Amine mediated synthesis of nickel oxide nanoparticles and their superior electrochemical sensing performance for glucose detection

Abstract

Nickel based materials with nanoscale is great attention in various electrochemical application owing to their good redox characteristics, easy preparation, low cost and less toxic in nature. In the present work, simple and ultra-small size of nickel oxide nanoparticles (NiO NPs) was prepared by simple calcination of nickel and p-Phenylene diammine complex. The synthesized NiO NPs were studied by FE-SEM, XRD, and cyclic voltammetry. The NiO NPs modified glassy carbon electrode (GCE) demonstrated good electro-catalytic performance for glucose oxidation with higher oxidation peak current (ipa :46.9 ± 0.2 µA) when correlated to that of bulk NiO (ipa : 10.3 ± 0.3 µA) and unmodified GCE (ipa: 1.7 ± 0.3 µA) electrodes. Further, the NiO NPs coated electrode surface exhibited good linear range (5 µM–2.49 mM), high sensitivity (0.310 µA µM−1 cm−2), low detection limit (3.5 µM), good response time (<f5 s), selectivity, and stability. The optimized work was successfully utilized for accurate determination of glucose in blood serum sample.