BackgroundThe Current study describes the construction of three carbon paste electrodes for the quantitative measurement of the third-generation antihistamines fexofenadine (FEX), Desloratadine (DES), and Levocetirizine (LEV). The different assembly steps of the sensor are described. The proposed potentiometric method Presents a green, fast, simple, and sensitive procedure for the determination of these drugs in their pure and pharmaceutical forms. ResultsThe quantitative determination of the antihistamines drugs was achieved using the constructed carbon paste electrodes. The presented analytical method obeyed linearity in the concentration range (5 × 10−6–1 × 10−2) M for FEX and DES, (1 × 10−5 – 1 × 10−2) M for LEV. The values of the Nernstian slopes (-57.40, -29.01, -56.01) mV/ decade indicate the closeness of these values from the ideal Nernstian slope value. The limits of quantification (LOQ) were (2.17 × 10−8- 6.31 × 10−8- 3.3 × 10−8) M, respectively. In addition, the electrodes exhibited good selectivity, repeatability (RSD<2%), stability, and fast response time. The method was validated and employed for the determination of the studied drugs in pharmaceutical dosage forms, the average recovery values were (99.13–99.53–99.90)% for FEX, DES, and LEV, respectively. ConclusionOur study included the construction of the first carbon paste electrodes for potentiometric determination of some of the third-generation antihistamines. The findings have shown that carbon paste electrodes excel over the traditional ion -selective electrodes and present an accurate, precise, green, robust, and cost-effective analytical method.