Objective To discuss about the application effect of nursing information IIFAR scheme to PICC cathetering patients. Methods A total of 100 PICC cathetering patients were divided into experimental group and control group randomly in average.Conventional health education was given to control group, and IIFAR health education mode was given to experimental group on this basis.Afterwards, the complication occurrence rate, relevant knowledge acquisition level and compliance were compared for the patients between two groups. Results The infection occurrence rate of puncture site of the observation group was lower than that of the control group. The thrombogenesis occurrence rate of the observation group was lower than that of the control group. The relevant knowledge acquisition and compliance of patients in observation group were apparently higher than that of the control group. Conclusion The nursing information IIFAR scheme can improve the relevant knowledge acquisition and compliance and reduce complications for PICC patients. Key words: Nursing information IIFAR scheme; PICC; Complications; Compliance