Effect of combined gastrointestinal internal and external nutritional support in the treatment of elderly patients with lung cancer

Abstract

Objective To explore the effect of combined gastrointestinal internal and external nutritional support in the treatment of elderly patients with lung cancer. Methods According to the random number table method, 86 patients with advanced non-small cell lung cancer(NSCLC) were divided into the control group and observation group, 43 cases in each group.The observation group was given nutritional intervention on the basis of treatment in the control group.The 12-month survival rate, median progression time and median survival time were evaluated.The clinical efficacy of the two groups was evaluated.The quality of life before and after treatment was evaluated by the KPS score. Results The 12-month survival rate of the observation group was 39.53%, which was significantly higher than 18.60% of the control group(χ2=4.56, P=0.03). The median survival time and median survival of the observation group were (7.85±1.27)months, (9.98±1.71)months, respectively, which were significantly higher than (6.07±0.98)months, (7.99±1.38)months of the control group(t=7.27, 5.93, P=0.00, 0.00). The total effective rate of the observation group was 88.37%, which was significantly higher than 55.81% of the control group(χ2=11.32, P=0.00). The KPS scores of the observation group and the control group after treatment were (73.17±2.75)points, (59.68±2.52)points, respectively, which were higher than (52.75±2.02)points, (53.01±1.98)points before treatment, and the KPS scores of the observation group were significantly higher than those of the control group(t=39.24, 13.64, P=0.00, 0.00). The incidence rate of adverse reaction in the observation group was 48.84%, which in the control group was 55.81%, the difference was not statistically significant(χ2=0.41, P=0.51). The CD4+ cells, CD4+/CD8+ and NK cells in the control group were significantly lower than those before treatment(t=6.14, 8.44, 7.48, P=0.00, 0.00, 0.00), which in the observation group were significantly higher than before treatment(t=4.89, 5.17, 6.33, P=0.00, 0.00, 0.00), the differences were statistically significant compared with the control group after treatment(t=8.11, 4.26, 5.88, P=0.00, 0.00, 0.00). The levels of hemoglobin and albumin in the observation group were significantly higher than those in the control group(t=3.88, 6.39, P=0.00, 0.00). Conclusion The combination of chemotherapy combined with nutritional intervention in the treatment of locally advanced NSCLC is beneficial to improve the immune function and nutritional status of patients, improve clinical efficacy and survival of patients, better improve their quality of life, and will not increase adverse reactions. Key words: Carcinoma, non-small-cell lung; Antineoplastic combined chemotherapy protocols; Parenteral nutrition; Enteral nutrition