Familiar Objects Research Articles

Can hologram technology promote family connection and combat anxiety and depression in oil and gas employees?

Younger oil and gas workers suffer more from anxiety and depression than their older counterparts. Several factors contribute to emotional distress, but isolation and family disconnect are two predominant contributing conditions. Separation from social support results in missed milestones such as holidays, birthdays and anniversaries. A large sector of oil and gas employees is young, primarily male, with an average age of 36, with 22% being between 20 and 24 years of age. For some, employment in oil and gas marks the first time they are separated from family. Others are parents with children under the age of ten. These young employees are members of Gen-Z and technology natives who have a natural preference for innovative telecommunications. Members in this demographic are familiar and comfortable with virtual reality in gaming and communication. In the post-Covid era, most have grown accustomed to web communication. Presently, technology has evolved beyond two-dimensional interaction. Mixed reality involves using holograms to provide ‘telepresence’ through holo-teleportation and provides an in vivo experience for both the employee and his family members. This technology allows participants to have a virtual presence resulting in a live-lived experience with loved ones complete with familiar surroundings and objects. A realistic virtual presence is thought to mitigate the effects of separation.

Diversity and Moral Address

ABSTRACTThis article evaluates communicative approaches to responsibility within the Strawsonian tradition. These approaches consider reactive attitudes to be forms of moral address and consider responsiveness to moral address a condition on responsible agency. The article consists of a critical and a positive part. In the first part, I identify a risk for these theories. They often provide an overly narrow account of how we can communicate with others about perceived moral disregard. I argue that, when read this way, a conversational approach has implausible implications and falls prey to a familiar objection to Strawsonian theory: it would incorporate social injustices inherent to our responsibility practices. In particular, it would affirm ableist attitudes towards autistic individuals, by exempting them as moral agents on the basis of irrelevant criteria. In the second part, I propose an inclusive reading of the communicative approach. This inclusive account steers clear of ableism towards autistic individuals and accommodates diversity. Although it is also derived from our practices and psychologies, it does not incorporate the biases and injustices that are part of those practices, and instead it provides us with a means to criticize them.

Can People Infer Distance in a 2D Scene Using the Visual Size and Position of an Object?

Depth information is limited in a 2D scene and for people to perceive the distance of an object, they need to rely on pictorial cues such as perspective, size constancy and elevation in the scene. In this study, we tested whether people could use an object’s size and its position in a 2D image to determine its distance. In a series of online experiments, participants viewed a target representing their smartphone rendered within a 2D scene. They either positioned it in the scene at the distance they thought was correct based on its size or adjusted the target to the correct size based on its position in the scene. In all experiments, the adjusted target size and positions were not consistent with their initially presented positions and sizes and were made larger and moved further away on average. Familiar objects influenced adjusted position from size but not adjusted size from position. These results suggest that in a 2D scene, (1) people cannot use an object’s visual size and position relative to the horizon to infer distance reliably and (2) familiar objects in the scene affect perceived size and distance differently. The differences found demonstrate that size and distance perception processes may be independent.

Glutamate released by Cajal-Retzius cells impacts specific hippocampal circuits and behaviors.

SUMMARYThe impact of Cajal-Retzius cells on the regulation of hippocampal circuits and related behaviors is unresolved. Here, we directly address this issue by impairing the glutamatergic output of Cajal-Retzius cells with the conditional ablation of vGluT2, which is their main vesicular glutamate transporter. Although two distinct conditional knockout lines do not reveal major alterations in hippocampal-layer organization and dendritic length of principal neurons or GABAergic cells, we find parallel deficits in specific hippocampal-dependent behaviors and in their putative underlying microcircuits. First, conditional knockout animals show increased innate anxiety and decreased feedforward GABAergic inhibition on dentate gyrus granule cells. Second, we observe impaired spatial memory processing, which is associated with decreased spine density and reduced AMPA/NMDA ratio of postsynaptic responses at the perforant- and entorhino-hippocampal pathways. We conclude that glutamate synaptically released by Cajal-Retzius cells is critical for the regulation of hippocampal microcircuits and specific types of behaviors.

Acute And Chronic Learning Impairment Following Seizures In Larval Zebrafish

Early‐life seizures (ELS) can disrupt brain development, often leading to cognitive impairments in humans and rodents. Here, we investigated whether seizures in larval zebrafish (Danio rerio) lead to acute and long‐term learning deficits. Based on ELS studies in rodents, we hypothesized that seizures in larval zebrafish would impair their performance in declarative memory tasks. To test this, we induced seizures in larval zebrafish using pentylenetetrazole (PTZ), which causes behavioral and electrical seizures in zebrafish. We modified the existing PTZ seizure model, exposing zebrafish to PTZ daily from 5‐7 days post‐fertilization (dpf). We then compared later‐life learning through short‐term memory tasks that lacked external punishment or motivation and focused on conscious recognition and interest in novel stimuli. To test learning and memory acutely after seizures, we used the visual lateralization novel object recognition (VLNOR) test, based on the novel object recognition test frequently used in rodents. Zebrafish show asymmetries in the use of left (LES) and right eye systems (RES), and will initially use LES to observe novel objects and RES to view familiar objects. We found that, when tested for recall of a previously novel object one hour after initially viewing it, 12‐14 dpf unhandled controls (UC group) reached a statistically significant majority of RES approaches by the end of the 8‐minute recall test (p=0.048). The PTZ group did not, and trended towards a significant decrease from 50% in the first 2 minute bin of the recall test (p=0.054). Taken together, these data indicate that the PTZ fish were not able to recall a previously viewed object, and when the object was reintroduced 1 hour later, responded as if the object were novel. We next used a y‐maze task to assess memory 3 months after seizures. In this task, fish had to recall the novel arm of the maze 90 minutes after being removed from the maze. The PTZ group spent significantly less time in the novel arm of the y‐maze during the recall test compared to their UC clutchmates (mean % time in novel arm +/‐ SE = 44.0+/‐3.2 for UC, 29.7+/‐2.1 for PTZ; p=0.002 by t‐test). Furthermore, our preliminary molecular studies show distinct expression profiles of synaptic plasticity genes between PTZ and UC groups by qPCR. Taken together, these results imply that inducing seizures in larval zebrafish leads to both acute and chronic learning and memory impairments. These findings expand the behavioral characterization of the larval zebrafish seizure model, strengthening the power of this model for researching the cognitive consequences of ELS.

A single brief stressful event time-dependently affects object recognition memory and promotes familiarity preference in marmoset monkeys

A stressful experience can enhance information storage and impair memory retrieval in the rodent novel object recognition (NOR) task. However, recent conflicting results underscore the need for further investigation. Nonhuman primates may provide a unique, underexplored and more translational means to investigate stress-mediated changes in memory. Therefore, we assessed whether a single brief extrinsic stress event affects information encoding, storage and/or retrieval in adult marmoset monkeys submitted to the NOR task. This consisted of an initial 10 min familiarization period with two identical neutral objects. After a 6 h delay, a 10 min test trial was held where a new and familiar object could be explored. Stress was induced by a 15 min restraint event held before or after the encoding phase, or prior to retrieval. Pre-encoding stress had no effect on task performance, as this group displayed above-chance novelty preference similar to non-stressed controls. Post-encoding stress induced memory deficits, with both objects being explored equally. Interestingly, pre-retrieval stress induced an above-chance familiarity preference. A single brief stressful event thus affects recognition memory in a time-dependent manner. Also, negative discrimination ratios can be used as a measure of memory in the NOR task and a change in strategy may not mean memory failure in spontaneous learning paradigms.

Influence of 2'-Fucosyllactose and Bifidobacterium longum Subspecies infantis Supplementation on Cognitive and Structural Brain Development in Young Pigs.

Development of the gut-brain axis during early-life is an important contributor of brain structural and functional development. Human milk oligosaccharides and gut microbiota have potential beneficial effects on various aspects of development; however, the effects of 2′-fucosyllactose (2′-FL) and Bifidobacterium longum subsp. infantis Bi-26 (Bi-26) administration during infancy separately and combined are still not clear. Therefore, we investigated the effects of early administration of dietary 2′-FL and Bi-26 on brain structural and functional development in the young pig. From postnatal day (PND) 2–34 or 35, fifty-two intact male pigs were randomly assigned to treatment groups in a 2 × 2 factorial arrangement and provided ad libitum access to a nutritionally adequate milk replacer without or with 1.0 g of 2′-FL/L of reconstituted liquid. Pigs within each diet group were further stratified to receive a daily oral dose of glycerol stock without or with Bi-26 (109 CFU). Pigs were subjected to the novel object recognition (NOR) task from PND 27–31 to assess recognition memory and subsequently underwent magnetic resonance imaging procedures at PND 32 or 33 to assess brain macrostructure and microstructure. Pigs that received Bi-26 had smaller absolute brain volumes for 9 of 27 brain regions of interest, and smaller relative volumes for 2 regions associated with kinesthesia (P < 0.05). Synbiotic administration of 2′-FL and Bi-26 elicited interactive effects (P < 0.05) on several microstructural brain components, where dual supplementation negated the effects of each test article alone. Behavioral outcomes indicated that pigs did not express novelty preference, regardless of treatment group, demonstrating no effects of 2′-FL and Bi-26 on recognition memory when supplemented alone or in combination. Interactive effects (P < 0.05) were observed for the number of all object visits, latency to the first object visit, and number of familiar object visits. Pigs that did not receive Bi-26 supplementation exhibited less time interacting with the familiar object in total (P = 0.002) and on average (P = 0.005). In conclusion, supplementation of 2′-FL and/or Bi-26 elicited some alterations in object exploratory behaviors and macro/micro-structures of the brain, but changes in recognition memory were not observed. Specifically in brain microstructure, synbiotic administration of 2′-FL and Bi-26 appeared to negate effects observed when each dietary article was supplemented separately.

Ameliorative effect of ethanol extract of Eragrostis tremula Hochst. ex Steud. against diazepam-induced amnesia in mice

BackgroundEragrostis tremula Hochst. ex Steud. (Poaceae) is used in ethno-medicine as a memory enhancer. Studies have shown that the whole plant possesses memory enhancing potentials and could be beneficial in the management of amnesia and cognitive deficit.AimThis study was aimed at investigating the actions of E. tremula extract on diazepam-induced amnesia in mice. Acute toxicity profiling was done as stated by the Organization for Economic Co-operation and Development (OECD 425). Oral doses of 125, 250 and 500 mg/kg of E. tremula extract were used for the diazepam-induced amnesia studies. Cognitive function was evaluated using elevated plus maze (EPM) and novel object recognition tests (NORT). The brain tissues were evaluated for the concentrations of malondialdehyde (MDA), reduced glutathione (GSH) and superoxide dismutase (SOD) using enzyme-linked immunosorbent assay kits.ResultsThe oral median toxic dose of E. tremula extract was assessed to be > 5000 mg/kg in mice. The extract substantially (p < 0.05) reduced the transfer latency of mice during the retention phase of EPM test. In the NORT, E. tremula extract at all the doses appreciably (p < 0.05) reduced the exploration time on the familiar object. Also, it substantially (p < 0.05) improved the recognition index. E. tremula extract substantially (p < 0.05) reduced the MDA levels, and at doses of 250 and 500 mg/kg, it prevented the cortical and hippocampal tissues from lesions produced by diazepam.ConclusionsEragrostis tremula extract is practically safe after acute administration and possesses anti-amnesic actions.

Does colour impact responses to images in geckos?

AbstractAnimals are exposed to different visual stimuli that influence how they perceive and interact with their environment. Visual information such as shape and colour can help animals detect, discriminate, and make appropriate behavioural decisions for mate selection, communication, camouflage, and foraging. Previous research indicates that at least some species within all major vertebrate groups prefer and can discriminate among certain colours and that colour may increase the response to a stimulus. However, since colour is often studied together with other potentially confounding factors such as movement and scent, it is still unclear what role colour plays in the perception of and attention to different stimuli. In this study, we test whether colour influences the response that an animal has to an object, and whether this influence changes depending on the type of object shown to the animal. We assessed the response of three gecko species,Correlophus ciliatus,Eublepharis macularius,andPhelsuma laticauda, to familiar and novel objects presented as colour or grayscale images. Our results indicate that colour does not change the response to objects. Specifically, we found that while all species responded more often to novel than to the familiar images, colour did not influence the response. We also found that the duration of interaction with images was significantly longer for the diurnal species,P. laticauda, than for the two nocturnal species, but this was also independent of colouration. Finally, no differences among sexes were observed within or between species. Our results show that geckos discriminate between 2D images of different content independent of colouration, suggesting that colour may not increase detectability or intensity of the response. These results are essential for uncovering which visual stimuli produce responses in animals.

Differences in learning and memory between middle-aged female and male rats.

We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both successfully form LTM of inhibitory avoidance, though males appeared to be amnesic for memory persistence. Habituation, locomotion, horizontal exploration, "stereotypies," fear, and anxiety-like behavior were similar for both, while vertical exploration was significantly higher in middle-aged and younger females. Therefore, sex-dependent differences in some cognitive functions and behaviors must be considered when designing and interpreting learning and memory studies.

Brain activities of streptozotocin-induced diabetic Wistar rats treated with gliclazide: Behavioural, biochemical and histomorphology studies.

Gliclazide (GLD), a sulphonylurea is efficacious in the treatment of diabetes type-2. However, there is limited information on its activity in the brain, especially in diabetics. This research investigated the brain activities of GLD following streptozotocin-induced diabetes in Wistar rats. Twenty five adult male Wistar rats (200–250 g) were grouped (n = 5) as: Control (distilled water, 5 mL/kg) and GLD (150 mg/kg) groups; and the diabetic groups, untreated streptozotocin (STZ, 35 mg/kg), and STZ (35 mg/kg) treated with GLD (150 mg/kg) for two and four weeks, and already on high fat diet. The animals’ body weights and blood glucose levels were checked weekly. After the experimental duration, spontaneous alternation and novel object recognition tests were carried out and the animals sacrificed. Perfusion with phosphate buffered saline preceded brain excision for biochemical analyses, with halves fixed in 10% neutral buffered formalin for histology. Compared with the control, results showed (p < 0.05) declined spontaneous alternation and exploratory activities with no preference for familiar or novel objects, body weights loss, raised blood glucose, increased malondialdehyde with decreased superoxide dismutase concentrations, and no apparent adverse effect on hippocampal and prefrontal cortical Nissl substance in the untreated diabetic group. The adverse observations were attenuated in the GLD treated diabetic groups; although the spontaneous alternation in the four weeks GLD treated diabetic group improved (p < 0.05), exploration of objects increased (p < 0.05) without preference. The present results showed that treatment with GLD for two and four weeks mitigated STZ activities, even though there was less improvement in neurocognitive activities.

“Conjoint Communicated Experience”: Art as an Instrument of Democracy

“Conjoint Communicated Experience”: Art as an Instrument of Democracy

Ellis Island: A People's History

Ellis Island: A People's History

Acquisition of novel word meaning via cross situational word learning: An event-related potential study

Cross-situational statistical word learning (CSWL) refers to the process whereby participants learn new words by tracking ambiguous word-object co-occurrences across time. This study used event-related potentials to explore the acquisition of novel word meanings via CSWL in healthy adults. After learning to associate novel auditory words (e.g., ‘ket’) with familiar objects (e.g., sword), participants performed a semantic judgement task where the learned novel words were paired with a familiar word belonging to either the same (e.g., dagger) or a different (e.g., harp) semantic category. As a comparison, the task also included word pairs comprising two familiar words. The analyses revealed that the unrelated novel word pairs elicited a similar N400 to that of the unrelated familiar word pairs, but with a different hemispheric distribution (left hemisphere for novel words, right hemisphere for familiar words). These findings demonstrate rapid meaning acquisition via CSWL, which is reflected at a neurophysiological level.

Investigation of the optimal dose for experimental lipopolysaccharide-induced recognition memory impairment: behavioral and histological studies.

Lipopolysaccharide (LPS) administration is one of the most commonly used methods for inducing inflammation in animal models. Several animal studies have investigated the effects of acute and chronic peripheral administration of LPS on cognitive impairment. However, no previous study has compared the effects of different doses of chronically administered LPS on recognition memory performance. Here, we aimed to investigate the optimal dose of chronically administered LPS for the induction of recognition memory impairment in mice. LPS at different doses (0.25, 0.50 and 0.75 mg/kg) was administered to SWR/J mice daily for 7 days. On day 9, the open field, novel object recognition and novel arm discrimination behavioral tests were performed. Additionally, prefrontal cortical histological examination was conducted. Compared with the control group, mice injected with 0.75 mg/kg LPS notably showed no object preference (familiar vs. novel), a reduction in the discrimination index, and spatial recognition impairment. Administration of the 0.25 and 0.50 mg/kg doses of LPS showed a preference for the novel object compared with the familiar object, had no significant impact on the discrimination index, and caused spatial recognition impairment. These behavioral results are in line with the histological examination of the prefrontal cortex, which revealed that the 0.75 mg/kg dose produced the most histological damage. Our findings suggest that for chronic peripheral administration of LPS, 0.75 mg/kg is the optimal dose for inducing neuroinflammation-associated recognition memory deficits.

Characteristics of the Reminder that Triggers Object Recognition Memory Reconsolidation in Mice

Memories are initially labile and become stable through consolidation. Once consolidated, a memory can be destabilized by a reminder, requiring reconsolidation to become stable again. Memory reconsolidation has been evidenced in several learning tasks, including novel object recognition (NOR). But the features of the reminder that trigger memory destabilization and reconsolidation in this task are poorly characterized. Memory reconsolidation can be evidenced by delivering either an amnesic agent or a memory enhancer after reactivation and testing the resulting long-term memory alteration. Here we trained male mice for 15 min to induce a strong memory formation. Sulfasalazine, a specific inhibitor of the NF-κB pathway, was administered as an amnesic agent in the dorsal hippocampus. NF-κB is a key transcription factor required for consolidation and reconsolidation. We found that reconsolidation was induced when animals were re-exposed for 5 min to a combination of novel and familiar objects, but not to either two familiar or two novel objects. No destabilization was induced by re-exposure to the context without objects. Re-exposure to a combination of novel and familiar objects induced destabilization with a reactivation session as brief as 1 min. One minute of training induced a weak memory that could be enhanced by sodium butyrate, an inhibitor of histone deacetylases (HDACs), after 1 min of re-exposure. Histone acetylation is an epigenetic mechanism involved in gene expression regulation which positively correlates with memory. Thus, in this study we have performed an accurate characterization of the features of the reminder effective in triggering hippocampal NF-κB-dependent reconsolidation.

Modality Effects Examined by Means of an Online Sentence-Picture Comparison Task.

Are oral sentences accompanied by pictures easier to understand than written sentences accompanied by the same pictures? This question-intensely discussed for more than two decades in educational, psychological, and psycholinguistic research in terms of modality effect in multimedia learning, split-attention effect, or visuospatial load effect-was examined by means of an online sentence-picture comparison task, with participants reading or listening to short sentences accompanied by pictures. Sentences and pictures referred to a conceptually and linguistically basic universe that was constructed from a limited number of familiar objects and characteristics. Mixed repeated-measures ANOVAs were calculated separately for simultaneously and sequentially presented sentence-picture versions, with modality (oral, written), picture complexity (complex, simple), and sentence-picture compatibility (compatible, incompatible) as within-subject factors, and age (6th-graders, adults) as between-subjects factor. The experiment was based on reaction time and acuity measures. The online sentence-picture comparison task requires participants to take note of both components (verbal and pictorial information). The presence of two age groups made it possible to examine modality effects from a developmental point of view by suggesting that learners' written comprehension and monitoring skills at some point equal and then surpass their oral comprehension and monitoring skills. The experiment showed the necessity to interpret modality main effects in the context of their two-way and three-way interactions with other variables since modality effects taken alone do not tell the whole story. The concepts of split attention, temporal contiguity, and element interactivity were discussed in this context.

Association of depression and COVID-induced PTSD with cognitive symptoms after COVID-19 illness

ObjectiveMany patients recovering from COVID-19 report persistent psychological and cognitive symptoms months after viral clearance. We examined the association of depression and COVID-induced PTSD with cognitive symptoms following COVID-19 illness. MethodsPatients treated for COVID-19 between March 26 and May 27, 2020 were surveyed three months later. Cognitive symptoms were assessed by asking “Since your COVID-19 illness, do you now have more difficulty: 1) Remembering conversations a few days later? 2) Remembering where you placed familiar objects? 3) Finding the right words while speaking?” Patients endorsing at least one such complaint were coded positive for cognitive symptoms. Logistic regression was used to estimate the association of depression (PHQ-8 ≥ 10) and COVID-induced PTSD (PCL-5 ≥ 30) with cognitive symptoms, adjusting for demographic and clinical factors. ResultsAmong 153 participants, 44.4% reported at least one cognitive symptom, 18.3% were depressed, and 23.5% had COVID-induced PTSD. Adjusting for covariates, depression (OR 5.15, 95% CI 1.30–20.35, p = 0.02) and COVID-induced PTSD (OR 3.67, 95% CI 1.13–11.89, p = 0.03) were significantly associated with cognitive symptoms; self-reported history of mental illness was also associated (OR 4.90, 95% CI 1.24–19.41, p = 0.02). ConclusionsDepression, COVID-induced PTSD, and prior mental illness were strongly associated with cognitive symptoms three months after acute COVID-19 illness.

Novel and familiar object recognition rely on the same ability.

There is recent evidence for a domain-general object recognition ability, called O, which is distinct from general intelligence and other cognitive and personality constructs. We extend the study of O by characterizing how it generalizes to the ability to recognize familiar objects and to the ability to make judgments of the average identity of ensembles of objects. We applied latent variable modeling to data collected from a sample of adults (N = 284) in three different tasks and for six different object domains (three novel and three familiar). The results replicated prior work in finding that on average 88% of the variance of lower-order factors could be accounted by O for novel objects. The latent constructs recruited by the higher-order factor for novel objects and for familiar objects were almost perfectly correlated and therefore functionally identical. A latent factor for ensemble perception shared about 42% of the variance with O, suggesting at least strong overlap between abilities supporting judgments about individual objects and ensemble of objects. This work extends the theoretical reach of O by showing generalization across two dimensions (familiar vs. novel objects; individual vs. ensemble object perception). With respect to the structure of individual differences in high-level vision, researchers would benefit from accounting for the contribution of O when seeking to understand various domain-specific abilities. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The effect of task on object processing revealed by EEG decoding.

Recent studies showed that task demand affects object representations in higher-level visual areas and beyond but not so much in earlier areas. There are, however, limitations in those studies including the relatively weak manipulation of task due to the use of familiar real-life objects, the low temporal resolution in functional magnetic resonance imaging (fMRI) and the emphasis on the amount and not the source of information carried by brain activations. In the current study, observers categorised images of artificial objects in one of two orthogonal dimensions, shape and texture, while their brain activity was recorded with electroencephalogram (EEG). Results showed that object processing along the texture dimension was affected by task demand starting from a relatively late time (320- to 370-ms time window) after image onset. The findings are consistent with the view that task exerts an effect on the later phases of object processing.