This study proposes a tripartite cognitive model of information dissemination based on the symbiosis and antagonism of multiple types of messages, as well as the polymorphism of user cognitive process under the influence of multi-messages. To begin, the euphoric state induced by users’ exposure to multi-messages is proposed, which can be used to more realistically describe the complex psychological state of users during the cognitive game of multi-messages. Secondly, the tripartite cognitive game theory is used to construct the user’s state transformation drive force. Meanwhile, the information entropy is introduced to further quantify message forwarding drive force, taking into account differences in the amount of information that users’ cognitive processes transform. Finally, a comprehensive macro model based on the tripartite cognitive game and the rumor & anti-rumor & stimulate-rumor information dissemination model is proposed. Meanwhile, the Lotka–Voltaila equation is used to analyze and evaluate the coexistence/confrontation relationship of multi-messages and the game state of user cognitive process from a micro perspective. Experiments show that the model can not only depict the coexistence/confrontation relationship of multiple messages, but it can also perceive the game situation of multiple messages.