This paper presents a comparative study of two joining processes, self piercing riveting (SPR) and mechanical clinch, used to join DP590 high-strength steel and Al5754 aluminum alloy. A comparative study of microhardness, tensile shear properties, fatigue properties, and economics of joints from both processes was conducted. The findings indicate that the highest hardness levels are observed in the rivet leg region for SPR joints and in the neck region for mechanical clinch joints. The maximum failure load and energy absorption values of SPR joints were found to be 1.46 and 9.07 times higher, respectively, than those of mechanical clinch joints. The static tensile test results demonstrate that the strength and hardness of SPR joints in aluminum sheets subjected to cold work hardening are significantly lower than those of steel sheets. Therefore, the failure of SPR joints is primarily attributed to the deformation and fracture of the lower aluminum sheet. Mechanical clinch joints fail by neck fracture because the steel sheet neck becomes brittle by cold work hardening and the neck thickness is small. The fatigue behavior of SPR joints was observed to be superior to that of mechanical clinch joints. The findings of the scanning electron microscopy and energy spectrum analysis suggest that fretting wear between the upper and lower sheets results in fatigue fracture of the lower sheet in the joints. When joining the same material on a large scale, the selection of mechanical clinch over SPR can prove an effective method of reducing costs. Furthermore, the selection of a set of dies with an extended life can contribute to the reduction of joining costs.