Retrospective analysis of concurrent radiotherapy for locally advanced head and neck squamous cell carcinoma combined with platinum based chemotherapy

Abstract

Objective To observe the efficacy of nedaplatin (NDP), Asha Leigh Per (L-OHP) and cisplatin (DDP) combined with radiotherapy and chemotherapy in the treatment of locally advanced head and neck squamous cell carcinoma. Methods The clinical data of ninety-seven cases of locally advanced squamous cell carcinoma of head and neck treated in Guigang City People′s Hospital from May 2012 to May 2017 were retrospectively analyzed.33 cases were treated with NDP+ 5-Fu (5- fluorouracil, 5-Fu) (group NDP), 32 cases were treated with L-OHP+ 5-Fu (group L-OHP), 32 cases were treated with DDP+ 5-Fu (group DDD). The three groups were treated with radiotherapy.Curative effect and adverse reaction of the three groups were compared. Results The results showed that the effective rate of the NDP group was 78.8%, slightly higher than that in the group L-OHP(75.0%) and group DDP(62.5%), the difference among the 3 groups was statistically significant (χ2=2.365, P=0.031). In the course of treatment, there were various degrees of adverse reactions in the three groups, no grade IV adverse reactions occurred.The incidence rate of adverse reactions in group NDP was (49.78±3.22)%, lower than that of group L-OHP (50.89±3.47)%, and that of group L-OHP was lower than that of group DDP (53.26±4.19)%.But the difference among the three groups was not statistically significant (P=0.099). Conclusion NDP and L-OHP have good curative effect on head and neck squamous cell carcinoma, and NDP performs better than L-OHP. Key words: NDP; L-OHP; DDP; HNSCC