You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II (MP36)1 Sep 2021MP36-07 ASSOCIATION BETWEEN LOW TESTOSTERONE AND ANEMIA: ANALYSIS OF THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY 8.6.1 Sirpi Nackeeran, Ruben Blachman-Braun, David Valancy, Manish Kuchakulla, and Ranjith Ramasamy Sirpi NackeeranSirpi Nackeeran More articles by this author , Ruben Blachman-BraunRuben Blachman-Braun More articles by this author , David ValancyDavid Valancy More articles by this author , Manish KuchakullaManish Kuchakulla More articles by this author , and Ranjith RamasamyRanjith Ramasamy More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002045.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Androgen effect on hematopoiesis has been long studied. Multiple clinical studies have shown an association between secondary polycythemia and testosterone replacement therapy (TRT) in hypogonadal men, however, the effect of endogenous serum testosterone on hemoglobin levels still needs to be elucidated. We analyzed data from the Third National Health And Nutrition Examination Study (NHANES III) to explore the association of total serum testosterone, low testosterone (≤300 ng/dL), hemoglobin concentration and prevalence of anemia in a nationally representative sample of men. METHODS: We collected de-identified, publicly available population data from the NHANES III database. Men between the age of 18 to 80 years of age were selected. We defined anemia as hemoglobin ≤13.5 ng/dL, and low serum testosterone as ≤300 ng/dL. Clinical and demographic characteristics such as race/ethnicity, smoking status, history of diabetes mellitus was recorded. We performed a univariable linear regression analysis between each independent variable and anemia, and multiple regression analysis considering hemoglobin predicting a negative linear relationship between anemia prevalence and serum testosterone. RESULTS: A total of 5888 men were analyzed. Those with anemia had a higher prevalence of low serum testosterone (32.3%) compared to those without anemia (24.1%) (p<0.001). After adjusting for the variables mentioned above, multiple linear regression showed that for each 10 ng/dL increase in serum testosterone is associated with an expected increase of 0.01 ng/dL of hemoglobin (p<0.001). Furthermore, having low testosterone was significantly associated with anemia (OR=1.44; 95% CI: 1.17-1.78; p=0.001). CONCLUSIONS: In a well-characterized American cohort, it was shown that men with low serum testosterone have a higher risk of anemia, and there is a positive association between serum testosterone and serum Hb. Further prospective studies need to be performed to confirm our findings. Source of Funding: © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e638-e638 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sirpi Nackeeran More articles by this author Ruben Blachman-Braun More articles by this author David Valancy More articles by this author Manish Kuchakulla More articles by this author Ranjith Ramasamy More articles by this author Expand All Advertisement Loading ...
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