HPMC Based Gastro Retentive Drug Delivery System of Effervescent Guifenesine Tablet for Dry Cough

Abstract

Recent advances in Novel Drug Delivery System is aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The controlled release drug delivery systems owning the capacity to be engaged in the stomach remains entitled as Gastro Retentive Drug Delivery Systems. One of the novel approaches for better patient compliance is floating drug delivery. Number of Gastro Retentive dosage forms has been designed to prolong gastric residence time. We are trying to overcome less gastric retention time and trying to reduce the dosing frequency. Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Present study involves preparation of floating tablet of Guaifenesin with HPMC K10 and K15M floating tablet were designed to achieve the extended release or retention in GIT, which may result enhance in absorption and leads to increase in bioavaibility. The aim of the present work is to develop safe, effective HPMC based gastro retentive drug delivery system of effervescent Guaifenesin tablet for dry cough with extended release profile.