A 52-year-old male patient with high blood pressure and hypothyroidism, ex-smoker, who reports previous diagnosis of lichen planus and underwent treatment during 10 years, was referred to the stomatology service to evaluate a palatal lesion with a 4-month evolution. No significant alterations were observed during extraoral examination. In oroscopy, a single and ulcerated lesion on the hard palate in the right side was found near the molars region, approximately 2 cm, with firm consistency and irregular border extending to the gingiva in the form of a white, rough plaque and poorly defined limits. After radiography evaluation, the diagnostic hypothesis was squamous cell carcinoma. An incisional biopsy and anatomopathologic analysis of the surgical specimen were performed, confirming the diagnosis. Two months after surgical excision of the carcinoma, white plaques and gingival erosion were observed. A new biopsy and anatomopathologic analysis were performed with hyperkeratosis results. The patient remains in follow-up and is being treated with corticoid for pain control.