In this paper we aim at presenting a concise but also comprehensive study of time-dependent (t-dependent) Hamiltonian dynamics on a locally conformal symplectic (lcs) manifold. We present a generalized geometric theory of canonical transformations in order to formulate an explicitly time-dependent geometric Hamilton-Jacobi theory on lcs manifolds, extending our previous work with no explicit time-dependence. In contrast to previous papers concerning locally conformal symplectic manifolds, the introduction of the time dependency that this paper presents, brings out interesting geometric properties, as it is the case of contact geometry in locally symplectic patches. To conclude, we show examples of the applications of our formalism, in particular, we present systems of differential equations with time-dependent parameters, which admit different physical interpretations as we shall point out.