Abstract
Gastro retentive drug delivery system is one of the approaches to achieve controlled drug delivery. The gastro retentive drug delivery system is a way to prolong residence time of active pharmaceutical ingredient in gastrointestinal tract. It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. Controlled drug delivery creates a window of absorption that release drug for a longer duration of time before reaching absorption site. Gastro retentive drug delivery systems have gained wide variation of oral drug distribution in the area of late. It includes all the approaches that keep the dosage form in the stomach for a longer duration of time. This also enables sustained release of active pharmaceutical ingredient which in turn overcomes many limitations of conventional drug delivery systems. It has begun tremendous advances in the field of gastro-retention to meet controlled release of drugs. Aim of research. The main aim of this survey to prolong the gastric retention dosage form in the stomach and improve the medication concentration in the stomach. Material and Method. To prepare this manuscript, various keywords were searched in different search engines such as Google, Yahoo, Bing etc. The available information in public domain was collected and classified according to delivery system. This review paper aim to provide complete information about different delivery systems related to Gastro retentive drug delivery systems (GRDDS). It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. Result. After going through various literatures, it can be said that the GRDDS can improve local bioavailability and therapeutic efficacy and dosing frequency possible reduction in dose size. This paper is focused on various physiological contemplation and obtainable formulation approaches for development of gastro retentive drug delivery system. Conclusions. This article discusses various types of GRDDS and their approaches. The gastric retentive drug delivery systems improve drug absorption. Prolonged gastric retention time of therapeutic mutations provide several benefits such as improving absorption, bioavailability and enhance the therapeutic action of drug
Highlights
Floating drug delivery system is popularly known by the name of hydro dynamically controlled system
Gastro retentive drug delivery systems (GRDDS) shows some sort of disadvantages: Following are the disadvantages of gastro retentive drug delivery system: – Floating drug delivery systems require high fluid level in stomach to float and work effectively [1] – Drugs that absorb selectively in colon, e.g. corticosteroids [1] – Drugs that have very limited acid solubility – The drug that undergoes a significant first pass metabolism – The needs for high levels of abdominal fluids for the delivery system to float and function efficiently [10] – The presence of food is required to delay gastric emptying
Magnetic system: attainment of patient compliance is a major challenge for this type of dosage form
Summary
Floating drug delivery system is popularly known by the name of hydro dynamically controlled system. The dosage form keep floating on gastric content and release drug in slow manner at desired rate, resulting in increased gastric retentive time in the stomach. It helps in reducing the drug concentration variation in plasma. GRDDS shows some sort of disadvantages: Following are the disadvantages of gastro retentive drug delivery system: – Floating drug delivery systems require high fluid level in stomach to float and work effectively [1] – Drugs that absorb selectively in colon, e.g. corticosteroids [1] – Drugs that have very limited acid solubility (e.g. phenytoin) – The drug that undergoes a significant first pass metabolism (e.g. nifedipine) – The needs for high levels of abdominal fluids for the delivery system to float and function efficiently [10] – The presence of food is required to delay gastric emptying [11] Factor affecting of GRDDS. Magnetic system: attainment of patient compliance is a major challenge for this type of dosage form
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