Formulation and evaluation of gastro retentive drug delivery system of candesartan cilexetil

Abstract

It had became a challenging experience and effort for a formulator to develop and innovate a drug with maximum bioavailability. In the present study the focus of research is in the treatment of Hypertension, which is one of the most prevalent cardiovascular diseases in the world, affecting a big proportion of the adult and old age population. Candesartan Cilexetil angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands, used for the treatment of high blood pressure. The drug has poor bioavailability due to limited oral absorption and maximum absorption at proximal intestine. This warrants and offers the use of Gastro Retentive Drug Delivery System (GRDDS) for sustained release formulation in order to achieve prolonged action and to improve patients compliance. Wet granulation technique was selected for preparation of tablets and the drug is formulated with HPMC K100M, ethylcellulose, sodium bicarbonate, Micro crystalline cellulose, Gelucire, talc and Aerosil etc. For around twelve formulations were made and evaluated for General appearance, Thickness, Hardness or Crushing strength Test, Friability Test, Estimation of drug content, In-vitro buoyancy studies and In-vitro drug release and the results obtained for the performed tests were found with in the range specified limits.