Hyperplasia Research Articles

Effect of transurethral resection of the prostate on nocturia and sleep quality in men with benign prostatic hyperplasia

Objective To evaluate the effect of transurethral resection of the prostate on nocturia and sleep quality in men with benign prostatic hyperplasia. Methods This retrospective study included 122 patients who underwent TURP(transurethral resection of the prostate) for BPH(benign prostatic hyperplasia)from December 2016 to December 2018.The age was(69.7±7.9)years old. There was 20 cases with diabetes and 40 cases with hypertension. The preoperative mean prostate volume was (64.4±41.2)ml and mean BMI was (24.3±2.7)kg/m2. The preoperative IPSS score was (20.5±5.5) points, the number of nocturia events(assessed by the seventh question of IPSS) was (4.4±1.9) times, hours of undisturbed sleep (HUS) was (1.7±1.0) h, 110 cases with HUS 200 ml with nocturia (4.5±1.9) times, 9 cases had a maximum bladder capacity ≤200 ml with nocturia (4.7±1.7) times. All 122 patients were treated with TURP. Result 122 patients were followed up for 3-20 months. After operation the number of nocturia significantly decreased to (1.9±1.23) times (P 200 ml. The nocturia did not improve significantly after surgery (P>0.05) in the group with a maximum bladder volume ≤200 ml, and the nocturia in the group with a maximum bladder capacity >200 ml had significantly improvement (P 200 ml, and there was significant difference compared with before surgery (P<0.05). Conclusion TURP can significantly prolong the HUS of BPH patients with nocturia, and improve the life and sleep quality of patients. TURP partly reduces the number of nocturia, but some patients still suffer from nocturia after operation. The high total score of IPSS before operation and the maximum bladder volume ≤200 ml are the risk factors for nocturia after operation. Key words: Benign prostatic hyperplasia; Nocturia; Sleep; Transurethral resection of the prostate

The effect of transurethral prostatic dilatation on NIH-CPS, IPSS and related prostate symptoms in patients with benign prostatic hyperplasia and urinary retention

Objective To investigate the effect of transurethral prostatic dilatation on national institute of the health chronic prostatitis symptom index(NIH-CPS), international prostate symptom score(IPSS) and related prostate symptoms in patients with BPH and urinary retention. Methods From August 2017 to August 2018, 90 patients with benign prostatic hyperplasia(BPH) and urinary retention were selected in our hospital as subjects, were randomly divided into two groups according to computer-generated number table method, with 45 cases in each group. The control group was treated with transurethral prostate plasma resection. Transurethral prostatic dilatation was performed in the experimental group.The NIH-CPS, IPSS socre and the improvement of prostate symptoms before and after treatment were compared between the two groups. Results The duration of operation, intraoperative blood loss, bladder washing time, postoperative indwelling catheter and hospitalization time in the experimental group were less than those in the control group, with statistically significant(P<0.05). After the operation, the NIH-CPSI and IPSS scores of the experimental group were lower than those of the control group, with statistically significant(P<0.05). After the operation, the maximum urinary flow rate(Qmax) of the experimental group was higher than that of the control group, and residual urine volume(RUV) and international index of erectile dysfunction5(IIEF-5) scores were lower than those of the control group, with statistically significant(P<0.05). The incidence of complications in the experimental group was 4.44%, lower than that in the control group (17.78%), with statistically significant(P<0.05). Conclusions Transurethral prostatic dilatation for BPH can shorten the operation time, reduce the surgical trauma, improve the prostate symptoms with few complications. Key words: Prostatic Hyperplasia; Urinary Retention; transurethral columnar balloon dilation of prostate

Correlation of neutrophil-lymphocyte ratio and the clinical progression of benign prostatic hyperplasia

Objective To evaluate the relationship between neutrophil-lymphocyte ratio(NLR) and benign prostatic hyperplasia(BPH), and to explore the effect of NLR on clinical progression in patients with BPH. Methods A retrospective analysis of clinical data of 274 patients with BPH who admitted to the department of urology, the first affiliated hospital of Xiamen university from January 1, 2015 to December 31, 2017 was performed. Statistical methods were used to analyze the correlation between NLR and prostate volume(PV), international prostate symptom score(IPSS), maximum urinary flow rate(Qmax), and prostate-specific antigen(PSA). According to age, PV, IPSS, Qmax, PSA, the patients were divided into high-risk group and low-risk group, and NLR was compared between these groups. The receiver operating characteristic(ROC) curve was used to analyze the capability of NLR in identifying patients at a high-risk of progression. Then, according to whether the postoperative pathology contains inflammatory cell infiltration, it was divided into non-invasion group and infiltration group, and statistical analysis was performed between the infiltration group. Results NLR was positively correlated with PV and IPSS(r=0.126, P=0.038; r=0.139, P=0.021), and negatively correlated with Qmax(r=-0.169, P=0.005), but not correlated with PSA(P>0.05). When the patients were divided into group based on PV and Qmax, the high-risk group had a significantly higher NLR than the low-risk group(t=2.338, P=0.020; t=2.763, P=0.006). When the patients were divided into group based on age, IPSS and PSA, there was no significant difference in NLR between high-risk group and low-risk group(P>0.05). The ROC curve analysis showed that NLR had a cut-off value of 1.71, a sensitivity of 71.0%, and a specificity of 49.1% in predicting high-risk PV, while it had a cut-off value of 1.49, a sensitivity of 79.4%, and a specificity of 30.3% in predicting high-risk Qmax.The infiltration group had a significantly higher NLR than the non-invasion group(t=2.156, P=0.032), and the comparison between the infiltration group was also statistically significant(F=9.959, P<0.001). Conclusions NLR is positively correlated with the progression of BPH, and is one of the important factors in the clinical progress of BPH. It can provide serious information of patients and can be used as one of the indicators for follow.up. Key words: Prostatic Hyperplasia; neutrophil-lymphocyte ratio; Prostate-Specific Antigen

Aquablation—image-guided robot-assisted water-jet ablation of the prostate: current advance

In recent years robot system has been widely introduced into prostatic hyperplasia treatment. Rather than pay attention to traditional laparoscopic robot, this paper focused on Image-Guided Robot-Assisted Prostate Ablation Using Water Jet-Hydrodissection. This treatment system was very mini-invasive and easy to learn. Therefore, it reduced learning curve, operation time and related complications. This paper summarized current advance on the above fields. Key words: Benign prostatic hyperplasia; Aquablation; Minimally invasive robotic surgery; Water-jet ablation; Transurethral resection of prostate

The nephrogenic adenoma of the bladder: 8 cases and literature review

Objective To analyze the clinical characteristics of nephrogenic adenoma of the bladder. Methods The clinical and pathological data of 8 patients with bladder nephrogenic adenoma, during the period from July 2016 to June 2019, were retrospectively analyzed. Patients’ age were 33 to 71 years old and the average age was 55, including 5 males and 3 females. The clinical manifestations were hematuria in 7 cases, urinary tract irritation in 6 cases, and no obvious symptoms in 1 case. There were 7 cases with cystitis, 3 cases with urolithiasis, 2 cases with bladder cancer, 1 case with invasive colonic mesentery fibroma, and 1 case without other complications. 5 cases had the history of urological operation. The predilection site was the lateral wall with 5cases; 5 cases were solitary; the average maximum diameter of the tumor was 0.9 cm (range 0.1-1.8 cm). Under cystoscope, papillary mass can be seen, the surface is bright red, the pedicle is not obvious, the papilla is thick and short, easy to bleed when touching; some of them are scattered and lichen like changes. All patients received transurethral resection of bladder mucosa. Results Pathological examination shows that the bladder mucosa showed chronic inflammation, interstitial edema, granulation tissue hyperplasia, eosinophil infiltration and metaplasia of mesonephroid epithelium. All of the 8 patients were followed up by telephone for 2 to 38 months, with an average of 17.1 months. So far, neither recurrence has been detected. Conclusions The diagnosis of nephrogenic adenoma of the bladder depends on pathological examination. It must be totally removed during operation. The recurrence and malignancy should be treated in time after operation. Key words: Urinary bladder neoplasms; Nephrogenic adenoma; Pathology

Retrospective analysis clinical characteristics of female stress urinary incontinence and efficacy of transobturator tension-free vaginal tape procedure

Objective To explore the clinical characteristics of patients with female stress urinary incontinence(SUI) and efficacy of Transobturator Tension-free vaginal tape procedure. Methods We retrospectively analyzed the clinical data of 319 cases who were operated transobturator tension free vaginal tape in Shanghai Changhai Hospital Affiliated of Naval Medical University from Oct.2009 to Jun.2018. Patients age ranged from 39 to 91 years old, with the average age of(59.2±9.7)years old. 145(45.5%) patients aged ≥60 years old. Among them, 155 (48.6%) patients with moderate SUI, 164(51.4%) with severe SUI.96 cases(30.1%) hypertension, 24(7.5%)diabetes, 2(0.6%)had not given birth, 317(99.4%)patients had given birth more than once. 31(9.7%) coexisting pelvic organ prolapse with POP-Q stage 2 and above. Maximum urinary flow rate ranged 5.2-72.6 ml/s. Cystometric capacity ranged 56.7-1 013.6 ml. Average preoperative ICIQ-SF score was 13.9 (range 9-19). Results Operative time of 288 TVT-O procedures ranged 19-60 min, and 31 cases in the surgical management of cystocele with concomitant ranged 50-120 min. A total of 265 patients were evaluable followed up for 12-24 months, Objective cure rate and subjective cure rate were achieved in 95.8%(254 cases) and 93.6%(248 cases) respectively. POP was cured in 96.8% patients.Postoperative complications were 10.6% groin pain, 4.5% urgency, others including urinary tract infection(3.4%), de novo dysuresia(2.6%), dyspareunia(1.1%), and one case of bladder injury, one case sling erosion and one case scar hyperplasia. Conclusions Female stress urinary incontinence were mainly in middle-aged and elderly people who had severely psychological quality of life lasting for several years. TVT-O may achieve a high success or improvement rate and no serious adverse effects. One operation could correct the stress urinary incontinence and simultaneously correct prolapse. Key words: Urinary incontinence, stress; Clinical features; Transobturator tension-free vaginal tape

The role of FPSA/TPSA, PSAD combined with multi-parameter magnetic resonance imaging PI-RADS score in the diagnosis of PSA gray area prostate cancer

Objective To investigate the diagnostic value of prostate specific antigen free PSA and total PSA ratio, PSA density combined with multiparametric magnetic resonance imaging PI.RADS score in PSA gray area prostate cancer. Methods Patients with prostate cancer or benign prostatic hyperplasia(BPH) diagnosed by prostate biopsy from PSA gray area in the second affiliated hospital of Kunming medical university from May 2016 to August 2018 were selected.The FPSA, TPSA, multi-parameter magnetic and resonance PI-RADS score data were measured.FPSA/TPSA, PSAD were calculated, and the differences between the two groups of patients were compared.The role of FPSA/TPSA, PSAD combined with multi-parameter magnetic resonance imaging PI-RADS score in the diagnosis of PSA gray area prostate cancer was analyzed by receiver operating characteristic(ROC). Results A total of 117 patients were enrolled, including 30 patients in the PCa group and 87 patients in the BPH group. There were no significant differences in age, FPSA, TPSA, FPSA/TPSA between the two groups(P>0.05). However, there were significant differences in PSAD and PI-RADS scores between the two groups(P<0.01). ROC analysis showed that the FPSA/TPSA, PSAD combined with PI-RADS scores for the PCA and BPH patients under the curve AUC=0.771(P<0.01). Conclusions For patients with PSA in the gray zone. PSAD and PI-RADS scores are of significant value in the diagnosis of prostate cancer.FPSA/TPSA, PSAD combined with multi-parameter magnetic resonance imaging PI-RADS score has important application value in the diagnosis of PSA gray area prostate cancer. Key words: Prostatic Neoplasms; Prostate-Specific Antigen; Magnetic Resonance Spectroscopy

Corrigendum: The Complexities in Genotyping of Congenital Adrenal Hyperplasia: 21-Hydroxylase Deficiency.

[This corrects the article on p. 432 in vol. 10, PMID: 31333583.].

Ассоциация полиморфизма RS2414098 гена CYP19A1 с риском развития гиперплазии эндометрия

Ассоциация полиморфизма RS2414098 гена CYP19A1 с риском развития гиперплазии эндометрия

Эффективность индолкарбинола у пациенток с простой, без атипии, гиперплазией эндометрия в перименопаузе

Эффективность индолкарбинола у пациенток с простой, без атипии, гиперплазией эндометрия в перименопаузе

Clinical features of neuroendocrine cell hyperplasia of infancy

To study the clinical features of neuroendocrine cell hyperplasia of infancy (NEHI) in order to provide a basis for the management of diagnosis, treatment and prognosis of children with NEHI. A retrospective analysis was performed for the clinical data of seven children with NEHI who were diagnosed and treated from January 2014 to March 2016. Among the seven children with NEHI, there were five boys and two girls. Two children experienced tachypnea since the neonatal period, and five children developed respiratory tract symptoms within 1-6 months after birth. Of the 7 children, 6 had pulmonary crackles, 4 had hypoxemia, and 3 had gastroesophageal reflux. Lung high-resolution CT (HRCT) showed ground-glass opacities in the central region of the lungs in all children, which involved at least two lung lobes. Of the 7 children, 2 had the involvement of more than 4 lobes and 6 had air trapping. All 7 children had an improvement in clinical symptoms after two years of age. One child achieved clinical and CT remission. Four children achieved clinical remission, but still with CT changes. NEHI often occurs in infancy, with the major clinical manifestations of persistent tachypnea, pulmonary crackles, and hypoxemia. The children with NEHI often present ground-glass opacities in the central region of the lungs and air trapping on HRCT. There is no specific treatment for this disease and most cases have a good prognosis.

Analysis of related risk factors of vitreous hemorrhage after anti-vascular endothelial growth factor combined with vitrectomy for proliferative diabetic retinopathy

Objective To observe and analyze the risk factors related to vitreous re-hemorrhage (PVH) after anti-VEGF drugs combined with vitrectomy (PPV) in patients with proliferative diabetic retinopathy (PDR). Methods Retrospective analysis study. From April 2017 to July 2018, 100 eyes of 87 PDR patients who were diagnosed in Jiaxing Eye Hospital and received anti-VEGF drugs combined with 25G PPV were included in the study. Among them, there were 44 eyes in 38 males and 56 eyes in 49 females. The age ranged from 26 to 83 years, with an average age of 57.72±8.82 years. All patients were type 2 diabetes, with an average duration of diabetes 10.84±6.03 years. All affected eyes were assisted by the same doctor with a non-contact wide-angle lens under the standard three-channel 25G PPV of the flat part of the ciliary body. Five to 7 days before the operation, intravitreal injection of ranibizumab or conbercept 0.05 ml (10 mg/ml) was performed. The incidence of PVH was observed. The age of PVH patients, duration of diabetes, vision before operation, average fasting blood glucose and average postprandial blood glucose before operation, systolic blood pressure and diastolic blood pressure before surgery, laser treatment before surgery, lens removal during operation, intraocular filling during operation, retinal laser points during operation, and fundus lesions during operation (hyperplasia film, Retinal hemorrhage, vascular occlusion, proliferative retinal traction, retinal hiatus, retinal detachment, exudation, neovascularization) were analyzed to find out the cause of PVH. Spearman bivariate correlation analysis and binary logistic regression analysis were performed on the data. Results Of the 100 eyes of 87 patients, PVH occurred in 17 eyes (17%). There were statistically significant differences in the number of eyes with vascular occlusion and proliferative traction during surgery in patients with and without PVH (χ2=5.741, 8.103; P 0.05). Spearman's bivariate correlation analysis showed that patients with low vision, poor control of fasting blood glucose levels, vascular occlusion and proliferative retinal traction during the operation were related risk factors for PVH (rs=0.208, 0.229, 0.240, 0.285; P<0.05). Binary logistic regression analysis showed that fundus vascular occlusion and hyperplastic retinal traction may be independent risk factors for PVH during surgery (OR=5.175, 13.915; P<0.05). Conclusion Fundus vascular occlusion and retinal traction caused by fibrovascular membrane hyperplasia in PPV may be independent risk factors for PVH in patients with PDR after anti-VEGF drugs combined with PPV. Key words: Vitreous hemorrhage; Diabetic retinopathy; Vitrectomy; Angiogenesis inhibitors/therapeutic use; Root cause analysis

Comparison of efficacy between 577 nm micropulse laser and traditional laser retinal photocoagulation for the treatment of acute central serous chorioretinopathy

Objective To compare the clinical efficacy between 577 nm micropulse laser and traditional laser retinal photocoagulation for the treatment of acute central serous chorioretinopathy (CSC). Methods Prospective clinical randomized controlled study.Fifty-four eyes of 45 cases diagnosed as acute CSC from Jul.2017 to Jun.2018 in the First Affiliated Hospital of Zhengzhou University were included in this study.Patients were randomly divided into two groups.Group A, 29 eyes of 23 cases, received 577 nm laser photocoagulation, and group B, 25 eyes of 22 cases, received traditional laser photocoagulation.The efficacy of the two groups were observed in followed up time. Results BCVA of two groups were improved at 1 and 3 months after treatment, and the difference was statistically significant between before and after treatment (P 0.05). In the last follow-up, the fundus examination and OCT showed no laser spot or damage of retinal pigment epithelium in group A, while 13 eyes (52.00%, 13/25) in the laser pigmentation change or slight pigment epithelial hyperplasia could be seen, and 6 eyes (24.00%, 6/25) on OCT local retinal pigment epithelial change or defect could be seen in group B. Conclusion Both 577 nm micropulse laser and traditional laser photocoagulation are effective for acute CSC, which can improve BCVA, reduce CMT and SRF.But the damage of 577 nm micropulse laser is slight. Key words: Chorioretinopathy, serous, central; Photocoagulation, laser; Efficacy

Patterns of polyp histology: predictors of peril in the mucosa.

Precursor colonic polyps of varied subtypes correlate with the known neoplastic pathways. When patients present with synchronous pre-malignant polyps of multiple histologies, multiple genetic mechanisms are likely to be active, potentially resulting in a more unstable, tumourigenic mucosa. We hypothesized that patients with a combination of sessile serrated adenomas/polyps (SSA/Ps), hyperplastic (HP) polyps and adenomas would be at highest risk of developing dysplasia/cancer compared to SSA/Ps alone, due to the synergistic effect of multiple active carcinogenic pathways. A prospective colonoscopy database was examined for patients with a history of SSA/P. Patients were placed into four groups based on patterns of polyp histology as follows: (i) only SSA/Ps; (ii) SSA/P + HP; (iii) SSA/Ps + adenomas; and (iv) SSA/Ps + HP + adenomas. These groups were compared in terms of the numbers, size, location and histology of polyps and personal or family history of colorectal cancer. A total of 374 patients were included. The average age was 70 years (range 21-88), and 43% were male. There was a trend towards the most aggressive neoplastic pattern in group 4, associated with a tendency to larger SSA/Ps, more villous architecture in the adenomas and more high-grade dysplasia in both types of polyps. It was also associated with multiplicity of both SSA/Ps and adenomas. No SSA/Ps existing in the absence of adenomas had cytological dysplasia. The combination of SSA/Ps, HP and adenomas in the colorectal epithelium seems to be a marker for aggressive carcinogenesis and suggests that accurate and effective surveillance is important to manage this risk.

The repair of the defects of two fingertips with free tibial pedicle double flaps of the second toe

Objective To explore the surgical method and clinical efficacy of two free flaps pedicled with the tibial proper toe artery of the second toe for repair of the defects of two fingertips. Methods From November 2014 to September 2018, five patients with the defects of two fingertips were treated with one pedicle double flaps of the tibial side of the second toe in emergency. The proper artery of the tibial side of the second toe was used as the vascular pedicle. The blood circulation of the two flaps and the injured finger was reconstructed. The donor site was replanted with full thickness skin graft of the medial leg. Results All the 10 finger flaps survived uneventfully. The donor and recipient wounds achieved primary healing without vascular crisis. The postoperative follow-up ranged from 6 to 24 months with an average of 12 months. The appearance, sensation and function of the free flaps recovered well. No second operation was needed to thin the flaps. There were no obvious scar hyperplasia and contracture in the donor site, no abrasion resistance and pain. Conclusion The application of two free flaps from the tibial side of the second toe to repair fingertip defect of two fingers can cover the defect wound, ensure the appearance, sensation and function of the finger, reduce the number of donor sites and damage. It is an ideal repair method. Key words: Finger injuries; Surgical flaps; The second toe; One pedicle and double flaps

Experimental study on the effect of green tea polyphenols combined with Mecobalamin on the repair of peripheral nerve injury

Objective To investigate the effect of green tea polyphenols combined with Mecobalamin on nerve regeneration after sciatic nerve injury and repair. Methods Sixty adult Wistar rats were randomly divided into two groups, the experimental group and the control group, 30 rats in each group. Another 6 Wistar rats were taken as the blank control group. The experimental group was given green tea polyphenols 50 mg/(kg·d) and Mecobalamin 50 μ g/(kg·d) by gavage, while the control group was given Mecobalamin 50 μ g/(kg·d) by gavage for 2 weeks. Then the general condition, electrophysiological recovery, wet weight recovery rate of triceps surae muscle, the number of myelinated nerve fibers and the difference of histopathology were observed. Results The average nerve conduction velocity and myelinated nerve fiber count in the experimental group were significantly higher than those in the control group at the 2nd, 4th and 6th week after operation (P 0.05), and there was no significant difference between the experimental group, the control group and the blank control group at the 12th week after operation (P>0.05). The recovery rate of wet weight of triceps surae muscle in experimental group was significantly higher than that in control group (P<0.05). In the experimental group, the regenerated myelinated nerve fibers were evenly distributed, arranged relatively orderly, with high density and less hyperplasia of connective tissue. Conclusion The green tea polyphenols may play an important role in promoting peripheral nerve regeneration. Key words: Peripheral nerve; Nerve regeneration; Green tea polyphenols; Mecobalamin

A case report of congenital hyperinsulinemia with focal hyperplasia of the pancreas and literature review

目的 探讨先天性高胰岛素血症(CHI)患儿的临床特征、组织学分型，为儿科工作者提供诊断和治疗经验。 方法 回顾性分析我院收治的1例局灶增生型CHI患儿临床资料及预后，同时复习相关文献。 结果 患儿因反复低血糖、抽搐入院，我院诊断CHI，外院进一步18F-Dopa PET-CT及组织病理学检查，确诊为局灶增生型CHI。手术病灶切除治疗有效，随访血糖正常，但继发癫痫。 结论 CHI比较罕见，并且具有致死性及遗留神经系统后遗症，临床医生依据临床特征对高度怀疑CHI的患儿，应尽早完善18F-Dopa PET-CT检查，有助于早期确定CHI组织学分型，且能指导CHI的远期临床管理，减少神经系统损伤。

Effect of Yuanbei mixture on transforming growth factor alpha and urine flow rate in patients with benign prostatic hyperplasia

Objective To analyze the effect of Yuanbei mixture on transforming growth factor-alpha (TGF-α) and urinary flow rate in patients with benign prostatic hyperplasia (BPH), evaluate the curative effect of Yuanbei mixture on BPH and analyze its mechanism. Methods From January 2017 to April 2018, 92 patients with benign prostatic hyperplasia admitted to the urology department of our hospital were treated conservatively. All patients were randomly divided into the control group and the observation group, each group with 46 cases. The two groups were given basic treatment, while the control group was treated with 5 mg, 1 time a day for 2 weeks, and lasted for 4 weeks. The observation group combined with the Yuanbei mixture, one dose daily, lasted for 4 weeks. The clinical efficacy, urinary TGF-α, urinary flow rate and international prostate symptom score (IPSS) were compared before and after treatment. During the treatment, two groups of adverse reactions were observed. Results After treatment, the levels of urinary TGF-α in observation group and control group were significantly lower than those before treatment (P<0.05). After treatment, the levels of urinary TGF-αin observation group were significantly lower than those in control group (P<0.05). After treatment, the contrast urinary flow rate (Qmax, Qave) in the observation group and the control group was higher than that before treatment, and the difference between the two groups was statistically significant (P<0.05). After treatment, the IPSS score of observation group and control group was lower than that before treatment, and the IPSS score of observation group was lower than that of control group (P<0.05). The overall efficacy of the observation group was better than that of the control group (P<0.05). Conclusions Yuanbei mixture has definite curative effect on benign prostatic hyperplasia. It can reduce the level of urinary TGF-α, improve urinary flow rate and relieve the patient's condition. Key words: Prostatic Hyperplasia; CHINESE PATENT DRUGS; Receptor, Epidermal Growth Factor; Urination

Study on the difference of green laser in the treatment of prostatic hyperplasia

Objective To compare the safety and efficacy of different green laser surgery in the treatment of benign prostatic hyperplasia. Methods A retrospective comparative analysis was made of the data of patients who underwent various green laser prostatectomy(GL-PVP), green laser vaporization of the prostate(GL-PVRP) and green laser enucleation of the prostate(GEL-EP) in our hospital during May 2016 and May 2018. The short-term clinical indexes such as operation time, bleeding volume, bladder irrigation time and indwelling time of urethral catheter after prostatectomy were compared and analyzed.The long-term clinical data, such as urodynamic data, postoperative IPSS score, postoperative QOL score, international erectile function index questionnaire score, postoperative complications were analyzed between groups. Results There was no statistically significant difference between preoperative general data(age, preoperative prostate volume, preoperative PSA, preoperative IPSS score, preoperative QOL score, preoperative maximum urine flow rate, preoperative residual bladder urine, international erectile function index questionnaire score) of patients in GL-PVP group, GL-PVRP group and GEL-EP group(P>0.05). Compared with the preoperative patients in postoperative maximum urinary flow rate, postoperative bladder residual urine, postoperative IPSS score, postoperative QOL scores improved were statistically significant(P<0.01). The mean operative time of PVP, PVRP and EP in BPH treatment, .intraoperative mean blood loss, duration of continuous bladder irrigation and indwelling catheter time were statistically significant(P<0.05). However, there was no statistically significant difference in postoperative IPSS change value, postoperative QOL change value, urinary flow rate change value, and bladder residual urine change value, international erectile function index questionnaire score change value and incidence of postoperative complications. Conclusions Green laser can effectively and safely treat prostatic hyperplasia. Compared with PVRP and GL-EP, PVP has advantages of shorter operative time, less intraoperative blood loss, shorter postoperative bladder rinsing time and shorter time of indwelling urinary catheter. Key words: Prostatic Hyperplasia; Lasers, Solid-State

Correlation study between benign prostatic fluid interleukin levels and prostate specific antigen in patients with benign prostatic hyperplasia complicated with prostatitis

Objective To study the correlation between benign prostatic fluid interleukin levels and prostate specific antigen(PSA) in patients with benign prostatic hyperplasia(BPH) complicated with prostatitis. Methods The clinical data of 115 patients with BPH treated in our hospital from July 2014 to January 2018 were retrospectively analyzed. The situation of concurrent prostatitis, prostatic fluid interleukin levels, total PSA(TPSA) and free PSA(FPSA) and FPSA/TPSA were analyzed. Results In the 115 BPH patients, 76 patients had prostatitis, including 37 cases of grade I inflammation, 25 cases of II-grade inflammation, and 13 cases of grade III inflammation. The extent of inflammation and the degree of inflammation in the grade III-grade inflammation group were significantly higher than those in the I-grade and II-grade inflammation groups, and the differences were statistically significant(P 0.05). According to Pearson linear correlation analysis, there was no significant correlation between prostatic fluid IL-2 and PSA and FPSA in patients with BPH complicated with prostatitis(P>0.05). Prostatic fluid IL-6, IL-8, IL-10 were positively correlated with TPSA and FPSA(P<0.05). Conclusions BPH complicated with prostatitis is a risk factor for elevated PSA in patients, and the levels of IL-6, IL-8, IL-10 in prostatic fluid have a good correlation with PSA. Clinically, the diagnosis and treatment of BPH complicated with prostatitis can be performed according this, and improve clinical efficacy. Key words: Prostatic Hyperplasia; Interleukins; Prostate-Specific Antigen