Excessive Accumulation Of Body Fat Research Articles

Prediction model of weight control experience in men with obesity in their 30 s and 40 s using decision tree analysis

Obesity is an abnormal and potentially dangerous condition caused by excess body fat accumulation. The number of people with obesity is increasing worldwide. Obesity is the primary cause of various diseases; therefore, it is crucial to make efforts to control body weight. Identifying the factors that influence men with obesity to attempt to control and not control their weight is essential. The objective of this study was to create a prediction model for weight control experience among Korean men in their 30 s and 40 s. We analyzed data from the 2022 Community Health Survey and included 12,311 men who were overweight or obese. The men were divided into two groups based on their weight control experience: (1) Yes group (n = 9405) and (2) No group (n = 2906). Chi-square and independent t-tests were used to compare general and health-related characteristics between the groups. Decision tree analysis was used to build a prediction model for weight control experience. A split-sample test was conducted to validate the model. From the results of this study, various models predicting weight control experience were derived. From the decision tree model without setting the first node, those who weighed below average, had a high school diploma or less, and did not know their blood sugar levels had the highest probability of not controlling their weight at 55.3%. In the prediction model where the first node was set to age, those in their 40 s who thought their weight was below average and were unaware of their blood sugar levels had the highest rate of not trying to control their weight at 50.1%. In the prediction model where the first node was set to BMI, those who were overweight but thought their weight was below average and had a high school diploma or less had the highest rate of not trying to control their weight at 51.5%. There is an urgent need to provide obesity prevention and management education to those who have no weight control experience, particularly those at high risk, as identified in this study.

Molecular Docking and Pharmacokinetics Prediction of Piperine and Capsaicin as Human Pancreatic Lipase Inhibitors: An In Silico Study.

Introduction Obesity is a complexmultifaceted disease, characterized by excessive body fat accumulation. It is a major public health concern globally, affecting individuals of all ages, genders, and socioeconomic backgrounds. Lipase, a key enzyme involved in lipid metabolism, plays a crucial role in the hydrolysis of dietary fats. Pancreatic lipase performs hydrolysis of nearly 50%-70% of total dietary fats. Thus, inhibition of pancreatic lipase isrecognized as one of the strategies for managing obesity. Aim To predict the effect of phytocompounds from pepper as pancreatic lipase inhibitors using computational approaches. Methodology The drug-likeness and pharmacokinetic properties of compounds were evaluated using Lipinski rule of fiveand absorption, distribution, metabolism, and excretion (ADME) analysis, respectively. The drug score value was computed using Molinspiration, while the lipase inhibitor potential of ligands was evaluated using prediction of activity spectra for substances. Molecular docking was carried out to evaluate the stability and ligand binding affinity. Results Computational approaches identified bothpiperine and capsaicin as potential candidates, exhibiting favorable affinities with binding energy values of -9.9 and -7.7 kcal/mol, respectively. Both piperine and capsaicin interacted with Ser-152 and His-263, demonstrating their binding at the substrate binding site. Conclusions Findings provide insights into the underlying anti-obesity potential of these bioactive compounds from pepper and support further experimental investigations for obesity treatment.

Current Updates on the Understanding of the Role of DNA Methylation on Obesity.

Obesity is a condition in which there is an accumulation of excess body fat leading to a weight far above the normal range that poses significant health risks. According to WHO, 8 billion people in the world were obese in 2022. Consequently, obesity has become a pandemic with negative impacts on both global health and economies. Obesity is influenced by various factors including environmental influences, lifestyle choices, gut microbiota, genetic factors, and epigenetic mechanisms such as DNA methylation. DNA methylation can affect an individual's phenotype and condition without altering their DNA sequence. It is the most extensively studied epigenetic alteration and it plays an important part in controlling gene activity associated with obesity. Numerous studies have indicated that DNA methylation is implicated in obesity, thus this review aims to elaborate the roles of DNA methylation to inform the development of preventive measures for obesity.

SELECT: Glucagon-like peptide-1 receptor agonist in obese patients with cardiovascular disease in the absence of diabetes.

Obesity is a global epidemic affecting 2.5 billion people and is recognized as the fourth leading cause of global mortality. Obesity is characterized by excessive accumulation of body fat and is associated with a range of health consequences, including an elevated risk of cardiovascular disease (CVD). Glucagon-like peptide-1 (GLP-1) receptor agonists have been proven to reduce cardiovascular outcomes in patients with diabetes. Study and results: The SELECT trial was a multicenter, double-blind, randomized, placebo-controlled, event-driven superiority trial, conducted at 804 clinical sites in 41 countries. Patients were randomly assigned in a 1:1 ratio, to receive once-weekly subcutaneous semaglutide at a dose of 2.4 mg or placebo. The primary cardiovascular efficacy endpoint was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, assessed in a time-to-first-event analysis. A total of 17,604 patients were recruited, with a mean age of 61.6 years and 72.3% males. The mean duration of exposure to semaglutide or placebo in the overall trial population was 34.2±13.7 months. The primary CVD endpoint occurred in 6.5% (n=569) of the semaglutide group and 8% (n=701) in the placebo group (hazard ratio, 0.80; 95% CI, 0.72 to 0.90; P<0.001). There was also a significant reduction of 9.39% in body weight among the patients taking semaglutide over 104 weeks after randomization versus 0.88% among the placebo group. Semaglutide reduces the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke in obese and overweight non-diabetic patients with preexisting cardiovascular disease.

Anti-obesity effects of Lactiplantibacillus plantarum BHP03 on high-fat diet mice and its regulatory function on intestinal microbiota

Obesity is defined as abnormal or excessive accumulation of body fat, which always causes serious harm to body health. In this work, an anti-obesity strain, Lactiplantibacillus plantarum BHP03 (L. plantarum), was explored. This strain showed good reproductive and acid production abilities. And its simulated intestinal fluid tolerance was better than that of Lacticaseibacillus rhamnosus GG（LGG). The in vitro lipid-lowering indicators (inhibition rate of pancreatic lipase, bile-acid salt binding capacity) of L. plantarum BHP03 were at the same level as LGG, but L. plantarum BHP03 exhibited better ability to clear cholesterol. Further, L. plantarum BHP03 was used to intervene high-fat diet mice by oral administration. The results showed that high (109 CFU/day) and low (108 CFU/day) doses of L. plantarum BHP03 could alleviate excessive weight gain caused by high-fat diet and improve the symptoms of hepatorenal enlargement and liver fatty lesions. In addition, high dose L. plantarum BHP03 significantly reduced the content of the serum total cholesterol and low-density lipoprotein cholesterol in mice. Moreover, high dose L. plantarum BHP03 enhanced the species richness of intestinal flora in mice fed with high-fat diet, decreasing the abundance of harmful bacteria such as Staphylococcus and increasing the abundance of beneficial bacteria such as Dubosiella, Akkermansia, Bifidobacterium and Lactobacillus. Therefore, it could be concluded that high dose L. plantarum BHP03 was more effective in preventing obesity and balancing gut microbiota. These findings may provide a theoretical basis for the application of lactobacilli to develop functional foods related to anti-obesity.

Obesity in Adults: Causes, Health Consequences, and Treatment Methods

Introduction Obesity is defined as an excessive accumulation of body fat that can negatively affect a person's physical as well as mental health. It results not only from excessive caloric intake relative to energy expenditure, but also from a myriad of genetic, metabolic, environmental and behavioral factors. Obesity poses the risk of a number of chronic diseases that impair quality of life and increase the risk of death. Understanding the causes of obesity, the consequences it brings, and learning about treatments can help improve health and public awareness. Aim of the Study This study aims to analyze the causes, health consequences, and available treatment methods for obesity in adults, providing a comprehensive overview of the current knowledge on the subject. Materials and Methods This review utilized data from recent literature published over the last 15 years, sourced primarily from PubMed. The focus was on identifying and synthesizing information related to the epidemiology, risk factors, health consequences, and treatment strategies for adult obesity. Keywords such as "obesity," "adult," "treatment," "epidemiology," and "health consequences" were used to search relevant studies. Conclusions Obesity in adults is a multifaceted issue requiring a comprehensive approach to treatment. Addressing this epidemic necessitates a combination of dietary changes, increased physical activity, behavioral therapies, pharmacological interventions, and surgical options when necessary. Ongoing support and monitoring are essential for achieving long-term success in weight management and improving overall health outcomes.

The Association between Marital Status and Obesity: A Systematic Review and Meta-Analysis.

Obesity was included in the International Classification of Diseases in 1990 as a chronic disease characterized by the excessive accumulation of body fat and a body mass index (BMI) greater than 30 kg/m2. This systematic review was aimed to examine the role of marital status in determining body mass index and the risk of obesity. We performed a systematic literature search using three databases (PubMed (Medline), Embase, and Google Scholar) with the search query. Of the 105 studies included in the systematic review, 76 studies (72%) reported a greater risk of obesity in married individuals compared to unmarried individuals. A meta-analysis of 24 studies included a total population of 369,499 participants: 257,257 married individuals (40,896 of whom had obesity) and 112,242 comparison subjects (single, divorced, or widowed individuals, 15,084 of whom had obesity). Odds ratios for obesity found a significant pooled odds ratio for obesity in married individuals compared with controls (OR 1.70; 95% CI 1.38-2.10). The socioeconomic environment was not the same throughout the period of studies analyzed. The odds of obesity in married individuals during economic crises was greater than during the period between crises: OR 2.56 (95% CI 2.09-3.13) during crises vs. OR 1.55 (95% CI 1.24-1.95) between crises. The results of this review confirm the importance of considering marital status in determining the risk of obesity.

Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning.

Our understanding of the pathophysiology of obesity remains at best incomplete despite a century of research. During this time, two alternative perspectives have helped shape thinking about the etiology of the disorder. The currently prevailing view holds that excessive fat accumulation results because energy intake exceeds energy expenditure, with excessive food consumption being the primary cause of the imbalance. The other perspective attributes the initiating cause of obesity to intrinsic metabolic defects that shift fuel partitioning from pathways for mobilization and oxidation to those for synthesis and storage. The resulting reduction in fuel oxidation and trapping of energy in adipose tissue drives a compensatory increase in energy intake and, under some conditions, a decrease in expenditure. This theory of obesity pathogenesis has historically garnered relatively less attention despite its pedigree. Here, we present an updated comprehensive formulation of the fuel partitioning theory, focused on evidence gathered over the last 80 years from major animal models of obesity showing a redirection of fuel fluxes from oxidation to storage and accumulation of excess body fat with energy intake equal to or even less than that of lean animals. The aim is to inform current discussions about the etiology of obesity and by so doing, help lay new foundations for the design of more efficacious approaches to obesity research, treatment and prevention.

Evaluation of tauroursodeoxycholic acid in liver cells' cultures by MEKC: Initial hints to comprehend its role in diabetes mellitus of obese individuals.

Genetic factors, diet, lifestyle, and other factors lead to various complications in the body, such as obesity and other chronic diseases. The inflammatory state caused by excessive accumulation of body fat affects the pathways related to the control of glycemic homeostasis, leading to a high demand for insulin, to subsequent failure of stressed β cells, and development of type 2 diabetes mellitus (T2DM). The study of new endocrine signalers, such as bile acids (BAs), becomes necessary as it allows the development of alternatives for T2DM treatment. In this work, a methodology was developed to quantify tauroursodeoxycholic BA (TUDCA) in liver cells of the HepG2 strain treated in hyperlipidic medium. This BA helps to improve insulin clearance by increasing the expression of the insulin-degrading enzyme, restoring sensitivity to this hormone, and making it viable for treating T2DM. Herein, a targeted metabolomic method for TUDCA determination in extracellular medium of hepatocyte matrices by micellar electrokinetic chromatography-UV was optimized, validated, and applied. The optimized background electrolyte was composed of 40mmol/L sodium cholate and 30mmol/L sodium tetraborate at pH 9.0. The following figures of merit were evaluated: linearity, limit of quantification, limit of detection, accuracy, and precision. Data obtained with the validated electrophoretic method showed a self-stimulation of TUDCA production in media supplemented only with BA. On the other hand, TUDCA concentration was reduced in the hyperlipidic medium. This suggests that, in these media, the effect of TUDCA is reduced, such as self-stimulated production and consequent regulation of glycemic homeostasis. Therefore, the results reinforce the need for investigating TUDCA as a potential T2DM biomarker as well as its use to treat several comorbidities, such as obesity and diabetes mellitus.

Relationship of Overweight and Obesity with Chronic Kidney Disease: A Narrative Review

Abstract Globally, chronic kidney disease (CKD) has become the foremost cause of global illness and death. Previously, it was considered a health issue in developed countries only; as of now, 4 out of 5 deaths occurring in low- and middle-income countries is due to chronic kidney disease. Obesity is defined as the accumulation of excessive body fat uncharacteristically, which may develop into impaired health. In literature, by the WHO, overweight is characterized by a body mass index (BMI) ≥25 kg/m2; and obesity is characterized by a BMI greater than or equal to 30 Kg/m2. The prevalence of obesity-associated renal disorders has become greater than before by 10-fold in recent years. Glomerulomegaly, enlargement of the glomerulus, is one of the characterized clinical features of obesity, followed by an increase in glomerular filtration rate. All prospective, retrospective cohort observational studies focused on assessing the relationship between higher BMI, overweight, obesity, and CKD were included. Articles published in Electronic databases (PubMed, CENTRAL, Web of Science, Google scholar) were analyzed for the present study. Obesity has been increasing with years, as of the data of 1975 to 2020 it has increased three times, categorically 13% of grown people aged 18 years and above were obese, 39% of adults were overweight, and the number of children under the age of 5 reported obese and, overweight was 39 million in 2020. Twenty-one studies were assessed based on the requirement, after which eight articles were included. Finding suggests central obesity has major role in impairment of renal function and resulting in CKD. It is clear that obesity has a very significant association with CKD. The present narrative review supports the hypothesis that a higher BMI of 25 or above, overweight, and obesity might be risk factors for CKD.

Normal Weight Obesity Associated with Enhanced Echo Intensity, Insulin Resistance, and Decreased Muscle Strength in Young Adults

Abstract Context: Obesity refers to the accumulation of excess body fat. Even individuals with a normal body mass index (BMI) of &lt;23 Kg/m2 but a high percentage of body fat have an increased risk for noncommunicable disease. This condition is referred to as normal weight obesity (NWO). Aim: To assess the association between muscle strength, ultrasound-derived muscle thickness, insulin resistance, and echo intensity in NWO and normal weight nonobese (NWNO) young adults. Methods and Material: Eighty young adults of a normal BMI of 18.5 to 22.9 Kg/m2 were recruited in this current study. Forty subjects with cutoff points of body fat percentage ≥ 20.6% for men and ≥ 33.4% for women were taken as NWO group and 40 were NWNO. Fasting glucose and insulin were used for calculating insulin resistance, sensitivity, and beta cell function. Ultrasonography (USG) was done to measure forearm radial and ulna muscle thickness. The echo intensity was measured from an ultrasound image as a mean pixel value using Adobe Photoshop. Subjects were tested for handgrip strength using hand dynamometry. Results: Hand grip strength was higher in NWNO group, and subcutaneous fat thickness and echo intensity were higher in the NWO group. Glucose, insulin, and insulin resistance were significantly higher in the NWO group. Linear regression showed a significant correlation between ulna muscle thickness, forearm circumference, echo intensity, and insulin resistance with handgrip strength (r = 0.835 P &lt; 0.001). Conclusions: NWO adults have higher insulin resistance and echo intensity, indicating decreased muscle quality compared to NWNO individuals.

Understanding the relationship between quality of life, anthropometric measures and mental health in individuals with obesity.

Obesity is a chronic medical condition caused by an excessive accumulation of body fat that represents a major risk factor for public health. The relationship between obesity, quality of life (QoL) and mental health has been examined in some previous literature. However, the studies found have not linked anthropometric variables with QoL factors, as they have used generic questionnaires. The present study aimed to analyse the influence of anthropometric variables on the QoL of people with obesity and examine its relationship with psychological variables. It was a cross-sectional study composed of 77 Spanish participants adults (M=45.12years; SD=10.29) collected from two different research projects. The measurements were carried out in the Faculty of Health Sciences of the University of Alicante (Spain), including sociodemographic variables, anthropometric data and psychological questionnaires. The finding demonstrated the relationship between anthropometric variables and all QoL factors. Also, individuals with lower QoL exhibit more symptoms of depression, anxiety and stress and are more prone to emotional eating. The findings highlight the necessity of integrating psychological support into obesity treatment strategies, as well as the importance of using QoL questionnaires specific to people with obesity.

Effect of leash walking on weight loss and assessment of hair cortisol in overweight dogs

Abstract Obesity results from excessive body fat accumulation. Leash-walking is a practical way to increase activity in treating obesity; however, limited studies have focused on the frequency and duration of dog leash-walking. There is few research reporting on whether initiating exercise or increasing physical activity in obese dogs can induce stress. Therefore, the present study conducted a clinical trial of the leash-walking effect on weight management and identified the relationship between stress and weight management. Thirty-one dogs participated in a 4-week weight management and were divided into four groups according to their leash-walking frequency and duration. Low walking group (LW): approximately 30 min, 3 times per week; Group 1: approximately 60 min, 3 times per week; Group 2: approximately 30 min, 5 to 7 times per week; Group 3: approximately 60 min, 5 to 7 times per week. Body weight and hair cortisol concentrations of participated dogs were also evaluated. There were significant () differences in the weight loss rate between the Group 2 (−1.08 ± 0.34%/week) and Group 3 (−1.26 ± 0.54%/week) compared to the LW (−0.13 ± 0.49%/week). However, there was an increasing tendency of hair cortisol concentration in Group 1 (0.15 ± 0.10 μg/dl to 0.20 ± 0.19 μg/dl) and Group 3 (0.19 ± 0.19 μg/dl to 0.45 ± 0.76 μg/dl) which are approximately 60 min of leash-walking duration groups. The results of this study suggest that it is more efficient to increase leash-walking frequency than duration for weight loss. However, suddenly increasing leash-walking may be a stress-inducing factor during weight management in overweight dogs. Therefore, it is important to start weight management with appropriate frequency and manageable duration of leash-walking and gradually increase the leash-walking times step by step.

The thin fat paradox: Understanding normal weight obesity and its clinical relevance

Obesity, defined by the World Health Organization (WHO) as an excess accumulation of body fat or body fat percentage (BFP) associated with clear health risks, presents a significant global challenge. While Body Mass Index (BMI) serves as a conventional metric for identifying obesity, it fails to account for body composition variations, such as distinguishing between fat-free mass and adipose tissue. Consequently, individuals with normal BMI may exhibit excessive body fat (BFP≥30%), termed Normal Weight Obesity (NWO). In contrast, others with normal BMI and normal body fat are termed Normal Weight Lean (NWL). NWO significantly elevates the risks of various metabolic disorders, including hyperglycemia, diabetes, hypertension, dyslipidemia, and reduced HDL levels. Moreover, NWO is associated with an increased risk of cardiovascular diseases (CVD), hypertension, low HDL, central obesity, and muscle weakness. Individuals with NWO face a heightened risk of developing cardiometabolic diseases, including atherosclerosis, coronary artery disease, stroke, and heart failure, due to the adverse effects of excess body fat on cardiovascular health. Furthermore, NWO is associated with insulin resistance, inflammation, and endothelial dysfunction, further exacerbating the risk of metabolic disorders and cardiovascular complications. Early identification of NWO is crucial for implementing preventive measures and lifestyle interventions to mitigate these health risks. Integrating body fat percentage measurements into nutritional screening protocols in healthcare facilities is essential for identifying individuals at risk of NWO and initiating appropriate interventions to prevent the onset of cardiometabolic diseases. This study aims to provide comprehensive insights into Normal-Weight Obesity (NWO) and its potential health implications.

The different association between fat mass distribution and intake of three major nutrients in pre- and postmenopausal women.

Obesity, characterized by excessive body fat accumulation, is associated with various chronic health conditions. Body fat plays a crucial role in health outcomes, and nutrient intake is a contributing factor. Menopause further influences body fat, but the precise relationships between nutrients and fat mass distribution in pre- and post-menopausal women are unclear. Data from 4751 adult women aged ≥18 years old (3855 pre-menopausal, 896 post-menopausal) with completed information were obtained from the National Health and Examination Survey (NHANES) from 2011 to 2018. Multivariate linear regression models were used to examine the associations between protein, carbohydrate, fat intake and total percent fat (TPF), android percent fat (APF), gynoid percent fat (GPF), android to gynoid ratio (A/G), subcutaneous adipose tissue mass (SAT), visceral adipose tissue mass (VAT). Subgroup analyses, stratified by menopausal status, were also conducted. Additionally, we employed smoothing curve fitting techniques to investigate potential non-linear relationships between fat mass distribution and nutrient intake. Compared with pre-menopausal women, post-menopausal women had higher body fat, BMI, and metabolic indicators but lower nutrient intake (All p<0.05). In the overall analysis, we found significant correlations between nutrient intake and fat mass. Specifically, protein intake was negatively correlated with TPF (β = -0.017, 95% CI: -0.030, -0.005), APF (β = -0.028, 95% CI: -0.044, -0.012), GPF (β = -0.019, 95% CI: -0.030, -0.008), while fat intake showed positive correlations with these measures (SAT: β = 2.769, 95% CI: 0.860, 4.678). Carbohydrate intake exhibited mixed associations. Notably, body fat mass-nutrient intake correlations differed by menopausal status. Generally speaking, protein intake showed negative correlations with body fat distribution in pre-menopausal women but positive correlations in post-menopausal women. Carbohydrate intake revealed significant negative associations with abdominal and visceral fat in post-menopausal women, while fat intake was consistently positive across all fat distribution indices, especially impacting visceral fat in post-menopausal women. Dietary intake plays a crucial role in body fat distribution, with menopausal status significantly influencing the impact of nutrients on specific fat distribution metrics. The study emphasizes the need for dietary guidelines to consider the nutritional needs and health challenges unique to women at different life stages, particularly concerning menopausal status, to effectively manage obesity.

NUTRITIONAL STATUS AND SOME RELATED FACTORS IN MEDICAL STUDENTS

Background: Today, the global challenge of malnutrition encompasses both undernutrition and overweight, particularly prevalent in low and middle-income nations. Excessive body fat accumulation poses health risks for overweight and obese individuals. Objectives: To assess nutritional status and identify related factors among Can Tho University of Medicine and Pharmacy (CTUMP) medical students. Materials and methods: A cross-sectional study was conducted on 137 first-year medical students at CTUMP to evaluate their body fat percentage using the Harpenden Skinfold Caliper. Skinfold measurements were taken from the bicipital, tricipital, subscapular, and suprailiac sites. Furthermore, physical activity levels were classified using the World Health Organization (WHO) Global Physical Activity Questionnaire (GPAQ) consisting of 16 questions on 4 domains. The research was carried out at CTUMP from December 2022 to June 2023. Results: Compared to urban areas, a higher percentage of male students engage in physical activity in rural areas; however, this trend is not observed among female students. Additionally, female students exhibited thicker skin folds in four areas (biceps, triceps, suprailiac, and subscapular) compared to male students. Conversely, the fold thickness in the suprailiac region was greater in female students. The mean body fat percentage was 20.40±4.61% in male students and 30.48±4.32% in female students. Non-obese students comprised the majority in this study, with 84.3% of male students being non-obese. Among female students, 53.7% were classified as obese and 46.3% as non-obese. There was insufficient evidence to indicate differences between residential student groups and physical activity levels. Conclusions: The study reveals that the majority of participating students are non-obese. Furthermore, the average body fat percentage among women is found to be higher compared to both men and the general population. However, there is inadequate evidence to show variances among student groups residing in diverse areas or partaking in varying levels of physical activity.

Assessment of Serum Insulin and VASPIN Levels Among Type 2 Diabetes Mellitus Patients with or Without Obesity: A Cross-sectional Analytical Study.

A collection of diverse conditions together referred to as diabetes mellitus frequently manifest as periods of hyperglycemia and glucose intolerance, which can be caused by insufficient insulin, improper insulin action, or both. A medical condition known as obesity is the accumulation of excess body fat to the point that it may be harmful to one's health. It has been determined that the adipokine vaspin (visceral adipose tissue-derived serpin A12) belongs to the family of serine protease inhibitors. Insulin, a polypeptide hormone, is released by the pancreatic beta cells. This hormone is both anti-catabolic and anabolic. Insulin decreases blood glucose levels by preventing its synthesis and encouraging its storage and use. In total, 125 male and female participants of various ages participated in the current study. They included 25 healthy controls, 50 non-obese and 50 obese non-insulin-dependent diabetes mellitus patients, who visited the MDM Hospital's outpatient clinic in Jodhpur, Rajasthan. Commercially available reagents and kits were utilized for the analysis of serum insulin and vaspin samples. Standard statistical tools were utilized to evaluate the parameters. When results were compared with healthy participants and non-obese NIDDM subjects, obese NIDDM subjects showed statistically significant higher fasting serum insulin and serum vaspin levels (P < 0.0001). Our study's conclusions demonstrated a strong correlation between blood insulin and vaspin levels and diabetes and obesity. Vaspin has a positive impact on insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. It also enhances glucose tolerance and insulin sensitivity, reducing diabetes complications. This novel biomarker has the potential to enhance diabetes mellitus outcomes by facilitating prompt diagnosis, improved management, and reduction of complications.

Kegiatan Pengukuran Antropometri Pada Populasi Lanjut Usia Sebagai Deteksi Dini Obesitas Dan Komplikasi Terkait Obesitas

Obesity, characterized by excessive accumulation of body fat, increases susceptibility to chronic disease and adversely impacts overall quality of life. Elderly people often exhibit higher fat mass and lower muscle mass and bone density, influenced by reduced physical activity, hormonal changes, and metabolic adjustments. Visceral fat accumulation is of particular concern because of its association with metabolic syndrome, insulin resistance, diabetes, hypertension, and cardiovascular disease. This activity uses the PDCA (Plan-Do-Check-Act) framework to screen for obesity in the elderly using Body Mass Index (BMI) and waist circumference measurements. Activities were held at St. Fransiskus Assisi, Jakarta involving 36 participants. The study revealed that 16 participants (44.5%) and 30 people (83.3%) were obese and centrally obese, respectively. Early detection and intervention through anthropometric measurements are very important in managing health risks related to obesity in the elderly, so as to improve their quality of life and reduce morbidity and mortality.

Anti-adipogenesis effect of indole-3-acrylic acid on human preadipocytes and HFD-induced zebrafish.

Obesity, defined as excessive or abnormal body fat accumulation, which could significantly increase the risk of cardiovascular disease, type 2 diabetes mellitus (T2DM) diseases and seriously affect people's quality of life. More than 2 billion people are overweight, and the incidence of obesity is increasing rapidly worldwide, it has become a widely concerned public health issue in the world. Diverse evidence show that active metabolites are involved in the pathophysiological processes of obesity. However, whether the downstream catabolite of tryptophan, 3-indole acrylic acid (IA), is involved in obesity remains unclear. We collected the samples of serum from peripheral blood of obesity and health controls, and liquid chromatography-mass spectrometry (LC-MS) was performed to identify the plasma levels of IA. Additionally, we verified the potential benefits of IA on human preadipocytes and HFD- induced zebrafish by cell viability assay, flow cytometry assay, Oil red O staining, total cholesterol (T-CHO), triglyceride (TG) and nonesterified free fatty acids (NEFA) measurements and Nile Red staining. RNA-Seq, functional analysis and western blot revealed the mechanisms underlying the function of IA. We found that the content of IA in peripheral blood serum of overweight people was significantly lower than that of normal people. In addition, supplementation with IA in zebrafish larvae induced by a high fat diet (HFD) dramatically reduced HFD induced lipid accumulation. IA had no effect on proliferation and apoptosis of preadipocytes, but significantly inhibited adipogenesis of preadipocytes by down-regulate CEBPα and PPARγ. RNA-Seq and functional analysis revealed that IA regulated the adipogenesis of preadipocytes through stimulate the phosphorylation of STAT1. Taken together, IA has been identified as a potent metabolite for the prevention or treatment of obesity.

Treadmill has a more beneficial effect than cycling on fat loss through myokines secretion in obese women

Obesity is a condition characterized by the excessive accumulation of body fat beyond normal limits. Irisin and IL-6 are myokines that have a function to convert white adipose tissue into brown adipose tissue, resulting in thermogenesis that induces energy expenditure and has implications for reducing excess fat accumulation. This study aims to demonstrate the response of moderate-intensity treadmill and ergo cycle exercise on fat loss and increasing myokines secretion in obese adolescent females. A total of 30 obese women met the criteria with body mass index (BMI) of 30.02±2.97 kg/m2, age 21.27±1.31 years were recruited into the study and given single session of aerobic ergo cycle exercise (AEEG) and aerobic treadmill exercise (ATEG) during 45 min. Measurement of myokines, i.e., irisin and IL-6, using Enzyme-Linked Immunosorbent Assay (ELISA) on all samples. Statistical analysis was performed using a one-way ANOVA test and Tukey's HSD post hoc test with significance at the 5% level. The results showed that the average levels of irisin post-exercise were 72.82±42.96 ng/mL at CTLG, 282.50±75.96 ng/mL at AEEG, 488.14±61.30 ng/mL at ATEG, and p = 0.000. Average levels of IL-6 post-exercise were 51.09±15.68 pg/mL at CTLG, 58.94±3.62 pg/mL at AEEG, 129.29±52.65 pg/mL at ATEG, and p = 0.000. Average ∆ FAT were -0.02±0.34 % at CTLG, -0.35±0.19 % at AEEG, -0.46±0.18 pg/mL at ATEG, and p = 0.002. Both intervention of exercise consistently increased irisin levels, while IL-6 levels were found to increase only with aerobic treadmill exercise. Likewise, body fat only decreased after one session of treadmill aerobic exercise compared to ergo cycle aerobic exercise. Keywords: Aerobic exercise, interleukin 6, irisin, obesity, metabolism