Gastroretentive Drug Delivery Research Articles

Development of Mucoadhesive Microsphere of Quinapril Hydrochloride for Treatment of Hypertension

Mucoadhesive drug delivery systems are very widely functional approach for delivery of system within the lumen of GIT to enhance drug absorption through the part of stomach with specific manner. Quinapril hydrochloride is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat. The quinapril hydrochloride microspheres was prepared with a coat consisting of alginate polymer i.e. sodium alginate in combination of mucoadhesive polymer chitosan/ guargum by an ionic gelation process. The microspheres were evaluated for morphological character, particle size, micromeritic properties, percentage entrapment efficiency, in-vitro wash-off test and in-vitro release studies. The drug quinapril hydrochloride was study for the release over 24 h duration. The retarding nature of system maximizing the medication discharge rate at the appropriate site within specified time period for enhancing the bioavailability of drug at desired site of action to give successful treatment to the patients experiencing hypertension The drug release of the microspheres (QLMM1 – QLMM10) was slow, extended and dependent on the composition of galactomannan concentration of polymer and stirring speed during formulation used. The mucoadhesive microspheres were adhered at intestinal pH due to highly swelling nature of composition of polymers at this pH. So, increase the adhesive strength and retarded the drug release of best composition of CH:GG in the ratio of 1:3 (QLMM6). Guargum is a highly viscous material having a property of more swelling nature due to presence of galactommannan constituent. Thus, drug release from QLMM6 was slow and extended over a period of 24 h and these microcapsules were found suitable for oral controlled release formulations.
 Keywords: Gastro-retentive drug delivery, Mucoadhesive microsphere, Quinapril hydrochloride, Pulsatile drug delivery system, Treatment of hypertension, Natural polymers

Gastroretentive Sustained-Release Tablets Combined with a Solid Self-Micro-Emulsifying Drug Delivery System Adsorbed onto Fujicalin®.

Gastroretentive drug delivery systems (GRDDS) get retained in the stomach for a long time, thus facilitating the absorption of drugs in the upper gastrointestinal tract. However, drugs that are difficult to dissolve or unstable in an acidic environment are not suitable for GRDDS. The current study designs GRDDS combined with a self-micro-emulsifying drug delivery system (SMEDDS) for drugs with solubility or stability problems in the stomach. The model drug fenofibrate was formulated into the optimized liquid SMEDDS composed of 50 w/w% Capryol® PGMC, 40 w/w% Kolliphor® RH40, and 10 w/w% Transcutol® HP and solidified through adsorption on several porous adsorbents. In a dissolution medium at pH 1.2, the powdered SMEDDS using Fujicalin® dissolved quickly and achieved higher drug dissolution than other adsorbents. Based on these results, a gastroretentive bilayer tablet consisting of a drug release layer and a swelling layer was designed. The drug release layer was formulated with the powdered SMEDDS and hydroxypropyl methylcellulose (HPMC) as a release modifier. HPMC was also added to the swelling layer as a water-swellable polymer. The dissolution rate depended on the viscosity of the HPMC in the drug release layer. The time for 90% drug release was extended from 3.7 to 12.0h by increasing the viscosity grade of HPMC from 0.1 to 100K. Moreover, the tablet swelled and maintained a size comparable to a human pylorus diameter or more for at least 24h. This GRDDS could apply to a broader range of drug candidates.

Fabrication and Applications of Raft-Forming System - An Emerging Trend in Gastro-retentive Drug Delivery System

Background and Objective: In the past several decades, the gasto-retentive drug delivery system is considered as a novel approach and has gained immense popularity in the field of novel drug delivery systems. Among several approaches to achieve gastric retention raft forming system which comes under the classification of floating drug delivery system is a subject of special research interest. This advanced drug delivery system has the potential to attain a prolonged and predictable drug delivery at specific sites of the GI tract mainly in the stomach and intestine thereby exhibiting a relatively constant plasma profile. Thus, the floating raft forming system finds useful over conventional therapeutics to treat several gastrointestinal disorders viz., gastro esophageal reflux disorder, acid reflux, peptic ulcer, oesophagitis, etc. Methods: In this current manuscript, an extensive search is performed for original research papers using databases viz., Google Scholar, PubMed, Science Direct, etc. Further, painstaking efforts are made to compile and update the recent findings of the formulation scientists working exclusively in the area of raft forming systems. This article portrays a detailed survey about several applications of raft forming systems in the form of tables. Conclusion: The floating raft forming system has the potential for controlled drug release in the upper part of the GI tract and exerts improved bioavailability of the medications having a narrow absorption window. Thus, it is concluded that this advanced dosage form is the caliber candidate for the treatment of several gastrointestinal ailments.

Recent Advance in Gastroretantive Drug Delivery System (GRDDS)

The drug delivery system is most important and preferable drug delivery system. This route has high patient acceptability, primarily due to easy of administration. Effective oral drug delivery depends upon the factors such as gastric emptying process, the gastrointestinal transit time of the dosage form drug release from the dosage form, and site of absorption of drug. In recent years, scientific and technological advancements have been made in the research and development of gastro retentive drug delivery systems. Hence forth a wide spectrum of dosage forms has been developed for the drugs which have narrow absorption window, unstable at intestinal pH, are soluble in acidic pH, and have a site of action specific to stomach. The purpose of writing this review was to investigate, compile and present the recent as well as past literature in a more concise way with a special focus on approaches that are currently utilized in the prolongation of gastric residence time. These include floating system, swelling and expanding system, bio/mucoadhesive system, high-density system, and other delayed gastric emptying devices. The present review addresses briefly the classification, formulation consideration for Gastroretantive drug delivery system (GRDDS), factors controlling gastric retention, merits, demerits, and applications of gastro retentive drug delivery systems.

Formulation and Evaluation of Superporus Hydrogel Composite as a Gastro Retentive Drug Delivery for Cefditoren Pivoxil

The purpose of this work was to incorporate superporus hydrogels for cefditoren pivoxil by using polymer like poly acrylic acid aqua cc polymer and composite agent like cross linked sodium carboxy methyl cellulose in the presence of N,N-methylene-bis-Acrylamide as crosslinking agent. Pluronic F-127 as a stabilizer and ammonium per sulfate and tetramethylene diamine as a initiator pair. Poly acrylic acid aqua cc polymer-cross linked sodium carboxy methyl cellulose superporus hydrogels of cefditoren pivoxil were incorporate by gas blowing technique. The reaction of pH on the swelling ratio was decisive. Swelling reversibility research was also achieve. Fourier transform infrared spectroscopy analysis and scanning electron microscopy studies were assume to indicate the drug loaded superporous hydrogels, while dissolution studies were achieve to assess release characteristics. Swelling was hugely depending on the term of crosslinking and the quantity of the polymer existing in formulation. The huge amount of cross-linking agent reduced the swelling ratio. The superporous hydrogels were hugely perceptive to pH of swelling medium, and exhibit reversible swelling and de-swelling behavior during still keep their mechanical stability. Apparent density was reliant on the amount of the superporous hydrogels and reduced with developing crosslink density. Degradation kinetics reveals that poly acrylic acid aqua cc polymer superporous hydrogels had good water holding potential. Drug release was similar to quantity of cross-linking agent. The studies report that poly acrylic acid aqua cc polymer superporous hydrogels can be used as a Gastroretentive drug delivery system in view of their swelling characteristics in acidic pH.

In-vivo study of quetiapine fumarate superporous hydrogels

This study aims to design and evaluate a gastroretentive drug delivery system using second generation Superporous hydrogels using Factorial design approach. Optimized formulation was assessed for pharmacokinetic parameters by In-vivo study. Pharmacokinetic analysis of Quetiapine Fumarate plasma concentration–time data provided the following pharmacokinetic parameters like Cmax values ranging (690.58 ± 1.1 ng/mL to 524.37 ± 1.6 ng/mL), Tmax values ranging (1.5 ± 0.0 to 6.0 ± 0.0 Hours), AUC values ranging (5345.67 ± 11.34 h.ng/mL to 5345.67 ± 4.59 h.ng/mL). Results obtained for the formulated product prepared with superporous hydrogel technology shows prolonged release while maintaining Q Value with reduce plasma drug fluctuations in comparison to the Pure drug.

COMPREHENSIVE OVERVIEW ON RECENT UPDATES OF GASTRORETENTIVE RAFT-FORMING SYSTEMS

A Raft-forming system is an auspicious approach for systematic drug delivery with steady plasma profiles and drug sustained release manner. It has advantages like enhanced bioavailability, better floating capabilities than other floating systems, more patient compliance, and promoting drug efficacy. Although, it has some problems as it can’t be used for drugs that possess low acid solubility, drugs that are unstable in gastric media, and drugs used for selective release in the colon along with stability difficulties. This system can be successfully prepared by three methods: the physical approach, chemical approach, and physiologically-stimuli approach. The comparative studies showed that the raft-forming system has more advantage over the other comparatives in the antacid potency and in vitro gastric residence time, allowing an intact prolonged delivery of the antacid drug. All the listed applications of the raft system were, fortunately, possessing promising drug delivery with a well-designed drug delivery system. There was a good variety in the active ingredients formulated in a raft, starting from some anti-coughs, anti-spasmodic, anti-inflammatories, and antacids to drugs treating osteoporosis and finally anti-depressants and anti-epileptic drugs. This diversity along with simple in vitro and in vivo evaluations, gives the potentiality to raft for leading the other gastro retentive drug delivery systems for decades.

The Development of Gastro-Retentive Tablet using Hot Melt Extrusion and 3D Printing Technology

In this study, a three-dimensional (3D) printed gastro-retentive tablet (3DPGRT) containing sarpogrelate HCl was prepared by changing the amount of the polymers (Eudagit？？L100-55 (EuL), pectin, and polyethylene oxide (PEO)) by coupling hot melt extrusion (HME) and 3D printing technology. The study aims to evaluate the swelling and dissolution behavior for application as a gastro-retentive drug delivery system and optimize the formulation of 3DPGRT based on the design of experiment using central composite design. The flexibility and elasticity of the extruded filaments were affected by EuL, pectin, and PEO, which either showed a linear or quadratic pattern. 3DPGRT containing sarpogrelate HCl was fabricated successfully by coupling HME and a fused deposition modeling 3D printer without being affected by EuL, pectin, and PEO. Compatibility studies of the drug-excipient through FT-IR and DSC revealed the absence of any interaction between the drug and polymers. The developed 3DPGRT possessed the ability to float over 10 h. The dissolution rate of sarpogrelate HCl was significantly affected by the interaction between EuL and pectin. The results confirmed that the mechanism of drug release of 3DPGRT is caused by a combination of non-Fickian diffusion and dilatation, which fits well with the Higuchi and Korsmeyer-Peppas model. The optimized formulation have been obtained by numerical optimization, which yielded excellent floating properties and a desirable swelling ratio with controlled drug release. This study showed the application of quality by design in the formulation development of 3DPGRT coupled with HME, which can be used to control the swelling characteristics and dissolution behavior through the interaction between EuL and pectin.

HPMC Based Gastro Retentive Drug Delivery System of Effervescent Guifenesine Tablet for Dry Cough

Recent advances in Novel Drug Delivery System is aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The controlled release drug delivery systems owning the capacity to be engaged in the stomach remains entitled as Gastro Retentive Drug Delivery Systems. One of the novel approaches for better patient compliance is floating drug delivery. Number of Gastro Retentive dosage forms has been designed to prolong gastric residence time. We are trying to overcome less gastric retention time and trying to reduce the dosing frequency. Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Present study involves preparation of floating tablet of Guaifenesin with HPMC K10 and K15M floating tablet were designed to achieve the extended release or retention in GIT, which may result enhance in absorption and leads to increase in bioavaibility. The aim of the present work is to develop safe, effective HPMC based gastro retentive drug delivery system of effervescent Guaifenesin tablet for dry cough with extended release profile.

Flaxseed Mucilage Hydrogel based Floating Drug Delivery System: Design and Evaluation

Natural polymer-based plant polysaccharides and proteins have been most widely explored as an adjuvant in the dosage form formulation. Here we design a novel gastro-retentive floating tablet, based on a polysaccharide material from Flaxseed (Linum usitatissimum L.) for Domperidone. After oral administration; Domperidone showed good solubility in acidic pH but significantly reduced solubility in alkaline medium. So that to increase the absorption and bioavailability of Domperidone, it is necessary to increase the retention time in the upper part of the Gastrointestinal tract (GIT) by developing a floating sustained drug delivery system. The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose K 100 M (HPMC K100 M), Carbopol 934 and Flaxseed mucilage. Hardness, friability, weight variation, thickness, disintegration time of tablet formulations were within acceptable limits. The overall results explained that the optimized formulation F5 prepared by the exact ratio of Flaxseed mucilage, HPMC K100 M, Carbopol, could be more efficient on floating and sustained release of Domperidone in the upper part of GIT as compared to the tablets prepared by using HPMC K100 M and Carbopol 934 only. These findings indicated that Flaxseed can be used to develop novel gastro-retentive sustained release drug delivery system with the double advantage of sustained drug release at the upper part of GIT.

Formulation and evaluation of gastro retentive drug delivery system of candesartan cilexetil

It had became a challenging experience and effort for a formulator to develop and innovate a drug with maximum bioavailability. In the present study the focus of research is in the treatment of Hypertension, which is one of the most prevalent cardiovascular diseases in the world, affecting a big proportion of the adult and old age population. Candesartan Cilexetil angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands, used for the treatment of high blood pressure. The drug has poor bioavailability due to limited oral absorption and maximum absorption at proximal intestine. This warrants and offers the use of Gastro Retentive Drug Delivery System (GRDDS) for sustained release formulation in order to achieve prolonged action and to improve patients compliance. Wet granulation technique was selected for preparation of tablets and the drug is formulated with HPMC K100M, ethylcellulose, sodium bicarbonate, Micro crystalline cellulose, Gelucire, talc and Aerosil etc. For around twelve formulations were made and evaluated for General appearance, Thickness, Hardness or Crushing strength Test, Friability Test, Estimation of drug content, In-vitro buoyancy studies and In-vitro drug release and the results obtained for the performed tests were found with in the range specified limits.

Novel approaches of gastro retentive drug delivery system

Oral route of drug administration is the most convenient route and accepted route of drug delivery. It is probable that at least 90% of all the drugs given by oral route. There are different drug deliveries to cure the diseases through oral route. Among them Gastroretentive drug delivery system plays an important and significant role in novel drug delivery systems. The floating systems, bioadhesive drug delivery system, expandable drug delivery system, high density systems, effervescent systems (Gas Generating systems), non-effervescent systems etc are various approaches. The wide applications can be achieved through this delivery system are enhanced bioavailability, sustained drug delivery, site-specific drug delivery, absorption enhancement, mitigating adversity at colon etc. In addition to specified above, the advantages and disadvantages, drugs and polymers used and the method of evaluation is also summarized in this review.

Formulation and evaluation of gastroretentive drug delivery system of eprosartanmesylate

It had became a challenging experience and effort for a formulator to develop and innovate a drug with maximum bioavailability. Objective: In the present study the focus of research is in the treatment of Hypertension, which is one of the most prevalent cardiovascular diseases in the world, affecting a big proportion of the adult and old age population. Eprosartan mesylate(EPM) is angiotensin-II receptor antagonist used for the treatment of high blood pressure. The drug has poor bioavailability due to limited oral absorption and maximum absorption at proximal intestine. This warrants and offers the use of Gastro Retentive Drug Delivery System (GRDDS) for sustained release formulation in order to achieve prolonged action and to improve patients compliance. Method: Wet granulation technique was selected for preparation of tablets and the drug is formulated with hydroxyl propyl methyl cellulose K100m, hydroxyl propyl methyl cellulose K15m, polyox WSR coagulant, polyox WSR301,polyox WSR N80, Lactose Monohydrate, Micro crystalline cellulose(Avicel), magnesium sterate, ethylcellulose, sodium bicarbonate, tromethamine, etc. Results: For around twenty formulations were made and evaluated for General appearance, Thickness, Hardness or Crushing strength Test, Friability Test, Estimation of drug content.

Design and Evaluation of Gastro-retentive Drug Delivery System for Glimepiride using Design of Experiment

Glimepiride, oral sulfonyl urea, BCS class-II drug is used to treat diabetes (type-II). Due to its low solubility, it is an ideal candidate for solubility enhancement, leading to better bioavailability and subsequent dose. In the present study, the solid dispersion technique was used to improve the solubility using solvent evaporation method. The solid dispersions were prepared using affnisol 912 as a solubility enhancer. The prepared solid dispersions were evaluated for solubility in 0.1N HCl pH 1.2 and phosphate buffer pH 7.8 medium. The solubility of glimepiride in optimized solid dispersion (SD1) formulation was 682.44 µg/mL compared to 6.88 µg/mL for pure drug in pH 7.8 medium. The solid dispersion (SD1) was further formulated into the tablets. The gastro-retentive and mucoadhesive properties were contributed to the tablets by HPMC K4M and Carbopol 940, respectively. Factorial design (Central composite design) was used to optimize the gastro-retentive tablets. The tablet formulations showed good mucoadhesive properties and drug release up to 12 hours in pH 1.2 with 0.5% SLS medium. The optimized formulation (F2) showed cumulative drug release up to 97.20 ± 0.99% in 12 hours. The drug release kinetics also showed that the drug is release by dissolution and diffusion from the drug matrix. The gastro-retention studies in rabbits also showed the tablets remain within the GIT up to 12 hours as confirmed by x-ray images.

Development of Floating 3D-Printed Devices for Carvedilol Tablet

A floating drug delivery device is one type of gastro-retentive drug delivery system (GRDDS). Carvedilol (CAR) is poorly soluble in alkaline pH (intestinal environment) and has good solubility in the acidic pH (stomach environment). Hence, floating 3D-printed devices (FD) were developed from polylactic acid (PLA) filaments using fused deposition modeling (FDM) and designed to be a tablet shape with an anti-flip-up property as GRDDS of carvedilol tablets. There were two parts of FD, including the cap and the base. The base was designed with different hole diameters (2.5, 3.5, and 4.5 mm) for a controlled drug release. The FD had a smooth texture and white color. All the FD showed the anti-flip-up property. The drug release showed that the FD with 2.5- and 3.5-mm hole diameters had the potential to control the drug release. The CAR tablet-incorporated FD with a 3.5 mm hole diameter showed an optimal sustained-release profile, 99.8 % of drug release in 10 h. Moreover, zero-order kinetic was achieved. Therefore, this device may be promising to provide an extended drug release in the stomach.

Design and Evaluation of Gastroretentive Multiple Units of Dipyridamole: in-vitro and in-vivo human studies

Objective: The pH dependent solubility of Dipyridamole was made to select as a model drug for the formulation of gastroretentive drug delivery system. Dipyridamole is highly soluble in acidic pH and as the pH increases the solubility of the drug decreases. The study was planned to formulate, characterize with in-vitro and in-vivo evaluation in human volunteers.
 Method: In this study floating mini matrix tablets of Dipyridamole was formulated using HPMC grade polymers by wet granulation method and prepared multiple units equivalent to one dose were filled in one 000 size empty gelatin capsule. The prepared multiple units were subjected to physical evaluation, in-vitro drug release, and stability studies as per ICH guidelines. The in-vivo radiographic studies were conducted for determining the residence time of dosage form in human subjects.
 Results: All the prepared batches showed good physical properties and in-vitro buoyancy. The optimized FD7 formulation remained buoyant for more than 12 h with drug release of more than 90% in 12 h. The drug release kinetics for optimized formulation FD7 followed a first order kinetics with non fickian mechanism. Formulation FD7 was selected as the best formulation based on the in-vitro characteristics and subjected for stability and in-vivo radiographic studies. These studies revealed that the multiple units were stable during the stability period and remained in the stomach for upto 6 h in human subjects.
 Conclusion: Based on in-vitro characteristics and in-vivo radiographic studies, formulation FD7 was concluded as the best formulation among others. Due to increase in gastric retention time, by choosing floating mini matrix tablets we can improve patient compliance and ensure better disease management.
 Keywords: Dipyridamole, Mini matrix tablets, In-vitro buoyancy, Stability studies Radiographic Studies

DEVELOPMENT AND EVALUATION OF RAFT FORMING GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM OF NIZATIDINE BY DESIGN OF EXPERIMENT

Objective: The current research involves the formulation of a sustained-release gastro-retentive drug delivery system of nizatidine. Methods: Using 33 Box-Behnken designs, about 17 experiments were performed and evaluated for various parameters like physical appearance, pH, in vitro gelling study, in vitro buoyancy study, measurement of viscosity, density measurement, gel strength, raft resilience, drug content, acid neutralization capacity, in vitro dissolution, release kinetics and stability studies. Results: All the formulations exhibited good viscosity, density less than gastric fluid, gelling capacity retained, and buoyant for 12 h. Drug content ranges from 97.98 to 99.34 %, with a long neutralization period. The buoyancy lag time was found to be in the range of 15.34 to 26.12 sec and the % drug release at 12 h was between range from 85.67 to 99.45, with the highest release exhibited by F3. All formulations displayed zero order in vitro drug release>10 h with exceptional buoyancy properties. F3 was the optimized formulation and further subjected to FTIR and DSC study, concluding that compatibility of nizatidine with excipients in the formulation blend. Stability studies show no significant changes. Conclusion: Results indicate that gastric-floating formulations of nizatidine have the prospective for superior gastric residence time and sustained drug release.

Prescription optimization of gastroretentive furosemide hollow-bioadhesive microspheres via Box-Behnken design: In vitro characterization and in vivo evaluation

The synergistic gastroretentive drug delivery systems are capable of delivering drugs with a narrow absorption window. The purpose of this study is to prepare furosemide hollow-bioadhesive microspheres to improve bioavailability. The emulsion solvent volatilization method was adopted, through Box-Behnken design, with polymer ratio (X1), dosage (X2), organic solvent volume (X3) and PVA concentration (X4) as independent variables, and drug loading (Y1), encapsulation rate (Y2), yield rate (Y3) and 8 h floating rate (Y4) were response variables. The interaction effects of the independent and response variables were explored. The optimized hollow-bioadhesive microspheres showed the in vitro floating rate of 93.33 ± 5.24% for 8 h, the in vitro retention rate of 90.67 ± 3.21%, and the sustained drug release of 93.79 ± 4.90% for 12 h. Compared with the hollow microspheres, the hollow-bioadhesive microspheres significantly increase the retention time in the stomach. The results of Differential Scanning Calorimetry, Fourier Transform InfraRed, and X-ray diffraction showed that furosemide had good biocompatibility with excipients. Compared with commercial tablets, the relative bioavailability of hollow-bioadhesive microspheres was increased by 163.84%, and the long-term therapeutic concentration was maintained. The safety evaluation proved the oral safety of microspheres. In conclusion, the safe and economical furosemide hollow-bioadhesive microsphere is a valuable preparation for development, which can improve clinical application.

The Impact of Microsponge and Microsphere on Improving Oral Bioavailability of Medications: A Short Review

While many diseases require an efficient drug delivery technology that has the ability to improve bioavailability and alleviate side effects, various types of gastroretentive drug delivery systems (GRDDS) have been developed in order to overcome the obstacles, which are related to a narrow absorption window, instability, site of action, side effects, and dosing frequency. In this context, microsponge and microsphere systems depict two different types of GRDDS, aiming to provide adequate time for active ingredients to be absorbed in the stomach despite the variation in releasing mechanisms of the entrapped ingredients. For the successful designing of these systems, it is essential to optimize the characterizations of the formulated microparticles by considering physiological, pharmaceutical, and patient-related factors, which have a dramatic impact on the efficacy. Consequently, they will demonstrate different behaviors at the desired site of action, determining which systems are showing superiority compared to others. However, each microparticle system has some advantages over the others, providing more options for researchers to ease the difficulties that exist with conventional oral dosage forms. Therefore, this review aims to shed the light on critical factors that have significant impacts on microsponge and microsphere systems and addresses their advantages and disadvantages, providing an understanding of these criteria in order to optimize the drug systems.

Gastro retentive floating drug delivery system of model drug using central composite design

The work plans to build up a Gastro retentive floating drug delivery system of Model drug using central composite design. The model drug is a drug which is used in the treatment of antiulcer. Extended-release tablets of model drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. This could extend its safe administration and improve patient compliance. The present study aims to develop floating tablets of model drug using HPMC K4M, Carbopol 934 and an effervescent agent which can float on gastrointestinal fluid for sustained release and evaluate the model drug tablets in-vitro for their TFT, FLT, and drug release pattern. Gastro retentive drug delivery system (GRDDS) refers to systems in which the drug retained in the stomach for a prolonged period that improves the bioavailability of drug substances. Any delivery system aims to deliver a therapeutic amount of drug to the specific site in the body to obtain rapid and then maintain a requisite amount of drug. The formulated tablets evaluated for both pre-compression and post compression parameters including weight variation, hardness, friability, in vitro drug release and different pharmacokinetic plots. Final formulation was agreeable when assessed for all assessment parameters.