Emotional Distress In Patients Research Articles

Influence of age, performance status, cancer activity, and IL-6 on anxiety and depression in patients with metastatic breast cancer

Depression and anxiety are the core disorders causing emotional distress in patients (pts) with metastatic breast cancer. The aim of our study was to screen metastatic breast cancer outpatients for anxiety and depression, and to investigate the influence of age, Karnofsky Performance Status (KPS), cancer activity, and inflammation as represented by IL-6 levels on these two mood disorders. Pts treated with chemotherapy for metastatic breast cancer (n = 70) were assessed using the Hospital Anxiety and Depression Scale (HADS) for symptoms (scores 0-21) and caseness (score ≥11) of clinical depression and anxiety. Blood samples for IL-6 concentrations were collected at 10:00 a.m. A total of 22 (31.4 %) pts were diagnosed with caseness of clinical depression and 23 (32.9 %) pts with clinical anxiety, while 12 pts were diagnosed positive for both mood disorders. Depression and anxiety were positively but moderately correlated (Spearman's r (2) = 0.24, p < 0.001). IL-6 was significantly correlated with symptoms of depression (r (2) = 0.42, p < 0.001) and to a lesser extent to symptoms of anxiety (r (2) = 0.16, p = 0.001). In addition, IL-6 was positively associated with tumor progression (p < 0.001). Multiple linear regression analysis showed that tumor progression (standardized b = 0.226, p = 0.047), symptoms of anxiety (b = 0.292, p = 0.016), and IL-6 (b = 0.314, p = 0.007) were independently associated with clinical depression, whereas anxiety was linked to tumor progression (b = 0.238, p = 0.030), symptoms of depression (b = 0.407, p < 0.001) and age (b = -0.381, p < 0.001), but not to IL-6 (b = 0.168, p = 0.134). Even though a positive correlation between depression and anxiety exists, clinical parameters like age, cancer activity, KPS, and IL-6 do influence depression and anxiety differently. Unlike clinical depression, anxiety is not associated with increased IL-6 levels, however, shows a reciprocal correlation with age.

Conspiración de silencio y malestar emocional en pacientes diagnósticados de glioblastoma multiforme

Aim: For those patients suffering serious illnesses with a poor prognosis, there continues to be a significant percentage of well-meaning family members who, out of a desire to protect the patient, decide to hide the truth, even if the patient wishes to know what the real situation is. Methods: To measure the incidence of conspiracies of silence within families and their repercussions on levels of anxiety and depression of patients diagnosed Glioblastoma Multiforme (GBM). Findings: 19.3 % of the families taking part thought that it would not be appropriate to give the patient information about their disease, despite the patient stating that he or she would like to know more about their disease. This conspiracy had an impact on the anxiety levels of the patient even a month after the discharge from hospital. At this point in the disease process, those patients where there was a conspiracy of silence demonstrated psychopathological levels of anxiety (12.71±2.28), whereas the levels of anxiety for those patients who were allowed more open communication showed levels which were below clinical significance (7.00±3.27). Conclusions: The needs for information of family members and patients with GBM are different and their repercussions on emotional distress in patients can continue during a prolonged period of time.

Under the tip of the iceberg: Psychological factors in incontinence

To highlight two main psychological factors (cognitive barriers and safety-behaviors) involved in the development and maintenance of emotional distress in patients with urinary incontinence (UI) and thus facilitate a better understanding of this condition and contribute to a more comprehensive treatment. Articles and books were reviewed up to December 2010 using a non-systematic research in MEDLINE and PsycINFO, focusing on the situations more frequently seen in our clinical experience. Several emotional symptoms that hinder a person's ability to benefit from urological treatment were found. An "accident" places a person at risk of developing a constant state of heightened worry and increased vigilance that predisposes the individual to develop significant anxiety and depression. Cognitive barriers such as dysfunctional beliefs, automatic negative thoughts, and cognitive biases are frequent. They affect patients' behavior and influence the development of coping strategies (safety-seeking behaviors) to manage symptoms and prevent feared consequences. Cognitions may act as barriers that lead to a misperception of one's health and maintain emotional distress. Safety behaviors are negatively reinforced and prevent disconfirmation of dysfunctional cognitions, thus maintaining the trouble and distress. Clinical examples are outlined. Cognitive barriers and safety behaviors explain some of the atypical psychological patterns seen in patients with UI. Future research should be oriented to design multimodal interventions and assess their impact on health outcomes. Whenever possible, the assessment of emotional, cognitive, and behavioral responses in individuals with UI could improve the management of this condition. Cognitive-behavioral therapy should be recommended to certain patients.

Detection of patient psychological distress and longitudinal patient–doctor relationships: a cross-sectional study

Psychological distress in patients who attend their GP is thought to be under-recognised. However, it is likely that both disclosure and detection are influenced by how well the patient and doctor know each another. To examine whether patient-doctor depth of relationship is associated with identification of psychological distress. Cross-sectional study in general practices in and around Bristol, England. Patients (aged ≥16 years) were asked to complete a questionnaire and consent to their electronic medical records being reviewed. Study GPs independently assessed patient psychological distress. Multivariable logistic regression was used to look for associations between patient-doctor depth of relationship and GP detection of patient psychological distress (defined according to the 12-item General Health Questionnaire, GHQ-12). There were 643 eligible appointments with 31 GPs. In total, 541 (84.1%) patients returned questionnaires and 490 (76.2%) consented to their records being reviewed. Patient-doctor depth of relationship was not associated with GP detection of mild to severe patient psychological distress (adjusted odds ratio [OR] 0.94, 95% CI = 0.87 to 1.02) but, in secondary analyses, it was associated with the identification of moderate to severe distress (adjusted OR 1.13, 95% CI = 1.02 to 1.26). GPs reported more patient psychological distress in patients who reported a greater depth of relationship but this did not relate to patients' GHQ-12 scores. Evidence to support an association between patient-doctor depth of relationship and improved GP detection of patients with psychological distress was weak, except in those patients who GPs thought were more distressed. GPs may overestimate emotional distress in patients who report deeper patient-doctor relationships.

The Problem Areas in Diabetes (PAID) scale: psychometric evaluation survey in a Greek sample with type 2 diabetes

Several instruments have been developed for the assessment of emotional distress in patients with diabetes. The Problem Areas in Diabetes Scale (PAID) is a brief self-report scale that evaluates diabetes-related distress. There is a lack of validated instruments for the evaluation of psychological aspects in patients with diabetes in Greek language. The current study was conducted to translate and adapt the PAID scale in Greek language and to evaluate the psychometric properties in two different study populations of patients with diabetes. The aim of this study was to translate the Problem Areas in Diabetes (PAID) scale into Greek, adapt it culturally to Greece and determine its psychometric properties. The translation process included two forward translations, reconciliation, backward translation and pre-testing steps. The validation incorporated the exploration of internal consistency (Cronbach's alpha), test-retest reliability (interclass correlation coefficient), construct validity (exploratory factor analysis) and responsiveness (Spearman correlation coefficient). Participants included 101 consecutive patients from a rural primary healthcare centre and 101 patients from an urban hospital. All patients completed the PAID scale and the Short Form-36 (SF-36) version 2. Internal consistency considered good (Cronbach's alpha = 0.948). Interclass correlation coefficient was 0.942 (95% CI 0.915-0.961). Factor analysis yielded three factors: 'Diabetes-related emotional problems' (51.79% variance, Cronbach's alpha = 0.910), 'Food-related problems' (9.55% variance, Cronbach's alpha = 0.824) and 'Social support-related problems' (5.96% variance, Cronbach's alpha = 0.704). Screen plot test and conceptual congruency of items supported a three-factor solution. Total PAID showed a negative correlation with both SF-36 mental component summary (r = -0.733, P < 0.0001) and SF-36 physical component summary (r = -0.594, P < 0.0001). Our findings indicate that the Greek version of the PAID questionnaire is reliable and valid for patients with diabetes mellitus in Greece.

The Relationship Between the Severity of Depressive Symptoms and Diabetes-Related Emotional Distress in Patients with Type 2 Diabetes

To examine the relationship between the severity of depressive symptoms and the burden through diabetes care, or diagnosed diabetes in patients with type 2 diabetes, irrespective of the diabetic complications and glycemic control. Subjects were 126 outpatients with type 2 diabetes who completed the Beck Depression Inventory-II (BDI-II), Problem Areas in Diabetes (PAID) scale, and Short Form-36 (SF-36). The factor with a significant impact on the BDI-II score in the multiple regression model was the PAID score (standardized coefficient =0.17, 95% confidence interval [CI], 0.12-0.21). The factors having a significant impact on the physical component summary of SF-36 (PCS) in the multiple regression model were BDI-II score (-0.95; 95% CI, -1.32 - -0.58), age (-0.43; 95% CI, -0.61 - -0.25), and the number of complicated macroangiopathies (-8.90; 95% CI, -12.71 - -5.08). The factors with a significant impact on the mental component summary of SF-36 (MCS) in the multiple regression model were BDI-II score (-0.90; 95% CI, -1.16 - -0.65) and age (0.13; 95% CI, 0.00-0.25). These findings show that diabetes-related emotional distress is significantly related to the severity of depressive symptoms in patients with type 2 diabetes, independent of the severity of complications and glycemic control. Moreover, the severity of depressive symptoms is negatively correlated with comprehensive health-related QOL in patients with type 2 diabetes. Clinicians need to consider factors other than indices of metabolic control and diabetic complications, in determining the adverse effects of depressive symptoms on the physical QOL of patients with type 2 diabetes.

Health-related quality of life in high-grade glioma patients: a prospective single-center study

In this single center study, we aimed to assess quality of life and cognitive and emotional distress in patients treated for high-grade glioma. A hundred and eighteen patients with high-grade glioma were prospectively enrolled. We assessed HRQoL at baseline (after surgery before radiotherapy), at the end of radiotherapy and during follow-up (every 3 months for the first 2 years and every 6 months between 2 and 5 years) using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC-C30), Brain Cancer Module-20 (BN-20), Minimental State Examination (MMSE) and Hospital Anxiety and Depression Scale (HADS). Baseline scores, and first 18-month follow-up period scores were included to statistical analysis. Sixty-five (55%) patients had progressive tumor. Global score, physical, role and emotional function, insomnia (p for each <0.001) and appetite loss (p: 0.008) scores of EORTC-C30 significantly related to disease progression. According to BN-20 seizure and leg weakness (p < 0.001), drowsiness and bladder control (p: 0.002), motor dysfunction (p: 0.001), future uncertainty (p: 0.04), visual disorder (p: 0.008) and communication deficit (p: 0.006) symptoms significantly related to disease progression. There were significant decrements in orientation, attention and calculation and language scores (p values were 0.017, 0.005 and 0.003, respectively) of MMSE. The baseline and follow-up anxiety and depression scores did not differ significantly. We conclude that there were many changes in patients with high-grade glioma during the course of the disease and most of them were related to disease progression.

P32 Emotional distress in patients with an implantable defibrillator and their partners

P32 Emotional distress in patients with an implantable defibrillator and their partners

Predictors of emotional distress in patients with head and neck cancer

Patients with head and neck cancer are known to be more commonly emotionally distressed than patients with other tumors. This study investigates reasons for this difference. Patients in this prospective cohort study included those with head and neck cancer (n = 113) and those with other cancers (n = 1690). The Hospital Anxiety and Depression Scale, measuring emotional distress, along with additional questions regarding emotional support wished and provided were administered. Patients with head and neck tumors were 1.5-fold (at the time of admission), 1.2-fold (before discharge), and 2.7-fold (half a year after admission) more frequently distressed than the other patients with cancer. This association was confounded by perceived social support and sociodemographic factors. Patients with head and neck cancer expressed less frequently the wish for and received less support by psycho-oncologists. Emotional distress is more common in patients with head and neck tumors; this is largely a result of the psychosocial context the patients live in, especially the amount of social support received.

The management of depressive symptoms in patients with COPD: a postal survey of general practitioners

We examined the management of depression by general practitioners (GPs), through the use of case vignettes, in patients with chronic obstructive pulmonary disease (COPD), severe osteoarthritis and depressive symptoms alone. Depression is common in patients with COPD. Untreated depression leads to poor compliance with medical treatment and increases health-care utilisation. We surveyed a random sample of GPs (n = 3956) in England using a postal questionnaire. The questionnaire explored how GPs would approach the management of emotional distress in patients with and without a chronic condition and gauged their views of and experiences with depression in patients with COPD. A total of 864 completed responses were received (22%). In the vignettes, a significantly greater percentage of GPs reported that they would explore or offer the diagnosis of depression in a patient with COPD (95.4%) compared with patients with either severe osteoarthritis (88.3%) or depressive symptoms alone (86.3%). In each case, the vast majority of GPs reported that they would explore a diagnosis of depression using a clinical diagnostic tool. The preferred method of treatment, if offered, in all three cases was a combination of anti-depressant drugs and psychological therapy. GPs endorsed the importance of routinely screening for depression in patients who have COPD and acknowledged that depression impairs patient self-management of COPD.In conclusion, GPs in England were able to diagnose depression from the vignettes and plan appropriate treatment strategies in patients with chronic diseases. This should be complemented with thorough physical examination by GPs to rule out other factors such as the impact of physical illness. GPs believe depression interferes with patient self-management of COPD.

The ToT Study: Helping with Touch or Talk (ToT): a pilot randomised controlled trial to examine the clinical effectiveness of aromatherapy massage versus cognitive behaviour therapy for emotional distress in patients in cancer/palliative care

Distress associated with cancer often presents with symptoms of depression and/or anxiety. Cognitive Behaviour Therapy (CBT) is one of the most effective psychological treatments. Complementary therapies, especially aromatherapy massage (AM), are also popular and alleviate anxiety. No studies have directly compared these two treatments. The aim of this study is to (1) test the feasibility of recruitment into a randomised controlled trial of AM versus CBT in patients with cancer; (2) test and modify the intervention; (3) determine whether changes in outcomes were consistent with published data. Patients at all stages of cancer, recruited from oncology outpatient clinics and screening eight or more for anxiety and/or depression on the HADS, were randomised to Treatment as Usual (TAU) plus up to eight sessions weekly of either AM or CBT, offered within 3 months. The POMS was collected at baseline and 3 and 6 months post baseline. Of those suitable, over 60% (39/63) participated (AM, n = 20; CBT, n = 19) and over 90% (36/39) were followed up. Both packages were well received. The preference was for AM, with more sessions were taken up; (Mean number sessions AM = 7.2 (SD 2.0) and CBT = 5.4 (SD 3.1); P<0.05). Significant improvements in POMS (Total Mood, depression and anxiety scores) occurred with both interventions. Between-group comparison showed a non-significant trend towards greater improvement in depression with CBT. Recruitment was feasible; the interventions acceptable and engagement with treatment was high. Improvements with both interventions were observed. The beneficial effects on depression with CBT appeared to be sustained.

P32 Poster Emotional distress in patients with an implantable defibrillator and their partners

P32 Poster Emotional distress in patients with an implantable defibrillator and their partners

Cognitive-Behavioral Therapy in Patients with Coronary Artery Disease

Despite the general benefits of cognitive-behavioral therapy (CBT) in reducing emotional distress in patients with cardiovascular disease (CVD), prior

Emotional Distress in Patients with Advanced Heart Failure

Chronic heart failure (CHF) is a leading cause of death, with a rising prevalence. The disease has a high symptom burden and a negative impact on patients’ quality of life. However, as a result of difficulties in prognostication in relation to CHF, palliative care services do not always become involved in the care of patients with CHF. Emotional distress is especially common in the advanced stages of disease, including CHF. The term ‘emotional distress’ encompasses psychiatric symptoms such as depression and anxiety, as well as the wider spectrum of entities such as low mood. Emotional distress is a less stigmatising term than the more psychiatric-based terms. This article provides an overview of the prevalence, pathophysiology and symptoms of emotional distress in patients in the advanced stages of CHF. It summarises evidence on the psychological needs of patients and provides recommendations regarding the assessment of emotional distress at the end of life. It is hoped that the article will increase understanding of the psychological symptom burden in patients with advanced heart failure. Conflicts of interest: none

High Prevalence of Mental Disorders and Emotional Distress in Patients with Chronic Spontaneous Urticaria

Quality of life, which is impaired in patients with chronic spontaneous urticaria (CSU), is influenced by comorbid mental disorders. The aim of this study was to assess the prevalence and spectrum of mental disorders and to determine levels of emotional distress in patients with CSU. One hundred patients with CSU were investigated for mental disorders (by specialized diagnostic interviews and psychometric instruments), levels of emotional distress (by the Global Severity Index of the Symptom Check List; SCL-90R GSI) and underlying causes of their urticaria (by dermatological assessment). Forty-eight percent of patients with CSU were diagnosed with one or more psychosomatic disorders; most common were anxiety disorders (especially phobias), followed by depressive and somatoform disorders. The use of psychometric instruments confirmed these findings. Levels of emotional distress were significantly higher and more commonly increased in patients with CSU with mental disorders. In conclusion, patients with CSU frequently experience anxiety, depression, and somatoform disorders, and these disorders are linked to increased emotional distress. These findings call for screening of patients with CSU for mental disorders in routine clinical practice as well as for controlled clinical trials.

Impacto do cancro do osso e tecidos moles no ajustamento emocional e qualidade de vida

Introduction The aim of the present study was the comparison of emotional adjustment and quality of life (QoL) of bone and soft tissue cancer patients that were in different phases of the disease trajectory. Material and methods Fifty five patients between diagnosis and treatment initiation, 55 under treatment and 74 in follow-up consultations were assessed using self-report questionnaires. Seventy persons from the general population were used as control group. In the different phases of the disease the majority of patients revealed normal or mild levels of anxiety and depression but, an important minority showed moderate to severe levels. Results In general, the emotional distress of patients in each phase of the disease was not clinically relevant and was comparable to that of healthy individuals. Only patients under treatment exhibited significant higher levels of depression compared to survivors in the follow-up phase. In diagnostic and treatment phase patients reported a poorer perception of overall and physical QoL compared to survivors and healthy controls. The impact on QoL, in general, seems more marked in the treatment phase given the worse levels of functioning in several domains of life, and the higher experience of physical symptoms, mainly compared with the follow-up phase. Free-disease survivors showed a QoL comparable to that of healthy individuals, in its different dimensions. Conclusions The number of patients with significant levels of emotional distress (between 25% and 29.6% for anxiety, and 8.3% and 23.6% for depression), and the impact of bone and soft tissue cancer on QoL, mainly in diagnostic phase and during treatments, call to the need of implementing multidisciplinary interventions in patients with this specific cancer diagnose. These interventions should include a psychosocial component and be adapted to each phase of the disease trajectory.

The distressed (Type D) personality in both patients and partners enhances the risk of emotional distress in patients with an implantable cardioverter defibrillator

BackgroundA subgroup of patients with an implantable cardioverter defibrillator (ICD) experiences emotional distress. This may be related to partner factors. We examined the impact of the personality of the partner (i.e., the distressed (Type D) personality) in combination with that of the patient on anxiety and depression levels in ICD patients. MethodsConsecutively implanted ICD patients (N=281; 80.1% men; mean age=58.3±11.0) and their partners (N=281; 20.6% men; mean age=56.5±11.7) completed the Type D Scale at baseline; patients also completed the Hospital Anxiety and Depression Scale at baseline and 6months post-implantation. ResultsANOVA for repeated measures, using the Type D main effects and the interaction effect, showed that the interaction time by Type D patient by Type D partner was significant (F(1,277)=7.0, p=.009) for depression as outcome, but not for anxiety (F(1,277)=3.1, p=.08). Post-hoc comparisons revealed that Type D patients with a Type D partner (n=23/281, 8.2%) experienced the highest depression levels compared to other personality combinations (all ps<.05). LimitationsThe group of Type D patients with a Type D partner was rather small. ConclusionsICD patients with a Type D personality report more depressive symptoms, but not anxiety, if the partner also has a Type D personality. This may be due to poor communication and lack of emotional support in the relationship. These results emphasize the importance of taking into account the psychological profile of the partner in the management and care of the ICD patient, and to direct behavioural support not only at the ICD patient but also at the partner.

Surgical resection margins do not influence health related quality of life or emotional distress in patients with cutaneous melanoma: Results of a prospective randomised trial

In a prospective randomised Scandinavian trial, patients with localised invasive cutaneous melanoma of the trunk or extremities with tumours more than 2 mm thick were randomly assigned to excision with narrow (2 cm) or wide (4 cm) margins after primary surgery. The aims of the present study were to find out if there were any differences in health-related quality of life (QoL) and emotional distress between patients in the two arms over time. Patients were assessed at four time points: before randomisation, and at 3, 9, and 15 months after inclusion, using the EORTC QLQ-C30, the Hospital Anxiety and Depression Scale and the Impact of Event Scale. A study-specific questionnaire was used to assess patient-reported problems related to the scar. A total of 144 patients were included; 70 randomised to narrow excision and 74 to wide excision margins. The response rate was >85% at all assessment points. No differences between the two arms were found for health-related QoL or emotional distress. Emotional functioning, insomnia, anxiety, intrusion, and avoidance improved over time (p ≤ 0.0001). Thirty patients (32%) reported problems with the scar but there was no difference between the two arms. No differences in health-related QoL or emotional distress were found between the two arms, indicating that resection margins have limited impact on these variables.

Debilitating beliefs and emotional distress in patients given immunotherapy for insect sting allergy: A prospective study

Patients who receive venom immunotherapy (VIT) for systemic reactions (SRs) to insect stings are advised that once they reach the maintenance dose they are almost 100% protected against future SRs. However, initial evidence indicates that some patients continue to perceive themselves as highly debilitated by the allergy and are preoccupied with the allergic event. These factors have significant impact on their emotional well-being and allergy-related quality of life (ARQOL). We aimed to explore prospectively whether patients would experience these adverse psychological outcomes after receiving VIT coupled with professional explanation and reassurance of protection. Thirty-four patients who received VIT for systemic insect allergy and were under close medical surveillance were included. Before and 1 year after initiation of treatment, patients completed a questionnaire that measured debilitating beliefs, preoccupation with the SR event, emotional distress ARQOL, and QOL in general. Physician-graded severity of the reaction was recorded as well. VIT had a beneficial effect on all allergy-related variables. Self-imposed debilitating beliefs, preoccupation with the anaphylactic event, and ARQOL significantly but modestly improved over time. No association was found between ARQOL and QOL in general. The later variable as well as emotional distress remained unchanged after the VIT. This study shows that patients with sting allergy guided by trained personnel and treated with VIT show a reduction in dysfunctional beliefs and an improvement in ARQOL. Disputing medically unfounded beliefs that persist in some patients might improve their ARQOL.

Uncertainty and Emotional Distress in Patients with Heart Failure and Their Primary Caregivers – A Novel Study

Background: Qualitative studies have reported feelings of uncertainty in patients with heart failure and their primary caregivers. Even though uncertainty has been associated with emotional distress in a variety of populations, there have not been any published quantitative studies exploring the relationship between uncertainty and emotional status in HF patients and their primary caregivers. Purpose: The purpose of this study was to determine if there were relationships among feelings of uncertainty and symptoms of depression and anxiety in HF patients and their primary caregivers.