Abstract
The work plans to build up a Gastro retentive floating drug delivery system of Model drug using central composite design. The model drug is a drug which is used in the treatment of antiulcer. Extended-release tablets of model drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. This could extend its safe administration and improve patient compliance. The present study aims to develop floating tablets of model drug using HPMC K4M, Carbopol 934 and an effervescent agent which can float on gastrointestinal fluid for sustained release and evaluate the model drug tablets in-vitro for their TFT, FLT, and drug release pattern. Gastro retentive drug delivery system (GRDDS) refers to systems in which the drug retained in the stomach for a prolonged period that improves the bioavailability of drug substances. Any delivery system aims to deliver a therapeutic amount of drug to the specific site in the body to obtain rapid and then maintain a requisite amount of drug. The formulated tablets evaluated for both pre-compression and post compression parameters including weight variation, hardness, friability, in vitro drug release and different pharmacokinetic plots. Final formulation was agreeable when assessed for all assessment parameters.
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