Familiar Objects Research Articles

Twelve-month-olds disambiguate new words using mutual-exclusivity inferences

Representing objects in terms of their kinds enables inferences based on the long-term knowledge made available through kind concepts. For example, children readily use lexical knowledge linked to familiar kind concepts to disambiguate new words (e.g., “find the toma”): they exclude members of familiar kinds falling under familiar kind labels (e.g., a ball) as potential referents and link new labels to available unfamiliar objects (e.g., a funnel), a phenomenon dubbed as ‘mutual exclusivity’. Younger infants' failure in mutual exclusivity tasks has been commonly interpreted as a limitation of early word-learning or inferential abilities. Here, we investigated an alternative explanation, according to which infants do not spontaneously represent familiar objects under kind concepts, hence lacking access to the information necessary for rejecting them as referents of novel labels. Building on findings about conceptual development and communication, we hypothesized that nonverbal communication could prompt infants to set up kind-based representations which, in turn, would promote mutual exclusivity inferences. This hypothesis was tested in a looking-while-listening task involving novel word disambiguation. Twelve-month-olds saw pairs of objects, one familiar and one unfamiliar, and heard familiar kind labels or novel words. Across two experiments providing a cross-lab replication in two different languages, infants successfully disambiguated novel words when the familiar object had been pointed at before labeling, but not when it had been highlighted in a non-communicative manner (Experiment 1) or not highlighted at all (Experiment 2). Nonverbal communication induced infants to recruit kind-based representations of familiar objects that they failed to recruit in its absence and that, once activated, supported mutual-exclusivity inferences. Developmental changes in children's appreciation of communicative contexts may modulate the expression of early inferential and word learning competences.

Using environmental nudges to reduce academic cheating in young children.

Previous research on nudges conducted with adults suggests that the accessibility of behavioral options can influence people's decisions. The present study examined whether accessibility can be used to reduce academic cheating among young children. We gave children a challenging math test in the presence of an answer key they were instructed not to peek at, and manipulated the accessibility of the answer key by placing various familiar objects on top of it. In Study 1, we used an opaque sheet of paper as a two-dimensional occluder, and found that it significantly reduced cheating compared to a transparent plastic sheet. In Study 2, we used a three-dimensional occluder in the form of a tissue box to make the answer key appear even less accessible, and found it was significantly more effective in reducing cheating than the opaque paper. In Study 3, we used two symbolic representations of the tissue box: a realistic color photo and a line drawing. Both representations were effective in reducing cheating, but the realistic photo was more effective than the drawing. These findings demonstrate that manipulating accessibility can be an effective strategy to nudge children away from cheating in an academic context. They further suggest that different types of everyday objects and their symbolic representations can differentially impact children's moral behavior.

The presence of semantic content in a visual recognition memory task reduces the severity of neglect

Patients with right hemisphere damage often show a lateral bias when asked to report the left side of mental images held in visual working memory (i.e. representational neglect). The neural basis of representational neglect is not well understood. One hypothesis suggests that it reflects a deficit in attentional-exploratory mechanisms, i.e. an inability to direct attention to the left side of the image. Another proposition states that intact visual working memory (VWM) is necessary for correctly creating a mental image. Here we examined two components of VWM in patients with unilateral spatial neglect (USN): memory for identity, and memory for spatial position. We manipulated the strength of memory representations by presenting two distinct categories of objects, in separate blocks. These were familiar namable objects (fruits, etc.), and unfamiliar abstract objects. The former category elicits stronger working-memory traces, thanks to preexisting visual and semantic representations in long-term memory. We hypothesized that if USN patients show a lateralized deficit in VWM, it should be more pronounced for abstract objects, due to their weaker working-memory traces. Importantly, to isolate a spatially lateralized deficit in memory from a failure to fully perceive the object-arrays, we ensured that all included patients perceived every item during the encoding phase. We used a working-memory task: participants viewed object arrays and had to memorize items' identities and spatial positions. Then, single objects were presented requiring ‘old/new’ recognition, and retrieval of ‘old’ items’ original positions. Our results show a lateral bias in patients’ recognition-memory performance. Remarkably, it was threefold milder for namable objects compared to abstract objects. We conclude that VWM lateralized deficit is substantial in USN patients and could play a role in representational neglect.

APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE-TR mice.

The impact of sex and menopausal status in Alzheimer's disease remains understudied despite increasing evidence of greater female risk, particularly in APOE4 carriers. Utilizing female APOE-TR mice maintained on a high-fat diet background we induced ovarian failure through repeated VCD injections, to mimic human menopause. At 12 months of age, recognition memory and spatial memory were assessed using object recognition, Y-maze spontaneous alternation, and Barnes maze. A VCD*genotype interaction reduced the recognition memory (P<.05), with APOE4 VCD-treated animals unable to distinguish between novel and familiar objects. APOE4 mice displayed an additional 37% and 12% reduction in Barnes (P<.01) and Y-maze (P<.01) performance, indicative of genotype-specific spatial memory impairment. Molecular analysis indicated both VCD and genotype-related deficits in synaptic plasticity with BDNF, Akt, mTOR, and ERK signaling compromised. Subsequent reductions in the transcription factors Creb1 and Atf4 were also evident. Furthermore, the VCD*genotype interaction specifically diminished Ephb2 expression, while Fos, and Cnr1 expression reduced as a consequence of APOE4 genotype. Brain DHA levels were 13% lower in VCD-treated animals independent of genotype. Consistent with this, we detected alterations in the expression of the DHA transporters Acsl6 and Fatp4. Our results indicate that the combination of ovarian failure and APOE4 leads to an exacerbation of cognitive and neurological deficits.

Face pareidolia is associated with right striatal dysfunction in drug-naïve patients with Parkinson's disease.

Some patients with Parkinson's disease (PD) present with pareidolia, an illusion of a meaningless stimulus as a familiar object known to the observer. Since the striatum is associated with processing of visual information, we investigated correlations of pareidolia with motor symptoms and striatal dopaminergic function. A noise pareidolia test, assessment of motor symptoms using MDS-UPDRS and 123I-Ioflupane SPECT were performed in 58 drug-naïve PD patients. A number of images in which a participant noticed an illusory face (number of illusory responses) were compared with motor assessment scores and uptake of 123I-ioflupane in the striatum. Of the 58 participants, 22 had at least one illusory response. Mean scores for MDS-UPDRS part III (p<0.05), rigidity (p<0.05), and rigidity on the left side of the body (p<0.01) in patients with pareidolia were significantly higher than those in patients without pareidolia. Uptake of 123I-ioflupane in the right caudate nucleus (p<0.05), anterior putamen (p<0.01), and posterior putamen (p<0.01) in patients with pareidolia was significantly lower than in patients without pareidolia. In the 22 patients with pareidolia, the number of illusory responses was significantly correlated with total scores for MDS-UPDRS part III (r=0.443, p<0.05) and subscores for bradykinesia (r=0.440, p<0.05) and bradykinesia on the left side of the body (r=0.564, p<0.01). The prevalence of pareidolia in left-dominant parkinsonism (16/30 patients) was higher than that in right-dominant parkinsonism (6/28 patients) (p<0.05 by chi-square test). Pareidolia in PD patients is associated with dysfunction in the right striatum.

A New Paradigm for Training Hyperactive Dopamine Transporter Knockout Rats: Influence of Novel Stimuli on Object Recognition.

Attention deficit hyperactivity disorder (ADHD) is believed to be connected with a high level of hyperactivity caused by alterations of the control of dopaminergic transmission in the brain. The strain of hyperdopaminergic dopamine transporter knockout (DAT-KO) rats represents an optimal model for investigating ADHD-related pathological mechanisms. The goal of this work was to study the influence of the overactivated dopamine system in the brain on a motor cognitive task fulfillment. The DAT-KO rats were trained to learn an object recognition task and store it in long-term memory. We found that DAT-KO rats can learn to move an object and retrieve food from the rewarded familiar objects and not to move the non-rewarded novel objects. However, we observed that the time of task performance and the distances traveled were significantly increased in DAT-KO rats in comparison with wild-type controls. Both groups of rats explored the novel objects longer than the familiar cubes. However, unlike controls, DAT-KO rats explored novel objects significantly longer and with fewer errors, since they preferred not to move the non-rewarded novel objects. After a 3 months’ interval that followed the training period, they were able to retain the learned skills in memory and to efficiently retrieve them. The data obtained indicate that DAT-KO rats have a deficiency in learning the cognitive task, but their hyperactivity does not prevent the ability to learn a non-spatial cognitive task under the presentation of novel stimuli. The longer exploration of novel objects during training may ensure persistent learning of the task paradigm. These findings may serve as a base for developing new ADHD learning paradigms.

Task set and instructions influence the weight of figural priors: A psychophysical study with extremal edges and familiar configuration

In figure–ground organization, the figure is defined as a region that is both “shaped” and “nearer.” Here we test whether changes in task set and instructions can alter the outcome of the cross-border competition between figural priors that underlies figure assignment. Extremal edge (EE), a relative distance prior, has been established as a strong figural prior when the task is to report “which side is nearer?” In three experiments using bipartite stimuli, EEs competed and cooperated with familiar configuration, a shape prior for figure assignment in a “which side is shaped?” task.” Experiment 1 showed small but significant effects of familiar configuration for displays sketching upright familiar objects, although “shaped-side” responses were predominantly determined by EEs. In Experiment 2, instructions regarding the possibility of perceiving familiar shapes were added. Now, although EE remained the dominant prior, the figure was perceived on the familiar-configuration side of the border on a significantly larger percentage of trials across all display types. In Experiment 3, both task set (nearer/shaped) and the presence versus absence of instructions emphasizing that familiar objects might be present were manipulated within subjects. With familiarity thus “primed,” effects of task set emerged when EE and familiar configuration favored opposite sides as figure. Thus, changing instructions can modulate the weighing of figural priors for shape versus distance in figure assignment in a manner that interacts with task set. Moreover, we show that the influence of familiar parts emerges in participants without medial temporal lobe/ perirhinal cortex brain damage when instructions emphasize that familiar objects might be present.

Effects of Acute and Chronic Exposure to a Mixed Field of Neutrons and Photons and Single or Fractionated Simulated Galactic Cosmic Ray Exposure on Behavioral and Cognitive Performance in Mice.

During space missions, astronauts experience acute and chronic low-dose-rate radiation exposures. Given the clear gap of knowledge regarding such exposures, we assessed the effects acute and chronic exposure to a mixed field of neutrons and photons and single or fractionated simulated galactic cosmic ray exposure (GCRsim) on behavioral and cognitive performance in mice. In addition, we assessed the effects of an aspirin-containing diet in the presence and absence of chronic exposure to a mixed field of neutrons and photons. In C3H male mice, there were effects of acute radiation exposure on activity levels in the open field containing objects. In addition, there were radiation-aspirin interactions for effects of chronic radiation exposure on activity levels and measures of anxiety in the open field, and on activity levels in the open field containing objects. There were also detrimental effects of aspirin and chronic radiation exposure on the ability of mice to distinguish the familiar and novel object. Finally, there were effects of acute GCRsim on activity levels in the open field containing objects. Activity levels were lower in GCRsim than sham-irradiated mice. Thus, acute and chronic irradiation to a mixture of neutrons and photons and acute and fractionated GCRsim have differential effects on behavioral and cognitive performance of C3H mice. Within the limitations of our study design, aspirin does not appear to be a suitable countermeasure for effects of chronic exposure to space radiation on cognitive performance.

The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory.

Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty.

Stability and individual variability of social attachment in imprinting

Filial imprinting has become a model for understanding memory, learning and social behaviour in neonate animals. This mechanism allows the youngs of precocial bird species to learn the characteristics of conspicuous visual stimuli and display affiliative response to them. Although longer exposures to an object produce stronger preferences for it afterwards, this relation is not linear. Sometimes, chicks even prefer to approach novel rather than familiar objects. To date, little is known about how filial preferences develop across time. This study aimed to investigate filial preferences for familiar and novel imprinting objects over time. After hatching, chicks were individually placed in an arena where stimuli were displayed on two opposite screens. Using an automated setup, the duration of exposure and the type of stimuli were manipulated while the time spent at the imprinting stimulus was monitored across 6 days. We showed that prolonged exposure (3 days vs 1 day) to a stimulus produced robust filial imprinting preferences. Interestingly, with a shorter exposure (1 day), animals re-evaluated their filial preferences in functions of their spontaneous preferences and past experiences. Our study suggests that predispositions influence learning when the imprinting memories are not fully consolidated, driving animal preferences toward more predisposed stimuli.

Visualization of Lighting Quality and Object Appearance When Using Multichannel Light Sources

ABSTRACT The availability of quasi-monochromatic Light Emitting Diodes (LEDs) with peak wavelengths distributed over the visible spectrum has opened the way to the development of multichannel LED light sources generating tunable illumination spectra. As the color appearance of an object is strongly influenced by the spectral power distribution of the light source, these multichannel light sources are also commonly used as a research tool in color quality studies. In a number of studies, spectrum optimization algorithms are applied in order to generate a target spectrum directly. Other papers report on the calculation of an illumination spectrum with the aim to optimize one or a set of general quality metrics such as the luminous efficacy of radiation and the color rendering index Ra or Rf. The approach followed in this paper is to explore and visualize, for a given multichannel LED light source, the lighting quality parameters which can be reached within the chromaticity gamut for a selected object. For any predefined target white point chromaticity, the illumination metamers are calculated analytically within the constraints defined by the multichannel LED light source under consideration. The solution space is sampled with a brute force method and the values of any general or specific color quality index can be evaluated. For a predefined object spectral reflectance (or one typical spectral reflectance representative for a set of objects), the object chromaticity gamut is derived. Several object chromaticity targets within the gamut, such as the memory color of familiar objects, can be selected and the impact of “local” variations of the hue and chroma within this gamut on the general and special lighting quality indices and on the user preference can be checked. This can simplify the selection of an object-based optimum illumination spectrum. The approach is illustrated in practice using a five-channel LED light source which was developed in-house.

Caring for Things Helps Humans Grow: Effects of Courteous Interaction with Things on Pro-Environmental Behavior

The purpose of this study was to clarify the influence of courteous interaction with familiar objects on pro-environmental behavior and well-being. We explored the process of interaction with everyday objects, such as pens and glasses in a preliminary study (N = 64), and to reveal two aspects that define these interactions, namely active care for objects and awareness of learning from the interaction (N = 687; Study 1). The more people cared for and learned through their interactions with a particular object, the more they perceived a connectedness to it (N = 195; Study 2). Furthermore, caring for and learning with familiar objects promoted various environmentally conscious behaviors and contributed to individual well-being (Study 3; N = 600). In this way, we discussed the relationship between interaction with everyday objects, the aspects of these interactions, and the influence of these interactions on an individual’s perspective toward the wider environment.

GOT-10k: A Large High-Diversity Benchmark for Generic Object Tracking in the Wild.

We introduce here a large tracking database that offers an unprecedentedly wide coverage of common moving objects in the wild, called GOT-10k. Specifically, GOT-10k is built upon the backbone of WordNet structure [1] and it populates the majority of over 560 classes of moving objects and 87 motion patterns, magnitudes wider than the most recent similar-scale counterparts [19], [20], [23], [26]. By releasing the large high-diversity database, we aim to provide a unified training and evaluation platform for the development of class-agnostic, generic purposed short-term trackers. The features of GOT-10k and the contributions of this article are summarized in the following. (1) GOT-10k offers over 10,000 video segments with more than 1.5 million manually labeled bounding boxes, enabling unified training and stable evaluation of deep trackers. (2) GOT-10k is by far the first video trajectory dataset that uses the semantic hierarchy of WordNet to guide class population, which ensures a comprehensive and relatively unbiased coverage of diverse moving objects. (3) For the first time, GOT-10k introduces the one-shot protocol for tracker evaluation, where the training and test classes are zero-overlapped. The protocol avoids biased evaluation results towards familiar objects and it promotes generalization in tracker development. (4) GOT-10k offers additional labels such as motion classes and object visible ratios, facilitating the development of motion-aware and occlusion-aware trackers. (5) We conduct extensive tracking experiments with 39 typical tracking algorithms and their variants on GOT-10k and analyze their results in this paper. (6) Finally, we develop a comprehensive platform for the tracking community that offers full-featured evaluation toolkits, an online evaluation server, and a responsive leaderboard. The annotations of GOT-10k's test data are kept private to avoid tuning parameters on it.

"La representación de la experiencia del cautiverio a través de la confrontación / correlación simbólica entre espacio público y privado en 'Frazadas del Estadio Nacional' de Jorge Montealegre"

Making memory through writing, that is, recomposing one's own personal experience as a victim of state terrorism in many Latin American countries through its literary representation, entails, among many other consequences, considering places and objects, normally belonging to different semantic spheres, within the optic of violence and disappearance. In 2003, Jorge Montealegre published the novel-testimony Frazadas del Estadio Nacional, in which he reconstructs the months spent in captivity, from the first days of Pinochet's coup, in September 28th, 1973, in the National Stadium in Santiago, together with thousands of prisoners, until November of the same year, when the writer was transferred to another clandestine centre, Chacabuco, and then expelled from the country in July 1974. Right from the title, Montealegre's work attributes a connotative value to a public sporting space – the National Stadium – and to an everyday, familiar object – the blanket – in addition to their ordinary significance, turning them into symbols of the traumatic experience of the condition of detainees in clandestine concentration camps. The process of conversion of these two terms, reiterated within the pages of the novel, into signs of identification of the symbolic space of the testimonial discourse is the subject of my intervention.

The mouth matters most: A functional magnetic resonance imaging study of how dogs perceive inanimate objects.

The perception and representation of objects in the world are foundational to all animals. The relative importance of objects' physical properties versus how the objects are interacted with continues to be debated. Neural evidence in humans and nonhuman primates suggests animate-inanimate and face-body dimensions of objects are represented in the temporal cortex. However, because primates have opposable thumbs and interact with objects in similar ways, the question remains as to whether this similarity represents the evolution of a common cognitive process or whether it reflects a similarity of physical interaction. Here, we used functional magnetic resonance imaging (fMRI) in dogs to test whether the type of interaction affects object processing in an animal that interacts primarily with its mouth. In Study 1, we identified object-processing regions of cortex by having dogs passively view movies of faces and objects. In Study 2, dogs were trained to interact with two new objects with either the mouth or the paw. Then, we measured responsivity in the object regions to the presentation of these objects. Mouth-objects elicited significantly greater activity in object regions than paw-objects. Mouth-objects were also associated with activity in somatosensory cortex, suggesting dogs were anticipating mouthing interactions. These findings suggest that object perception in dogs is affected by how dogs expect to interact with familiar objects.

Equal performance but distinct behaviors: sex differences in a novel object recognition task and spatial maze in a highly social cichlid fish.

Sex differences in behavior and cognition can be driven by differential selection pressures from the environment and in the underlying neuromolecular mechanisms of decision-making. The highly social cichlid fish Astatotilapia burtoni exhibits dynamic and complex social hierarchies, yet explicit cognitive testing (outside of social contexts) and investigations of sex differences in cognition have yet to be fully explored. Here we assessed male and female A. burtoni in two cognitive tasks: a novel object recognition task and a spatial task. We hypothesized that males outperform females in a spatial learning task and exhibit more neophilic/exploratory behavior across both tasks. In the present study we find that both sexes prefer the familiar object in a novel object recognition task, but the time at which they exhibit this preference differs between the sexes. Females more frequently learned the spatial task, exhibiting longer decision latencies and quicker error correction, suggesting a potential speed-accuracy tradeoff. Furthermore, the sexes differ in space use in both tasks and in a principal component analysis of the spatial task. A model selection analysis finds that preference, approach, and interaction duration in the novel object recognition task reach a threshold of importance averaged across all models. This work highlights the need to explicitly test for sex differences in cognition to better understand how individuals navigate dynamic social environments.

Colonial Relations in Miniature: Affective Networks, Race, and the Portrait in Victor Séjour’s “Le Mulâtre”

AbstractThis essay attends to the presence of a small portrait carried by an enslaved character, Georges, in Victor Séjour’s 1837 sketch “Le Mulâtre” (“The Mulatto”). While most eighteenth- and nineteenth-century fiction deploys miniature portraits to mediate social ties and signal emotional connection, in “Le Mulâtre” the carrying of a miniature departs from this trope, marking alienation, not affiliation. Reading Séjour’s text against popular depictions and material histories of ivory portrait miniatures, I demonstrate that these familiar objects of eighteenth- and nineteenth-century life function not merely as emblems of intimacy, as past scholars have argued, but rather as tools of what Elizabeth Maddock Dillon calls “intimate distance”—a social configuration that depends on asserting closeness with geographically distributed white populations while disavowing intimacy with physically present Black and Indigenous peoples. Although the portrait is said to depict Georges’s father, who readers know is also the man’s white enslaver, the object remains hidden from view in a bag until the final moments of the sketch, which concludes with the father’s beheading and the son’s suicide. I argue that by emplotting the miniature in a moment of bloodshed rather than of sentiment, Séjour registers the affective and material violence that undergirds white colonial definitions of the family, and invites broader critical comparison of the ways that both sentimental and colonial structures depend on racialized distributions of affections. In the concluding portion of this essay, I turn to the “little buckskin pouch” containing Alfred’s miniature and consider how its resemblance to Afro-Atlantic folk charms recasts the racialized binaries traditionally advanced by miniature portraits. Viewed as part of a charm, the portrait underscores that whiteness is a ritualized notion dependent on material signifiers.

Semantic Grounding of Novel Spoken Words in the Primary Visual Cortex

Embodied theories of grounded semantics postulate that, when word meaning is first acquired, a link is established between symbol (word form) and corresponding semantic information present in modality-specific—including primary—sensorimotor cortices of the brain. Direct experimental evidence documenting the emergence of such a link (i.e., showing that presentation of a previously unknown, meaningless word sound induces, after learning, category-specific reactivation of relevant primary sensory or motor brain areas), however, is still missing. Here, we present new neuroimaging results that provide such evidence. We taught participants aspects of the referential meaning of previously unknown, senseless novel spoken words (such as “Shruba” or “Flipe”) by associating them with either a familiar action or a familiar object. After training, we used functional magnetic resonance imaging to analyze the participants’ brain responses to the new speech items. We found that hearing the newly learnt object-related word sounds selectively triggered activity in the primary visual cortex, as well as secondary and higher visual areas.These results for the first time directly document the formation of a link between the novel, previously meaningless spoken items and corresponding semantic information in primary sensory areas in a category-specific manner, providing experimental support for perceptual accounts of word-meaning acquisition in the brain.

High-definition transcranial direct current stimulation of the lateral occipital cortex influences figure-ground perception

Prior work has shown that the lateral occipital cortex (LO) is involved in recognition of objects and their parts, as well as segregation of that object (or “figure”) from its background. No studies, though, have examined how LO's functioning is influenced by non-invasive brain stimulation, particularly during a figure-ground perception task. The present study tested whether high-definition transcranial direct current stimulation (HD-tDCS) to right LO influences the effects of familiarity on figure-ground perception. Following 20 min of offline anodal stimulation (or sham), participants viewed masked stimuli consisting of two regions separated by a vertical border and were asked to report which region they perceived as figure. One region was the “critical” region, which either depicted a portion of a familiar object (“Familiar” stimuli), or a familiar object with its parts rearranged into a novel configuration (“Part-rearranged” stimuli). Previous research using these stimuli has found higher reports of the critical region as figure for Familiar vs. Part-rearranged displays, demonstrating the effect of familiarity on figure assignment. The results of the current study showed that HD-tDCS to right LO significantly influenced this typical behavioral pattern. Specifically, stimulation (vs. sham) increased reports of the critical region as figure for Part-rearranged stimuli, bringing perception of these displays up to the level of the Familiar stimuli. We interpret this finding as evidence that stimulation of right LO increased participants' reliance on the familiarity of the parts in their figure-ground judgements—a finding consistent with and extending previous research showing that LO is indeed sensitive to object parts. This is the first study showing that HD-tDCS to LO can influence the effects of familiarity on figure-ground perception.

Beta2 Oscillations in Hippocampal-Cortical Circuits During Novelty Detection.

Novelty detection is a core feature of behavioral adaptation and involves cascades of neuronal responses—from initial evaluation of the stimulus to the encoding of new representations—resulting in the behavioral ability to respond to unexpected inputs. In the past decade, a new important novelty detection feature, beta2 (~20–30 Hz) oscillations, has been described in the hippocampus (HC). However, the interactions between beta2 and the hippocampal network are unknown, as well as the role—or even the presence—of beta2 in other areas involved with novelty detection. In this work, we combined multisite local field potential (LFP) recordings with novelty-related behavioral tasks in mice to describe the oscillatory dynamics associated with novelty detection in the CA1 region of the HC, parietal cortex, and mid-prefrontal cortex. We found that transient beta2 power increases were observed only during interaction with novel contexts and objects, but not with familiar contexts and objects. Also, robust theta-gamma phase-amplitude coupling was observed during the exploration of novel environments. Surprisingly, bursts of beta2 power had strong coupling with the phase of delta-range oscillations. Finally, the parietal and mid-frontal cortices had strong coherence with the HC in both theta and beta2. These results highlight the importance of beta2 oscillations in a larger hippocampal-cortical circuit, suggesting that beta2 plays a role in the mechanism for detecting and modulating behavioral adaptation to novelty.