Event Abstract Back to Event Oxytocin systems as a therapeutic target for methamphetamine addiction Jennifer L. Cornish1*, Nicholas A. Everett1 and Sarah J. Baracz1, 2 1 Macquarie University, Department of Psychology, Faculty of Human Sciences, Australia 2 University of Sydney, School of Psychology, Faculty of Science, Australia Drug abuse and addiction are significant problems worldwide. The abuse of “ice” (methamphetamine, “METH”) continues to destroy families, careers and lives of users, with current treatments (pharmacological or psychological) inadequate for curing addiction and the associated mental health disorders that develop with repeated METH abuse (psychoses, depression, anxiety). Our aim, using rodent models, is to discover the neurobiological underpinnings of METH abuse and addiction to develop effective pharmacotherapies. One of the most promising pharmacological leads for reducing METH abuse and addiction comes from our work using the neuropeptide oxytocin. Using the model of intravenous METH self-administration in rats we have demonstrated that the systemic administration of oxytocin significantly reduced the relapse potential of re-exposure to METH (1mg/kg, i.p.). We have also shown that the direct administration of oxytocin into reward-related brain areas, such as the nucleus accumbens core (NAc) or subthalamic nucleus (STh), significantly reduced METH-seeking behaviour. Surprisingly, the effect of oxytocin to reduce METH-seeking behaviour did not occur through oxytocin receptor activation, as selective antagonists for this receptor failed to reverse the effect, either systemically or directly in the NA or STh. This suggests that oxytocin is working via alternate mechanisms to reduce METH-seeking behaviour. This symposium presentation will explore possible alternate neurobiological mechanisms and how they may be engaged by oxytocin to reduce METH abuse and addiction. Keywords: Methamphetamine, Oxytocin, Subthalamic Nucleus, drug addiction, nucleus accumbens core Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Symposium 9: Neurochemical Mechanisms Underlying Vulnerability to Drug Addiction Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Cornish JL, Everett NA and Baracz SJ (2016). Oxytocin systems as a therapeutic target for methamphetamine addiction. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00037 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Jul 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Jennifer L Cornish, Macquarie University, Department of Psychology, Faculty of Human Sciences, Sydney, New South Wales, Australia, jennifer.cornish@mq.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jennifer L Cornish Nicholas A Everett Sarah J Baracz Google Jennifer L Cornish Nicholas A Everett Sarah J Baracz Google Scholar Jennifer L Cornish Nicholas A Everett Sarah J Baracz PubMed Jennifer L Cornish Nicholas A Everett Sarah J Baracz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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