Pomegranate crop is affected by several insect pests and requires usage of a large number of pesticides, but the information on their behavior in pomegranate tissues is limited. A study was conducted to assess the behavior of acetamiprid, azoxystrobin, pyraclostrobin, and lambda-cyhalothrin in pomegranate fruits and leaves. The QuEChERS analytical method and LC-MS/MS and GC-MS were used for quantification of the analytes. The LOD (limit of detection) of acetamiprid, azoxystrobin, and pyraclostrobin was 0.0015 mg kg-1 and lambda-cyhalothrin was 0.003 mg kg-1. The respective LOQ (limit of quantification) was 0.005 and 0.01 mg kg-1. The dissipation of the analytes best fitted into first-order rate kinetics and the half-lives of the chemicals in pomegranate fruits were 9.2-13 days and in the leaves were 13.5-17 days. In the pomegranate aril, the residue levels of acetamiprid, lambda-cyhalothrin, and pyraclostrobin were always < LOQ of these chemicals. Azoxystrobin was detected in pomegranate aril, and its residue was highest at 0.04 mg kg-1 on the 10th day and reached < LOQ by the 25th day. The pre-harvest interval (PHI) required for acetamiprid, azoxystrobin, pyraclostrobin, and lambda-cyhalothrin at standard-dose treatment was 50, 58, 44, and 40 days, respectively. From double-dose treatment, the PHIs were 70, 75, 58, and 54 days, respectively. The pesticides used in this study were more persistent in the pomegranate leaves compared to the fruits. The outcome of this study can be incorporated into production of pomegranate fruits safe for consumption and to meet the domestic and export quality control requirements.