Incidence Rate Of Adverse Reactions Research Articles

Effect of pidotimod in the treatment of pediatric asthma

Objective To study the effect of pidotimod in the treatment of children with asthma. Methods 100 children with asthma were selected and randomly divided into control group and observation group, 50 cases in each group.The control group received routine treatment, the observation group was given pidotimod on the basis of routine treatment.The asthma control effects, symptoms remission time, hospitalization time, pulmonary function index, the incidence rate of adverse reactions were compared between the two groups. Results The total effective rate of asthma control in the observation group (96%) was significantly higher than that in the control group (P 0.05). Conclusion Pidotimod in the treatment of children with asthma can effectively improve the asthma control effect, promote the alleviation of clinical symptoms, improve the pulmonary ventilation function, and with less adverse reactions, it is safe and reliable. Key words: Pediatrics; Asthma; Pi do Maude

Efficacy and adverse reaction of azithromycin sequential therapy for the treatment of mycoplasma pneumonia in children

Objective To investigate the efficacy and adverse reactions of azithromycin sequential therapy for the treatment of children with mycoplasma pneumonia. Methods 84 children with mycoplasma pneumonia were randomly divided into study group and control group according to the digital table, with 42 cases in each group.The study group was given azithromycin treatment, and the control group was given erythromycin treatment.The clinical curative effect and adverse reaction were compared between the two groups. Results The total effective rate of the study group (97.62%) was significantly higher than that of the control group (76.19%), and the difference was statistically significant (χ2=11.95, P<0.05). The pyretolysis time[(3.78±1.57)d], cough improvement time[(3.29±0.74) d], rale disappearance time[(5.88±2.35)d], average hospitalization time[(8.89±1.76)d]of the study group were significantly shorter than those of the control group[(4.49±1.71)d, (4.28±0.77)d, (7.69±2.54)d, (10.05±2.27)d], and the differences were statistically significant (t=2.01, 6.33, 3.29, 2.46, all P<0.05). The incidence rate of adverse reactions such as nausea, abdominal distention, abdominal discomfort, local injection pain, rash, elevated alanine aminotransferase of the study group (4.76%) was significantly lower than that of the control group (19.05%), and the difference was statistically significant (χ2=4.86, P<0.05). Conclusion Azithromycin sequential therapy is effective in the treatment of children with mycoplasma pneumonia.It can effectively shorten the disappearance time of clinical symptoms and signs, and average hospitalization time, and has low incidence rate of adverse reactions.It is worthy of clinical use. Key words: Mycoplasma pneumonia; Azithromycin; Children; Curative effect; Adverse reaction

Clinical observation of methimazole combined with Selenious in the treatment of hyperthyroidism

Objective To assess the efficacy and safety of methimazole combined with selenium therapy in the treatment of hyperthyroidism. Methods 130 cases with hyperthyroidism were selected, and according to the digital table they were randomly divided into methimazole plus selenium treatment group(ATD+ Se group) and methimazole treatment group(ATD group), 65 cases in each group.The patients were followed up for 3 months.The thyroid function index and thyroid antibody index were observed before and after treatment.The adverse reactions were observed, too. Results After treatment, the serum levels of FT3, FT4, TSH in the ATD+ Se group were (3.32±0.53)pg/mL, (1.02±0.17)ng/dL, (2.72±0.32)mIU/L, respectively, which in the ATD group were (4.82±0.75)pg/mL, (2.41±0.32)ng/dL, (2.72±0.32)mIU/L, respectively.The change ranges of the ATD+ Se group were better than those of the ATD group, the differences were statistically significant(t=4.591, 3.814, 3.567, all P<0.05). The TPOAb, TGAb, TRAb in the ATD+ Se group were (120.3±23.1)IU/mL, (123.3±26.5)IU/mL, (1.72±0.89)IU/mL, respectively, which in the ATD group were (132.8±21.1)IU/mL, (134.8±21.3)IU/mL, (3.68±1.06)IU/mL, respectively.The changes of the ATD+ Se group were more significant than those of the ATD group, the differences were statistically significant (t=4.291, 3.514, 3.767, all P<0.05 ). The total effective rate of the ATD+ Se group was higher than that of the ATD group (90.77%vs.76.92%χ2=13.147, P<0.05 ). The incidence rate of adverse reactions in the ATD+ Se group was lower than that in the ATD group (12.31%vs.27.69%χ2=18.685, P<0.05 ). Conclusion The results suggest that methimazole combined with selenium treatment is effective and safe for hyperthyroidism. Key words: Thiamazole; Selenious; Hyperthyroidism

Application effect of dexmedetomidine combined with oxycodone in traditional lysis method of shoulder joint adhesions

Objective To observe the effect of dexmedetomidine(Dex) combined with oxycodone in the traditional lysis method of shoulder joint adhesions. Methods Sixty patients with shoulder joint adhesions in ASA Ⅰ or Ⅱ by the traditional lysis method were selected, and they were randomly divided into control group and observation group, 30 cases in each group.The control group was administered with Dex1.0μg/kg+ fentanyl 1μg/kg.The observation group was administered with Dex1.0μg/kg+ oxycodone 0.10mg/kg.The VAS scores and postoperative adverse reactions were compared. Results The VAS score of each group decreased with the prolong of postoperative analgesia time.The VAS scores in the observation group at postoperative 1h, 4h, 8h[(3.00±0.54)points, (1.98±0.56)points, (1.55±0.36)points]were lower than those in the control group[(3.91±0.33)points, (2.88±0.66)points, (2.26±0.77)points], the differences were statistically significant(t=3.42, 4.11, 2.43, all P 0.05). The incidence rates of adverse reactions of respiratory depression, tachycardia, intraoperative awareness in the control group were 26.7%(8/30), 50.0%(15/30), 13.3%(4/30), respectively, which in the observation group were 6.7%(2/30), 20.0%(6/30), 0.0(0/30), respectively, the differences were statistically significant between the two groups(χ2=4.320, 5.934, 5.333, all P<0.05). Conclusion Dex combined with oxycodone can ensure good sedation and forgetting effect, and the incidence rate of adverse reactions is low. Key words: Shoulder joint; Tissue adhesions; Dexmedetomidine; Oxycodone

Comparison of the clinical effect of disposable balloon cervical dilator and dinoprostone suppository on promoting the cervical ripening in full-term pregnancy

Objective To explore the clinical effect of disposable cervical dilator balloon and dinoprostone suppository on promoting cervical ripening in full-term pregnancy. Methods 92 cases of primipara with labor indications were selected as the research subjects.According to the random number table method, the patients were randomly divided into two groups, 46 cases in each group.The observation group of cervical ripening used disposable cervical dilator balloon, the control group used dinoprostone suppository.The cervical Bishop score and cervical ripening effect, delivery conditions, and the incidence of adverse reactions were compared between the two groups.The full-term pregnancy cervical ripening in disposable balloon dilator, the application effect of dinoprostone suppository was evaluated. Results The cervical Bishop score after induction of the observation group was (8.92±0.17)points, which was higher than (6.11±0.38) points of the control group, the difference was statistically significant (t=45.781, P 0.05). The incidence rate of adverse reactions in the observation group was 8.70%, which was lower than 28.26% in the control group(χ2=9.757, P<0.05). Conclusion Disposable balloon cervical dilator used in term pregnancy cervical ripening has significant effect, can improve cervical ripening rate, shorten delivery time and labor, with less adverse reaction, high safety, it is worthy of reference. Key words: Cervical ripening; Tissue expansion device; Dinoprostone

Efficacy of nystatin vaginal effervescent tablets and nifuratel tablet combined with recombinant human interferon alpha 2b suppository in the treatment of candida vaginitis

Objective To explore the efficacy of nystatin vaginal effervescent tablets, nifuratel tablet combined with recombinant human interferon alpha 2b suppository in the treatment of candida vaginitis. Methods 124 patients with candida vaginitis were selected as the research subjects.The patients were randomly divided into two groups according to different treatment.The control group was treated with nystatin vaginal effervescent tablets + nifuratel tablet, the study group was given recombinant human interferon alpha 2b suppository on the basis of the control group.The symptoms, clinical curative effect, quality of life score, adverse reaction rate were observed and compared in the two groups. Results There were no statistically significant differences between the two groups in symptom and physical signs before treatment(all P>0.05). After treatment, the vulvar itching, burning pain, abnormal leucorrhea, redness symptoms and signs of the study group were (0.95±0.44)points, (1.02±0.51)points, (1.13±0.62)points, (1.09±0.56)points, which were significantly lower than those of the control group[(1.42±0.98)points, (1.28±1.02)points, (1.38±1.17)points, (1.37±1.12)points, t=2.529, 2.512, 2.505, 2.618, all P<0.05]. The total effective rate of the study group was 95.2%, which was significantly higher than 74.2% of the control group (Z=-2.839, P<0.05). After treatment, the quality of life scores of physiological function, bodily pain, mental health, emotional function and social function in the study group were (80.16±9.23)points, (84.22±9.95)points, (87.49±10.46)points, (89.27±12.35)points, (88.21±11.74)points, which were significantly higher than those in the control group[(67.58±5.34)points, (71.49±7.28)points, (73.52±7.61)points, (76.83±8.32)points, (75.51±8.16) points, t=9.728, 8.577, 9.036, 7.039, 7.537, all P<0.05]. The incidence rate of adverse reactions of the study group was significantly lower than that of the control group(χ2=10.978, P<0.05). Conclusion Nystatin vaginal effervescent tablets, nifuratel tablet combined with recombinant human interferon alpha 2b suppository in the treatment of candida vaginitis can significantly improve clinical symptoms, improve the therapeutic effect, and improve the quality of life of patients with significant clinical value, it is worthy of reference. Key words: Candidiasis, vulvovaginal; Nystatin; Nifuratel; Interferon alpha 2b

Analysis of feasibility, safety and effectiveness of ultrasound-guided percutaneous microwave ablation of splenic neoplasm.

The present study aimed to analyze the feasibility, safety and effectiveness of ultrasound-guided percutaneous microwave ablation of splenic neoplasm. A total of 62 patients with splenic neoplasm admitted to Second People's Hospital of Liaocheng between January 2009 and December 2012 were selected, and randomly divided into the observation group (n=31) and control group (n=31). The control group was treated with open ablation, while the observation group was treated with ultrasound-guided percutaneous microwave ablation. The splenic hemodynamics and ablation effects of patients after treatment were detected via color Doppler ultrasound. The changes in peripheral blood cell count before treatment, and at 3, 7 and 14 days after treatment were monitored. The side effects and complications were compared between the two groups. Patients were followed up for 5 years to observe the survival rates of the two groups. At 1 week after treatment, the peak velocity of splenic artery in observation group was significantly lower than that in control group, and the diameter, velocity and flow of splenic vein were significantly lower than those in control group (P<0.05). After treatment, the white blood cell and platelet counts in both groups were significantly increased compared with those before treatment, and the counts in observation group were obviously higher than those in control group (P<0.05). There were no significant changes in the red blood cell counts in both groups before and after treatment (P>0.05). The ablation volume, ablation ratio and 1-week shrink ratio in both groups had no significant differences (P>0.05). The incidence rates of side effects and complications in observation group were significantly lower than those in control group (P<0.05). The 5-year survival rates of both groups were >50%, and the survival time and survival rate were not significantly different (P<0.05). The curative effects of open ablation and ultrasound-guided percutaneous microwave ablation in the treatment of splenic neoplasm were significant, and the 5-year survival rate of patients was higher; compared with open ablation. The ultrasound-guided percutaneous microwave ablation is characterized by the small trauma, lower incidence rates of adverse reactions and complications and better safety, which can increase the peripheral blood cell count, and improve the splenic blood flow and coagulation function, playing a role in the regulation of the patient's body status.

Application of pre-injection of dexmedetomidine of different doses in pediatric intravenous general anesthesia without tracheal intubation.

This study observed the clinical efficacy of pre-injection of dexmedetomidine of different doses before surgery and the adverse reactions during the recovery period in pediatric intravenous general anesthesia without tracheal intubation. Pediatric patients who received general anesthesia without tracheal intubation before surgery from January 2016 to March 2017 were randomly divided into four groups (n=30), and were respectively treated with intravenous pump infusion of loaded dexmedetomidine of high-dose (2.5 µg/kg), middle-dose (1.5 µg/kg) and low-dose (0.5 µg/kg), while the children in the control group received injection of normal saline in same dose. Then, the mean arterial pressure (MAP) at different time points (5 and 10 min after administration, after anesthesia and after surgery), heart rate, Ramsay sedation score changes and adverse reactions during recovery period of anesthesia of pediatric patients were compared among four groups. At 5 and 10 min after administration, Ramsay scores of high-dose group and middle-dose group were higher than that of the control group, and the differences had statistical significance (P<0.05). There was no significant difference in comparison of Ramsay scores between low-dose group and the control group. The MAP and heart rate after anesthesia and after surgery of pediatric patients with pump infusion of dexmedetomidine in the three groups were decreased significantly compared to those of the control group, and the differences had statistical significance (P<0.05). The incidence rate of adverse reaction of pediatric patients during the recovery period after pump infusion in the three groups and the control group was, respectively, 13/30, 8/30, 7/30 and 8/30, and the differences were statistically significant (P<0.05). The sedative effect and safety of pre-injection of dexmedetomidine in pediatric intravenous general anesthesia without tracheal intubation are promising, and the medium dosage can maximize the anesthetic effect with less side effects.

Clinical study on central venous catheter drainage and intrapleural injection of urokinase in the treatment of tuberculous pleurisy

Objective To observe the therapeutic effect of central venous catheter drainage and intrapleural injection of urokinase on tuberculous pleurisy patients. Methods 60 hospitalized patients with tuberculous pleurisy were selected, and they were divided into two groupsby simple random grouping method.Both two groups received 3HRZE/6HR anti-tuberculosis treatment.30 patients in the observation group were treated with central venous catheter drainage and intrapleural injection of urokinase.30 patients in the control group were treated with conventional pleurocentesis.The duration of pleural effussion drainage, incidence of pleural thickening, hospitalization time and expense, and the adverse reaction rate were observed during treatment. Results In the observation group, the curative effect at 1 week was 46.7%, the duration of pleural effussion drainage was (20.5±6.7)days, the incidence rate of pleural thickening was 26.7%, the hospitalization time was (9.4±2.7)days, the hospitalization expense was (6 675.4±1 818.4)RMB, the incidence rate of adverse reaction was 3.3%.In the control group, the curative effect at 1 week was 20.0%, the duration of pleural effussion drainage was (25.1±7.7)days, the incidence rate of pleural thickening was 46.7%, the hospitalization time was (10.3±2.8)days, the hospitalization expense was (7 508.9±1 692.1)RMB, the incidence rate of adverse reaction was 20.0%.There were statistically significant differences between the two groups in the curative effect at 1 week(χ2=4.800, P=0.028), duration of pleural effussion drainage (t=2.484, P=0.016), incidence of pleural thickening (t=4.444, P=0.035) and incidence rate of adverse reaction (χ2=4.043, P=0.044). No statistically significant differences were observed between the two groups in hospitalization time(t=1.270, P=0.209) and expense(t=1.838, P=0.071). Conclusion In comparison to conventional pleurocentesis, the treatment of central venous catheter drainage and intrapleural injection of urokinase for tuberculous pleurisy is markedly efective, it is safe and worthy of popularizing in clinical application. Key words: Pleurisy; Tuberculosis, pleural; Central venous catheter drainage; Urokinase

Clinical study with randomized control on the therapy of integrated Chinese and Western medicine in treating neurological autoimmune diseases: A meta-analysis

Objective: The main objective of this study is to evaluate the effects of integrated Chinese and Western medicine in the treatment of neurological autoimmune diseases. Materials and Methods: The literature was comprehensively searched to collect the randomized controlled trials about integrated Chinese and Western medicine in the treatment of neurological autoimmune diseases. Neurological autoimmune diseases mainly occur in the central nervous system (CNS) and peripheral nervous system. Therefore, multiple sclerosis (MS) was chosen as the representative in the CNS, and Guillain–Barre syndrome (GBS) was chosen as the representative in the peripheral nervous system. Extended Disability Status Scale (EDSS) score, effective rate, clinical symptom score, neurological functional sign score, recurrence frequency, and incidence rate of adverse reactions were chosen as the markers of outcome variables of MS, and the effective rate and Hughes score were also chosen as the markers of outcome variables of GBS. Results: For MS, the results showed that there was a significant difference in statistical analysis between the experimental group and the control group in EDSS score, the effective rate, and the recurrence frequency. However, through the comparison of clinical symptom score, neurological functional sign score, and incidence rate of adverse reaction of both two groups, the results showed that there was no significant difference in the statistical analysis. For GBS, through the comparison of effective rate and Hughes score of both two groups, the results showed that there was a significant difference in statistical analysis. Conclusions: The study demonstrated that compared with Western medicine, the therapy of integrated Chinese and Western medicine was more effective in treating neurological autoimmune diseases.

Effect of compound glycyrrhizin on alcoholic fatty liver disease

Objective To observe the clinical effect of compound glycyrrhizin in the treatment of alcoholic fatty liver disease(AFLD). Methods 68 AFLD patients according to the different treatment methods were divided into two groups.34 cases in the control group received conventional therapy, 34 cases in the observation group were given compound glycyrrhizin based on the conventional treatment.The clinical effect of the two groups was compared. Results The total effective rate of the observation group was 91.18%, which was higher than 64.71% of the control group, the difference was statistically significant(χ2=6.928, P<0.05). The TBIL, GGT, AST, ALT of the observation group were (6.39±1.15)μmol/L, (157.79±17.39)U/L, (37.49±2.61)U/L, (24.45±2.16)U/L, respectively, which of the control group were (26.14±2.79)μmol/L, (417.59±45.89)U/L, (97.28±11.39)U/L, (54.33±4.05)U/L, respectively, the differences between the two groups after treatment were statistically significant(t=41.392, 33.482, 32.361, 41.171, all P<0.05). The incidence rate of adverse reactions of the observation group was 5.88%, which was lower than 26.47% of the control group(χ2=4.250, P<0.05). Conclusion Compared with conventional treatment, compound glycyrrhizin in the treatment of AFLD can effectively improve the patients' TBIL, GGT, AST, ALT index, improve the clinical efficacy. Key words: Fatty liver, alcoholic; Compound glycyrrhizin

Clinical research on the efficacy of self-made sichongsan in combination with gefitinib on NSCLC patients with EGFR mutation

This study is to investigate the efficacy of self-made sichongsan in combination with gefitinib on non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation. A total of 47 NSCLC patients in advanced stage with EGFR mutation who had not received any treatment before admission were divided into the control group (n = 23) and the observation group (n = 24). Patients in the control group underwent gefitinib treatment, while those in the observation group additionally took self-made sichongsan for treatment. The objective response rate of the observation group was 75%, significantly higher than 52.18% in the control group ( P &lt; 0.05). Before treatment, comparisons of the carcinoembryonic antigen (CEA) and carbohydrate antigen 153 (CA153) levels in serum showed no statistical significance ( P &gt; 0.05). At the 12th week of treatment, the levels of CEA and CA153 in the observation group were significantly lower than those in the control group ( P &lt; 0.05). In the observation group, the incidence rate of adverse reaction was 16.7%, which was significantly lower than 47.8% in the control group ( P &lt; 0.05). In conclusion, in terms of the first-line treatment for advanced NSCLC patients with EGFR mutation, the efficacy of self-made sichongsan in combination with gefitinib is superior to the single administration of gefitinib, and the former can more effectively decrease the levels of CEA and CA153 in serum of patients and reduce the incidence rate of adverse effects.

Effect of red and blue light combined with erythromycin gel in ther treatment of acne

Objective To study the effect of red and blue light combined with erythromycin gel in ther treatment of acne. Methods 100 acne patients were selected, they were randomly divided into two groups according to the digital table, 50 cases in each group.The observation group was treated with red and blue light combined with erythromycin gel, the control group was treated with erythromycin gel alone.The improvement of the quality of life and treatment effect were compared. Results The difference of total effective rate between the observation group and the control group was statistically significant (90% vs.70%, χ2=6.250, P=0.023). After treatment, the self-perception[(14.28±1.05)points vs.(14.28±1.05)points, t=6.009, P=0.007], acne distribution[(14.00±2.25)points vs.(14.69±2.05)points, t=6.028, P=0.006], emotional function[(13.50±2.20)points vs.(13.27±2.01)points, t=7.827, P=0.001], social function[(11.03±1.84)points vs.(11.30±1.79)points, t=5.892, P=0.012], overall cognition[(13.33±1.05)points vs.(13.00±1.23)points, t=5.772, P=0.015]had statistically significant differences between the two groups (all P<0.05). The incidence rate of adverse reactions between the two groups had statistically significant difference (4% vs.24%, χ2=8.306, P=0.008). Conclusion Red and blue light combined with erythromycin gel in the treatment of acne has good effect, less complications, it can significantly improve quality of life of patients. Key words: Red and blue light; Acne; Erythromycin gel

Effect of dexmedetomidine on reviving period of general anesthesia in thyroid surgery patients

Objective To explore the effect of dexmedetomidine on reviving period of general anesthesia in thyroid surgery patients. Methods A total of 80 patients undergoing thyroid surgery were selected as the subjects.These patients were randomly divided into two groups according to the random table method, 40 cases in each group.The patients in the observation group were given intravenous drip of dexmedetomidine before anesthesia induction, and those in the control group were given intravenous drip of saline.After that, the two groups were given the same method of anesthesia induction.Recovery of the patients, biochemical indicators[including systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate(HR), oxygen saturation(SpO2)], sedation and analgesia effects, and the incidence of adverse reactions in the two groups were compared. Results The eye opening recovery time, extubation time, spontaneous breathing time and time for orientation recovery in the observation group were (11.24±1.31)min, (8.67±0.78)min, (6.36±0.43)min and (14.39±1.56)min, respectively, which were shorter than those in the control group[(15.57±2.63)min, (10.42±1.12)min, (8.54±0.65)min and (17.24±2.33)min], the differences were statistically significant(t=9.320, 8.109, 17.691, 6.428, all P<0.05). The SBP levels in the observation group at T1 and T2 were (124.69±10.25)mmHg and (105.54±12.87)mmHg, respectively, which were lower than those in the control group[(138.72±13.84)mmHg and (135.25±13.63)mmHg]; DBP at T2 and T3 in the observation group were (71.53±8.95)mmHg and (76.21±7.34)mmHg, respectively, which were lower than those in the control group[(80.45±10.75)mmHg and (80.29±10.39)mmHg]; HR at T2 in the observation group was (65.18±5.75)times, which was lower than (79.84±8.42) in the control group; and all the above differences were statistically significant(t=5.512, 10.024, 4.033, 2.028, 9.094, all P<0.05). The sedation score, pains score in the observation group were (2.89±0.54)points, (1.42±0.34)points, respectively, which were better than those in the control group[(1.02±0.27)points and (3.71±1.12)points], the differences were statistically significant(t=19.589, 12.374, all P<0.05). The incidence rate of adverse reactions in the observation group was 7.50%, which was lower than 35.00% in the control group, and the difference was statistically significant(χ2=9.038, P<0.05). Conclusion For patients given general anesthesia for thyroid surgery, pre-injection of dexmedetomidine can significantly reduce the stress response in patients during recovery period, and has no impact on the patients' awaking and extubation; besides, it has high safety, and can improve the patients' comfort during recovery, thus serve as an ideal drug for the control of restlessness; therefore, it is of significant value to be popularized in clinical application. Key words: Dexmedetomidine; Thyroid surgery; Anesthesia, general; Recovery period

Efficacy and survival rate of intensity-modulated radiotherapy combined with chemotherapy for elderly patients with locally advanced oropharyngeal cancer.

The efficacy of intensity-modulated radiotherapy (IMRT) combined with chemotherapy in the treatment of elderly patients with locally advanced oropharyngeal cancer and its effect on survival rate were studied. Elderly patients (n=150) diagnosed with locally advanced oropharyngeal cancer by histopathology were selected and randomly divided into the observation group (n=75) and the control group (n=75). Patients in the observation group were treated with IMRT combined with chemotherapy, while those in the control group were treated with conventional radiotherapy and chemotherapy. The two groups were treated with docetaxel + cisplatin (TP regimen). All patients received 1 to 2 cycles of docetaxel + cisplatin-induced chemotherapy, and after the radiotherapy began, the chemotherapy with docetaxel was synchronously conducted. The recent efficacy (tumor regression condition was observed at 3 months after the treatment), 1-year, 3-year and 5-year overall survival (OS), local-regional control (LRC), progression-free survival (PFS), disease-free survival (DFS) and the incidence rate of adverse reactions of patients in the two groups were compared. In the observation group, 73 patients completed the radiotherapy and chemotherapy, while all the patients in the control group completed the treatments. The 1-year OS of the observation group and the control group was 97.3 and 85.3%, respectively. In the observation group, the 3-year LRC, OS, PFS and DFS of the observation group was 94.5, 91.8, 90.4 and 87.7%, respectively; the 5-year LRC, OS, PFS and DFS was 64.4, 56.2, 56.2 and 54.8%, respectively. In the control group, the 3-year LRC, OS, PFS and DFS was 86.7, 73.3, 82.7 and 68.0%, respectively; the 5-year LRC, OS, PFS and DFS were 54.7, 45.3, 44.0 and 56.7%, respectively. The differences were statistically significant (P<0.05). In the observation group, the number of leukocytes was decreased, and the incidence rates of acute oropharyngeal mucosa reaction and radiation dermatitis were significantly lower than those in the control group. The differences were statistically significant (P<0.05). In conclusion, IMRT combined with chemotherapy can improve the OS and the 3-year and 5-year LRC, PFS and DFS of elderly patients with locally advanced oropharyngeal cancer, reduce toxic and side effects, and improve patients' quality of life.

Influence of hydroxyethyl starch combined with strengthening anti-platelet therapy on the short-term clinical efficacy, TCD index and recurrence rate of patients with TIA secondary to cerebral artery stenosis

Objective To investigate the influence of hydroxyethyl starch combined with strengthening anti-platelet therapy on the short-term clinical efficacy, TCD index and recurrence rate of patients with TIA secondary to cerebral artery stenosis. Methods 80 patients with TIA secondary to cerebral artery stenosis were chosen, and they were randomly divided into two groups according to the digital table, each group in 40 cases.The control group received strengthening anti-platelet therapy alone, and the observation group received hydroxyethyl starch on the basis of control group.The short-term clinical efficacy, the blood flow velocity of ACA and MCA before and after treatment, the TIA recurrence rate, the incidence of cerebral infarction and adverse reactions of both two groups were compared. Results The short-term effective rates of the control group and observation group were 77.50%, 97.50%, respectively.The short-term effective rate of the observation group was significantly higher than that of the control group(χ2=12.33, P<0.05). The blood flow velocity of ACA and MCA of the control group after treatment were (51.05±9.83)cm/s, (54.88±6.62)cm/s, respectively, which were significantly lower than those of the observation group[(59.12±12.07)cm/s, (62.65±8.09)cm/s, t=3.17, 2.96, 4.03, 4.74, 3.67, 4.05, all P<0.05]. The TIA recurrence rate and the incidence rate of cerebral infarction of the control group were 22.50%, 12.50%, respectively, which were significantly higher than those of the observation group(5.00%, 0.00%, χ2=11.75, 14.06, all P<0.05). The incidence rates of adverse reactions of the control group and observation group were 12.50%, 10.00%, respectively.There was no significant difference in the incidence rate of adverse reactions between the two groups(χ2=1.75, P<0.05). Conclusion Hydroxyethyl starch combined with strengthening anti-platelet therapy in the treatment of patients with TIA secondary to cerebral artery stenosis can efficiently relieve the symptoms of neurological function, higher the level of cerebral blood perfusion, reduce the risk of TIA recurrence and cerebral infarction, and not increase the incidence of adverse reactions. Key words: Cerebral artery diseases; Ischemic attack, transiet; Hydroxyethyl starch

The curative effect and safety of icotinib hydrochloride in the treatment of advanced non-small cell lung cancer

Objective To explore the effect of icotinib hydrochloride in the treatment of advanced non-small cell lung cancer (NSCLC). Methods 52 patients with advanced NSCLC were selected as the research subjects, and they were divided into conventional group and study group by the computer random grouping method, 26 cases in each group.The conventional group took docetaxel treatment, and the study group took icotinib hydrochloride treatment.The treatment effect of the two groups was compared. Results The disease control rate of the study group was 84.62%, which was significantly higher than 57.69% of the conventional group, the difference was statistically significant(χ2=4.591, P=0.032). The progression free survival of the study group was (5.54±0.23)months, which was longer than (4.52±0.22)months of the conventional group, the difference was statistically significant(t=16.341, P=0.000). The incidence rate of adverse reaction of the study group was 23.08%, which was significantly lower than 50.00% of the conventional group, the difference was statistically significant(χ2=4.063, P=0.044). Conclusion The effect of icotinib hydrochloride in the treatment of advanced NSCLC is distinct, and drug safety is relatively high, it can help prolong survival of patients, and it is worthy of popularizing practice. Key words: Carcinoma, Non-Small-Cell Lung; Icotinib Hydrochloride; Treatment Outcome

Curative effect of nursing intervention in the treatment of children with bronchial pneumonia and its effects on pulmonary function

Objective To observe the curative effect of nursing intervention in the treatment of children with bronchial pneumonia and its effects on pulmonary function. Methods 100 children with bronchial pneumonia were selected as the research subjects, they were randomly divided into control group (50 cases) and observation group (50 cases) according to the digital table.The control group received routine nursing, the observation group received high quality nursing.The pulmonary function indicators(FVC, FEV1, PEF), the adverse reactions and the clinical curative effect were observed in the two groups after treatment. Results After treatment, the FVC, FEV1, PEF of the observation group were (3.96±0.80)L, (3.15±0.80)L, (6.32±2.01)L/s, respectively, which were better than those of the control group [(2.85±0.91)L, (2.43±0.63)L, (4.90±1.35)L/s](t=6.478, P=0.000; t=5.000, P=0.000; t=4.147, P=0.000). The incidence rate of adverse reactions of the observation group was 14.00%(7/50), which was lower than 38.00%(19/50) of the control group (χ2=7.484, P=0.006). The total effective rate of the observation group was 98.00%(49/50), which was higher than 80.00%(40/50) of the control group (χ2=8.274, P=0.004). Conclusion To give children symptomatic treatment of infantile bronchial pneumonia at the same time, take the high quality nursing intervention can effectively improve lung function in children, reduce the incidence of complications, it is conducive to prognosis and can improve the therapeutic efficacy. Key words: Bronchopneumonia; Pediatric nursing; Intervention studies; Respiratory function tests

Effect of combined gastrointestinal internal and external nutritional support in the treatment of elderly patients with lung cancer

Objective To explore the effect of combined gastrointestinal internal and external nutritional support in the treatment of elderly patients with lung cancer. Methods According to the random number table method, 86 patients with advanced non-small cell lung cancer(NSCLC) were divided into the control group and observation group, 43 cases in each group.The observation group was given nutritional intervention on the basis of treatment in the control group.The 12-month survival rate, median progression time and median survival time were evaluated.The clinical efficacy of the two groups was evaluated.The quality of life before and after treatment was evaluated by the KPS score. Results The 12-month survival rate of the observation group was 39.53%, which was significantly higher than 18.60% of the control group(χ2=4.56, P=0.03). The median survival time and median survival of the observation group were (7.85±1.27)months, (9.98±1.71)months, respectively, which were significantly higher than (6.07±0.98)months, (7.99±1.38)months of the control group(t=7.27, 5.93, P=0.00, 0.00). The total effective rate of the observation group was 88.37%, which was significantly higher than 55.81% of the control group(χ2=11.32, P=0.00). The KPS scores of the observation group and the control group after treatment were (73.17±2.75)points, (59.68±2.52)points, respectively, which were higher than (52.75±2.02)points, (53.01±1.98)points before treatment, and the KPS scores of the observation group were significantly higher than those of the control group(t=39.24, 13.64, P=0.00, 0.00). The incidence rate of adverse reaction in the observation group was 48.84%, which in the control group was 55.81%, the difference was not statistically significant(χ2=0.41, P=0.51). The CD4+ cells, CD4+/CD8+ and NK cells in the control group were significantly lower than those before treatment(t=6.14, 8.44, 7.48, P=0.00, 0.00, 0.00), which in the observation group were significantly higher than before treatment(t=4.89, 5.17, 6.33, P=0.00, 0.00, 0.00), the differences were statistically significant compared with the control group after treatment(t=8.11, 4.26, 5.88, P=0.00, 0.00, 0.00). The levels of hemoglobin and albumin in the observation group were significantly higher than those in the control group(t=3.88, 6.39, P=0.00, 0.00). Conclusion The combination of chemotherapy combined with nutritional intervention in the treatment of locally advanced NSCLC is beneficial to improve the immune function and nutritional status of patients, improve clinical efficacy and survival of patients, better improve their quality of life, and will not increase adverse reactions. Key words: Carcinoma, non-small-cell lung; Antineoplastic combined chemotherapy protocols; Parenteral nutrition; Enteral nutrition

Clinical application of gabapentin in the treatment of recurrent trigeminal neuralgia

Objective To investigate the clinical application effects of gabapentin in the treatment of recurrent trigeminal neuralgia. Methods 68 patients with recurrent trigeminal neuralgia were chosen as study subjects, and they were divided into control group and research group according to the digital table.The research group was treated with gabapentin, the control group was treated with carbamazepine. After treatment for 4 weeks, the clinical effects, life satisfactory index, pain, drug dosage and adverse reaction between the two group were compared. Results Each group had 32 patients completed the study.The total effective rate of the research group was higher than that of the control group(68.75% vs.59.37%), the difference was not statistically significant(χ2=0.611, P 0.05). At 7 d after treatment, the VAS scores in the research group was lower than that in the control group[(4.09±0.83)points vs.(4.63±0.79)points], the difference was statistically significant (t=2.666, P 0.05). Before treatment and 7 d after treatment, the life satisfaction index B(LSI-B) scores between the two groups had no statistically significant difference(t=0.049, 0.224, all P>0.05). At 14 d and 28 d after treatment, LSI-B scores in the two groups were both increased, which in the research group was higher than taht in the control group[14 d: (15.09±3.68)points vs.(12.91±3.45)points, 28 d: (16.48±3.43)points vs.(13.35±3.14)points], the differences were statistically different(t=2.445, 3.808, all P<0.05). The incidence rate of adverse reaction of the research group was lower than that of the control group(15.63% vs.37.50%), the difference was statistically significant (χ2=3.925, P<0.05). Conclusion Gabapentin has similar treatment effects in recurrent trigeminal neuralgia as carbamazepin, and gabapentin has better improvement in patients' life quality, and with better safety. Key words: Trigeminal neuralgia; Gabapentin; Carbamazepine