is suitable for clinical application. Key words: Neoplasms, squamous cell; Lung neoplasms; Angiostatins; Cisplatin; Paclitaxel

Efficacy and safety of aceclofenac and tramadol on bladder spastic pain after TURP

Objective To investigate the efficacy and safety of aceclofenac and tramadol on bladder spastic pain after TURP. Methods A total of 196 patients with prostatic hyperplasia in our hospital were chosen as study objects, and who were randomly divided into two groups, the patients in the group A received aceclofenac dispersible tables and the patients in the group B received tramadol sustained-release tablets after the TURP. The VAS pain score, frequency and duration of bladder spasm and the occurrence of adverse drug reactions were compared between the two groups in 24 hours after TURP. Results Within 24 hours after TURP, the VAS pain score of each time node, the frequency and duration of bladder spasm between the two groups had no statistical difference(P>0.05). The incidence rate of adverse reactions such as nausea, dizziness, headache, lethargy and fever in group B was significantly higher than group A(P<0.05). Conclusions Aceclofenac and tramadol have equivalent curative efficacy on bladder spastic pain after TURP and aceclofenac has better satety. Key words: Prostatic Hyperplasia; Transurethral Resection of Prostate; Electrosurgery; Pain; Tramadol

Effect of nutritional status and inflammatory markers on acute adverse reactions during concurrent chemoradiotherapy for esophageal carcinoma

Objective To examine the effects of different pre-treatment nutritional status and inflammatory markers on acute adverse reactions in esophageal cancer patients during concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy. Methods The acute adverse reactions of 338 eligible esophageal cancer patients who received concurrent IMRT and chemotherapy in our hospital from 2006 to 2014 were reviewed. The effects of different pre-treatment nutritional status, such as body mass index level (BMI), albumin level (ALB), total lymphocyte count (TLC), the presence or absence of anemia, and inflammatory indicators including neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), on acute adverse reactions in the patients were examined. Data were analyzed using the chi-square test with continuity correction and logistic regression analysis. Results The incidence rate of malnutrition in the patients based on their nutritional status was 5.62%-54.14%. The incidence rate of grade≥2 acute radiation esophagitis (RE) was significantly higher in the low ALB group than in the normal ALB group (P=0.000). The incidence rate of adverse reactions in the hematologic system increased as TLC decreased (P=0.006), but the incidence rate of acute radiation pneumonitis (RP) was reduced as TLC decreased (P=0.001). In addition, the incidence rate of grade ≥2 acute RE was significantly higher in the anemia group than in the non-anemia group. Inflammatory marker analysis demonstrated that the incidence rate of acute RE was significantly higher in the high NLR group and high PLR group than in the low NLR group and low PLR group (P=0.000 and P=0.024, respectively). Logistic regression analysis of nutritional status and inflammatory markers showed that TLC was an independent risk factor for acute adverse reactions in the hematologic system (P=0.001), and ALB and PLR were independent risk factors for acute RE (P=0.017 and P=0.011, respectively). Conclusions Nutritional status and inflammatory markers are associated with concurrent chemoradiotherapy-induced acute adverse reactions in esophageal carcinoma patients, and hence may be valuable indicators of acute adverse reactions during treatment. In addition, nutritional treatment and support care should be actively provided to the patients to prevent the development of acute adverse reactions during treatment. Key words: Esophageal neoplasms/radiotherapy; Nutritional status; Inflammation

Clinical observation of phentolamine in the treatment of infantile pneumonia complicated with heart failure and improvement of pulmonary rales

Objective To investigate the clinical effect of phentolamine in the treatment of heart failure in children with pneumonia and its effect on improvement of pulmonary rale. Methods 100 children with infantile pneumonia complicated with heart failure who admitted in our hospital were selected as the research subjects.According to the order of admission, the patients were divided into two groups.The control group was given routine treatment, patients in the observation group were given phentolamine on the basis of routine treatment.The treatment efficacy, symptoms relief time, hospitalization time, heart ultrasound index were compared between the two groups. Results The effective rate of the observation group was 96.00%, which was significantly higher than 76.00% of the control group (χ2=16.611, P=0.000). The pulmonary rales, wheezing disappearance time, hospitalization time of the observation group were (54.32±10.04)h, (87.32±11.23)h, and (7.71±1.23)d, respectively, which of the control group were (113.82±43.42)h, (158.49±45.82)h and (12.05±3.92)d, and there were statistically significant differences between the two groups (t=18.703, P=0.000; t=16.647, P=0.000; t=10.156, P=0.000). The E/A of the observation group was higher than that of the control group (t=2.890, P=0.000), and EF was lower than that of the control group (t=4.779, P=0.000). CK-Mb of the observation group was lower than the control group (t=2.045, P=0.013). The incidence rate of adverse reactions of the observation group was 2.00%, which of the control group was 4.00%, there was no significant difference between the two groups(χ2=0.687, P=0.407). Conclusion Phentolamine in the treatment of patients with infantile pneumonia complicated with heart failure, can reduce pulmonary rales, relieve clinical symptoms, shorten the hospitalization time, improve the treatment efficacy, and has less adverse reaction, high safety. Key words: Pneumonia; Heart failure; Phentolamine; Child

The application effect of insulin pump in diabetes treatment

Objective To study the application effect of insulin pump in diabetes treatment. Methods From December 2014 to December 2015, 120 diabetic patients in our hospital were selected as the research subjects.The patients were randomly divided into observation group and control group, 60 cases in each group.The patients of observation group were treated by insulin pump, and patients of control group were treated with the traditional subcutaneous injection of insulin.The therapeutic effect and adverse reactions of the two groups were observed. Results After treatment, the two groups had significantly lower in blood sugar.After treatment, the morning fasting blood sugar, 2 hours blood sugar after breakfast, 2 hours blood sugar after dinner, nocturnal blood sugar of the observation group were (5.13 ±1.05)mmol/L, (6.47±1.23)mmol/L, (5.14 ±1.07)mmol/L, (6.12 ± 1.47)mmol/L, respectively, which were obviously improved compared with the control group (t=10.839 4, 11.792 2, 10.839 4, 11.792 2, all P<0.05). The total effective rate of the observation group was 96.66%, which was significantly higher than 76.66% of the control group.The incidence rate of adverse reactions of the observation group was 3.33%, which was significantly lower than 13.33% of the control group, there was statistically significant differences between the two groups (χ2=7.72, 6.72, all P<0.05). Conclusion Insulin pump in the treatment of diabetes can improve the treatment effect, reduce the incidence of adverse reactions, it is a safe, effective method to treat diabetes, is worth popularizing in the clinical application. Key words: Diabetes; Insulin; Infusion pumps

Clinical effect of sequential radiotherapy and chemotherapy after surgery in the treatment of 40 cases with advanced gastric cancer

Objective To analyze and discuss the clinical effect of sequential radiotherapy and chemotherapy in 40 patients with advanced gastric cancer after operation. Methods 80 postoperative gastric cancer patients who received sequential radiotherapy and chemotherapy in our hospital were prospectively analyzed.According to the order of admission, 80 patients were divided into two groups, 40 cases of the control group (chemotherapy) and 40 cases of the observation group (sequential chemotherapy). The clinical effects of the two groups were compared. Results In the observation group, 1 year survival rate and 2-year survival rate (77.50%, 47.50%) were higher than those in the control group (50.00%, 25.00%), there were statistically significant differences between the two groups (χ2=19.20, 32.65, all P<0.05). The incidence rate of adverse reactions of the control group was 12.50%, which was lower than 30.00% of the observation group, there was statistically significant difference between the two groups (χ2=9.15, P<0.05). The mortality rate of the observation group was 32.50%, which was lower than 45.00% of the control group, the difference was statistically significant (χ2=5.29, P<0.05). Conclusion Compared with the simple chemotherapy after the operation of gastric cancer, sequential radiotherapy and chemotherapy can effectively improve the clinical efficacy, significantly reduce the rate of postoperative metastasis and recurrence of gastric cancer, and it is worthy of promoting. Key words: Radiotherapy; Chemotherapy, adjuvant; Stomach neoplasms

Curative efficacy of different doses of atorvastatin combined with fenofibrate in treatment of mixed type hyperlipidemia and its effects on blood lipid and prognosis

Objective To study the curative efficacy of different doses of atorvastatin combined with fenofibrate in treatment of mixed type hyperlipidemia and its effects on blood lipid and prognosis. Methods 120 patients of mixed type hyperlipidemia who received therapy were selected as research subjects.According to random number table, the patients were divided into A group (n=60) and B group (n=60). The two groups were treated with atorvastatin and fenofibrate, the dose of atorvastatin in A group was 10mg, which in B group was 20mg, fenofibrate dose was 200mg.After 4 weeks of treatment, the therapeutic effect was compared. Results After treatment, the blood lipids of the two groups were improved(P 0.05). The incidence rate of adverse reactions in A group was lower than that in B group[96.67%(58/60) vs.76.67%(46/60)](χ2=6.171, P<0.05). Conclusion Low dose (10 mg) of atorvastatin combined with fenofibrate for mixed type hyperlipidemia has good lipid regulating effect, and adverse reaction is low, has little effect on the liver function of patients, which can effectively improve the prognosis, it is worthy of application and promotion. Key words: Hyperlipidemia, familial combined; Atorvastatin; Fenofibrate

Adverse reaction caused by rabies vaccine in China: a Meta-analysis

Objective: To conduct a Meta-analysis on the rate of adverse reaction related to rabies vaccine, so as to provide reference for rabies vaccine immunization in China. Methods: We electronically searched databases including CNKI, VIP information resource integration service platform, WanFang Data, CBM, PubMed and The Cochrane Library, to collect studies on Chinese people who had received full rabies vaccination and recording all the adverse reactions, from January 2000 to July 2016. Inclusion and exclusion criteria were strictly followed. Meta-analysis for the adverse reaction rate was performed using the R software. Results: A total of 29 related papers had met the inclusion criteria, with no publication bias noticed. A total number of 11 020 cases had adverse reactions, among all the 94 222 respondents, with an incidence of adverse reactions as 1.04%-47.78%. The overall incidence rate of adverse reaction was 9.82% (95%CI: 7.58%-12.72%). A combined local adverse reaction rate appeared as 12.05% (95% CI: 9.26%-15.69%). The systemic adverse reaction rate was 9.06% (95%CI: 7.07%-11.61%). The overall adverse reaction rate on aqueous vaccine was 32.39% (95%CI: 21.88%-47.94%). Combined adverse reaction rate of freeze dried vaccine appeared as 8.65% (95%CI: 4.54%-16.51%). Significant differences were seen between both groups (P<0.05). Conclusions: The local adverse reaction rate caused by rabies vaccination was higher than the systemic adverse reaction rate. The adverse reaction rate of aqueous rabies vaccine was higher than that of freeze dried rabies vaccine. Our results suggested that the aqueous vaccine should gradually be eliminated.

Analysis of the biological effects of dose radiotherapy for primary liver cancer patients with stereotactic body portion

Objective To study the biological effects of dose radiotherapy for primary liver cancer patients with stereotactic body portion. Methods 80 patients with primary liver cancer were selected. According to a random number table method, all patients were divided into observation group and control group, 40 patients in each group. All patients were treated with stereotactic body radiotherapy treatment, the observation group was treated with high dose, while the control group received low-dose. The radiotherapy effects of different doses were analyzed and compared. Results After treatment, the effective rate of the observation group was 77.5%, which of the control group was 55.0%, , the difference between the two groups was statistically significant (χ2=4.528, P=0.033). After treatment for 6 months, 1 year and 2 years, the survival rates of the observation group were 77.5%, 75.0%, 72.5%, which were significantly higher than 55.5%, 52.5%, 50.0% of the control group (P<0.05). The incidence rate of adverse reactions of the observation group was 42.5%, which was significantly lower than 72.5% of the control group (χ2=7.365, P=0.006). Conclusion Stereotactic body radiotherapy treatment with different therapeutic dose has different treatment efficacy, high-dose SBRT treatment has significantly higher efficacy, survival rate and lower adverse reactions, which is worthy of clinical application. Key words: Liver neoplasms; Radiotherapy dosage