Fouling and virus resistance membranes were prepared by the blending of polyvinylchloride (PVC) with a solution (NS) of manganese acetylacetonate Mn(acac)3 . Mixed matrix membranes PVC/Mn(acac)3 exhibit enhancement in properties and performance compared with the blank membrane. In a comparison among the fabricated mixed matrix membranes, U4 which was prepared from 14 wt% PVC with 1wt% nano-solution of Mn(acac)3 exhibits the highest mechanical properties compared with the blank membrane and other prepared membrane samples of U3 (15% PVC &1%NS), U5 (14% PVC & 0.5% NS), U6 (14% PVC & 0.2% NS), and U7 (14% PVC & 1.2% NS). The addition of Mn(acac)3 nano-solution to polymeric solution improved the hydrophilicity of the membrane samples, where the blank membrane U1 ( 16% PVC) exhibited a contact angle of 127.1°±0.5° compared with 40.1°±0.1° for U7 and 48.5°± 0.1° for U4. Moreover, the membranes' performance was improved, where U1 (blank) provided the permeate flux of 65, 51, 40, and 26 L/m2 .h and U4 provided 90, 86, 76, and 73 L/m2 .h for separation of various concentrations of humic acid 0.05, 0.1, 0.2, and 1 g/L, respectively. A virus removal test was carried out on real sewage wastewater. U4 provides 100% removal for all virus removal, while U1 provides 100% removal for rotavirus only. The fouling test results indicate that U4 exhibited antifouling properties, where the flux recovery ratio (FRR) was 99.47%. So, the mixed matrix membrane U4 can be considered as a fouling and virus resistance membrane.