The article presents the results of studies carried out in 2020-2021 in soil and climatic conditions of the Mountain-Valley viticultural zone of Crimea to determine the efficiency of small-volume spraying in pest control of industrial vineyards of wine grape variety ‘Muscat Rose’. In experimental variant, when using small-volume spraying, the amount of working solution and the rate of pesticide application were reduced (operations on the concentration of working solution). It was established that against the background of protective measures of grape plantings in experimental and example (full-volume spraying) variants, a low level of oidium development was observed: up to 1.3% on leaves, 1.1% on bunches; and of black rot - up to 1.2% on bunches. At the same time, there was no significant difference in the intensity and dynamics of disease development in these variants. It was experimentally determined that in the experiment, when using small-volume (200-250 l/ha) and full-volume (example, 400-800 l/ha) sprayings, a good conditional yield of wine grapes ‘Muscat Rose’ was obtained - 2.5-2.6 kg/bush (52.4-54.7 c/ha). The use of full-volume and small-volume sprayings on experimental plots did not have a negative effect on the process of sugar accumulation (25.1-25.5 g/100 cm3) and the level of titratable acids (6.0-6.2 g/dm3) in grape yield. Thus, in the course of studies, it was found that using of small-volume spraying made it possible to increase the productivity of sprayers and reduce the pesticide load on ampelocenosis.