The article defines the structural specifics of the scientific periodicals of the Kazan Physicians Society, characterizes the logic of its evolution, shows its place in the development of the general logic of qualitative changes in the methods of constructing and manifesting medical knowledge broadcast on its pages. The stages of the evolutionary transformation of the Diaries of the Physicians Society, which were the printed organ of the Physicians Society at the Imperial Kazan University, into a special edition the Kazan Medical Journal are analyzed in detail, the date of its official approval as a printed organ is specified. Based on the materials of the State Archives of the Republic of Tatarstan, many of which were not previously introduced into scientific circulation, the succession of the development of scientific periodicals was demonstrated, which makes it possible to reasonably indicate 1872 as the year when the Kazan Medical Journal started to be published. The article gives a brief description of the published volumes of this stage of the transformation of the Diaries of the Physicians Society, indicates the specifics of their formal, as well as content and, in particular, intertextual structure. The role and place of various types of published materials, such as original scientific articles, abstracts of current scientific literature of that time, annual literature reviews in various medical specialties, meeting reports of representatives of scientific societies, reports of medical congresses and the so-called doctoral disputes at Kazan University at that time, reports of practical health care institutions of Kazan, special correspondence, reviews of scientific works, scientific bibliography, were determined. An analysis of these elements evolution in the content of scientific periodicals made it possible to substantiate the logical model of the structural transformation of this printed organ as a special type of historical source, to determine the forms of its cultural and communicative functioning, to indicate its role in the development of the professional culture of the medical corporation of Kazan University and the city of Kazan.