Emotional Distress In Patients Research Articles

Screening diagnostics of emotional distress in patients with facial neuropathy

Patients with facial nerve neuropathy (NLN) are often emotionally labile, inadequately assess the severity of symptoms and prognosis of the disease, have low compliance and motivation for treatment and rehabilitation.The purpose of the study: to develop a screening method for assessing the attitude of a patient with NLN to the disease in order to determine his need for psychological assistance and identify factors affecting compliance and motivation for treatment and rehabilitation.Material and methods: the study included 80 patients with NLN of various genesis who applied during the first 3 months (group 1, n = 37) and 3 months after the onset of symptoms (group 2, n = 43). All patients underwent a neurological examination, an assessment of the severity of NLN on the House–Brackmann scale and were asked to fill out a questionnaire on screening diagnostics of indicators of emotional well-being.Results. In Group 1, the severity of the disease was due to weakness of facial muscles and lagophthalmos, in Group 2 — mainly complications in the form of muscle hypertonia (88.4% of patients) and synkinesias on the affected side (89.2%), while strength partially recovered from 6 [3; 6] to 3 [3; 4] points according to According to the House– Brackmann scale, and the frequency of lagophthalmos decreased by 2 times (from 78.4% to 32.6%). The severity of paresis was not correlated with the severity of emotional disorders (p = 0.607) and the presence of lagophthalmos — 3 [2; 6] versus 4 [2; 8] (p = 0.412). The total score of negative questionnaire responses was higher in patients with complications: muscle hypertonicity — 5 [3; 7] versus 3 [1; 5] (p = 0.033) and synkinesia — 6 [3.5; 7.5] versus 3 [2: 6] (p = 0.010). Moreover, the severity of emotional disorders was associated with the number of complications (p = 0.006). Patients believed that the disease made them less attractive (72.5%), others pay too much attention to the face (46.3%) and changed their attitude (18.8%). Since the acute period of NLN, the mood has changed in 65% of patients. Every second patient believed that the disease divided his life into “before” and “after”, every third answered: “this is the worst thing that happened to me in my life.” In three cases, statements of suicidal thoughts were noted. Patients who sought help in the chronic period of NLN are more dysfunctional in terms of emotional state — the total score of negative responses was 6 [3.5; 3] versus 3 [1; 5] (p = 0.001). A third of the patients were convinced that the main responsibility for recovery lies with doctors, so they are at risk of refusing treatment.Conclusion: in the debut of NLN, every second patient worries about appearance and notes a decrease in mood. Negative thoughts and feelings in patients in the chronic stage of the disease occur in 90% of cases. The developed screening method of psychological assessment of the patient’s attitude to the disease allows to determine the patient’s need for psychological help, to identify indications for consultation with a psychologist or psychiatrist.

Self-Hypnosis for Phantom Limb Pain: A Multiple-Case Study

Phantom limb pain occurs in more than half of the people who have undergone an amputation. Hypnosis can alleviate pain effectively in experimental, procedural, and chronic pain. Thus, in this multiple-case study, we determined whether hypnosis might be a successful complementary approach to help patients with phantom limb pain in alleviating their pain quality (i.e., sensitive and affective), intensity, fatigue, and emotional distress (i.e., anxiety and depression). Seven patients experiencing phantom limb pain were trained to perform self-hypnosis in five sessions over two and a half months. The patients were encouraged to practice at home daily throughout the study. Measures of the intensity of pain and fatigue, the severity of insomnia, anxiety, depression, and the quality of pain (i.e., sensitive and affective) were performed before and after self-hypnosis training. Six years after the completion of the study, the patients were contacted over the telephone to follow up on their practice of self-hypnosis. All patients reported a reduction in the intensity of pain, severity of insomnia, anxiety, and quality of pain. They also reported a positive change in their behaviors and the sensation of pain after performing hypnosis. At the six-year follow-up, three patients were still practicing hypnosis and reported better control over pain and being more relaxed. The main reason for most patients to stop practicing self-hypnosis was that they failed to find the time. Self-hypnosis can effectively ameliorate pain, fatigue, and emotional distress in patients suffering from phantom limb pain. Large-sample clinical trials with a mixed design are needed to confirm these results.

Patient efficacy in telehealth is moderated by distress among patients with cancer: A cross-sectional survey study.

1590 Background: The COVID-19 pandemic increased the use of telehealth to reduce exposure, which was critical for patients with cancer. The extent to which patients with cancer view telehealth visits as meeting their medical needs was investigated using a cross-sectional survey. Methods: Patients currently receiving cancer treatment at a single cancer institute who had had at least one telehealth visit were emailed an online survey. Response rate was 5% (94/1944). The survey measured patients’: 1) Emotional Thermometer (i.e. distress, anger, depression, anxiety, and need for help on a 0-10 scale); 2) Telehealth usability questionnaire (TUQ; 21-items with various subscales, like interaction quality; α=0.98).); and 3) Perceived Efficacy in Patient-Physician Interactions (PEPPI-5) scale (five items, e.g., “How confident are you in your ability to make the most of your visits with your doctors?”). Respondents completed the PEPPI-5 for in-person visits and for telehealth visits. Descriptive statistics were calculated for all measures. A generalized linear model was estimated predicting PEPPI-5 for telehealth visits from emotional thermometer and TUQ scores. The interaction between emotional thermometer and TUQ scores was estimated to test the hypothesis that emotional distress moderated the relationship between TUQ and efficacy in patient-provider interactions during telehealth visits. Results: Across all five thermometers, 30.8% (28/91) reported a high score on at least one metric. The most frequently reported high score was for anxiety, 23.3% (21/90) and least frequently reported high score was for anger, 12.2% (11/90). The mean TUQ score was 5.5 (SD=1.5) and mean PEPPI-5 score for telehealth visits was 8.1 (SD=2.4). As shown in Table, emotional thermometer scores did moderate the relation between TUQ and patient self-efficacy during telehealth visits. For high emotional thermometer scores, self-efficacy decreased as TUQ scores decreased. Conclusions: For patients experiencing high emotional distress, low comfort and ability with telehealth usability resulted in low patient self-efficacy in communicating with providers and getting medical needs met. Telehealth is a convenient and effective modality; however, in times of emotional distress for patients who are not familiar with telehealth, in-person clinic visits may result in greater patient self-efficacy.[Table: see text]

Silicone-induced granuloma of breast implant capsule mistaken for breast implant-associated anaplastic large cell lymphoma

For patients with breast implants who present with an isolated seroma, capsular contracture, or peri-implant mass, clinicians must rule out breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). As non-malignant silicone-induced granuloma of breast implant capsule (SIGBIC) may mimic BIA-ALCL, particular care must be exercised to prevent misdiagnosis. In this report, we describe three cases of SIGBIC misdiagnosed as BIA-ALCL. In each of these cases, a preoperative evaluation including breast magnetic resonance imaging and physical examination, as well as the fact that a textured silicone implant was used in the patients, indicated a high probability of malignancy. In all three cases, however, an explorative operation and pathologic results revealed foreign body granulomas without malignant features. While it is critical that potential cases of BIA-ALCL be diagnosed and treated quickly, hasty judgments may lead to misdiagnosis and severe emotional distress in patients. Increased awareness of SIGBIC, specifically its mimicry of BIA-ALCL, may be helpful to avoid these outcomes.

Silicone-induced granuloma of breast implant capsule mistaken for breast implant-associated anaplastic large cell lymphoma

For patients with breast implants who present with an isolated seroma, capsular contracture, or peri-implant mass, clinicians must rule out breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). As non-malignant silicone-induced granuloma of breast implant capsule (SIGBIC) may mimic BIA-ALCL, particular care must be exercised to prevent misdiagnosis. In this report, we describe three cases of SIGBIC misdiagnosed as BIA-ALCL. In each of these cases, a preoperative evaluation including breast magnetic resonance imaging and physical examination, as well as the fact that a textured silicone implant was used in the patients, indicated a high probability of malignancy. In all three cases, however, an explorative operation and pathologic results revealed foreign body granulomas without malignant features. While it is critical that potential cases of BIA-ALCL be diagnosed and treated quickly, hasty judgments may lead to misdiagnosis and severe emotional distress in patients. Increased awareness of SIGBIC, specifically its mimicry of BIA-ALCL, may be helpful to avoid these outcomes.

COVID-19 Pandemic: Psychosocial Distress and Social Burdens Experienced by Cancer Patients at Cancer Diseases Hospital, Lusaka, Zambia

Background: Cancer diagnosis has been reported in some studies to have a significant psychosocial impact on both the patients and their caregivers. The estimated prevalence of psychosocial distress is between 35% and 55%. Commonly encountered psychological issues include and are not limited to fear, anxiety, and emotional distress. Many sources of emotional distress in patients with cancer during the COVID-19 pandemic have been reported to include poorly controlled symptoms arising from a lack of access to symptom control services and treatment. Social distress is associated with social isolation, separation from family and loss of employment. Cancer patients and society have been reported to experience anxiety, despair, and stress due to the COVID-19 restrictions on community movement and hospital appointment rescheduling. The objective of this study was to explore psychosocial distress and social burdens experienced by cancer patients during the COVID-19 pandemic. Methods: A descriptive phenomenological design was employed to describe “lived experiences of patients with Cancer” during the COVID-19 Pandemic. A total of 20 participants with Cancer and COVID-19 positive were purposefully selected and interviewed. Thematic analysis was utilized for data analysis by the use of themes generated from participants’ responses. Findings: Five major themes emerged: fear, self-isolation compliance, anxiety, low income and emotional distress. The findings of the study indicated that participants experienced fear, emotional distress and anxiety when diagnosed with COVID-19. Conclusion: The experiences of psychosocial distress and social burdens were a result of a lack of psychosocial support by both caregivers and health care workers. This study recommends appropriate health education concerning psychosocial support for cancer patients and the need to have appropriate clinical protocols and materials in allaying anxiety and fear in cancer patients during the COVID-19 pandemic.

Psychological symptoms of illness and emotional distress in advanced cancer cachexia.

Cachexia induces both physical and psychological symptoms of illness in patients with advanced cancer and may generate emotional distress in patients and families. However, physical symptoms of cachexia received the most emphasis. The aims of this review are to elucidate a link between systemic inflammation underlying cachexia and psychological symptoms and emotional distress, and to advance care strategy for management of psychological symptoms and emotional distress in patients and families. The main themes in the literature covered by this review are psychological symptoms in patients and emotional distress in patients and families. Studies of the underlying biology of cachexia identify the role of the central nervous system to amplify tumor-induced systemic inflammation. The brain mediates a cluster of symptoms, such as sleep disruption, anxiety, cognitive impairment, and reduction in motivated behavior (notably anorexia). These are distressing to patients as well as to families. There is growing recognition that holistic multimodal interventions are needed to alleviate psychological symptoms and emotional distress and to improve quality of life in patients with cancer cachexia and families. This is an approach that addresses not only physical health but also psychological, emotional, and social well being issues.

Educational and Psychological Support Combined with Minimally Invasive Surgical Technique Reduces Perioperative Depression and Anxiety in Patients with Bladder Cancer Undergoing Radical Cystectomy.

Radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) is an extensive and morbid operation, often associated with permanent alteration of body image and disability. Combined with the aggressive malignant potential of MIBC and considerable risk of complications, it poses a serious threat to the psychological well-being of patients. Educational deficiencies causing uncertainty and confusion aggravate surgery-related anxiety and may lead to depression along with further social disability. We conceived a preoperative supportive program named “Cystocare” held by urologists, psychologists, stoma therapists and cancer survivors to facilitate patients’ adaptation and coping. We aimed to evaluate whether participation in Cystocare meetings would alleviate emotional distress in patients undergoing RC. We included 95 consecutive patients who filled Hospital Anxiety and Depression Score questionnaires before RC and on discharge. The intervention arm (A) comprised 32 Cystocare participants. The remaining 63 patients who received standard preparation constituted the control arm (B). Whilst there were no differences in median anxiety and depression scores preoperatively, in postoperative measurement, the intervention arm showed a lower median depression score than controls: 3 vs. 8 points, p = 0.015. On multivariate analysis we confirmed lower risk of postoperative depression in Cystocare participants: OR = 0.215 (95%CI: 0.066–0.699), p = 0.011, along with lower odds of preoperative anxiety in patients undergoing laparoscopic RC: OR = 0.365 (95%CI: 0.136–0.978), p = 0.045, and higher risk of prolonged hospital stay in patients experiencing postoperative anxiety OR = 17.114 (95%CI: 1.283–228.234) p = 0.032. Preoperative educational and supportive intervention complements laparoscopic RC in the alleviation of surgery-related anxiety and depression. The support group meetings provide an attractive and cost-effective opportunity to moderate emotional response in patients undergoing RC, and as such, deserve widespread adoption.

Virtual psychosocial services for the adult population in a large community oncology practice.

283 Background: Psychological and social supports are essential to address the emotional impact of cancer. The Covid-19 pandemic exacerbated emotional distress for patients with cancer and impeded many of the traditional service delivery models for supportive services. An increase in patient reported distress from routine distress screenings highlighted the need to transition to virtual Social Work (SW) services. Methods: Patients were referred to virtual SW services three ways: self-referral, distress screenings, and clinic staff. A virtual support group registration site was created to increase awareness which was promoted by our marketing team. Three different SW facilitated virtual support groups were offered: Stronger Together, Empower Your Recovery: A Program for Healing and Growth for Living Beyond Cancer©*, and Paving the Way for Your Journey: A Cancer Support Program (PTW). Of note, the PTW six-week psychoeducation support group curriculum was developed by six employed SW facilitators. Groups included closed and open formats with scheduled frequencies. In addition to virtual support groups, standard social support including, psychosocial assessments, Advance Care Planning, virtual counseling visits were offered virtually with patients via the VSee telemedicine platform. Results: Social Work referrals increased by 154% from 949 in 2019 to 2413 in 2020 due to positive distress screening. From March 2020-21, 14,948 patients received SW services which was an increase from 10,208 seen from March 2019-20. Of these, 372 received virtual psychosocial telemedicine services from March 2020-21. There were 4092 unique webpage views to the support group information and registration website. Total number of all virtual registrants in the 3 groups from May 2020 to February 2021 was 326. Conclusions: The COVID19 pandemic required us to use, technology and virtual tools to ensure continued patient access to psychosocial services and expand access to support groups, in addition to the in-person SW services that remained. Limitations of virtual support groups and telemedicine included lack of internet access felt to be from socioeconomic barriers. Further research is needed to evaluate the benefits of providing structured psychoeducational virtual support groups to patients with cancer. Virtual counseling and support groups may continue to benefit patients with cancer.

Interactions between macrophage inhibitor factor and emotional distress in patients with st-segment elevation myocardial infarction

Background and Aims: Acute and chronic stress and depression are risk factors of myocardial infarction (MI). Macrophage inhibitory factor (MIF) – pleotropic proinflammatory cytokine. High level of MIF promotes rupture of atherosclerotic plaque and development of MI. This is cytokine with neuroendocrinic properties which appears to be the link between atherosclerosis and depression. Aim: to investigate associations between MIF and anxiety, depression and stress in patients with ST-segment elevation MI (STEMI).

Identifying mindfulness and acceptance as mediators between negative affect, functional disability and emotional distress in patients with fibromyalgia.

Fibromyalgia (FM) is a prevalent disabling condition characterised by chronic widespread pain. It is considered a complex illness in which the prognosis is conditioned by affective and cognitive mediators still largely unknown in FM. To investigate the correlation between psychological variables (acceptance, negative affect, and mindfulness) and functional disability or physical impact, anxiety/depression symptoms and emotional distress, and also to evaluate the mediating role of acceptance and mindfulness between negative affect, physical impact, anxiety/depression and emotional distress in individuals with FM. Two hundred and fifty-one patients with FM who met the 2010 ACR criteria were included and filled out validated self-reported screening measures. The study explored Pearson's correlation coefficients and multiple mediation using a Preacher and Hayes's computational software tool, including the indirect effect associated with the two mediators (mindfulness and acceptance). Functional disability or physical impact, anxiety/depression symptoms and emotional distress correlated positively with negative affect (r= 0.580) and negatively with acceptance and mindfulness (r= -0.579 and r= -0.471; all p-values <0.001), respectively. The mediation analyses showed that acceptance and mindfulness mediated the relationship between negative affect and dependent variables such as physical impact, anxiety/depression symptoms and distress. The findings highlight that mindfulness and acceptance have a significant indirect effect on physical impact, anxiety/depression and emotional distress when controlling for negative affect as an independent variable in the FM patients. Future investigation should replicate and extend these outcomes in other study populations to determine the mediating role of mindfulness and acceptance in FM.

Exploratory Controlled Study of the Impact of a Hypnosis-Based Intervention on the Couple’s Communication and Coping in the Context of Cancer

ABSTRACT Emotional distress, communication, and dyadic coping difficulties are common among cancer patients and their partners. Hypnosis-based interventions can improve emotional distress in patients. We designed a group intervention combining self-hypnosis and self-care techniques. We hypothesized an effect of the intervention on emotional distress, conjugal communication, and dyadic coping, considered in patients and their partners. Our exploratory controlled study included 55 women with cancer and 55 partners. Participants completed questionnaires before and after the intervention, which was delivered to patients only. No significant effect of the intervention was revealed for patients or partners. Positive correlations between patients’ and partners’ communication and dyadic coping were revealed. However, to address couples’ or partners’ difficulties, interventions specifically designed for couples or partners must be tested.

Development of a brief screening instrument for emotional distress associated with thromboembolism

BackgroundVenous thromboembolism (VTE) is associated with emotional distress, including depression, anxiety, fear, and decreased quality of life. A method to rapidly screen patients at increased risk for VTE-related emotional distress could allow providers to facilitate appropriate interventions. ObjectiveTo develop a short, easily administered screening tool that can reliably identify emotional distress in patients recently diagnosed with VTE. MethodsAn analysis was performed on data from a national online survey of adult patients with recent VTE. The survey included eight questions developed to assess VTE-related emotional distress, as well as the validated Hospital Anxiety and Depression Scale (HADS). Psychometric analysis was used to evaluate our emotional distress questions for internal consistency and determine associations with HADS Anxiety and Depression subscale scores. ResultsA total of 907 surveys were included. Factor analysis of the proposed eight questions identified a single factor with an eigenvalue of 5.42. There was a significant and strong correlation with the HADS Anxiety (HADS-A) and HADS Depression (HADS-D) subscale scores, r ​= ​0.71 and r ​= ​0.57, respectively (both p-values <0.001). A total score of 10 or more using our new emotional distress screening tool correlated with HADS-A and HADS-D scores ≥11 indicating high anxiety and/or depression. ConclusionsWe developed and tested a new brief screening tool composed of eight questions that assesses patients for VTE-related emotional distress and is easily administered in a clinical setting. Additional investigations in broader populations and in validation studies are required to confirm these findings and foster the tool’s routine use in clinical practice.

Predicting Emotional Disturbance based on Self-empowerment Skills and Interpersonal Interactions in Breast Cancer Patients

Background and Objectives: The aim of this study was to determine the predictive variables of emotional distress and their relative importance in patients with breast cancer. The aim of this study was to determine the predictors of emotional disturbance variables and their relative importance in patients with breast cancer. Material and Methods: The present research method was fundamental in terms of purpose, descriptive and exploratory in nature, so a high sample size was applied. The sample was among the patients with breast cancer who referred to Shohada Hospital in Tajrish, 736 patients ,19 - to 80 years old people with breast cancer who referred to the hospital during the first 8 months of 2019. Whole samples were selected but screened based on inclusion and exclusion criteria. Then the psychological scale of self-empowerment skills, interpersonal interaction quality scale, and emotional turmoil Scale were administered to assess participants. Results: The results showed that self-empowerment skills, quality of interpersonal interactions, age and head of household status showed a significant relationship with emotional turmoil. More precisely, it was found that the variables of the quality of interpersonal interactions and self-empowerment skills have the greatest impact on predicting emotional turmoil, respectively. Conclusion: According to the results of this study, it can be said that interpersonal relationships, self-empowerment skills and demographic characteristics of patients with breast cancer play an important role in the emotional distress of patients. Therefore, it is suggested that psychologists pay special attention to these concepts in monitoring the mental state and improving the mental health of patients.

Introducing the concept sense of place: A mediator between place of care and emotional distress of patients with cancer at the end of life.

A sense of place (SOP) is defined as the emotional bonds, values, meaning, and symbols attached to a place. To assess SOP of patients with cancer during end-of-life care at home (home-hospice service) versus at a hospital in relation to place of care, social support, and emotional distress. Participants were 150, stage IV, cancer patients with a life expectancy of less than 6 months, as defined by oncological staff, who were not receiving any life-prolonging care. Seventy-five patients received care at home (home-hospice), and the other 75 received care at the oncology department at the hospital, by palliative unit staff. Participants completed the Brief Symptom Inventory anxiety and depression subscales, questionnaires on perceived support and both questionnaires on home SOP and hospital SOP. Mean scores of emotional distress were similar for patients in home-hospice and at the hospital. Home SOP among individuals receiving care at home was high, and hospital SOP was high among hospitalized individuals. The structural equation model had good fit indexes, showing that each of the SOP variables mediated the association between place of care and emotional distress. Perceived support was associated with lower distress only in the hospital setting. The SOP concept is relevant to understanding emotional distress in relation to place of care at end of life. Strengthening SOP in relation to place of care should be considered. As newly introduced concept regarding place of care at the EoL, SOP warrants further research.

An Algorithm to Stratify the Risk of Postoperative Emotional Distress in Cancer Patients with Advanced Metastatic Spinal Disease.

PurposeWe wish (1) to assess what variables are significantly associated with postoperative emotional distress in patients with the metastatic spinal disease after surgery and (2) to develop and validate an algorithm to stratify patients at risk of postoperative emotional distress.Patients and MethodsWe retrospectively enrolled 171 patients with the metastatic spinal disease treated with surgery. Twelve potential variables were used to analyze postoperative emotional distress. Postoperative emotional well-being was measured using the Hospital Anxiety and Depression Scales (HADS). Significant variables were included in the algorithm and assigned scores based on odds ratios (ORs) from the multiple logistic regression analysis. The predictive performance of the risk algorithm was validated on the basis of discrimination and calibration.ResultsTwenty-six (15.20%) patients had a HADS of 19 points or more. Of all the 12 variables, age (P=0.06), marital status (P=0.02), primary cancer types (P=0.004), and physical well-being (P=0.006) were included in the algorithm. This algorithm ranged from 0 to 24. Higher scores represented higher rates of postoperative emotional distress. Patients were stratified into three risk groups: patients in the group A had scores of 0 to 9 and the rate of postoperative emotional distress was only 1.14%, patient in the group B had scores of 10 to 15 and the rate of postoperative emotional distress was 21.31%, and patient in the group C had scores of 16 to 24 and the rate of postoperative emotional distress was up to 54.55%. The area under the receiver operating characteristic curve (AUROC) for the algorithm was 0.84, and the correct classification rate was 81.3%.ConclusionPostoperative emotional distress is common in patients with the metastatic spinal disease after surgery. We propose and validate an algorithm that can be used as a potential screening tool to identify patients at high risk of postoperative emotional distress.

Emotional distress in patients with type 1 diabetes mellitus.

This study aimed to analyze the association between emotional distress and glycated hemoglobin (HbA1c) values in adolescents and young adults with type 1 diabetes mellitus (T1DM), with respect to dental anxiety, microvascular diabetes chronic complications, demographic conditions. The cross-sectional study design included 100 adolescents and young adults with T1DM, from regional diabetes reference center. The clinical and laboratory data were obtained from medical records. Distress and dental anxiety scales were produced from questionnaires that were validated for emotional distress (DDS) and dental anxiety (Corah Scale). Multiple analyses estimated odds ratios and their respective 95% confidence intervals using a binary logistic regression model (P<.05). The mean participants age was 20.7±5.5 years, and 52% were female. Of the patients, 19% presented with chronic microvascular diabetes complications (nephropathy, retinopathy, neuropathy). Regarding the distress scale, 53% of the patients presented with high DDS and 83% had little to slight anxiety with dental procedures. There were statistically significant differences when variables were adjusted in the model, such as that of microvascular diabetes chronic complications and female gender with emotional distress. Our results showed that female sex and microvascular diabetes chronic complications are associated with greater emotional distress in patients with T1DM.

Coping Patterns and Emotional Distress in Patients With Chronic Obstructive Lung Disease Who Are Undergoing Lung Transplant Evaluation.

Living with severe lung disease like chronic obstructive pulmonary disease (COPD) is a very stressful situation. The way patients cope may impact their symptoms of anxiety and depression and physical function as well. We studied how ways of coping are associated with levels of emotional distress and lung function in patients with COPD being evaluated for lung transplantation. Sixty-five (mean age 57 years, 46% females) patients completed the General Health Questionnaire-30 (GHQ-30) assessing emotional distress and the Ways of Coping Questionnaire. Measurements of lung function and 6-minute walk test were included. Seventeen (26%) patients had elevated emotional distress. Logistic regression of chronic GHQ score with gender, age, body mass index, lung function, and coping scales as covariates showed that escape avoidance and self-controlling coping and forced vital lung capacity were significantly associated with high emotional distress. Odds ratio of emotional distress increased with 5.2 per tertile (P = .011) in escape avoidance coping score. Moreover, we revealed that emotionally distressed patients cope with their current situation by refusing to believe the current situation and taking their distress out on other people. Among patients with COPD, a high level of emotional distress was uniquely associated with escape-avoidance coping and lung function. Future work should ascertain whether coping style predicts distress or whether distress increases the use of escape-avoidance coping. Nevertheless, our findings indicate that if either element is present, health care professionals should be attentive to the need for interventions to improve patients' well-being.

Recovering together: building resiliency in dyads of stroke patients and their caregivers at risk for chronic emotional distress; a feasibility study

BackgroundA stroke is a sudden, life-altering event with potentially devastating consequences for survivors and their loved ones. Despite advances in endovascular and neurocritical care approaches to stroke treatment and recovery, there remains a considerable unmet need for interventions targeting the emotional impact of stroke for both patients and their informal caregivers. This is important because untreated emotional distress becomes chronic and negatively impacts quality of life in both patients and caregivers. Our team previously used mixed methods to iteratively develop a six-session modular dyadic intervention to prevent chronic emotional distress in patients with stroke and their informal caregivers called “Recovering Together” (RT) using feedback from dyads and the medical team. The aim of the current study is to test the feasibility of recruitment, acceptability of screening and randomization methods, acceptability of RT, satisfaction with RT, feasibility of the assessment process at all time points, and acceptability of outcome measures. Secondarily, we aimed to explore within-treatment effect sizes and change in clinically significant symptoms of depression, anxiety, and post-traumatic stress (PTS). The larger goal was to strengthen methodological rigor before a subsequent efficacy trial.MethodsWe conducted a feasibility randomized controlled trial to evaluate the RT intervention relative to minimally enhanced usual care (MEUC) in stroke patients admitted to a Neurosciences Intensive Care Unit (Neuro-ICU). Dyads were enrolled within 1 week of hospitalization if they met specific eligibility criteria. Assessments were done via paper and pencil at baseline, and electronically via REDCap or over the phone at post-intervention (approximately 6 weeks after baseline), and 3 months later. Assessments included demographics, resiliency intervention targets (mindfulness, coping, self-efficacy, and interpersonal bond), and emotional distress (depression, anxiety, and PTS). Primary outcomes were feasibility and acceptability markers. Secondary outcomes were depression, anxiety, PTS, mindfulness, coping, self-efficacy, and interpersonal bond.ResultsWe consented 20 dyads, enrolled 17, and retained 16. Although many patients were missed before we could approach them, very few declined to participate or dropped out once study staff made initial contact. Feasibility of enrollment (87% of eligible dyads enrolled), acceptability of screening, and randomization (all RT dyads retained after randomization) were excellent. Program satisfaction (RT post-test M = 11.33/12 for patients M = 12/12 for caregivers), and adherence to treatment sessions (six of seven RT dyads attending 4/6 sessions) were high. There were no technical difficulties that affected the delivery of the intervention. There was minimal missing data. For both patients and caregivers, participation in RT was generally associated with clinically significant improvement in emotional distress symptoms from baseline to post-test. Participation in MEUC was associated with clinically significant worsening in emotional distress. Although some of the improvement in emotional distress symptoms decreased in the RT group between post-test to 3 months, these changes were not clinically significant. RT was also associated with substantial decrease in frequency of individuals who met criteria for clinically significant symptoms, while the opposite was true for MEUC. There were many lessons that informed current and future research.ConclusionsThis study provided evidence of feasibility and signal of improvement in RT, as well as necessary methodological changes to increase recruitment efficiency before the future hybrid efficacy-effectiveness trial.Trial registrationNCT02797509.

Development of in situ gels of nano calcium oxide for healing of burns

Abstract Background Wound closure is the prime objective in the treatment of deep and extensive burns, where the dermis layer is partially or completely destroyed and the inherent capability of spontaneous re-epithelialization is greatly reduced or absent leading to high mortality rate. Scar formation as a result of burn wounds results in aesthetic and functional impairment, causing emotional distress in patients. Induced regeneration of skin could be a solution to improve the quality of life of burned patients. Materials and methods Nano calcium oxide (NCO) was prepared by thermal decomposition method. In situ gels (ISG) were formulated using micronized xanthan gum and NCO in different concentrations by geometric mixing. The formulations were evaluated for their particle size, surface morphology, elemental composition, clarity, pH, gelling and in vivo burn wound healing properties. Results The average particle size and polydispersity index of NCO was found to be 345.3 nm and 0.23 respectively. Three formulations were prepared, each containing varied concentrations of NCO (12.5, 25 and 50 ppm). The SEM analysis of the formulation exhibited particle sizes ranging from 1 nm to 468 nm and EDX characterization showed intense peaks of calcium and oxygen. The percentage of wound size reduction was significantly increased in wounds treated with prepared in situ gels in contrast to commercial product (calcium alginate dressing) and control (untreated) group. With an increase in concentration of NCO, the rate of healing also increased. In situ gels containing 50 ppm of NCO exhibited a better rate of wound healing in comparison to other formulations, within a period of 15 days. Histopathological analysis indicated that in situ gels had better wound healing properties. Conclusion In situ gels of NCO were developed as a formulation for effective treatment of burns and to aid in skin regeneration.