Granular Cell Tumor Research Articles

Granular Cell Tumour Masquerading as Carcinoma Breast

Granular Cell Tumour Masquerading as Carcinoma Breast

A Case of Anal Granular Cell Tumor for which Anal Ultrasonography was Useful

症例は41歳，女性．肛門腫瘤で当院を受診した．直腸診では，肛門皮膚部5時方向に硬い腫瘤を触知し，肛門エコーでは，肛門5時方向に，肛門管と連続しない低エコー病変を認め，エラストグラフィーでは，周辺とは明らかに性状の異なる，硬い腫瘤として描出された．悪性の可能性が否定できず腫瘍切除の適応とした．手術は腰椎麻酔下に肛門腫瘍切除を行い，病理では，細胞質の豊かな大型の細胞が密集する病変で，免疫組織学的染色では，S-100が陽性，顆粒細胞腫と診断された．

A Case Report of a Regressed Bronchial Granular Cell Tumor Followed by Bronchoscopy

A Case Report of a Regressed Bronchial Granular Cell Tumor Followed by Bronchoscopy

A Case of Granular Cell Tumor Originating from the Ansa Cervicalis

A Case of Granular Cell Tumor Originating from the Ansa Cervicalis

Comparison of longevity and common tumor profiles between Sprague-Dawley and Han Wistar rats.

The Sprague Dawley (SD) and Han Wistar (HW) are the two most commonly used rat strains in Europe and the US, with the Han Wistar increasing in popularity because of its greater longevity and lower tumor burden. This survey was undertaken at Covance CRS (Huntingdon and Eye) to compare in-house longevity and common spontaneous tumor profiles of the two strains with published data. Data were compiled from 104-week studies started between 2010 and 2017. Mean survival was greater for both sexes of HWs when compared with SDs. Pituitary tumors were the commonest in both strains, with slightly higher incidences and more malignant tumors in SDs of both sexes. Mammary tumors were the second most common tumor in both strains; the incidence being greater in SDs compared to HWs. Benign pheochromocytomas of the adrenal and fibromas of the skin/subcutis were commoner in male SDs than in HWs. Granular cell tumors of the uterine tract were recorded only in SDs, but uterine stromal and glandular tumors were more common in HWs, which also displayed a higher incidence of granulosa cell tumors of the ovaries. Vascular tumors of the mesenteric lymph nodes, thymomas and follicular cell tumors of the thyroids were recorded at a higher incidence in HWs than in SDs. Tumor profiles of other common tumors were broadly similar between the two strains. The results of this survey correlate closely with similar comparisons made at other laboratories, and with data compiled at our laboratories 10 years ago and published as a poster.

Granular cell tumor of the colon presenting as profound weight loss

Granular cell tumor of the colon presenting as profound weight loss

Granular cell tumor of the breast: correlations between imaging and pathology findings.

ObjectiveTo review the imaging features of granular cell tumors of the breast (on mammography, ultrasound, and magnetic resonance imaging), establishing a pathological correlation, in order to familiarize radiologists with this entity and make them aware of the differential diagnoses, other than malignancy, of lesions with spiculated margins.Materials and MethodsWe reviewed the medical records (from a clinical-pathology database and picture archiving and communication system) of five patients with a pathologically confirmed diagnosis of granular cell tumor of the breast, treated at the Portuguese Oncology Institute of Lisbon, in the city of Lisbon, Portugal, between January 2012 and December 2018.ResultsAll five tumors exhibited imaging features highly suggestive of malignancy (BI-RADS 5 lesions), namely spiculated margins, significant depth, and posterior acoustic shadowing (on ultrasound). One tumor showed a kinetic curve indicative of washout on magnetic resonance imaging, two were adherent to the pectoralis muscle, and one was accompanied by skin retraction. Pathology provided the definitive diagnosis in all cases.ConclusionGranular cell tumors of the breast pose a diagnostic challenge because they can present with clinical and imaging features mimicking malignancy, and the diagnosis is therefore provided by pathology. Radiologists should be familiarized with this entity, so they can be aware of the fact that breast lesions with spiculated margins can be indicative of diagnoses other than malignancy.

Endoscopic treatment of esophageal granular cell tumors (clinical case)

Endoscopic treatment of esophageal granular cell tumors (clinical case)

Malignant Granular Cell Tumour of the Thigh with Lung Metastases in a Young Woman; A Rare Presentation

Journal of Diagnostic Pathology is a peer reviewed journal published biannually by the College of Pathologists of Sri Lanka. The journal publishes manuscripts dealing with all aspects of pathology. The aim of the journal is to update knowledge and encourage original research in the field of pathology.

Rare Treatment for a Rare Tumor: Cryoablation of a Granular Cell Tumor

Background: Granular cell tumors (GCTs) or Abrikossoff’s tumors are rare neoplasms known to originate from Schwann cells in the peripheral nervous system. These lesions are usually benign; malignancy only occurs in 1–2% of cases. Surgical resection is the traditional treatment method for GCTs, but it poses several risks and disadvantages related to the surgical incompatibility of the patient, the extended recovery time, and the chance of relapse. Cryoablation is becoming an increasingly favored method of treatment for tumors, both benign and malignant, due to its minimal invasiveness, natural analgesic properties, and ability to stimulate antitumor immunity. Cryoablation may contribute to the prevention of secondary and metastatic tumor growth in cases of malignancy by preserving tumor-associated antigen molecules for recognition by cell-mediated immunity. Methods: This article describes a novel method for GCT treatment using cryoablation. This technique exposes tumor tissue to extreme cold temperatures, effectively destroying tumor cells by irreversibly compromising their plasma membranes. To our knowledge, this is the first report in the literature of cryoablative techniques being used for GCT. Results: Cryoablation of this mass was successful with no complications. CT images during the procedure demonstrated circumferential coverage of the entire lesion with no injury to the surrounding tissues. Conclusion: Cryoablation can be used as an alternative to surgical intervention to treat malignant GCTs. This procedure is minimally invasive, less painful, and potentially effective in promoting antitumor immunity.

GRANULAR CELL TUMOR: CASE REPORT

Patient D.S.O., a 38-year-old black woman who was a smoker for 27 years, sought dental care complaining of “a ball that appeared on the tongue after eating fish and the fishbone stuck into the tongue.” There was a gradual volumetric increase in region corresponding to the dorsum of the tongue for 5 years. On intraoral examination, a soft tissue nodule was found on the dorsum of the tongue, which was exophytic, sessile, single, well-delimited, elliptical, of firm consistency, smooth, white, asymptomatic, and measured about 5 cm. Preoperative laboratory testing was requested: complete blood count, coagulogram, and glucose, all with normal values. An excisional biopsy was performed for histopathologic examination. The clinical diagnosis was irritation fibroma. The histopathologic diagnosis was granular cell tumor. In the postoperative period there were no signs and symptoms. The granular cell tumor is rare tumor with the uncertain histogenesis and shows greater predilection for the oral cavity. Patient D.S.O., a 38-year-old black woman who was a smoker for 27 years, sought dental care complaining of “a ball that appeared on the tongue after eating fish and the fishbone stuck into the tongue.” There was a gradual volumetric increase in region corresponding to the dorsum of the tongue for 5 years. On intraoral examination, a soft tissue nodule was found on the dorsum of the tongue, which was exophytic, sessile, single, well-delimited, elliptical, of firm consistency, smooth, white, asymptomatic, and measured about 5 cm. Preoperative laboratory testing was requested: complete blood count, coagulogram, and glucose, all with normal values. An excisional biopsy was performed for histopathologic examination. The clinical diagnosis was irritation fibroma. The histopathologic diagnosis was granular cell tumor. In the postoperative period there were no signs and symptoms. The granular cell tumor is rare tumor with the uncertain histogenesis and shows greater predilection for the oral cavity.

GRANULAR CELL TUMOR ASSOCIATED WITH SUBGEMMAL NEUROGENOUS PLAQUE—A CASE REPORT

This study reports the occurrence of a granular cell tumor (GCT) and a subgemmal neurogenous plaque (SNP) in the same anatomic location. A female white 59-year-old patient presented with an asymptomatic fibrous nodule located in the right posterior border of the tongue. A second, slightly erythematous, hyperplastic lesion behind the first one was identified. Both lesions were submitted for excisional biopsy. Histopathologic analysis revealed a GCT and an SNP. GCT is an uncommon, benign, soft tissue neoplasm. It presents as an asymptomatic fibrous submucosal nodule. The SNP is a biphasic structure found in the lateral posterior region of the tongue, characterized as nerve plexus aggregates and ganglion cells. The patient is under follow-up care and after 1 year, no relapses were observed. The authors believe that this is the first case showing the association between GCT and SNP.

GRANULAR CELL TUMOR MIMICKING AN EOSINOPHILIC ULCER ON THE TONGUE

Granular cell tumor (GCT) is an uncommon benign neoplasia of soft tissue that possibly arises from neural cells, especially Schwann cells. In the oral cavity, the most frequent site is the tongue. Usually, the clinical appearance is a solitary submucosal nodule, painless and nonulcerated, located in the dorsum of the tongue. Women have twice more predilection than men, and mean age ranges from fourth to sixth decades. This case report consists in a 56-year-old man referred for evaluation of a 6-month evolution of an ulcerated lesion in the right lateral border of tongue. Clinically, a discoid ulceration with elevated erythematous center and whiteness halo was observed. The clinical hypothesis was an eosinophilic ulcer. After excisional biopsy and histologic processes, a predominant group of eosinophilic cells with granular cytoplasm raised from connective tissue to ulcerated surface could be visualized. S100 immunohistochemical reaction was made, and a strong staining of these cells confirmed the final diagnosis of GCT.

NEURAL LESIONS OF THE ORAL CAVITY: A CLINICOPATHOLOGIC STUDY OF 104 CASES

Neural lesions are uncommon in the head and neck region, particularly in the oral cavity. The diagnosis of oral neural lesions may be challenging since it may share clinical and microscopic features. Objective: The aim of the present study was to evaluate the clinical and microscopic features of neural lesions diagnosed in an oral pathology laboratory from Brazil in a period between 1971 and 2018. Study Design: Neural lesions were obtained from the review of the patient's files and the final diagnosis was confirmed after microscopic evaluation; the clinical and microscopic features of each case were presented descriptively. Results: One hundred and four neural lesions were identified, representing 0.6% from a total of 17,271 samples evaluated in this period. The lesions presented preferably as asymptomatic and normochromic nodules of tender consistency and smooth surface, located in the tongue of women with median age of 39.7 years. The most common diagnoses were traumatic neuroma (20.1%), neurovascular hamartoma (20.1%), and granular cell tumor (19.2%), followed by subgemmal neurogenous plaque (13.4%), neurofibroma (10.5%), schwannoma (8.6%), and circumscribed solitary neuroma (7.7%). Conclusions: The present study likely represents 1 of the largest well-documented series of neural lesions of the oral cavity of the literature.

GRANULAR CELL TUMOR OF LOWER LIP: CASE REPORT

Granular cell tumor is a rare benign soft-tissue neoplasm with a predilection for the mouth. Its most common location is in the tongue followed by buccal mucosa. There is a predilection for the female sex, and it occurs most often between the fourth and sixth decade. It is usually normochromic, but occasionally it may present a yellow coloration. Our aim is to report a case of a 21-year-old black male patient presenting a firm yellowish sessile nodule, measuring 1 cm in the lower lip with an evolution of 3 years. The clinical diagnoses were fibrolipoma and traumatic fibroma. An excisional biopsy was performed, and in the histopathologic examination a proliferation of large and polygonal cells with abundant eosinophilic and granular cytoplasm and vesicular nuclei were observed, leading to the diagnosis of granular cell tumor. The patient has been followed up for 5 months, and no recurrence was observed.

GRANULAR CELL TUMOR: REPORT OF A CASE IN A YOUNG PATIENT

Granular cell tumors are a rare benign neoplasm of uncertain etiology and probable origin from Schwann cells that in the oral cavity affect the tongue preferentially. The nature of their cytoplasmic granularity may be a result of cell senescence due to lysosome accumulation. This work reports a case of granular cell tumor arising in the dorsum of the tongue of an 18-year-old brown woman displaying a solitary, fast-growing, painful, and sessile 2-cm-sized swelling at the presentation. After excisional biopsy, the microscopic analysis revealed a massive and poorly demarcated proliferation of plump eosinophilic and polygonal cells showing central small dark nuclei and abundant granular cytoplasm. These cells are intimately associated to skeletal muscle. Immunohistochemical evaluation demonstrated an intense positive staining to S100 protein in tumor cells, establishing the diagnosis of granular cell tumor. Since 1 year of clinical follow-up, no recurrence was identified.

Image features analysis of intracranial granular cell tumor

本文报道2008年1月至2018年12月间首都医科大学附属北京天坛医院5例颅内颗粒细胞瘤（IGCT）资料。男1例、女4例，年龄25~50岁，中位年龄44岁。5例均行头颅MRI平扫及增强扫描，其中3例同期行CT平扫。影像检查示，4例病灶位于鞍区，1例位于左额，其中3例病灶与垂体柄分界不清；5例均为实性肿块，其中1例边缘可见弧形囊变，4例病灶呈T1WI稍高信号、T2WI等/低/稍高信号，另有1例T1WI和T2WI均为等信号，增强扫描5例均呈明显不均匀强化。3例病灶内可见不规则点状T2WI高信号，相应部位T1WI呈等或稍低信号，其中1例同时可见树枝状T2WI低信号，T2WI不均匀信号区均表现为极明显强化。CT平扫均呈均匀性稍高密度。

Meningeal Granular Cell Tumour in a Green Tree Python (Morelia viridis)

Granular cell tumours (GCTs) are uncommon neoplasms mostly reported in man, dogs and horses. The origin of GCT is thought to be Schwann cells, with the associated characteristics of neural crest morphology. Neoplastic cells often demonstrate positive immunoreactivity for S100, LC3, vimentin and p62. They are also periodic acid-Schiff (PAS) positive and diastase resistant. A female green tree python (Morelia viridis) was presented for severe constipation and hyporexia of 4 month's duration and, despite treatment, died the next day. A 4.8×3.4mm intracalvarial GCT was identified, compressing the overlying cerebrum without invasion. Neoplastic cells were immunoreactive to S100 and had brightly eosinophilic cytoplasmic granules that were PAS positive and diastase resistant. Electron microscopy revealed numerous cytoplasmic lysosomes in neoplastic cells. GCTs are reported rarely in non-mammalian species with three reports in birds. This represents the first report of a GCT in a reptile.

The malignancy among gastric submucosal tumor

The origin and characteristics of most submucosal tumors (SMTs) cannot easily be confirmed by gastrointestinal endoscopy or other radiological examinations. Excluding GISTs, for those other gastric SMTs, most of which are deemed benign, the necessity and timing of intervention has been ignored. Thus, the malignancy of gastric SMTs still remains unknown. In order to summarize the malignancy of these gastric SMTs, we reviewed literatures and analyzed cases of gastric SMTs including heterotopic pancreas, leiomyoma, schwannoma, glomus tumor, hemangioendothelioma, granular cell tumor (GCT), lipoma, hemangiopericytoma, lymphangioma and neurofibroma. In these literatures, there are cases of malignancy among heterotopic pancreas, leiomyoma, schwannoma, glomus tumor, hemangioendothelioma and GCT. As a result, it suggests that although most of gastric SMTs are considered benign, there are still possibilities of malignancy, which requires our attention, even active intervention and long-term follow-up.

Tumors of the Neurohypophysis: One Unit's Experience and Literature Review

To evaluate and understand the clinical behavior and radiologic correlates of tumors originating from the posterior pituitary gland. To review the management strategy for these rare tumors and add to the limited existing literature. Retrospective review of 8 cases (5 pituicytomas, 2 spindle cell oncocytomas, and 1 granular cell tumor) managed at our institution between 2004 and 2019. The patients' clinical course, histologic features, and radiologic findings were reviewed. Their management and long-term follow-up is presented and compared with the literature. Long-term follow-up ranged from 1 to 9 years. There was 1 recurrence in a patient with spindle cell oncocytoma, and this was treated with radiotherapy. The endoscopically managed cases resulted in complete tumor excision with no recurrence. Epidemiologic data on primary tumors of the neurohypophysis is limited because of the rarity of these tumors. This study adds to the literature that these tumors behave as World Health Organization grade I tumors, although close follow-up is recommended as a few cases have shown recurrence. The endoscopic approach resulted in better gross total tumor resection rate in this series.