Correlation of prostate volume with diabetes in elderly patients with benign prostatic hyperplasia

Abstract

Objectives To investigate the correlation of prostate volume(PV) with diabetes in elderly patients with benign prostatic hyperplasia(BPH). Methods One hundred and fifteen elderly (age ≥60 years) patients who were diagnosed as BPH in our hospital from April 2012 to December 2012 were selected in this study. Serum triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) , high-density lipoprotein cholesterol (HDL-C), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and prostate-specific antigen (PSA) were recorded. Results The values of PV[(51.5±19.1)mL vs. (41.2±10.1)mL], PSA [(3.2±1.1)ng/mL vs. (1.9±0.6)ng/mL]and IPSS[(12.5±1.3) vs. (8.9±1.1)] in BPH patients with DM group were higher than in BPH group, with statistically significant difference(P<0.05). Values of PV and PSA in BPH patients with elevated FBG were significantly higher than in BPH patients with normal FBG(P<0.05). BPH patient with elevated HbA1c had significantly higher PV. Furthermre, higher PV and longer duration of LUTS in BPH with hyperinsulinemia group and IR group than FINS group and insulin sensitive group. The logistic regression analysis showed that FBG and FINS were the risk factors for BPH. Conclusions Diabetes and PV have the significant correlation, which can affect the occurrence and development of BPH. Key words: Key words Prostatic Hyperplasia; Diabetes Mellitus; Aged