The role of FPSA/TPSA, PSAD combined with multi-parameter magnetic resonance imaging PI-RADS score in the diagnosis of PSA gray area prostate cancer

Abstract

Objective To investigate the diagnostic value of prostate specific antigen free PSA and total PSA ratio, PSA density combined with multiparametric magnetic resonance imaging PI.RADS score in PSA gray area prostate cancer. Methods Patients with prostate cancer or benign prostatic hyperplasia(BPH) diagnosed by prostate biopsy from PSA gray area in the second affiliated hospital of Kunming medical university from May 2016 to August 2018 were selected.The FPSA, TPSA, multi-parameter magnetic and resonance PI-RADS score data were measured.FPSA/TPSA, PSAD were calculated, and the differences between the two groups of patients were compared.The role of FPSA/TPSA, PSAD combined with multi-parameter magnetic resonance imaging PI-RADS score in the diagnosis of PSA gray area prostate cancer was analyzed by receiver operating characteristic(ROC). Results A total of 117 patients were enrolled, including 30 patients in the PCa group and 87 patients in the BPH group. There were no significant differences in age, FPSA, TPSA, FPSA/TPSA between the two groups(P>0.05). However, there were significant differences in PSAD and PI-RADS scores between the two groups(P<0.01). ROC analysis showed that the FPSA/TPSA, PSAD combined with PI-RADS scores for the PCA and BPH patients under the curve AUC=0.771(P<0.01). Conclusions For patients with PSA in the gray zone. PSAD and PI-RADS scores are of significant value in the diagnosis of prostate cancer.FPSA/TPSA, PSAD combined with multi-parameter magnetic resonance imaging PI-RADS score has important application value in the diagnosis of PSA gray area prostate cancer. Key words: Prostatic Neoplasms; Prostate-Specific Antigen; Magnetic Resonance Spectroscopy