The article presents the results of a clinical study of the severity of oxidative stress in the treatment with isoniazid on the material of bronchoalveolar flushes. The object of the study was patients with infiltrative pulmonary tuberculosis who had their bronchoalveolar lavage (BAS) removed during FBS. 19 patients received lymphotropic administration of isoniazid (group 1), 21 patients received intramuscular injection of isoniazid by needle-jet method (group 2), 20 patients were in the 3rd control group with traditional intramuscular administration of isoniazid as part of standard 4 ABP regimens. Lymphotropic injections were performed sequentially in the area of the jugular fossa, behind the xiphoid process, and in the parasternal zone. Group 2 patients were injected with a 10% isoniazid solution in an amount of 1.0 ml into the intercostal space in the projection of the inflammatory focus using a semi-automatic combined ISI-1 acupuncture injector. The content of total protein, malondialdehyde (the final product of lipid peroxidation) and isonicotinic acid hydrazide (non-metabolized GINK, which is part of the anti-tuberculosis drug isoniaziada) was studied in BAS using biochemical methods. Total protein and MDA in patients with tuberculosis are at a high level, reflect the intensity of inflammation and decrease with lymphotropic and intra-pulmonary administration of isoniazid. The content of GINK in BAS is higher with its lymphotropic administration. Based on the study of these tests and the content of GINK in bronchoalveolar flushes, it can be argued that local and regional lymphotropic administration of isoniazid has a greater anti-inflammatory effect on the membranes of the lungs and tracheobronchial tree than intramuscular administration.