Glucose Levels In Type Research Articles

IGF-1 levels in Patients with Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disorder group with mechanisms that include hyperglycemia, insulin resistance and hyperinsulinemia. Type 2 DM has a close association with IGF-1, where the active form of the IGF-1 becomes elevated by reason of the fact that hyperinsulinemia inhibits the production of IGF-binding proteins (IGFBP) 1/IGFBP 2. The active form of IGF-1 has the ability to promote cell proliferation and inhibit apoptosis, hence becomes one of the risk factors for cancer cell growth. This was an analytical study conducted in August at the Harapan Bunda Clinic, Medan, Indonesia to determine the difference between the IGF-1 level and blood glucose level in type 2 DM patients in different age groups. Twenty subjects with Type 2 DM participated in this study and were divided based on their age into 35-50 years old or Group 1 and 51-65 year old group or Group 2. The IGF-1 levels in both groups were compared and analyzed using the T-test dependent method. Results showed that the IGF-1 and blood glucose levels were higher in Group 1 (35-50 years old) when compared to Group 2 and the difference was significant. The change in the IGF-1 level in diabetic patients cannot be determined only by the blood sugar level.

A New Insights and Novel Targets for Hyperglycemia from Foxtail Millet (Setariaitalica L.) using Molecular Docking Studies

The inhibition of α-glucosidase and α- amylase, enzymes which are implicated in the digestion of carbohydrates, can evidently decrease the post-prandial increase of blood glucose levels. It can be an significant approach in the management of blood glucose level in type 2 diabetic and borderline patients. At present, there is renewed attention in plant-based medicines and functional foods modulating physiological reactions in the prevention and treatment of diabetes and obesity. The plant kingdom is a extensive field to investigate for natural effective oral hyperglycemic agents that have insignificant or no side effects. Consequently, natural α- glucosidase and α-amylase inhibitors from plant sources offer an prominent strategy for the control of hyperglycemia. Nowadays majority of the people divert towards millets and taken the millets as a meal in the place of rice as because they show key results on who are suffering from hyperglycemia. Foxtail millet [Setariaitalica (L.) P. Beauv.] is a member of poaceae grass family found in both arid and semi-arid regions which is principally used as a fodder and cereal crop. All the food products prepared from foxtail millet are efficient in reducing the blood glucose levels both in normal as well as diabetic patients. To identify human α-glucosidase and α-amylase inhibitors phenolic compounds (Vanillic acid, Ferulic acid) and flavonoid (Kaempferol) of foxtail millets were screened using the structural based molecular docking approach. The findings of this study revealed that all the tested compounds exhibited inhibitory activity against both the enzymes. Comparatively among the three inhibitors tested kaempferol flavonoid was more effective with - 261.79Kcal/mol and -404.66Kcal/mol of binding free energy values against α-amylase and α- glucosidase correspondingly. This insilco study paves the way to further research on foxtail millets (Setariaitalica L.) inhibitory compounds associated with hyperglycemia.

Varied Exercise Regimen and its Impact on Glucose Control among Type 2 Diabetes Mellitus Patients: A Systematic Review

Objectives: Systematic evaluation of study varied exercise regimen impact on Hemoglobin A1C and fasting blood glucose (FG) for type 2 diabetes mellitus patients in which age ranged from 30 to 88 years. Design: Systematic review, qualitative aspects of analysis followed guideline as per Cochrane handbook for systematic review of intervention and Preferred Reporting Items for Systematic Review and Meta-Analysis. Data sources: The 23 randomized controlled trails out of 237 studies paper English language only on Web of Science and PubMed database, as where search place search term used since May 2018 and still April 2019. Results: The articles showed that implementation varied exercise regimen of physical exercise consisted aerobic, resistance, both combine form, walking, and endurance based as high-intensity interval training and co-intervention of low calorie diet, medicine, education counseling, and training supervision impose motivation and proper guideline could be glycosylated hemoglobin and FG reduction about type 2 diabetes mellitus patients. Conclusion: Varied exercise regimen of physical activity, specifically combine exercise such as endurance based aerobic and resisted exercise could be treated with pure medication to reduce glucose level in type 2 diabetes patients mellitus, managed along with lifestyle change the prolong time risk factors.

A Retrospective Study on the Effect of the Co-Administration of Ojeok-san and Hypoglycemic Agents on Blood Glucose Levels in Type 2 Diabetes Mellitus

Objective This study was conducted to investigate the hypoglycemic effect and safety of Ojeok-san in patients with type 2 Diabetes Mellitus. Methods We investigated type 2 diabetes mellitus patients at Kyung-Hee University Korean Medical Hospital who were administered Ojeok-san for at least one day between January 2012 and September 2020, basal characteristics and laboratory tests were reviewed retrospectively. The hypoglycemic effect of Ojeok-san was assessed by comparing fasting blood sugar (FBS) and two hours post-prandial plasma glucose (PP2) levels from before and after taking Ojeok-san. Subgroup analyses were conducted according to baseline hypoglycemic treatments and glycated hemoglobin levels (< or ≥6.5%). The safety of Ojeok-san was assessed by comparing levels of aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase, blood urea nitrogen, and creatinine. Results After Ojeok-san administration, FBS and PP2 were significantly reduced to an average of 14.33 mg/dL and 27.67 mg/dL respectively. In the subgroup analysis, PP2 in patients receiving metformin mono therapy was significantly reduced to 28.67 mg/dL, and those receiving a dual therapy of metformin and DPP-4 inhibitor, it was significantly reduced to 32.33 mg/dL. In patients with glycated hemoglobin of lower than 6.5%, FBS was significantly reduced to 12.20 mg/dL, and both FBS and PP2 were significantly reduced, to 15.50 mg/dL and 40.00 mg/dL, respectively, in those with glycated hemoglobin levels of more than 6.5%. The safety profile showed no significant difference after Ojeok-san administration. Conclusions Ojeok-san has significant hypoglycemic effects in patients with type 2 diabetes mellitus who are also taking hypoglycemic agents. Keywords: Ojeok-san, type 2 diabetes mellitus, blood glucose level

Glucose Metabolic Regulation: Remotely Ameliorating Blood Glucose Levels in Type 2 Diabetes Via a Near‐Infrared Laser (Adv. Funct. Mater. 8/2021)

Glucose Metabolic Regulation: Remotely Ameliorating Blood Glucose Levels in Type 2 Diabetes Via a Near‐Infrared Laser (Adv. Funct. Mater. 8/2021)

The Effects of Vegetable Intake Order on Postprandial Blood Glucose Levels in Type 2 Diabetic Patients With a Mixed Meal

The Effects of Vegetable Intake Order on Postprandial Blood Glucose Levels in Type 2 Diabetic Patients With a Mixed Meal

Docking Interaction of Chromium(III) Picolinate and Chromate Ion Compounds with Protein Tyrosine Phosphatase as Insulin Receptors

The Chromium(III) compounds have been shown to reduce glucose levels in type 2 diabetics, however, the role of chromium(III) in glucose metabolism cannot be clearly explained. Based on in vitro studies, there are two opinions regarding the mechanism of the role of chromium(III), the first opinion states that the chromium(III) that enters the body directly interacts with protein tyrosine phosphatase (PTP). Second opinion, chromium(III) which enters the body undergoes oxidation to become chromium(VI), and chromium(VI) interacts with PTP. To determine the mechanism that occurs, modeling using chromium(III) picolinate as a chromium(III) complex and chromate ion as chromium(VI) interacts with PTP. The structure optimization compounds was carried out using the Hartree-Fock computation method based on the 6-31G(d). The interaction study was studied using the Autodock Vina and ONIOM methods. The interaction results of chromium(III) picolinate docking interact with Leu(13), Ile(16), Ser(47), Trp(49), Asn(50), and Tyr(131) with interaction energy of - 7.00 kcal.mol−1. Chromate ion interacts with amino acids Leu(13), Gly(14), Ile(16), Cys(17) and Arg(18) with an interaction energy of -4.10 kcal.mol−1. The result of interaction energy of chromium(III) picolinate is lower than that of chromate ion, which indicates that the interaction of chromium(III) picolinate with PTP is better than chromate ion.

EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS

Diabetes Mellitus is becoming fast growing epidemic all over the world. Despite several oral drugs available in the market, the most traditional as well as the most popular of them all are tolbutamide. tolbutamides have been a foundation for maintaining glucose levels in type II diabetes. Although having many side effects, this class of compounds is still being used as the second-line recommended choice of oral glucose-lowering treatment after metformin. In the present review, various stages involved in the development of these drugs have been discussed through important case studies. The mode of action of tolbutamide in biological system has been reviewed. Comparison of commercially available tolbutamide has been made while discussing their chemical synthesis and metabolism inside gastrointestinal tract.

SX-fraction: Promise for novel treatment of type 2 diabetes.

SX-fraction (SXF) is a bioactive glycoprotein with anti-diabetic and hypoglycemic activities that have been documented in several reports. We have reviewed those studies herein and also explored the possible mechanism of its hypoglycemic activity. The early animal studies of SXF using diabetic mice showed the significant reduction in the three diabetic parameters, serum glucose, insulin, and triglyceride, suggesting its anti-diabetic activity. The limited clinical studies also showed that SXF led to the significant reduction in the fasting blood glucose levels of type 2 diabetic patients within 2 wk or a month, suggesting its hypoglycemic activity. To explore the hypoglycemic mechanism of SXF, its possible effects on the insulin signal transduction pathway was examined in vitro. Particularly, activities of insulin receptor, insulin receptor substrate 1, and protein kinase B, which are essential elements playing a key regulatory role in the signal pathway, were studied using skeletal muscle L6 cells. The status of these three parameters were examined under a high glucose (35 mmol/L) milieu with SXF and assessed using the enzyme-linked immunosorbent assay. Such studies revealed that all three parameters (insulin receptor, insulin receptor substrate 1, and protein kinase B) were inactivated by high glucose, indicating a disruption of the signal pathway. However, such an inactivation was reversed or re-activated by SXF to successfully carry out the sequential signaling events. In fact, a measurement of glucose uptake in cells showed that SXF did increase a glucose uptake while high glucose decreased it. Therefore, SXF has anti-diabetic and hypoglycemic activities through activation of the insulin signal pathway and appears to be a safe, natural agent for lowering the serum glucose levels in type 2 diabetic patents and improving their diabetic conditions.

COMPARATIVE EFFICACY OF METFORMIN AND SULFONYLUREA IN MONOTHERAPY OR COMBINATION FOR TYPE 2 DIABETES

Despite the extensive efforts of physicians to achieve better control and management for blood glucose level in type 2 diabetics, maintaining near normal blood glucose level in these patients remain unsatisfactory. The objective of the study was to compare the effectiveness of sulfonylureas, metformin and combination of metformin plus sulfonylureas in controlling blood glucose in type 2 diabetics. Retrospective cohort research design conducted during the period of two months from 1st November 2019 to 1st March 2020 at Northern Area Armed Forces Hospital in Hafr Al Batin- Saudi Arabia on sample of 217 diabetic patients’ files, all data coded with serial number and analyzed by SPSS program through and inferential and descriptive statistics. Mean decrease in HbA1c for metformin therapy was 1.5(%), for sulfonylurea was 1.4(%), for combination therapy was 1.9(%). Mean decrease in HbA1c fasting blood glucose for metformin therapy was 1.8(mmol/l), for sulfonylurea was 1.6(mmol/l), for combination therapy was 3(mmol/l). Mean decrease in postprandial blood glucose for metformin therapy was 3.2(mmol/l), for sulfonylurea therapy was 3(mmol/l), for combination therapy was 3.7(mmol/l). There was a significant difference between levels of HbA1c between metformin group and combination group (metformin and sulfonylurea) (p = 0.002) and also there was a significant difference between sulfonylurea group and combination group (metformin and sulfonylurea) in relation to HbA1c levels (p = 0.001). However, there was no significant difference between metformin and sulfonylurea in decreasing HbA1c (p = 0.09). In conclusion, metformin or sulfonylurea as a single therapy is similar in efficacy in reducing glycosylated hemoglobin level, fasting and post-prandial plasma glucose levels to equal degree. However, combination of both therapies resulted in significant greater control of blood glucose level.

Correlation between stress level and family support towards fasting and postprandial glucose level in type 2 diabetes mellitus

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by increased blood glucose (hyperglycemia). Stress and family’s support in managing diabetic Mellitus are two critical external factors that influence blood glucose levels. This research aimed to analyze the relationship between stress level and family’s support with fasting blood glucose levels and 2 hours post prandial in T2DM patients.Method: Study design using cross sectional model. Eligible T2DM patients in Tabanan II primary health care center, between period September 2017- February 2018 were evaluated for fasting and post prandial blood glucose and stress level (Depression Anxiety Stres Scale-14) and family support. Spearman correlation test was used to determine correlation between family support and stress level toward fasting and post prandial glucose levels in T2DM patients.Result: The result suggested that 29 respondents (36.3%) get severe stress levels, 51 respondents (63.85%) get high family support, fasting blood glucose level was 168.42±63.57 and post prandial glucose level was 229.18±88.593. There was a positive correlation between family support and stress level toward fasting glucose level (r=0.341; p&lt;0,001) and post prandial glucose level (r=0.276; p&lt;0,001).Conclusion: Stress level and family support in diabetic mellitus management can influence fasting and post prandial glucose level T2DM patients. Managing stress and family support can assist in stabilizing fasting and post prandial glucose level.

Predisposing factors for the development of diabetic ketoacidosis with lower than anticipated glucose levels in type 2 diabetes patients on SGLT2-inhibitors: a review.

SGLT2-inhibitors (SGLT-2i) have been linked to the risk of potential life-threatening diabetic ketoacidosis (DKA). The U.S. Food and Drug Administration and the European Medicines Agency issued warnings in 2015 and 2016 respectively on the predisposing factors to the development of DKA in individuals on an SGLT2i. New predisposing factors to DKA are still being discovered with the use of SGLT-2i. The list by FDA and EMA is yet to be updated. This article aims to provide a holistic list that includes the newer factors that have been implicated in the development of DKA. The overall aim is to guide physicians in prescribing this class of drugs for type 2 diabetes mellitus (T2D). A search was done using PUBMED, Google Scholar, and Directory of Open Access Journals with the following words: SGLT-2 Inhibitors AND Ketoacidosis were entered. We included articles from 2000 to 2020, those in English, those involving any of the approved SGLT2i medications in T2D patients, and studies that focused on DKA linked to SGLT-2i. These articles were reviewed, and relevant data extracted and compiled. The review has revealed that predisposing factors include (excess) alcohol consumption, female gender, starvation due to illness or fasting, withholding the use of SGLT2i for less than 48h peri-operatively, and the existence of a variations in the expression of SGLT2 receptors. Patients should be advised on "sick day rules," and if a patient becomes unwell while on an SGLT2i, they should be advised to withhold the medication for the duration of the intercurrent illness.

Remotely Ameliorating Blood Glucose Levels in Type 2 Diabetes Via a Near‐Infrared Laser

AbstractType 2 diabetes, lowly responsive to insulin injection, is a difficult chronic disease which requires therapeutic breakthroughs. Herein, a new concept is proposed to remotely control the glucose metabolism by a near‐infrared (NIR) laser for the treatment of type 2 diabetes for the first time. This method integrates fluorescent upconversion nanoparticles with the optogenetic technique to selectively activate the phosphoinositide 3‐kinase/AKT signaling pathways, in an insulin‐independent manner for type 2 diabetic treatments. It features fast responsiveness (in seconds) to NIR, deep tissue penetration (up to centimeters), and tunable dosage by adjusting laser irradiation. Successful glucose metabolic regulation has been demonstrated both in vitro and in vivo, thus offering the possibility of developing new alternative strategies to meet the clinical challenges in the treatment of type 2 diabetes.

No changes in fasting and 24-hour glucose levels in type 2 diabetic subjects observed after 10 days of L-Isoleucine supplementation

Rationale: Isoleucine (ILE) is known to modulate glucose metabolism, but it remains unclear if daily ILE supplementation is able to lower fasting and 24-hour plasma glucose concentrations in patients with type 2 diabetes (T2D).

Effect of Exercise Intensity on Exogenous Glucose Requirements to Maintain Stable Glycemia At High Insulin Levels in Type 1 Diabetes.

Under basal insulin levels, there is an inverted U relationship between exercise intensity and exogenous glucose requirements to maintain stable blood glucose levels in type 1 diabetes (T1D), with no glucose required for intense exercise (80% V̇O2 peak), implying that high-intensity exercise is not conducive to hypoglycemia. This work aimed to test the hypothesis that a similar inverted U relationship exists under hyperinsulinemic conditions, with high-intensity aerobic exercise not being conducive to hypoglycemia. Nine young adults with T1D (mean ± SD age, 22.6 ± 4.7 years; glycated hemoglobin, 61 ± 14 mmol/mol; body mass index, 24.0 ± 3.3 kg/m2, V̇O2 peak, 36.6 ± 8.0 mL·kg-1 min-1) underwent a hyperinsulinemic-euglycemic clamp to maintain stable glycemia (5-6 mmol·L-1), and exercised for 40 minutes at 4 intensities (35%, 50%, 65%, and 80% V̇O2peak) on separate days following a randomized counterbalanced study design. Glucose infusion rates (GIR) and glucoregulatory hormones levels were measured. The GIR (± SEM) to maintain euglycemia was 4.4 ± 0.4 mg·kg-1 min-1 prior to exercise, and increased significantly by 1.8 ± 0.4, 3.0 ± 0.4, 4.2 ± 0.7, and 3.5 ± 0.7 mg·kg-1 min-1 during exercise at 35%, 50%, 65%, and 80% V̇O2 peak, respectively, with no significant differences between the 2 highest exercise intensities (P > .05), despite differences in catecholamine levels (P < .05). During the 2-hour period after exercise at 65% and 80% V̇O2 peak, GIRs did not differ from those during exercise (P > .05). Under hyperinsulinemic conditions, the exogenous glucose requirements to maintain stable glycemia during and after exercise increase with exercise intensity then plateau with exercise performed at above moderate intensity ( > 65% V̇O2 peak). High-intensity exercise confers no protection against hypoglycemia.

Evogliptin attenuates bleomycin-induced lung fibrosis via inhibiting TGF-β/Smad signaling in fibroblast.

Idiopathic pulmonary fibrosis (IPF) is a pulmonary interstitial fibrosis disease. Excessive activation of fibroblasts in the lung contributes to severe alveoli dysfunction and histological destruction. Evogliptin, a dipeptidyl peptidase IV inhibitor, has been widely used to reduce glucose level in type 2 diabetes, whereas evogliptin treatment to fibrosis process of lung IPF is elusive. The study aimed to investigate the mechanism of evogliptin in transforming growth factor-beta (TGF-β)-activated lung fibroblasts and evaluate the efficacy of evogliptin in lung fibrosis model. In lung fibroblast culture, the RNA expression of α-SMA in lung fibroblasts was detected, and α-SMA/COL-1 immunofluorescence co-staining after TGF-β stimulation and evogliptin administration was displayed. Mechanically, the phosphorylation level of Smad2/3 protein in cells was analyzed using Western blotting, and the scratch assay was used to reflect fibroblast proliferation. Furthermore, bleomycin was employed to induce lung fibrosis in mice, and IHC staining and hematoxylin and eosin (HE) & Masson staining were carried out to examine the extracellular matrix (ECM) expression and tissue fibrosis. The results demonstrated that evogliptin treatment attenuated the activation of fibroblasts and collagen deposition following TGF-β stimulation. Furthermore, the extracellular matrix expression was descended via evogliptin restraining the TGF-β/Smad pathway. Besides, it was also found that evogliptin affected the proliferation degree of lung fibroblasts. In vivo, the COL-1 and α-SMA were significantly reduced through evogliptin treatment compared with the bleomycin group, and fibroblasts and collagenous fiber were remarkably decreased. Evogliptin exerts an anti-fibrosis effect on TGF-β induced lung fibroblast activation, which restrains ECM formation and decreases cell proliferation level in fibroblasts. Moreover, the fibroblast infiltration and collagen deposition were ameliorated following evogliptin administration. Therefore, evogliptin serves as a potential implication to protect lung fibrosis.

Effect of bilateral needling at an acupuncture point, ST-36 (Zusanli) on blood glucose levels in type 2 diabetes mellitus patients: A pilot randomized placebo controlled trial.

Background Diabetes mellitus is one of the major current public health problems. Electro-acupuncture at ST-36 showed a significant reduction in plasma glucose levels in diabetic rats. There are lacks of studies reporting its hypoglycemic effect in humans and thus, the present study was conducted to evaluate the effect of needling at ST-36 (Zusanli) on blood glucose levels in patients with type 2 diabetes mellitus (T2DM). Methods Sixty T2DM participants were recruited and randomized into acupuncture group (n=30) and placebo control group (n=30). The participants of the acupuncture group received needling at ST-36 (one finger breadth lateral to the inferior border of the tibial tuberosity), and the participants those in the placebo control group received needling at placebo point (midpoint between the apex of the patella and tibial tuberosity). For both the groups, needles were retained for 30 min. Baseline and post-test assessments were performed prior to and after each intervention. Statistical analysis was performed using SPSS version 16. Results The present study showed a significant reduction in random blood glucose levels in the acupuncture group compared to the placebo control group. Conclusion This study suggests that 30 min of bilateral acupuncture needling at ST-36 with manual stimulation is effective in reducing blood glucose levels in T2DM patients.

제2형 당뇨 동물모델을 이용한 방풍통성산의 고혈당 개선효과

Background: Type II diabetes is considered as one of the common diseases. Bangpungtongseongsan (BPS) has been used as a traditional medicine for treating obesity and hypertension in Korea. According to previous reports, it has anti-obesity, anti-chronic asthma, anti-oxidant, and anti-inflammatory properties. However, the effects of BPS on type II diabetes have not yet been elucidated. Thus, in this sutudy, we evaluated the water extracts of BPS using type II diabetes animal models.<BR>Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 ㎎/㎏) for approximately 13 weeks. A mixture of 150 ㎎/㎏ metformin and 10 ㎎/㎏ sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 ㎎/㎏ BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 ㎎/㎏ BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models <BR>Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.

Immediate Effect of Stretching Versus Strengthening Excercises on Blood Glucose Level in Chronic Diabetes Mellitus

Background : Diabetes mellitus affects the muscles as muscle play notable role in the regulation of blood sugar level. The lack of glucose can lead to muscle cells atrophying and therefore loss of muscle mass. Stretching can increase cellular glucose uptake. Strengthening may improve strength , enlarged muscle mass and to improve insulin sensitivity and glycaemic control. Their paucity of literature on immediate effect of stretching versus strengthening exercises on blood glucose level in diabetes mellitus . Objective: To find out immediate effect of stretching on blood glucose level in diabetes mellitus individuals. To find out immediate effect of strengthening exercises on blood glucose level in diabetes mellitus individuals. To compare the immediate effectiveness of stretching and strengthening exercises on blood glucose level in diabetes mellitus individuals. Methodology: the study was conducted in Krishna hospital, in physiotherapy department. 44 subjects were selected with simple random sampling method. Chronic type 2 diabetes mellitus individuals were divided in to two groups. Group A (stretching) and group B (strengthening exercises)was given. The pre- and post –treatment postprandial Blood glucose values was measured by glucometer. Result: In conducted study, postprandial BGL showed statistically significant difference between pre and post treatment values in both group A and B. Conclusion: from the above conducted study it concludes that both stretching and strengthening exercises are effective in decreasing postprandial blood glucose level in type 2 diabetes mellitus, as there is no significant difference between both the groups . Strengthening exercises increased more flexibility in females than passive stretching and males were benefited with both stretching and strengthening exercises.

Perceived Stress and Adherence to the Dietary Recommendations and Blood Glucose Levels in Type 1 Diabetes.

Stress may negatively impact self-management of diabetes and thereby deteriorate glycaemic control. Eating is the most frequently reported stress-release method. In this study, we investigated the association between perceived stress (PS), dietary adherence, and glycaemic control. Data from participants in the FinnDiane Study with type 1 diabetes who had completed a diet questionnaire and Cohen's perceived stress scale (PSS) were included. In addition to using a continuous PSS score, participants were divided into three groups based on the PSS scores: the first PSS quartile, low levels of PS; second and third quartiles, moderate levels of PS; and fourth quartile, high levels of PS. A diet score reflecting the level of adherence to dietary recommendations was calculated. Analyses were conducted in the whole sample and in subgroups divided by body mass index (BMI < 25 kg/m2 vs. BMI ≥ 25 kg/m2). In the whole sample, high PS and continuous stress score were negatively associated with the diet score and with adherence to fish, fresh vegetable, low-fat liquid milk product, and vegetable oil-based cooking fat recommendations. The stress score was negatively associated with the diet score both in lean and in those overweight or obese. However, fish and fresh vegetable recommendations were only affected in those with corpulence. PS was not associated with mean blood glucose concentrations in the whole sample. When divided by BMI status, worse glycaemic control was observed in lean subjects reporting stress. In individuals with overweight or obesity, instead, high glucose concentrations were observed regardless of the level of perceived stress. Interventions to improve stress management could improve dietary adherence and glycaemic control and could thereby have the potential to improve long-term health and well-being of individuals with type 1 diabetes.