Abstract
Neural lesions are uncommon in the head and neck region, particularly in the oral cavity. The diagnosis of oral neural lesions may be challenging since it may share clinical and microscopic features. Objective: The aim of the present study was to evaluate the clinical and microscopic features of neural lesions diagnosed in an oral pathology laboratory from Brazil in a period between 1971 and 2018. Study Design: Neural lesions were obtained from the review of the patient's files and the final diagnosis was confirmed after microscopic evaluation; the clinical and microscopic features of each case were presented descriptively. Results: One hundred and four neural lesions were identified, representing 0.6% from a total of 17,271 samples evaluated in this period. The lesions presented preferably as asymptomatic and normochromic nodules of tender consistency and smooth surface, located in the tongue of women with median age of 39.7 years. The most common diagnoses were traumatic neuroma (20.1%), neurovascular hamartoma (20.1%), and granular cell tumor (19.2%), followed by subgemmal neurogenous plaque (13.4%), neurofibroma (10.5%), schwannoma (8.6%), and circumscribed solitary neuroma (7.7%). Conclusions: The present study likely represents 1 of the largest well-documented series of neural lesions of the oral cavity of the literature.
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